Cytochrome P450 2C18
Ensembl ID : ENSG00000108242
Gene: CYP2C18
UniProtKB Entry: P33260

>ENSG00000108242|Cytochrome P450 2C18
MDPAVALVLCLSCLFLLSLWRQSSGRGRLPSGPTPLPIIGNILQLDVKDMSKSLTNFSKVYGPVFTVYFGLKPIVVLHGYEAVKEALIDHGEEFSGRGSFPVAEKVNKGLGILFSNGKRWKEIRRFCLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTNASPCDPTFILGCAPCNVICSVIFHDRFDYKDQRFLNLMEKFNENLRILSSPWIQVCNNFPALIDYLPGSHNKIAENFAYIKSYVLERIKEHQESLDMNSARDFIDCFLIKMEQEKHNQQSEFTVESLIATVTDMFGAGTETTSTTLRYGLLLLLKYPEVTAKVQEEIECVVGRNRSPCMQDRSHMPYTDAVVHEIQRYIDLLPTNLPHAVTCDVKFKNYLIPKGTTIITSLTSVLHNDKEFPNPEMFDPGHFLDKSGNFKKSDYFMPFSAGKRMCMGEGLARMELFLFLTTILQNFNLKSQVDPKDIDITPIANAFGRVPPLYQLCFIPV

Identifier Resolution Method Chain Positions Source
2CIK 1.75 Å X-ray C 72-80 PDB
2H6P 1.90 Å X-ray C 72-80 PDB
Metabolism R-HSA-1430728
Biological oxidations R-HSA-211859
Cytochrome P450 - arranged by substrate type R-HSA-211897
Phase I - Functionalization of compounds R-HSA-211945
Xenobiotics R-HSA-211981
Expression Atlas ENSG00000108242
GeneCards 2620
HGNC Symbol HGNC:2620
MIM gene 601131
NCBI gene (formerly Entrezgene) 1562
UniProtKB Gene Name P33260
WikiGene 1562
Cytochrome P450 2J2
Ensembl ID : ENSG00000134716
Gene: CYP2J2
UniProtKB Entry: P51589

>ENSG00000134716|Cytochrome P450 2J2
MLAAMGSLAAALWAVVHPRTLLLGTVAFLLAADFLKRRRPKNYPPGPWRLPFLGNFFLVDFEQSHLEVQLFVKKYGNLFSLELGDISAVLITGLPLIKEALIHMDQNFGNRPVTPMREHIFKKNGLIMSSGQAWKEQRRFTLTALRNFGLGKKSLEERIQEEAQHLTEAIKEENGQPFDPHFKINNAVSNIICSITFGERFEYQDSWFQQLLKLLDEVTYLEASKTCQLYNVFPWIMKFLPGPHQTLFSNWKKLKLFVSHMIDKHRKDWNPAETRDFIDAYLKEMSKHTGNPTSSFHEENLICSTLDLFFAGTETTSTTLRWALLYMALYPEIQEKVQAEIDRVIGQGQQPSTAARESMPYTNAVIHEVQRMGNIIPLNVPREVTVDTTLAGYHLPKGTMILTNLTALHRDPTEWATPDTFNPDHFLENGQFKKREAFMPFSIGKRACLGEQLARTELFIFFTSLMQKFTFRPPNNEKLSLKFRMGITISPVSHRLCAVPQV

AF-P51589-F1
Identifier Resolution Method Chain Positions Source
None Predicted None 1-502 AlphaFold DB
Metabolism R-HSA-1430728
Biological oxidations R-HSA-211859
Cytochrome P450 - arranged by substrate type R-HSA-211897
Fatty acids R-HSA-211935
Phase I - Functionalization of compounds R-HSA-211945
Xenobiotics R-HSA-211981
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) R-HSA-2142670
Arachidonate metabolism R-HSA-2142753
Metabolism of lipids R-HSA-556833
Fatty acid metabolism R-HSA-8978868
Expression Atlas ENSG00000134716
GeneCards 2634
HGNC Symbol HGNC:2634
MIM gene 601258
NCBI gene (formerly Entrezgene) 1573
UniProtKB Gene Name P51589
UniProtKB Gene Name P51589
UniProtKB Gene Name P51589
UniProtKB Gene Name P51589
WikiGene 1573
Cytochrome P450 2E1
Ensembl ID : ENSG00000130649
Gene: CYP2E1
UniProtKB Entry: P05181

>ENSG00000130649|Cytochrome P450 2E1
MSALGVTVALLVWAAFLLLVSMWRQVHSSWNLPPGPFPLPIIGNLFQLELKNIPKSFTRLAQRFGPVFTLYVGSQRMVVMHGYKAVKEALLDYKDEFSGRGDLPAFHAHRDRGIIFNNGPTWKDIRRFSLTTLRNYGMGKQGNESRIQREAHFLLEALRKTQGQPFDPTFLIGCAPCNVIADILFRKHFDYNDEKFLRLMYLFNENFHLLSTPWLQLYNNFPSFLHYLPGSHRKVIKNVAEVKEYVSERVKEHHQSLDPNCPRDLTDCLLVEMEKEKHSAERLYTMDGITVTVADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRIPAIKDRQEMPYMDAVVHEIQRFITLVPSNLPHEATRDTIFRGYLIPKGTVVVPTLDSVLYDNQEFPDPEKFKPEHFLNENGKFKYSDYFKPFSTGKRVCAGEGLARMELFLLLCAILQHFNLKPLVDPKDIDLSPIHIGFGCIPPRYKLCVIPRS

Identifier Resolution Method Chain Positions Source
3E6I 2.20 Å X-ray A/B 32-493 PDB
3T3Z 2.35 Å X-ray A/B/C/D 32-493 PDB
3E4E 2.60 Å X-ray A/B 32-493 PDB
3GPH 2.70 Å X-ray A/B 32-493 PDB
3KOH 2.90 Å X-ray A/B 32-493 PDB
3LC4 3.10 Å X-ray A/B 32-493 PDB
Metabolism R-HSA-1430728
Biological oxidations R-HSA-211859
Cytochrome P450 - arranged by substrate type R-HSA-211897
Phase I - Functionalization of compounds R-HSA-211945
Xenobiotics R-HSA-211981
CYP2E1 reactions R-HSA-211999
Metabolism of lipids R-HSA-556833
Biosynthesis of DHA-derived SPMs R-HSA-9018677
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678
Biosynthesis of maresins R-HSA-9018682
Biosynthesis of maresin-like SPMs R-HSA-9027307
Drug ADME R-HSA-9748784
Aspirin ADME R-HSA-9749641
Paracetamol ADME R-HSA-9753281
Expression Atlas ENSG00000130649
GeneCards 2631
HGNC Symbol HGNC:2631
MIM gene 124040
NCBI gene (formerly Entrezgene) 1571
UniProtKB Gene Name P05181
UniProtKB Gene Name P05181
UniProtKB Gene Name P05181
UniProtKB Gene Name P05181
WikiGene 1571
Cytochrome P450 2C8
Ensembl ID : ENSG00000138115
Gene: CYP2C8
UniProtKB Entry: P10632

>ENSG00000138115|Cytochrome P450 2C8
MEPFVVLVLCLSFMLLFSLWRQSCRRRKLPPGPTPLPIIGNMLQIDVKDICKSFTNFSKVYGPVFTVYFGMNPIVVFHGYEAVKEALIDNGEEFSGRGNSPISQRITKGLGIISSNGKRWKEIRRFSLTTLRNFGMGKRSIEDRVQEEAHCLVEELRKTKASPCDPTFILGCAPCNVICSVVFQKRFDYKDQNFLTLMKRFNENFRILNSPWIQVCNNFPLLIDCFPGTHNKVLKNVALTRSYIREKVKEHQASLDVNNPRDFIDCFLIKMEQEKDNQKSEFNIENLVGTVADLFVAGTETTSTTLRYGLLLLLKHPEVTAKVQEEIDHVIGRHRSPCMQDRSHMPYTDAVVHEIQRYSDLVPTGVPHAVTTDTKFRNYLIPKGTTIMALLTSVLHDDKEFPNPNIFDPGHFLDKNGNFKKSDYFMPFSAGKRICAGEGLARMELFLFLTTILQNFNLKSVDDLKNLNTTAVTKGIVSLPPSYQICFIPV

Identifier Resolution Method Chain Positions Source
2NNJ 2.28 Å X-ray A 28-490 PDB
2NNH 2.60 Å X-ray A/B 28-490 PDB
1PQ2 2.70 Å X-ray A/B 19-490 PDB
2VN0 2.70 Å X-ray A 28-490 PDB
2NNI 2.80 Å X-ray A 28-490 PDB
Metabolism R-HSA-1430728
Biological oxidations R-HSA-211859
Cytochrome P450 - arranged by substrate type R-HSA-211897
Phase I - Functionalization of compounds R-HSA-211945
Xenobiotics R-HSA-211981
CYP2E1 reactions R-HSA-211999
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) R-HSA-2142670
Arachidonate metabolism R-HSA-2142753
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) R-HSA-2142816
Metabolism of lipids R-HSA-556833
Fatty acid metabolism R-HSA-8978868
Biosynthesis of DHA-derived SPMs R-HSA-9018677
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678
Biosynthesis of maresins R-HSA-9018682
Biosynthesis of maresin-like SPMs R-HSA-9027307
Drug ADME R-HSA-9748784
Aspirin ADME R-HSA-9749641
Expression Atlas ENSG00000138115
GeneCards 2622
HGNC Symbol HGNC:2622
MIM gene 601129
MIM morbid 618018
NCBI gene (formerly Entrezgene) 1558
UniProtKB Gene Name P10632
UniProtKB Gene Name P10632
UniProtKB Gene Name P10632
UniProtKB Gene Name P10632
UniProtKB Gene Name P10632
UniProtKB Gene Name P10632
WikiGene 1558
Cytochrome P450 2C9
Ensembl ID : ENSG00000138109
Gene: CYP2C9
UniProtKB Entry: P11712

>ENSG00000138109|Cytochrome P450 2C9
MDSLVVLVLCLSCLLLLSLWRQSSGRGKLPPGPTPLPVIGNILQIGIKDISKSLTNLSKVYGPVFTLYFGLKPIVVLHGYEAVKEALIDLGEEFSGRGIFPLAERANRGFGIVFSNGKKWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFHKRFDYKDQQFLNLMEKLNENIKILSSPWIQICNNFSPIIDYFPGTHNKLLKNVAFMKSYILEKVKEHQESMDMNNPQDFIDCFLMKMEKEKHNQPSEFTIESLENTAVDLFGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRSHMPYTDAVVHEVQRYIDLLPTSLPHAVTCDIKFRNYLIPKGTTILISLTSVLHDNKEFPNPEMFDPHHFLDEGGNFKKSKYFMPFSAGKRICVGEALAGMELFLFLTSILQNFNLKSLVDPKNLDTTPVVNGFASVPPFYQLCFIPV

Identifier Resolution Method Chain Positions Source
5X23 2.00 Å X-ray A 19-490 PDB
1R9O 2.00 Å X-ray A 18-490 PDB
5A5I 2.00 Å X-ray A 23-489 PDB
5W0C 2.00 Å X-ray A 18-489 PDB
7RL2 2.23 Å X-ray A 24-490 PDB
5XXI 2.30 Å X-ray A 28-489 PDB
5K7K 2.30 Å X-ray A 23-489 PDB
4NZ2 2.45 Å X-ray A/B 30-490 PDB
5X24 2.48 Å X-ray A 19-490 PDB
8VZ7 2.53 Å X-ray A 24-490 PDB
1OG5 2.55 Å X-ray A/B 30-490 PDB
1OG2 2.60 Å X-ray A/B 30-490 PDB
5A5J 2.90 Å X-ray A 23-489 PDB
8VX0 3.05 Å X-ray A 24-490 PDB
6VLT 3.12 Å X-ray A/B/C/D/E/F/G/H 19-490 PDB
Metabolism R-HSA-1430728
Biological oxidations R-HSA-211859
Cytochrome P450 - arranged by substrate type R-HSA-211897
Phase I - Functionalization of compounds R-HSA-211945
Xenobiotics R-HSA-211981
CYP2E1 reactions R-HSA-211999
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) R-HSA-2142670
Arachidonate metabolism R-HSA-2142753
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) R-HSA-2142816
Metabolism of lipids R-HSA-556833
Fatty acid metabolism R-HSA-8978868
Biosynthesis of DHA-derived SPMs R-HSA-9018677
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678
Biosynthesis of maresins R-HSA-9018682
Biosynthesis of maresin-like SPMs R-HSA-9027307
Drug ADME R-HSA-9748784
Aspirin ADME R-HSA-9749641
Expression Atlas ENSG00000138109
GeneCards 2623
HGNC Symbol HGNC:2623
LRG display in Ensembl gene LRG_1195
MIM gene 601130
MIM morbid 122700
NCBI gene (formerly Entrezgene) 1559
UniProtKB Gene Name S5RV20
UniProtKB Gene Name S5RV20
UniProtKB Gene Name S5RV20
WikiGene 1559
Cytochrome P450 2S1
Ensembl ID : ENSG00000167600
Gene: CYP2S1
UniProtKB Entry: Q96SQ9

>ENSG00000167600|Cytochrome P450 2S1
MEATGTWALLLALALLLLLTLALSGTRARGHLPPGPTPLPLLGNLLQLRPGALYSGLMRLSKKYGPVFTIYLGPWRPVVVLVGQEAVREALGGQAEEFSGRGTVAMLEGTFDGHGVFFSNGERWRQLRKFTMLALRDLGMGKREGEELIQAEARCLVETFQGTEGRPFDPSLLLAQATSNVVCSLLFGLRFSYEDKEFQAVVRAAGGTLLGVSSQGGQTYEMFSWFLRPLPGPHKQLLHHVSTLAAFTVRQVQQHQGNLDASGPARDLVDAFLLKMAQEEQNPGTEFTNKNMLMTVIYLLFAGTMTVSTTVGYTLLLLMKYPHVQKWVREELNRELGAGQAPSLGDRTRLPYTDAVLHEAQRLLALVPMGIPRTLMRTTRFRGYTLPQGTEVFPLLGSILHDPNIFKHPEEFNPDRFLDADGRFRKHEAFLPFSLGKRVCLGEGLAKAELFLFFTTILQAFSLESPCPPDTLSLKPTVSGLFNIPPAFQLQVRPTDLHSTTQTR

AF-Q96SQ9-F1
Identifier Resolution Method Chain Positions Source
None Predicted None 1-504 AlphaFold DB
Metabolism R-HSA-1430728
Biological oxidations R-HSA-211859
Cytochrome P450 - arranged by substrate type R-HSA-211897
Phase I - Functionalization of compounds R-HSA-211945
Miscellaneous substrates R-HSA-211958
Xenobiotics R-HSA-211981
CYP2E1 reactions R-HSA-211999
Expression Atlas ENSG00000167600
GeneCards 15654
HGNC Symbol HGNC:15654
MIM gene 611529
NCBI gene (formerly Entrezgene) 29785
UniProtKB Gene Name Q96SQ9
UniProtKB Gene Name Q96SQ9
UniProtKB Gene Name Q96SQ9
UniProtKB Gene Name Q96SQ9
UniProtKB Gene Name Q96SQ9
UniProtKB Gene Name Q96SQ9
WikiGene 29785
Cytochrome P450 2U1
Ensembl ID : ENSG00000155016
Gene: CYP2U1
UniProtKB Entry: Q7Z449 

>ENSG00000155016|Cytochrome P450 2U1
MSSPGPSQPPAEDPPWPARLLRAPLGLLRLDPSGGALLLCGLVALLGWSWLRRRRARGIPPGPTPWPLVGNFGHVLLPPFLRRRSWLSSRTRAAGIDPSVIGPQVLLAHLARVYGSIFSFFIGHYLVVVLSDFHSVREALVQQAEVFSDRPRVPLISIVTKEKGVVFAHYGPVWRQQRKFSHSTLRHFGLGKLSLEPKIIEEFKYVKAEMQKHGEDPFCPFSIISNAVSNIICSLCFGQRFDYTNSEFKKMLGFMSRGLEICLNSQVLLVNICPWLYYLPFGPFKELRQIEKDITSFLKKIIKDHQESLDRENPQDFIDMYLLHMEEERKNNSNSSFDEEYLFYIIGDLFIAGTDTTTNSLLWCLLYMSLNPDVQEKVHEEIERVIGANRAPSLTDKAQMPYTEATIMEVQRLTVVVPLAIPHMTSENTVLQGYTIPKGTLILPNLWSVHRDPAIWEKPEDFYPNRFLDDQGQLIKKETFIPFGIGKRVCMGEQLAKMELFLMFVSLMQSFAFALPEDSKKPLLTGRFGLTLAPHPFNITISRR

AF-Q7Z449-F1
Identifier Resolution Method Chain Positions Source
None Predicted None 1-544 AlphaFold DB
Metabolism R-HSA-1430728
Disease R-HSA-1643685
Biological oxidations R-HSA-211859
Cytochrome P450 - arranged by substrate type R-HSA-211897
Phase I - Functionalization of compounds R-HSA-211945
Miscellaneous substrates R-HSA-211958
Arachidonate metabolism R-HSA-2142753
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) R-HSA-2142816
Metabolism of lipids R-HSA-556833
Defective CYP2U1 causes SPG56 R-HSA-5579011
Metabolic disorders of biological oxidation enzymes R-HSA-5579029
Diseases of metabolism R-HSA-5668914
Fatty acid metabolism R-HSA-8978868
Expression Atlas ENSG00000155016
GeneCards 20582
HGNC Symbol HGNC:20582
MIM gene 610670
MIM morbid 615030
NCBI gene (formerly Entrezgene) 113612
UniProtKB Gene Name Q7Z449
UniProtKB Gene Name Q7Z449
WikiGene 113612
Cytochrome P450 2C19
Ensembl ID : ENSG00000165841
Gene: CYP2C19
UniProtKB Entry: P33261

>ENSG00000165841|Cytochrome P450 2C19
MDPFVVLVLCLSCLLLLSIWRQSSGRGKLPPGPTPLPVIGNILQIDIKDVSKSLTNLSKIYGPVFTLYFGLERMVVLHGYEVVKEALIDLGEEFSGRGHFPLAERANRGFGIVFSNGKRWKEIRRFSLMTLRNFGMGKRSIEDRVQEEARCLVEELRKTKASPCDPTFILGCAPCNVICSIIFQKRFDYKDQQFLNLMEKLNENIRIVSTPWIQICNNFPTIIDYFPGTHNKLLKNLAFMESDILEKVKEHQESMDINNPRDFIDCFLIKMEKEKQNQQSEFTIENLVITAADLLGAGTETTSTTLRYALLLLLKHPEVTAKVQEEIERVIGRNRSPCMQDRGHMPYTDAVVHEVQRYIDLIPTSLPHAVTCDVKFRNYLIPKGTTILTSLTSVLHDNKEFPNPEMFDPRHFLDEGGNFKKSNYFMPFSAGKRICVGEGLARMELFLFLTFILQNFNLKSLIDPKDLDTTPVVNGFASVPPFYQLCFIPV

Identifier Resolution Method Chain Positions Source
4GQS 2.87 Å X-ray A/B/C/D 23-489 PDB
Metabolism R-HSA-1430728
Biological oxidations R-HSA-211859
Cytochrome P450 - arranged by substrate type R-HSA-211897
Phase I - Functionalization of compounds R-HSA-211945
Xenobiotics R-HSA-211981
CYP2E1 reactions R-HSA-211999
Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET) R-HSA-2142670
Arachidonate metabolism R-HSA-2142753
Synthesis of (16-20)-hydroxyeicosatetraenoic acids (HETE) R-HSA-2142816
Metabolism of lipids R-HSA-556833
Fatty acid metabolism R-HSA-8978868
Drug ADME R-HSA-9748784
Aspirin ADME R-HSA-9749641
Expression Atlas ENSG00000165841
GeneCards 2621
HGNC Symbol HGNC:2621
LRG display in Ensembl gene LRG_584
MIM gene 124020
MIM morbid 609535
NCBI gene (formerly Entrezgene) 1557
UniProtKB Gene Name P33261
UniProtKB Gene Name P33261
WikiGene 1557
Cytochrome P450 2R1
Ensembl ID : ENSG00000186104
Gene: CYP2R1
UniProtKB Entry: Q6VVX0

>ENSG00000186104|Cytochrome P450 2R1
MWKLWRAEEGAAALGGALFLLLFALGVRQLLKQRRPMGFPPGPPGLPFIGNIYSLAASSELPHVYMRKQSQVYGEIFSDLGGISTVVLNGYDVVKECLVHQSEIFADRPCLPLFMKMTKMGGLLNSRYGRGWVDHRRLAVNSFRYFGYGQKSFESKILEEETKFFNDAIETYKGRPFDFKQLITNAVSNITNLIIFGERFTYEDTDFQHMIELFSENVELAASASVFLYNAFWIGILPFGKHQQLFRNAAVVYDFLSRLIEKASVNRKPQLPQHFVDAYLDEMDQGKNDPSSTFSKENLIFSVGELIIAGTETTTNVLRWAILFMALYPNIQGQVQKEIDLIMGPNGGPSWDDKCKMPYTEAVLHEVLRFCNIVPLGIFHATSEDAVVRGYSIPKGTTVITNLYSVHFDEKYWRDPEVFHPERFLDSSGYFAKKEALVPFSLGRRHCLGEHLARMEMFLFFTALLQRFHLHFPHELVPDLKPRLGMTLQPQPYLICAERR

Identifier Resolution Method Chain Positions Source
3CZH 2.30 Å X-ray A/B 32-501 PDB
3DL9 2.72 Å X-ray A/B 32-501 PDB
3C6G 2.80 Å X-ray A/B 32-501 PDB
Metabolism R-HSA-1430728
Disease R-HSA-1643685
Vitamin D (calciferol) metabolism R-HSA-196791
Biological oxidations R-HSA-211859
Cytochrome P450 - arranged by substrate type R-HSA-211897
Vitamins R-HSA-211916
Phase I - Functionalization of compounds R-HSA-211945
Metabolism of lipids R-HSA-556833
Defective CYP27B1 causes VDDR1B R-HSA-5579027
Metabolic disorders of biological oxidation enzymes R-HSA-5579029
Diseases of metabolism R-HSA-5668914
Metabolism of steroids R-HSA-8957322
Expression Atlas ENSG00000186104
GeneCards 20580
HGNC Symbol HGNC:20580
MIM gene 608713
MIM morbid 600081
NCBI gene (formerly Entrezgene) 120227
UniProtKB Gene Name Q6VVX0
UniProtKB Gene Name Q6VVX0
UniProtKB Gene Name Q6VVX0
WikiGene 120227
Cytochrome P450 2F1
Ensembl ID : ENSG00000197446
Gene: CYP2F1
UniProtKB Entry: P24903

>ENSG00000197446|Cytochrome P450 2F1
MDSISTAILLLLLALVCLLLTLSSRDKGKLPPGPRPLSILGNLLLLCSQDMLTSLTKLSKEYGSMYTVHLGPRRVVVLSGYQAVKEALVDQGEEFSGRGDYPAFFNFTKGNGIAFSSGDRWKVLRQFSIQILRNFGMGKRSIEERILEEGSFLLAELRKTEGEPFDPTFVLSRSVSNIICSVLFGSRFDYDDERLLTIIRLINDNFQIMSSPWGELYDIFPSLLDWVPGPHQRIFQNFKCLRDLIAHSVHDHQASLDPRSPRDFIQCFLTKMAEEKEDPLSHFHMDTLLMTTHNLLFGGTKTVSTTLHHAFLALMKYPKVQARVQEEIDLVVGRARLPALKDRAAMPYTDAVIHEVQRFADIIPMNLPHRVTRDTAFRGFLIPKGTDVITLLNTVHYDPSQFLTPQEFNPEHFLDANQSFKKSPAFMPFSAGRRLCLGESLARMELFLYLTAILQSFSLQPLGAPEDIDLTPLSSGLGNLPRPFQLCLRPR

AF-P24903-F1
Identifier Resolution Method Chain Positions Source
None Predicted None 1-491 AlphaFold DB
Metabolism R-HSA-1430728
Biological oxidations R-HSA-211859
Cytochrome P450 - arranged by substrate type R-HSA-211897
Fatty acids R-HSA-211935
Phase I - Functionalization of compounds R-HSA-211945
Xenobiotics R-HSA-211981
CYP2E1 reactions R-HSA-211999
Expression Atlas ENSG00000197446
GeneCards 2632
HGNC Symbol HGNC:2632
MIM gene 124070
NCBI gene (formerly Entrezgene) 1572
UniProtKB Gene Name P24903
UniProtKB Gene Name P24903
WikiGene 1572
Cytochrome P450 2W1
Ensembl ID : ENSG00000073067
Gene: CYP2W1
UniProtKB Entry: Q8TAV3

>ENSG00000073067|Cytochrome P450 2W1
MALLLLLFLGLLGLWGLLCACAQDPSPAARWPPGPRPLPLVGNLHLLRLSQQDRSLMELSERYGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIFFSSGARWRAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPFPLALLGWAPSNITFALLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYPWLGALLQLHRPVLRKIEEVRAILRTLLEARRPHVCPGDPVCSYVDALIQQGQGDDPEGLFAEANAVACTLDMVMAGTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQRFITLLPHVPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLDANGHFVKREAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASLDTTPARAFTMRPRAQALCAVPRP

Identifier Resolution Method Chain Positions Source
Metabolism R-HSA-1430728
Biological oxidations R-HSA-211859
Cytochrome P450 - arranged by substrate type R-HSA-211897
Phase I - Functionalization of compounds R-HSA-211945
Miscellaneous substrates R-HSA-211958
Xenobiotics R-HSA-211981
Expression Atlas ENSG00000073067
GeneCards 20243
HGNC Symbol HGNC:20243
MIM gene 615967
NCBI gene (formerly Entrezgene) 54905
UniProtKB Gene Name Q8TAV3
UniProtKB Gene Name Q8TAV3
UniProtKB Gene Name Q8TAV3
WikiGene 54905
Cytochrome P450 2A13
Ensembl ID : ENSG00000197838
Gene: CYP2A13
UniProtKB Entry: Q16696

>ENSG00000197838|Cytochrome P450 2A13
MLASGLLLVTLLACLTVMVLMSVWRQRKSRGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVKEALVDQAEEFSGRGEQATFDWLFKGYGVAFSNGERAKQLRRFSIATLRGFGVGKRGIEERIQEEAGFLIDALRGTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLRMMLGSFQFTATSTGQLYEMFSSVMKHLPGPQQQAFKELQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFFAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYTEAVIHEIQRFGDMLPMGLAHRVNKDTKFRDFFLPKGTEVFPMLGSVLRDPRFFSNPRDFNPQHFLDKKGQFKKSDAFVPFSIGKRYCFGEGLARMELFLFFTTIMQNFRFKSPQSPKDIDVSPKHVGFATIPRNYTMSFLPR

Identifier Resolution Method Chain Positions Source
2PG5 1.95 Å X-ray A/B/C/D 31-494 PDB
4EJI 2.10 Å X-ray A 31-494 PDB
2P85 2.35 Å X-ray A/B/C/D/E/F 26-494 PDB
4EJH 2.35 Å X-ray A/B/C/D/E/F/G/H 31-494 PDB
4EJG 2.50 Å X-ray A/B/C/D/E/F/G/H 31-494 PDB
2PG6 2.53 Å X-ray A/B/C/D 31-494 PDB
2PG7 2.80 Å X-ray A/B/C/D 31-494 PDB
3T3S 3.00 Å X-ray A/B/C/D/E/F/G/H 31-494 PDB
Metabolism R-HSA-1430728
Biological oxidations R-HSA-211859
Cytochrome P450 - arranged by substrate type R-HSA-211897
Fatty acids R-HSA-211935
Phase I - Functionalization of compounds R-HSA-211945
Xenobiotics R-HSA-211981
CYP2E1 reactions R-HSA-211999
Aflatoxin activation and detoxification R-HSA-5423646
Expression Atlas ENSG00000197838
GeneCards 2608
HGNC Symbol HGNC:2608
MIM gene 608055
NCBI gene (formerly Entrezgene) 1553
UniProtKB Gene Name Q16696
WikiGene 1553
Cytochrome P450 2A7
Ensembl ID : ENSG00000198077
Gene: CYP2A7
UniProtKB Entry: P20853

>ENSG00000198077|Cytochrome P450 2A7
MLASGLLLVALLACLTVMVLMSVWQQRKSRGKLPPGPTPLPFIGNYLQLNTEHICDSIMKFSECYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVAFSNGERAKQLLRFAIATLRDFGVGKRGIEERIQEESGFLIEAIRSTHGANIDPTFFLSRTVSNVISSIVFGDRFDYEDKEFLSLLSMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFKLLQGLEDFIAKKVEHNQRTLDPNSPQDFIDSFLIHMQEEEKNPNTEFYLKNLMMSTLNLFIAGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRTKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVFPMLGSVLRDPSFFSNPQDFNPQHFLDDKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVVFATIPRNYTMSFLPR

AF-P20853-F1
Identifier Resolution Method Chain Positions Source
None Predicted None 1-494 AlphaFold DB
Metabolism R-HSA-1430728
Biological oxidations R-HSA-211859
Cytochrome P450 - arranged by substrate type R-HSA-211897
Fatty acids R-HSA-211935
Phase I - Functionalization of compounds R-HSA-211945
Xenobiotics R-HSA-211981
CYP2E1 reactions R-HSA-211999
Expression Atlas ENSG00000198077
GeneCards 2611
HGNC Symbol HGNC:2611
MIM gene 608054
NCBI gene (formerly Entrezgene) 1549
UniProtKB Gene Name P20853
UniProtKB Gene Name P20853
UniProtKB Gene Name P20853
WikiGene 1549
Cytochrome P450 2A6
Ensembl ID : ENSG00000255974
Gene: CYP2A6
UniProtKB Entry: P11509

>ENSG00000255974|Cytochrome P450 2A6
MLASGMLLVALLVCLTVMVLMSVWQQRKSKGKLPPGPTPLPFIGNYLQLNTEQMYNSLMKISERYGPVFTIHLGPRRVVVLCGHDAVREALVDQAEEFSGRGEQATFDWVFKGYGVVFSNGERAKQLRRFSIATLRDFGVGKRGIEERIQEEAGFLIDALRGTGGANIDPTFFLSRTVSNVISSIVFGDRFDYKDKEFLSLLRMMLGIFQFTSTSTGQLYEMFSSVMKHLPGPQQQAFQLLQGLEDFIAKKVEHNQRTLDPNSPRDFIDSFLIRMQEEEKNPNTEFYLKNLVMTTLNLFIGGTETVSTTLRYGFLLLMKHPEVEAKVHEEIDRVIGKNRQPKFEDRAKMPYMEAVIHEIQRFGDVIPMSLARRVKKDTKFRDFFLPKGTEVYPMLGSVLRDPSFFSNPQDFNPQHFLNEKGQFKKSDAFVPFSIGKRNCFGEGLARMELFLFFTTVMQNFRLKSSQSPKDIDVSPKHVGFATIPRNYTMSFLPR

Identifier Resolution Method Chain Positions Source
2FDV 1.65 Å X-ray A/B/C/D 29-494 PDB
2FDU 1.85 Å X-ray A/B/C/D 29-494 PDB
1Z10 1.90 Å X-ray A/B/C/D 29-494 PDB
2FDY 1.95 Å X-ray A/B/C/D 29-494 PDB
2FDW 2.05 Å X-ray A/B/C/D 29-494 PDB
1Z11 2.05 Å X-ray A/B/C/D 29-494 PDB
3T3Q 2.10 Å X-ray A/B/C/D 29-494 PDB
3EBS 2.15 Å X-ray A/B/C/D 29-494 PDB
4EJJ 2.30 Å X-ray A/B/C/D 29-494 PDB
3T3R 2.40 Å X-ray A/B/C/D 29-494 PDB
4RUI 2.61 Å X-ray A/B/C/D/E/F 29-494 PDB
Metabolism R-HSA-1430728
Biological oxidations R-HSA-211859
Cytochrome P450 - arranged by substrate type R-HSA-211897
Phase I - Functionalization of compounds R-HSA-211945
Xenobiotics R-HSA-211981
CYP2E1 reactions R-HSA-211999
Expression Atlas ENSG00000255974
GeneCards 2610
HGNC Symbol HGNC:2610
MIM gene 122720
MIM morbid 211980
MIM morbid 211980
MIM morbid 211980
MIM morbid 211980
NCBI gene (formerly Entrezgene) 1548
UniProtKB Gene Name P11509
UniProtKB Gene Name P11509
WikiGene 1548
Cytochrome P450 2B6
Ensembl ID : ENSG00000197408
Gene: CYP2B6
UniProtKB Entry: P20813

>ENSG00000197408|Cytochrome P450 2B6
MELSVLLFLALLTGLLLLLVQRHPNTHDRLPPGPRPLPLLGNLLQMDRRGLLKSFLRFREKYGDVFTVHLGPRPVVMLCGVEAIREALVDKAEAFSGRGKIAMVDPFFRGYGVIFANGNRWKVLRRFSVTTMRDFGMGKRSVEERIQEEAQCLIEELRKSKGALMDPTFLFQSITANIICSIVFGKRFHYQDQEFLKMLNLFYQTFSLISSVFGQLFELFSGFLKYFPGAHRQVYKNLQEINAYIGHSVEKHRETLDPSAPKDLIDTYLLHMEKEKSNAHSEFSHQNLNLNTLSLFFAGTETTSTTLRYGFLLMLKYPHVAERVYREIEQVIGPHRPPELHDRAKMPYTEAVIYEIQRFSDLLPMGVPHIVTQHTSFRGYIIPKDTEVFLILSTALHDPHYFEKPDAFNPDHFLDANGALKKTEAFIPFSLGKRICLGEGIARAELFLFFTTILQNFSMASPVAPEDIDLTPQECGVGKIPPTYQIRFLPR

Identifier Resolution Method Chain Positions Source
5UFG 1.76 Å X-ray A 20-491 PDB
5UDA 1.93 Å X-ray A/B 20-491 PDB
4I91 2.00 Å X-ray A 27-491 PDB
3IBD 2.00 Å X-ray A 30-491 PDB
5UAP 2.03 Å X-ray A/B 20-491 PDB
3QOA 2.10 Å X-ray A 27-491 PDB
4RQL 2.10 Å X-ray A/B 27-491 PDB
4RRT 2.20 Å X-ray A/B 27-491 PDB
4ZV8 2.24 Å X-ray A 30-491 PDB
5UEC 2.27 Å X-ray A 20-491 PDB
3UA5 2.80 Å X-ray A/B 27-491 PDB
3QU8 2.80 Å X-ray A/B/C/D/E/F 27-491 PDB
5WBG 2.99 Å X-ray A/B/C/D/E/F 20-491 PDB
Metabolism R-HSA-1430728
Biological oxidations R-HSA-211859
Cytochrome P450 - arranged by substrate type R-HSA-211897
Fatty acids R-HSA-211935
Phase I - Functionalization of compounds R-HSA-211945
Xenobiotics R-HSA-211981
CYP2E1 reactions R-HSA-211999
Expression Atlas ENSG00000197408
GeneCards 2615
HGNC Symbol HGNC:2615
LRG display in Ensembl gene LRG_1267
MIM gene 123930
MIM morbid 614546
NCBI gene (formerly Entrezgene) 1555
UniProtKB Gene Name P20813
UniProtKB Gene Name P20813
WikiGene 1555
Cytochrome P450 2D6
Ensembl ID : ENSG00000100197
Gene: CYP2D6
UniProtKB Entry: P10635

>ENSG00000100197|Cytochrome P450 2D6
MGLEALVPLAVIVAIFLLLVDLMHRRQRWAARYPPGPLPLPGLGNLLHVDFQNTPYCFDQLRRRFGDVFSLQLAWTPVVVLNGLAAVREALVTHGEDTADRPPVPITQILGFGPRSQGVFLARYGPAWREQRRFSVSTLRNLGLGKKSLEQWVTEEAACLCAAFANHSGRPFRPNGLLDKAVSNVIASLTCGRRFEYDDPRFLRLLDLAQEGLKEESGFLREVLNAVPVLLHIPALAGKVLRFQKAFLTQLDELLTEHRMTWDPAQPPRDLTEAFLAEMEKAKGNPESSFNDENLRIVVADLFSAGMVTTSTTLAWGLLLMILHPDVQRRVQQEIDDVIGQVRRPEMGDQAHMPYTTAVIHEVQRFGDIVPLGVTHMTSRDIEVQGFRIPKGTTLITNLSSVLKDEAVWEKPFRFHPEHFLDAQGHFVKPEAFLPFSAGRRACLGEPLARMELFLFFTSLLQHFSFSVPTGQPRPSHHGVFAFLVSPSPYELCAVPR

Identifier Resolution Method Chain Positions Source
3TBG 2.10 Å X-ray A/B/C/D 34-497 PDB
4WNU 2.26 Å X-ray A/B/C/D 34-497 PDB
4WNV 2.35 Å X-ray A/B/C/D 48-497 PDB
6CSB 2.39 Å X-ray A/B/C/D 34-497 PDB
6CSD 2.39 Å X-ray A/B 34-497 PDB
4XRZ 2.40 Å X-ray A/B/C/D 34-497 PDB
4XRY 2.50 Å X-ray A/B/C/D 34-497 PDB
4WNT 2.60 Å X-ray A/B 34-497 PDB
3TDA 2.67 Å X-ray A/B/C/D 34-497 PDB
5TFT 2.71 Å X-ray A/B/C/D 34-497 PDB
5TFU 2.75 Å X-ray A/B/C/D 34-497 PDB
3QM4 2.85 Å X-ray A/B 34-497 PDB
2F9Q 3.00 Å X-ray A/B/C/D 34-497 PDB
4WNW 3.30 Å X-ray A/B 34-497 PDB
Metabolism R-HSA-1430728
Biological oxidations R-HSA-211859
Cytochrome P450 - arranged by substrate type R-HSA-211897
Fatty acids R-HSA-211935
Phase I - Functionalization of compounds R-HSA-211945
Miscellaneous substrates R-HSA-211958
Xenobiotics R-HSA-211981
CYP2E1 reactions R-HSA-211999
Metabolism of lipids R-HSA-556833
Biosynthesis of DHA-derived SPMs R-HSA-9018677
Biosynthesis of specialized proresolving mediators (SPMs) R-HSA-9018678
Biosynthesis of maresins R-HSA-9018682
Biosynthesis of maresin-like SPMs R-HSA-9027307
Drug ADME R-HSA-9748784
Aspirin ADME R-HSA-9749641
Expression Atlas ENSG00000100197
GeneCards 2625
HGNC Symbol HGNC:2625
LRG display in Ensembl gene LRG_303
MIM gene 124030
MIM morbid 608902
NCBI gene (formerly Entrezgene) 1565
UniProtKB Gene Name Q6NWU0
UniProtKB Gene Name Q6NWU0
UniProtKB Gene Name Q6NWU0
UniProtKB Gene Name Q6NWU0
UniProtKB Gene Name Q6NWU0
UniProtKB Gene Name Q6NWU0
UniProtKB Gene Name Q6NWU0
WikiGene 1565