Cytochrome P450 17A1
Ensembl ID : ENSG00000148795
Gene: CYP17A1
UniProtKB Entry: P05093
Gene Synonyms:
Assay organism Assay description Assay tissue Bioactivities Reference
METYRAPONE
Inhibition of human CYP17A1 expressed in Escherichia coli XL1 at 2 uM using [3H]-progesterone as substrate preincubated with substrate for 5 mins measured after 45 mins by HPLC analysis — Inhibition = 3.0 %
POSACONAZOLE
Inhibition of CYP17 lyase in human hepatocyte microsomes using 17a-hydroxypregnenolone substrate by HPLC/MS/MS method — IC50 = 42.0 nM

>ENSG00000148795|Cytochrome P450 17A1
MWELVALLLLTLAYLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPRHGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRKGIAFADSGAHWQLHRRLAMATFALFKDGDQKLEKIICQEISTLCDMLATHNGQSIDISFPVFVAVTNVISLICFNTSYKNGDPELNVIQNYNEGIIDNLSKDSLVDLVPWLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDSITNMLDTLMQAKMNSDNGNAGPDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVGFSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGEFAVDKGTEVIINLWALHHNEKEWHQPDQFMPERFLNPAGTQLISPSVSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQAEGST

Identifier Resolution Method Chain Positions Source
6WR1 1.85 Å X-ray A/B 24-508 PDB
6WW0 2.01 Å X-ray A/B/C/D 24-508 PDB
5IRQ 2.20 Å X-ray A/B/C/D 24-508 PDB
8FDA 2.20 Å X-ray A/B/C/D 24-508 PDB
5UYS 2.39 Å X-ray A/B/C/D 24-508 PDB
3SWZ 2.40 Å X-ray A/B/C/D 24-508 PDB
4NKW 2.50 Å X-ray A/B/C/D 24-508 PDB
4NKY 2.55 Å X-ray A/B/C/D 24-508 PDB
3RUK 2.60 Å X-ray A/B/C/D 24-508 PDB
6CIZ 2.60 Å X-ray A/B/C/D 24-508 PDB
4NKV 2.65 Å X-ray A/B/C/D 24-508 PDB
6CIR 2.65 Å X-ray A/B/C/D 24-508 PDB
6WR0 2.70 Å X-ray A/B/C/D 24-508 PDB
6CHI 2.70 Å X-ray A/B/C/D 24-508 PDB
4NKX 2.79 Å X-ray A/B/C/D 24-508 PDB
4NKZ 3.00 Å X-ray A/B/C/D 24-508 PDB
5IRV 3.10 Å X-ray A/B/C/D 24-508 PDB
Metabolism R-HSA-1430728
Disease R-HSA-1643685
Androgen biosynthesis R-HSA-193048
Glucocorticoid biosynthesis R-HSA-194002
Metabolism of steroid hormones R-HSA-196071
Metabolism of lipids R-HSA-556833
Defective CYP17A1 causes AH5 R-HSA-5579028
Metabolic disorders of biological oxidation enzymes R-HSA-5579029
Diseases of metabolism R-HSA-5668914
Metabolism of steroids R-HSA-8957322
Expression Atlas ENSG00000148795
GeneCards 2593
HGNC Symbol HGNC:2593
MIM gene 609300
MIM morbid 202110
NCBI gene (formerly Entrezgene) 1586
UniProtKB Gene Name Q1HB44
UniProtKB Gene Name Q1HB44
UniProtKB Gene Name Q1HB44
UniProtKB Gene Name Q1HB44
UniProtKB Gene Name Q1HB44
UniProtKB Gene Name Q1HB44
WikiGene 1586