Cytochrome P450 11A1
Ensembl ID : ENSG00000140459
Gene: CYP11A1
UniProtKB Entry: P05108

No data availalbe!

>ENSG00000140459|Cytochrome P450 11A1
MLAKGLPPRSVLVKGCQTFLSAPREGLGRLRVPTGEGAGISTRSPRPFNEIPSPGDNGWLNLYHFWRETGTHKVHLHHVQNFQKYGPIYREKLGNVESVYVIDPEDVALLFKSEGPNPERFLIPPWVAYHQYYQRPIGVLLKKSAAWKKDRVALNQEVMAPEATKNFLPLLDAVSRDFVSVLHRRIKKAGSGNYSGDISDDLFRFAFESITNVIFGERQGMLEEVVNPEAQRFIDAIYQMFHTSVPMLNLPPDLFRLFRTKTWKDHVAAWDVIFSKADIYTQNFYWELRQKGSVHHDYRGILYRLLGDSKMSFEDIKANVTEMLAGGVDTTSMTLQWHLYEMARNLKVQDMLRAEVLAARHQAQGDMATMLQLVPLLKASIKETLRLHPISVTLQRYLVNDLVLRDYMIPAKTLVQVAIYALGREPTFFFDPENFDPTRWLSKDKNITYFRNLGFGWGVRQCLGRRIAELEMTIFLINMLENFRVEIQHLSDVGTTFNLILMPEKPISFTFWPFNQEATQQ

Identifier Resolution Method Chain Positions Source
3N9Y 2.10 Å X-ray A/B 41-521 PDB
3N9Z 2.17 Å X-ray A/B 41-521 PDB
3NA1 2.25 Å X-ray A/B 41-521 PDB
3NA0 2.50 Å X-ray A/B 44-514 PDB
Metabolism R-HSA-1430728
Disease R-HSA-1643685
Metabolism of steroid hormones R-HSA-196071
Pregnenolone biosynthesis R-HSA-196108
Biological oxidations R-HSA-211859
Cytochrome P450 - arranged by substrate type R-HSA-211897
Phase I - Functionalization of compounds R-HSA-211945
Endogenous sterols R-HSA-211976
Metabolism of lipids R-HSA-556833
Defective CYP11A1 causes AICSR R-HSA-5579026
Metabolic disorders of biological oxidation enzymes R-HSA-5579029
Diseases of metabolism R-HSA-5668914
Metabolism of steroids R-HSA-8957322
Expression Atlas ENSG00000140459
GeneCards 2590
HGNC Symbol HGNC:2590
MIM gene 118485
MIM morbid 613743
NCBI gene (formerly Entrezgene) 1583
UniProtKB Gene Name P05108
UniProtKB Gene Name P05108
UniProtKB Gene Name P05108
UniProtKB Gene Name P05108
UniProtKB Gene Name P05108
UniProtKB Gene Name P05108
UniProtKB Gene Name P05108
WikiGene 1583
Cytochrome P450 11B1
Ensembl ID : ENSG00000160882
Gene: CYP11B1
UniProtKB Entry: P15538
Gene Synonyms:
Assay organism Assay description Assay tissue Bioactivities Reference
POSACONAZOLE
Inhibition of CYP11B1 in human hepatocyte microsomes using deoxycortisol substrate by HPLC/MS/MS method — IC50 = 310.0 nM
OSILODROSTAT
Inhibition of human CYP11B1 expressed in Chinese hamster V79 cells assessed as reduction in corticosterone production using deoxycorticosterone as substrate after 1.5 to 2 hrs in presence of NADPH by HTRF assay — IC50 = 22.0 nM

>ENSG00000160882|Cytochrome P450 11B1
MALRAKAEVCMAVPWLSLQRAQALGTRAARVPRTVLPFEAMPRRPGNRWLRLLQIWREQGYEDLHLEVHQTFQELGPIFRYDLGGAGMVCVMLPEDVEKLQQVDSLHPHRMSLEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPEVLSPNAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWTSPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFSRPQQYTSIVAELLLNAELSPDAIKANSMELTAGSVDTTVFPLLMTLFELARNPNVQQALRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVASSDLVLQNYHIPAGTLVRVFLYSLGRNPALFPRPERYNPQRWLDIRGSGRNFYHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHLQVETLTQEDIKMVYSFILRPSMFPLLTFRAIN

Identifier Resolution Method Chain Positions Source
7E7F 1.40 Å X-ray A 28-503 PDB
6M7X 2.10 Å X-ray A/B 31-503 PDB
Metabolism R-HSA-1430728
Disease R-HSA-1643685
Glucocorticoid biosynthesis R-HSA-194002
Metabolism of steroid hormones R-HSA-196071
Biological oxidations R-HSA-211859
Cytochrome P450 - arranged by substrate type R-HSA-211897
Phase I - Functionalization of compounds R-HSA-211945
Endogenous sterols R-HSA-211976
Metabolism of lipids R-HSA-556833
Defective CYP11B1 causes AH4 R-HSA-5579017
Metabolic disorders of biological oxidation enzymes R-HSA-5579029
Diseases of metabolism R-HSA-5668914
Metabolism of steroids R-HSA-8957322
Expression Atlas ENSG00000160882
GeneCards 2591
HGNC Symbol HGNC:2591
MIM gene 610613
MIM morbid 202010
MIM morbid 202010
NCBI gene (formerly Entrezgene) 1584
UniProtKB Gene Name Q4VAR0
UniProtKB Gene Name Q4VAR0
UniProtKB Gene Name Q4VAR0
WikiGene 1584
Cytochrome P450 11B2
Ensembl ID : ENSG00000179142
Gene: CYP11B2
UniProtKB Entry: P19099
Gene Synonyms:
Assay organism Assay description Assay tissue Bioactivities Reference
METYRAPONE
Inhibition of human CYP11B2 expressed in hamster V79MZ cells using [1,2-3H]-11-deoxycorticosterone as substrate after 6 hrs by HPLC analysis — IC50 = 72.0 nM
POSACONAZOLE
Inhibition of CYP11B2 in human hepatocyte microsomes using deoxycorticosteroid substrate by HPLC/MS/MS method — IC50 = 21.0 nM
OSILODROSTAT
Inhibition of human CYP11B2 expressed in hamster V79MZ cells using [1,2-3H]-11-deoxycorticosterone as substrate after 6 hrs by HPLC analysis — IC50 = 0.2 nM

>ENSG00000179142|Cytochrome P450 11B2
MALRAKAEVCVAAPWLSLQRARALGTRAARAPRTVLPFEAMPQHPGNRWLRLLQIWREQGYEHLHLEMHQTFQELGPIFRYNLGGPRMVCVMLPEDVEKLQQVDSLHPCRMILEPWVAYRQHRGHKCGVFLLNGPEWRFNRLRLNPDVLSPKAVQRFLPMVDAVARDFSQALKKKVLQNARGSLTLDVQPSIFHYTIEASNLALFGERLGLVGHSPSSASLNFLHALEVMFKSTVQLMFMPRSLSRWISPKVWKEHFEAWDCIFQYGDNCIQKIYQELAFNRPQHYTGIVAELLLKAELSLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRQESLAAAASISEHPQKATTELPLLRAALKETLRLYPVGLFLERVVSSDLVLQNYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDIRGSGRNFHHVPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVETLTQEDIKMVYSFILRPGTSPLLTFRAIN

No data available!

Metabolism R-HSA-1430728
Disease R-HSA-1643685
Mineralocorticoid biosynthesis R-HSA-193993
Glucocorticoid biosynthesis R-HSA-194002
Metabolism of steroid hormones R-HSA-196071
Biological oxidations R-HSA-211859
Cytochrome P450 - arranged by substrate type R-HSA-211897
Phase I - Functionalization of compounds R-HSA-211945
Endogenous sterols R-HSA-211976
Metabolism of lipids R-HSA-556833
Defective CYP11B2 causes CMO-1 deficiency R-HSA-5579009
Metabolic disorders of biological oxidation enzymes R-HSA-5579029
Diseases of metabolism R-HSA-5668914
Metabolism of steroids R-HSA-8957322
Expression Atlas ENSG00000179142
GeneCards 2592
HGNC Symbol HGNC:2592
MIM gene 124080
MIM morbid 610600
MIM morbid 610600
MIM morbid 610600
NCBI gene (formerly Entrezgene) 1585
UniProtKB Gene Name P19099
WikiGene 1585