Mechanism of Action

Select Keyword(s):

11-beta-hydroxysteroid dehydrogenase 1 inhibitor (4)

70S ribosome inhibitor (4)

ALK tyrosine kinase receptor inhibitor (7)

Acetylcholinesterase inhibitor (8)

Adenosine A1 receptor agonist (7)

Adenosine A1 receptor antagonist (6)

Adenosine A2a receptor agonist (7)

Adenosine A2a receptor antagonist (8)

Adenosine A2b receptor antagonist (3)

Adenosine receptor antagonist (4)

Adrenergic receptor alpha-1 antagonist (3)

Adrenergic receptor alpha-2 agonist (3)

Adrenergic receptor alpha-2 antagonist (5)

Aldose reductase inhibitor (3)

Anandamide amidohydrolase inhibitor (3)

Androgen Receptor agonist (13)

Androgen Receptor antagonist (11)

Androgen Receptor modulator (9)

Angiotensin-converting enzyme inhibitor (7)

Arachidonate 5-lipoxygenase inhibitor (5)

Bacterial 70S ribosome inhibitor (26)

Bacterial DNA gyrase inhibitor (16)

Bacterial DNA-directed RNA polymerase inhibitor (5)

Bacterial dihydrofolate reductase inhibitor (3)

Bacterial dihydropteroate synthase inhibitor (17)

Bacterial penicillin-binding protein inhibitor (43)

Beta-1 adrenergic receptor antagonist (9)

Beta-2 adrenergic receptor agonist (16)

Beta-2 adrenergic receptor antagonist (5)

Beta-3 adrenergic receptor agonist (6)

Beta-secretase 1 inhibitor (3)

Bile acid receptor FXR agonist (7)

Bradykinin B1 receptor antagonist (3)

Bromodomain and extra-terminal motif (BET) inhibitor (3)

C-C chemokine receptor type 1 antagonist (3)

C-C chemokine receptor type 2 antagonist (6)

C-C chemokine receptor type 5 antagonist (7)

CRL4(CRBN) E3 ubiquitin ligase inhibitor (3)

Calcitonin gene-related peptide type 1 receptor antagonist (6)

Cannabinoid CB1 receptor agonist (4)

Cannabinoid CB1 receptor antagonist (5)

Cannabinoid CB2 receptor agonist (7)

Carbonic anhydrase I inhibitor (5)

Carbonic anhydrase II inhibitor (6)

Carbonic anhydrase IV inhibitor (4)

Catechol O-methyltransferase inhibitor (4)

Cell division cycle 7-related protein kinase inhibitor (4)

Cell membrane disrupting agent (4)

Cell membrane inhibitor (3)

Cholesteryl ester transfer protein inhibitor (6)

Coagulation factor X inhibitor (5)

Corticotropin releasing factor receptor 1 antagonist (4)

Cyclin-dependent kinase 1 inhibitor (8)

Cyclin-dependent kinase 2 inhibitor (10)

Cyclin-dependent kinase 4 inhibitor (10)

Cyclin-dependent kinase 5 inhibitor (3)

Cyclin-dependent kinase 6 inhibitor (4)

Cyclin-dependent kinase 7 inhibitor (4)

Cyclin-dependent kinase 9 inhibitor (6)

Cyclin-dependent kinase inhibitor (4)

Cyclooxygenase inhibitor (35)

Cyclooxygenase-2 inhibitor (15)

Cysteinyl leukotriene receptor 1 antagonist (3)

Cystic fibrosis transmembrane conductance regulator positive modulator (5)

Cytochrome P450 17A1 inhibitor (3)

Cytochrome P450 19A1 inhibitor (4)

Cytochrome P450 51 inhibitor (12)

D2-like dopamine receptor antagonist (3)

DNA cross-linking agent (10)

DNA disrupting agent (10)

DNA gyrase inhibitor (8)

DNA inhibitor (62)

DNA polymerase (alpha/delta/epsilon) inhibitor (4)

DNA polymerase/reverse transcriptase inhibitor (6)

DNA topoisomerase I inhibitor (9)

DNA topoisomerase II alpha inhibitor (4)

DNA topoisomerase II inhibitor (8)

Diagnostic agent (44)

Dihydrofolate reductase inhibitor (5)

Dihydroorotate dehydrogenase inhibitor (5)

Dipeptidyl peptidase IV inhibitor (11)

Dopamine D2 receptor agonist (3)

Dopamine D2 receptor antagonist (33)

Dopamine D2 receptor partial agonist (6)

Dopamine D3 receptor antagonist (5)

Dopamine transporter inhibitor (4)

Dopamine transporter releasing agent (3)

Dual specificity mitogen-activated protein kinase kinase 1 inhibitor (13)

Dual specificity mitogen-activated protein kinase kinase 2 inhibitor (12)

Endothelin receptor ET-A antagonist (7)

Endothelin receptor ET-B antagonist (3)

Endothelin receptor, ET-A/ET-B antagonist (4)

Epidermal growth factor receptor erbB1 inhibitor (45)

Epidermal growth factor receptor inhibitor (3)

Ergosterol sequestering agent (3)

Estrogen receptor agonist (7)

Estrogen receptor alpha agonist (8)

Estrogen receptor beta agonist (5)

Estrogen receptor modulator (12)

FK506-binding protein 1A inhibitor (7)

Fibroblast growth factor receptor 1 inhibitor (8)

Fibroblast growth factor receptor 2 inhibitor (6)

Fibroblast growth factor receptor 3 inhibitor (5)

Fibroblast growth factor receptor inhibitor (12)

Focal adhesion kinase 1 inhibitor (6)

G protein-coupled receptor 44 antagonist (14)

GABA receptor alpha-2 subunit positive allosteric modulator (3)

GABA-A receptor; anion channel positive allosteric modulator (34)

GABA-A receptor; anion channel positive modulator (6)

GABA-B receptor agonist (3)

Gamma-secretase inhibitor (4)

Ghrelin receptor agonist (3)

Glucagon receptor antagonist (4)

Glucocorticoid receptor agonist (34)

Glucocorticoid receptor antagonist (4)

Glucocorticoid receptor modulator (3)

Glutamate NMDA receptor; GRIN1/GRIN2B antagonist (4)

Glutamate [NMDA] receptor antagonist (7)

Glutamate receptor ionotropic AMPA antagonist (7)

Glutamate receptor ionotropic AMPA positive allosteric modulator (5)

Glutamate receptor ionotropic kainate antagonist (3)

Glycine receptor (alpha-1/beta) positive modulator (4)

Glycine transporter 1 inhibitor (3)

Gonadotropin-releasing hormone receptor antagonist (5)

HERG blocker (4)

Heat shock protein HSP90 inhibitor (7)

Hepatitis C virus NS5B RNA-dependent RNA polymerase inhibitor (14)

Hepatitis C virus serine protease, NS3/NS4A inhibitor (15)

Hepatocyte growth factor receptor inhibitor (25)

Hexokinase type IV activator (4)

Histamine H1 receptor antagonist (30)

Histamine H2 receptor antagonist (4)

Histamine H3 receptor antagonist (11)

Histamine H3 receptor inverse agonist (3)

Histone deacetylase inhibitor (6)

Human herpesvirus 1 DNA polymerase inhibitor (6)

Human immunodeficiency virus type 1 integrase inhibitor (5)

Human immunodeficiency virus type 1 protease inhibitor (7)

Human immunodeficiency virus type 1 reverse transcriptase inhibitor (23)

Ileal bile acid transporter inhibitor (5)

Inhibitor of nuclear factor kappa B kinase beta subunit inhibitor (7)

Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor (5)

Insulin-like growth factor I receptor inhibitor (6)

Interleukin-8 receptor B antagonist (4)

Iron chelating agent (3)

Iron sequestering agent (4)

Janus Kinase (JAK) inhibitor (4)

Kappa opioid receptor antagonist (3)

Kelch-like ECH-associated protein 1 inhibitor (3)

Kinesin-like protein 1 inhibitor (4)

LXR-alpha agonist (3)

LXR-beta agonist (4)

MAP kinase ERK1 inhibitor (3)

MAP kinase ERK2 inhibitor (3)

MAP kinase p38 alpha inhibitor (35)

MAP kinase p38 beta inhibitor (3)

Macrophage colony stimulating factor receptor inhibitor (9)

Matrix metalloproteinase 7 inhibitor (3)

Matrix metalloproteinase-1 inhibitor (3)

Melatonin receptor agonist (5)

Metabotropic glutamate receptor 2 agonist (4)

Metabotropic glutamate receptor 3 agonist (3)

Metabotropic glutamate receptor 5 modulator (4)

Mineralocorticoid receptor antagonist (11)

Monoamine oxidase A inhibitor (3)

Monoamine oxidase B inhibitor (3)

Monoamine oxidase inhibitor (5)

Monoamine transporter inhibitor (9)

Mu opioid receptor agonist (6)

Mu opioid receptor antagonist (6)

Mu opioid receptor partial agonist (3)

Muscarinic acetylcholine receptor M1 agonist (4)

Muscarinic acetylcholine receptor M1 antagonist (4)

Muscarinic acetylcholine receptor M2 antagonist (5)

Muscarinic acetylcholine receptor M3 antagonist (12)

NT-3 growth factor receptor inhibitor (3)

Nerve growth factor receptor Trk-A inhibitor (5)

Neuraminidase inhibitor (6)

Neurokinin 1 receptor antagonist (9)

Neurokinin 3 receptor antagonist (3)

Neuronal acetylcholine receptor protein alpha-7 subunit agonist (7)

Neuronal acetylcholine receptor protein alpha-7 subunit partial agonist (5)

Neuronal acetylcholine receptor; alpha4/beta2 agonist (4)

Neuronal acetylcholine receptor; alpha4/beta2 partial agonist (5)

Neuropeptide Y receptor type 5 antagonist (3)

Neurotrophic tyrosine kinase receptor inhibitor (6)

Neurotrophic tyrosine kinase receptor type 2 inhibitor (3)

Nonstructural protein 5A inhibitor (9)

Norepinephrine transporter inhibitor (12)

Norepinephrine transporter releasing agent (6)

Opioid receptors; mu/kappa/delta agonist (4)

Orexin receptor 2 antagonist (3)

Orexin receptor antagonist (3)

Oxytocin receptor antagonist (4)

P2X purinoceptor 7 antagonist (3)

PARP 1, 2 and 3 inhibitor (3)

PI3-kinase class I inhibitor (23)

PI3-kinase p110-alpha subunit inhibitor (6)

PI3-kinase p110-beta subunit inhibitor (5)

PI3-kinase p110-delta subunit inhibitor (16)

PI3-kinase p110-gamma subunit inhibitor (5)

Peroxisome proliferator-activated receptor agonist (3)

Peroxisome proliferator-activated receptor alpha agonist (20)

Peroxisome proliferator-activated receptor delta agonist (6)

Peroxisome proliferator-activated receptor gamma agonist (18)

Peroxisome proliferator-activated receptor gamma modulator (6)

Phosphate sequestering agent (3)

Phosphodiesterase 10A inhibitor (3)

Phosphodiesterase 3 inhibitor (6)

Phosphodiesterase 3A inhibitor (3)

Phosphodiesterase 4 inhibitor (16)

Phosphodiesterase 5A inhibitor (6)

Platelet-derived growth factor receptor alpha inhibitor (3)

Platelet-derived growth factor receptor beta inhibitor (11)

Platelet-derived growth factor receptor inhibitor (19)

Polymerase acidic protein inhibitor (4)

Potassium channel subfamily K member 10 opener (4)

Potassium channel subfamily K member 18 opener (4)

Potassium channel subfamily K member 2 opener (4)

Potassium channel subfamily K member 3 opener (4)

Potassium channel subfamily K member 9 opener (4)

Potassium-transporting ATPase inhibitor (5)

Progesterone receptor agonist (14)

Progesterone receptor antagonist (4)

Progesterone receptor modulator (3)

Prostanoid DP receptor antagonist (3)

Prostanoid EP2 receptor agonist (5)

Prostanoid FP receptor agonist (6)

Prostanoid IP receptor agonist (5)

Protein kinase C (PKC) inhibitor (5)

RNA disrupting agent (3)

RNA inhibitor (8)

RNA-directed RNA polymerase L inhibitor (5)

Receptor protein-tyrosine kinase erbB-2 inhibitor (21)

Receptor protein-tyrosine kinase erbB-4 inhibitor (8)

Retinoic acid receptor agonist (3)

Retinoid receptor agonist (3)

Reverse transcriptase inhibitor (4)

Rho-associated protein kinase inhibitor (6)

Ribonucleoside-diphosphate reductase RR1 inhibitor (5)

Ribosomal protein S6 kinase (P70S6K) inhibitor (3)

SRC inhibitor (5)

Serine/threonine-protein kinase AKT inhibitor (11)

Serine/threonine-protein kinase Aurora inhibitor (9)

Serine/threonine-protein kinase Aurora-A inhibitor (10)

Serine/threonine-protein kinase Aurora-B inhibitor (8)

Serine/threonine-protein kinase B-raf inhibitor (11)

Serine/threonine-protein kinase Chk1 inhibitor (9)

Serine/threonine-protein kinase PIM inhibitor (3)

Serine/threonine-protein kinase PLK1 inhibitor (8)

Serine/threonine-protein kinase RAF inhibitor (6)

Serine/threonine-protein kinase mTOR inhibitor (24)

Serotonin 1a (5-HT1a) receptor agonist (8)

Serotonin 1a (5-HT1a) receptor antagonist (4)

Serotonin 1a (5-HT1a) receptor partial agonist (5)

Serotonin 2a (5-HT2a) receptor antagonist (30)

Serotonin 2c (5-HT2c) receptor antagonist (11)

Serotonin 3 (5-HT3) receptor antagonist (6)

Serotonin 4 (5-HT4) receptor agonist (9)

Serotonin 4 (5-HT4) receptor partial agonist (3)

Serotonin 6 (5-HT6) receptor antagonist (3)

Serotonin transporter inhibitor (9)

Smoothened homolog antagonist (7)

Sodium channel alpha subunit blocker (25)

Sodium channel protein type IX alpha subunit blocker (7)

Sodium channel protein type V alpha subunit blocker (4)

Sodium channel protein type X alpha subunit blocker (3)

Sodium-(potassium)-chloride cotransporter 2 inhibitor (4)

Sodium/glucose cotransporter 2 inhibitor (13)

Sodium/potassium-transporting ATPase inhibitor (6)

Soluble guanylate cyclase activator (6)

Solute carrier family 22 member 12 inhibitor (7)

Sphingosine 1-phosphate receptor Edg-1 agonist (5)

Stem cell growth factor receptor inhibitor (25)

Sulfonylurea receptor 1, Kir6.2 blocker (9)

Sunscreen (4)

Supplement (14)

Synaptic vesicular amine transporter inhibitor (8)

Thiazide-sensitive sodium-chloride cotransporter inhibitor (13)

Thrombopoietin receptor agonist (4)

Thromboxane A2 receptor antagonist (3)

Thromboxane-A synthase inhibitor (3)

Thymidylate synthase inhibitor (9)

Thyroid peroxidase inhibitor (3)

Toll-like receptor 7 agonist (5)

Topoisomerase IV inhibitor (18)

Tubulin inhibitor (18)

Tubulin stabiliser (6)

Type-1 angiotensin II receptor antagonist (9)

Tyrosinase inhibitor (3)

Tyrosine-protein kinase ABL inhibitor (13)

Tyrosine-protein kinase BTK inhibitor (14)

Tyrosine-protein kinase JAK1 inhibitor (9)

Tyrosine-protein kinase JAK2 inhibitor (14)

Tyrosine-protein kinase JAK3 inhibitor (8)

Tyrosine-protein kinase Lyn inhibitor (3)

Tyrosine-protein kinase SRC inhibitor (8)

Tyrosine-protein kinase SYK inhibitor (11)

Tyrosine-protein kinase TIE-2 inhibitor (7)

Tyrosine-protein kinase receptor FLT3 inhibitor (30)

Tyrosine-protein kinase receptor RET inhibitor (9)

Tyrosine-protein kinase receptor UFO inhibitor (4)

Unknown (146)

Vanilloid receptor antagonist (14)

Vascular endothelial growth factor receptor 1 inhibitor (3)

Vascular endothelial growth factor receptor 2 inhibitor (23)

Vascular endothelial growth factor receptor 3 inhibitor (4)

Vascular endothelial growth factor receptor inhibitor (32)

Vasopressin V1a receptor antagonist (5)

Vasopressin V2 receptor antagonist (4)

Vitamin D receptor agonist (18)

Vitamin k epoxide reductase complex subunit 1 isoform 1 inhibitor (4)

Voltage-gated L-type calcium channel blocker (16)

Voltage-gated N-type calcium channel alpha-1B subunit blocker (4)

Voltage-gated T-type calcium channel blocker (5)

Voltage-gated calcium channel modulator (5)

Voltage-gated potassium channel blocker (4)

Xanthine dehydrogenase inhibitor (4)

PREMIER has received funding from the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information this manuscript contains.

Elements of the website have been developed under projects from the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT is thanked for providing computational resources. Content of the website is provided without guarantee for correctness. Data has been collected and integrated from multiple public sources, for the largest: FDA, HUGO Gene Nomenclature Committee, ChEMBL, IUPHAR/BPS guide to pharmacology, Reactome, UniProt, and Ensembl. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).