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MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Tubulin inhibitor
ROUTE OF ADMINISTRATION: INJECTION
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Fibromatosis, Aggressive; Kidney Neoplasms; Melanoma; Mesothelioma; Sarcoma; Urethral Neoplasms; Lung Neoplasms; Neoplasms, Germ Cell and Embryonal; Ovarian Neoplasms; Prostatic Neoplasms, Castration-Resistant; Testicular Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Communicable Diseases; Hodgkin Disease; Lymphoma; Lymphoma, Large B-Cell, Diffuse
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Glucocorticoid receptor agonist
ROUTE OF ADMINISTRATION: INJECTION
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Dry Eye Syndromes; Osteoarthritis; Periarthritis; Tendinopathy; Colitis, Ulcerative; Eye Diseases; Hemorrhoids; Lung Diseases, Obstructive; Nasal Obstruction
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Panic Disorder; Respiratory Tract Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Sodium channel alpha subunit blocker
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Carcinoma, Squamous Cell; Chronic Pain; Keratosis, Actinic; Neuralgia, Postherpetic; Pregnancy; Skin Diseases; Pain
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Enoyl-[acyl-carrier-protein] reductase inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary; Tuberculosis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Pancreatic Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Sodium channel alpha subunit blocker
ROUTE OF ADMINISTRATION: INJECTION
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Glucocorticoid receptor agonist
ROUTE OF ADMINISTRATION: TOPICAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Renal Insufficiency, Chronic; Skin Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Glucocorticoid receptor agonist
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Osteoarthritis; Tendinopathy; Anemia; Asthma; Colitis, Ulcerative; Dermatitis; Eye Diseases; Hemorrhoids; Lung Diseases, Obstructive; Nasal Obstruction; Nephrotic Syndrome; Serum Sickness
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: GABA-A receptor; anion channel positive allosteric modulator
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: HIV Infections; Tobacco Use Disorder; Dementia; Depressive Disorder; Schizophrenia; Anxiety; Anxiety Disorders; Mental Disorders
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Penicillin-binding protein inhibitor
ROUTE OF ADMINISTRATION: INJECTION; ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Central Nervous System Neoplasms; Brain Neoplasms; Carcinoma, Renal Cell; Constriction, Pathologic; Glioma; Leukemia, Myeloid, Acute; Neurofibromatosis 1; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Histiocytosis, Langerhans-Cell; Hodgkin Disease; Leukemia; Lung Neoplasms; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, T-Cell, Peripheral; Melanoma; Prostatic Neoplasms, Castration-Resistant; Skin Neoplasms; Testicular Neoplasms; Urethral Neoplasms; Urinary Bladder Neoplasms; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Bacterial penicillin-binding protein inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Dystonic Disorders; Chorioamnionitis; Cleft Palate; Pneumonia; Sepsis; Bacterial Infections; Eye Infections; Gonorrhea; Infections; Meningitis; Meningitis, Bacterial
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Adrenergic receptor agonist
ROUTE OF ADMINISTRATION: INHALATION
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Pain
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Bacteremia; Gram-Positive Bacterial Infections; Infections; Osteomyelitis; Bacterial Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: DNA inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Lymphoma, Non-Hodgkin; Glioblastoma; Histiocytosis, Langerhans-Cell; Hodgkin Disease; Leukemia, Lymphoid; Anemia, Refractory; Anemia, Refractory, with Excess of Blasts; Brain Neoplasms; Leukemia; Leukemia, Basophilic, Acute; Leukemia, Biphenotypic, Acute; Leukemia, Erythroblastic, Acute; Leukemia, Megakaryoblastic, Acute; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Acute; Leukemia, Myelomonocytic, Chronic; Lymphoma; Myelodysplastic Syndromes; Myeloproliferative Disorders; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Progesterone receptor agonist
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Xanthine dehydrogenase inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Inflammatory Bowel Diseases; Leukemia, Biphenotypic, Acute; Osteoarthritis; Small Cell Lung Carcinoma; Tuberculosis; Angina, Stable; Diabetes Mellitus; Essential Hypertension; Fallopian Tube Neoplasms; Hand-Foot Syndrome; Heart Failure; Kidney Calculi; Leishmaniasis; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myeloid, Acute; Metabolic Syndrome; Multiple Myeloma; Myelodysplastic Syndromes; Myeloproliferative Disorders; Ovarian Neoplasms; Peritoneal Neoplasms; Renal Insufficiency, Chronic; Bipolar Disorder; Cardiovascular Diseases; Colitis, Ulcerative; Diabetes Mellitus, Type 2; Heart Diseases; Hernias, Diaphragmatic, Congenital; Hypertension; Hyperuricemia; Lymphoma, Non-Hodgkin; Obesity; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sprains and Strains; Tumor Lysis Syndrome; Gout; Leukemia; Lymphoma; Neoplasms; Response Evaluation Criteria in Solid Tumors
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Sodium-(potassium)-chloride cotransporter 2 inhibitor
ROUTE OF ADMINISTRATION: INJECTION; ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Diabetes Mellitus; Dyspnea; Edema; Leukemia; Leukemia, Myeloid, Acute; Melanoma; Schizophrenia; Acute Kidney Injury; Acute Lung Injury; Bronchopulmonary Dysplasia; Hypertension, Pregnancy-Induced; Keratosis, Actinic; Nasal Polyps; Neoplasms; Renal Insufficiency, Chronic; Atherosclerosis; Bronchiolitis; Coronary Disease; Diabetes Mellitus, Type 2; Essential Hypertension; Hypercholesterolemia; Kidney Diseases; Lung Diseases; Myocardial Infarction; Pre-Eclampsia; Pulmonary Embolism; Renal Insufficiency; Tachypnea; Warts; Cardiovascular Diseases; Fibrosis; Heart Failure; Hypertension; Liver Cirrhosis; Nephrotic Syndrome; Pulmonary Edema; Syndrome
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: DNA inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Polycythemia Vera; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Sulfonylurea receptor 1, Kir6.2 blocker
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Diabetes Mellitus; Diabetes Mellitus, Type 2
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Bacterial dihydropteroate synthase inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Bacterial Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Tubulin inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Helminthiasis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Dysuria; Bacterial Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: D2-like dopamine receptor inverse agonist
ROUTE OF ADMINISTRATION: INJECTION; ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Huntington Disease; Tobacco Use Disorder; Aggression; Amphetamine-Related Disorders; Mood Disorders; Alzheimer Disease; Anxiety; Bipolar Disorder; Delirium; Dementia; Depressive Disorder; Nausea; Postoperative Complications; Psychomotor Agitation; Conduct Disorder; Psychotic Disorders; Schizophrenia; Tics; Tourette Syndrome
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Bacterial 70S ribosome inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Melanoma; Rhinoscleroma; Adenomatous Polyposis Coli; Amyloidosis; Amyloidosis, Familial; Aneurysm; Aortic Aneurysm, Abdominal; Blepharitis; Carcinoma, Non-Small-Cell Lung; Colitis, Ulcerative; Colorectal Neoplasms; Crohn Disease; Cystic Fibrosis; Dermatitis, Atopic; Diabetic Foot; Diabetic Retinopathy; Dry Eye Syndromes; Eczema; Emphysema; Eye Burns; Graves Ophthalmopathy; Immunoglobulin Light-chain Amyloidosis; Lichen Planus, Oral; Lymphoma, Follicular; Lymphoma, Non-Hodgkin; Mansonelliasis; Marfan Syndrome; Mycosis Fungoides; Myocardial Infarction; Neoplasms; Pain; Pancreatic Neoplasms; Parkinson Disease; Pelvic Inflammatory Disease; Plague; Reperfusion Injury; Seizures; Sezary Syndrome; Squamous Cell Carcinoma of Head and Neck; Alzheimer Disease; Arthritis, Reactive; Chlamydia Infections; Elephantiasis, Filarial; Hemorrhage; Idiopathic Pulmonary Fibrosis; Lyme Disease; Lymphoma; Osteoarthritis; Persian Gulf Syndrome; Pleural Effusion; Pulmonary Disease, Chronic Obstructive; Scrub Typhus; Severe Acute Respiratory Syndrome; Syphilis; Tuberculosis; Urethritis; Acne Vulgaris; Anthrax; Bacterial Infections; Brucellosis; Cholera; Gonorrhea; Infections; Malaria; Periodontitis; Pneumonia; Psittacosis; Rocky Mountain Spotted Fever; Rosacea; Spotted Fever Group Rickettsiosis; Tularemia; Typhus, Epidemic Louse-Borne
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Arabinosyltransferase A inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: HIV Infections; Mycobacterium avium-intracellulare Infection; Tuberculosis; Tuberculosis, Pulmonary
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Leiomyoma; Acromegaly; Anovulation; Hypogonadism; Infertility, Female; Obesity; Paget Disease, Extramammary; Azoospermia; Infertility; Polycystic Ovary Syndrome
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Norepinephrine transporter inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Depressive Disorder
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Bacterial 70S ribosome inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Peroxisome proliferator-activated receptor alpha agonist
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Myocardial Infarction; Myocardial Ischemia; Cardiovascular Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Bacterial 70S ribosome inhibitor
ROUTE OF ADMINISTRATION: INJECTION; ORAL; PERIODONTAL
STATUS: Approved
THERAPEUTIC AREA: DENTISTRY; OTHER
THERAPEUTIC INDICATION: Pelvic Inflammatory Disease; Tennis Elbow; Graves Ophthalmopathy; Macular Degeneration; Mucositis; Sexually Transmitted Diseases, Bacterial; Telangiectasia, Hereditary Hemorrhagic; Chlamydia Infections; Periodontitis; Rosacea; Acne Vulgaris
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Depressive Disorder, Major; Fibromyalgia; Hemangioma, Cavernous, Central Nervous System; Kidney Diseases; Memory Disorders; Orthostatic Intolerance; Pulmonary Disease, Chronic Obstructive; Alcohol Drinking; Anemia, Sickle Cell; Asthma; Breast Neoplasms; Burns; Carcinoma, Hepatocellular; Carcinoma, Renal Cell; Cocaine-Related Disorders; Diabetes Mellitus, Type 1; Dystocia; Hemangiosarcoma; Hypertension; Hypotension; Hypotension, Orthostatic; Low Back Pain; Lymphedema; Macular Degeneration; Marfan Syndrome; Melanoma; Migraine with Aura; Migraine without Aura; Multiple Myeloma; Pain; Pancreatic Neoplasms; Panic Disorder; Papilloma; Retinopathy of Prematurity; Shoulder Pain; Sleep Apnea, Obstructive; Stomach Neoplasms; Stress Disorders, Traumatic, Acute; Stroke; Substance-Related Disorders; Syncope; Wounds and Injuries; Anxiety; Ascites; Brain Injuries; Colorectal Neoplasms; Death, Sudden, Cardiac; Esophageal and Gastric Varices; Headache; Hemangioma; Hypertension, Portal; Liver Cirrhosis; Migraine Disorders; Myocardial Infarction; Myocardial Ischemia; Smoking Cessation; Stress Disorders, Post-Traumatic; Tachycardia, Supraventricular; Telangiectasia, Hereditary Hemorrhagic; Ventricular Fibrillation; Cardiovascular Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: DNA inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Infections; Urinary Tract Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Cyclooxygenase inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Diabetes Mellitus; Pain; Hemorrhage; Dysmenorrhea; Rheumatic Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Thyroid hormone receptor agonist
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Down Syndrome; Cardiovascular Diseases