DOXAPRAM HYDROCHLORIDE

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Search structure


Trade Names	DOPRAM DOXAPRAM HYDROCHLORIDE
Synonyms	AHR-619 Dopram Doxapram hcl Doxapram hydrochloride Doxapram hydrochloride hydrate Doxapram hydrochloride monohydrate NSC-170958 NSC-760347 Stimulexin
Status
Molecule Category	Salt-form
UNII	P5RU6UOQ5Y
Parent Compound:	DOXAPRAM

Structure


InChI Key	ZOMBFZRWMLIDPX-UHFFFAOYSA-N
Smiles	CCN1CC(CCN2CCOCC2)C(c2ccccc2)(c2ccccc2)C1=O.Cl.O
InChI	InChI=1S/C24H30N2O2.ClH.H2O/c1-2-26-19-22(13-14-25-15-17-28-18-16-25)24(23(26)27,20-9-5-3-6-10-20)21-11-7-4-8-12-21;;/h3-12,22H,2,13-19H2,1H3;1H;1H2

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C24H33ClN2O3
Molecular Weight	432.99
AlogP	3.17
Hydrogen Bond Acceptor	3.0
Number of Rotational Bond	6.0
Polar Surface Area	32.78
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	28.0

Pharmacology

Mechanism of Action	Action	Reference
Potassium channel subfamily K member 3 blocker	BLOCKER	PubMed FDA

Target Conservation


Protein: Potassium channel subfamily K member 3 Description: Potassium channel subfamily K member 3 Organism : Homo sapiens O14649 ENSG00000171303











Protein: Potassium channel subfamily K member 9 Description: Potassium channel subfamily K member 9 Organism : Homo sapiens Q9NPC2 ENSG00000169427

Cross References

Resources	Reference
ChEBI	31520
ChEMBL	CHEMBL3989519
FDA SRS	P5RU6UOQ5Y
PubChem	64648
SureChEMBL	SCHEMBL40643

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025