| Assay organism | Assay description | Assay tissue | Bioactivities | Reference | |
|---|---|---|---|---|---|
|
METYRAPONE
|
|
Inhibition of human placental microsomal CYP19A1 at 2 uM using [1beta-3H]androstenedione after 21 mins by liquid scintillation spectrometry | — | Inhibition = 0.0 % |
>ENSG00000137869|Cytochrome P450 19A1
MVLEMLNPIHYNITSIVPEAMPAATMPVLLLTGLFLLVWNYEGTSSIPGPGYCMGIGPLISHGRFLWMGIGSACNYYNRVYGEFMRVWISGEETLIISKSSSMFHIMKHNHYSSRFGSKLGLQCIGMHEKGIIFNNNPELWKTTRPFFMKALSGPGLVRMVTVCAESLKTHLDRLEEVTNESGYVDVLTLLRRVMLDTSNTLFLRIPLDESAIVVKIQGYFDAWQALLIKPDIFFKISWLYKKYEKSVKDLKDAIEVLIAEKRRRISTEEKLEECMDFATELILAEKRGDLTRENVNQCILEMLIAAPDTMSVSLFFMLFLIAKHPNVEEAIIKEIQTVIGERDIKIDDIQKLKVMENFIYESMRYQPVVDLVMRKALEDDVIDGYPVKKGTNIILNIGRMHRLEFFPKPNEFTLENFAKNVPYRYFQPFGFGPRGCAGKYIAMVMMKAILVTLLRRFHVKTLQGQCVESIQKIHDLSLHPDETKNMLEMIFTPRNSDRCLEH
| Identifier | Resolution | Method | Chain | Positions | Source |
|---|---|---|---|---|---|
| 5JKV | 2.75 Å | X-ray | A | 1-503 | PDB |
| 5JL6 | 3.00 Å | X-ray | A | 1-503 | PDB |
| 5JKW | 3.00 Å | X-ray | A | 1-503 | PDB |
| 5JL9 | 3.10 Å | X-ray | A | 1-503 | PDB |
| 5JL7 | 3.10 Å | X-ray | A | 1-503 | PDB |
| 3S7S | 3.21 Å | X-ray | A | 1-503 | PDB |
| 4KQ8 | 3.29 Å | X-ray | A | 45-503 | PDB |
| 4GL5 | 3.48 Å | X-ray | A | 1-503 | PDB |
| 4GL7 | 3.90 Å | X-ray | A | 1-503 | PDB |
Metabolism
R-HSA-1430728
Disease
R-HSA-1643685
Estrogen biosynthesis
R-HSA-193144
Metabolism of steroid hormones
R-HSA-196071
Biological oxidations
R-HSA-211859
Cytochrome P450 - arranged by substrate type
R-HSA-211897
Phase I - Functionalization of compounds
R-HSA-211945
Endogenous sterols
R-HSA-211976
Metabolism of lipids
R-HSA-556833
Metabolic disorders of biological oxidation enzymes
R-HSA-5579029
Defective CYP19A1 causes AEXS
R-HSA-5579030
Diseases of metabolism
R-HSA-5668914
Metabolism of steroids
R-HSA-8957322
| Expression Atlas | ENSG00000137869 |
| GeneCards | 2594 |
| HGNC Symbol | HGNC:2594 |
| MIM gene | 107910 |
| MIM morbid | 613546 |
| NCBI gene (formerly Entrezgene) | 1588 |
| UniProtKB Gene Name | P11511 |
| UniProtKB Gene Name | P11511 |
| UniProtKB Gene Name | P11511 |
| UniProtKB Gene Name | P11511 |
| UniProtKB Gene Name | P11511 |
| UniProtKB Gene Name | P11511 |
| UniProtKB Gene Name | P11511 |
| UniProtKB Gene Name | P11511 |
| WikiGene | 1588 |
