Cytochrome P450 1B1
Ensembl ID : ENSG00000138061
Gene: CYP1B1
UniProtKB Entry: Q16678

>ENSG00000138061|Cytochrome P450 1B1
MGTSLSPNDPWPLNPLSIQQTTLLLLLSVLATVHVGQRLLRQRRRQLRSAPPGPFAWPLIGNAAAVGQAAHLSFARLARRYGDVFQIRLGSCPIVVLNGERAIHQALVQQGSAFADRPAFASFRVVSGGRSMAFGHYSEHWKVQRRAAHSMMRNFFTRQPRSRQVLEGHVLSEARELVALLVRGSADGAFLDPRPLTVVAVANVMSAVCFGCRYSHDDPEFRELLSHNEEFGRTVGAGSLVDVMPWLQYFPNPVRTVFREFEQLNRNFSNFILDKFLRHCESLRPGAAPRDMMDAFILSAEKKAAGDSHGGGARLDLENVPATITDIFGASQDTLSTALQWLLLLFTRYPDVQTRVQAELDQVVGRDRLPCMGDQPNLPYVLAFLYEAMRFSSFVPVTIPHATTANTSVLGYHIPKDTVVFVNQWSVNHDPLKWPNPENFDPARFLDKDGLINKDLTSRVMIFSVGKRRCIGEELSKMQLFLFISILAHQCDFRANPNEPAKMNFSYGLTIKPKSFKVNVTLRESMELLDSAVQNLQAKETCQ

Identifier Resolution Method Chain Positions Source
3PM0 2.70 Å X-ray A 51-543 PDB
6IQ5 3.70 Å X-ray A/B 68-530 PDB
Metabolism R-HSA-1430728
Disease R-HSA-1643685
Biological oxidations R-HSA-211859
Cytochrome P450 - arranged by substrate type R-HSA-211897
Phase I - Functionalization of compounds R-HSA-211945
Endogenous sterols R-HSA-211976
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) R-HSA-2142670
Arachidonate metabolism R-HSA-2142753
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) R-HSA-2142816
Metabolism of lipids R-HSA-556833
Defective CYP1B1 causes Glaucoma R-HSA-5579000
Metabolic disorders of biological oxidation enzymes R-HSA-5579029
Diseases of metabolism R-HSA-5668914
Fatty acid metabolism R-HSA-8978868
Expression Atlas ENSG00000138061
GeneCards 2597
HGNC Symbol HGNC:2597
MIM gene 601771
MIM morbid 617315
MIM morbid 617315
MIM morbid 617315
NCBI gene (formerly Entrezgene) 1545
UniProtKB Gene Name Q16678
UniProtKB Gene Name Q16678
WikiGene 1545
Cytochrome P450 1A1
Ensembl ID : ENSG00000140465
Gene: CYP1A1
UniProtKB Entry: P04798

>ENSG00000140465|Cytochrome P450 1A1
MLFPISMSATEFLLASVIFCLVFWVIRASRPQVPKGLKNPPGPWGWPLIGHMLTLGKNPHLALSRMSQQYGDVLQIRIGSTPVVVLSGLDTIRQALVRQGDDFKGRPDLYTFTLISNGQSMSFSPDSGPVWAARRRLAQNGLKSFSIASDPASSTSCYLEEHVSKEAEVLISTLQELMAGPGHFNPYRYVVVSVTNVICAICFGRRYDHNHQELLSLVNLNNNFGEVVGSGNPADFIPILRYLPNPSLNAFKDLNEKFYSFMQKMVKEHYKTFEKGHIRDITDSLIEHCQEKQLDENANVQLSDEKIINIVLDLFGAGFDTVTTAISWSLMYLVMNPRVQRKIQEELDTVIGRSRRPRLSDRSHLPYMEAFILETFRHSSFVPFTIPHSTTRDTSLKGFYIPKGRCVFVNQWQINHDQKLWVNPSEFLPERFLTPDGAIDKVLSEKVIIFGMGKRKCIGETIARWEVFLFLAILLQRVEFSVPLGVKVDMTPIYGLTMKHACCEHFQMQLRS

Identifier Resolution Method Chain Positions Source
4I8V 2.60 Å X-ray A/B/C/D 35-512 PDB
Metabolism R-HSA-1430728
PPARA activates gene expression R-HSA-1989781
Biological oxidations R-HSA-211859
Cytochrome P450 - arranged by substrate type R-HSA-211897
Phase I - Functionalization of compounds R-HSA-211945
Xenobiotics R-HSA-211981
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) R-HSA-2142670
Arachidonate metabolism R-HSA-2142753
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) R-HSA-2142816
Regulation of lipid metabolism by PPARalpha R-HSA-400206
Metabolism of lipids R-HSA-556833
Fatty acid metabolism R-HSA-8978868
Biosynthesis of DHA-derived SPMs R-HSA-9018677
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678
Biosynthesis of protectins R-HSA-9018681
Expression Atlas ENSG00000140465
GeneCards 2595
HGNC Symbol HGNC:2595
LRG display in Ensembl gene LRG_1262
MIM gene 108330
NCBI gene (formerly Entrezgene) 1543
UniProtKB Gene Name P04798
UniProtKB Gene Name P04798
UniProtKB Gene Name P04798
UniProtKB Gene Name P04798
WikiGene 1543
Cytochrome P450 1A2
Ensembl ID : ENSG00000140505
Gene: CYP1A2
UniProtKB Entry: P05177

>ENSG00000140505|Cytochrome P450 1A2
MALSQSVPFSATELLLASAIFCLVFWVLKGLRPRVPKGLKSPPEPWGWPLLGHVLTLGKNPHLALSRMSQRYGDVLQIRIGSTPVLVLSRLDTIRQALVRQGDDFKGRPDLYTSTLITDGQSLTFSTDSGPVWAARRRLAQNALNTFSIASDPASSSSCYLEEHVSKEAKALISRLQELMAGPGHFDPYNQVVVSVANVIGAMCFGQHFPESSDEMLSLVKNTHEFVETASSGNPLDFFPILRYLPNPALQRFKAFNQRFLWFLQKTVQEHYQDFDKNSVRDITGALFKHSKKGPRASGNLIPQEKIVNLVNDIFGAGFDTVTTAISWSLMYLVTKPEIQRKIQKELDTVIGRERRPRLSDRPQLPYLEAFILETFRHSSFLPFTIPHSTTRDTTLNGFYIPKKCCVFVNQWQVNHDPELWEDPSEFRPERFLTADGTAINKPLSEKMMLFGMGKRRCIGEVLAKWEIFLFLAILLQQLEFSVPPGVKVDLTPIYGLTMKHARCEHVQARLRFSIN

Identifier Resolution Method Chain Positions Source
2HI4 1.95 Å X-ray A 27-516 PDB
Metabolism R-HSA-1430728
Phase II - Conjugation of compounds R-HSA-156580
Methylation R-HSA-156581
Biological oxidations R-HSA-211859
Cytochrome P450 - arranged by substrate type R-HSA-211897
Phase I - Functionalization of compounds R-HSA-211945
Aromatic amines can be N-hydroxylated or N-dealkylated by CYP1A2 R-HSA-211957
Xenobiotics R-HSA-211981
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) R-HSA-2142670
Arachidonate metabolism R-HSA-2142753
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) R-HSA-2142816
Aflatoxin activation and detoxification R-HSA-5423646
Metabolism of lipids R-HSA-556833
Fatty acid metabolism R-HSA-8978868
Biosynthesis of DHA-derived SPMs R-HSA-9018677
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678
Biosynthesis of protectins R-HSA-9018681
Biosynthesis of maresins R-HSA-9018682
Biosynthesis of maresin-like SPMs R-HSA-9027307
Expression Atlas ENSG00000140505
GeneCards 2596
HGNC Symbol HGNC:2596
LRG display in Ensembl gene LRG_1274
MIM gene 124060
MIM morbid 124060
NCBI gene (formerly Entrezgene) 1544
UniProtKB Gene Name P05177
WikiGene 1544