Cytochrome P450 24A1
Ensembl ID : ENSG00000019186
Gene: CYP24A1
UniProtKB Entry: Q07973
Assay organism Assay description Assay tissue Bioactivities Reference
KETOCONAZOLE
Inhibition of CYP24A1 in human epidermal keratinocytes — IC50 = 126.0 nM
KETOCONAZOLE
Inhibition of human CYP24A1 expressed in chinese hamster V79 cells — IC50 = 312.0 nM
KETOCONAZOLE
Inhibition of human recombinant CYP24A1 expressed in chinese hamster V79 cells using [3H-1-beta]calcitriol after 60 mins by scintillation counting — IC50 = 520.0 nM

>ENSG00000019186|Cytochrome P450 24A1
MSSPISKSRSLAAFLQQLRSPRQPPRLVTSTAYTSPQPREVPVCPLTAGGETQNAAALPGPTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYRTESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNEPVEMLHSGTLVPSRELPIAFCQR

Identifier Resolution Method Chain Positions Source
3K9V 2.50 Å X-ray A/B 34-514 PDB
3K9Y 2.80 Å X-ray A/B 34-514 PDB
Metabolism R-HSA-1430728
Disease R-HSA-1643685
Vitamin D (calciferol) metabolism R-HSA-196791
Biological oxidations R-HSA-211859
Cytochrome P450 - arranged by substrate type R-HSA-211897
Vitamins R-HSA-211916
Phase I - Functionalization of compounds R-HSA-211945
Metabolism of lipids R-HSA-556833
Defective CYP24A1 causes HCAI R-HSA-5579010
Metabolic disorders of biological oxidation enzymes R-HSA-5579029
Diseases of metabolism R-HSA-5668914
Metabolism of steroids R-HSA-8957322
Expression Atlas ENSG00000019186
GeneCards 2602
HGNC Symbol HGNC:2602
MIM gene 126065
MIM morbid 143880
NCBI gene (formerly Entrezgene) 1591
UniProtKB Gene Name Q07973
WikiGene 1591