EcoDrugPlus


Trade Names	SULLA
Synonyms	AHR-857 BAY-5400 Bayrena NSC-683528 NSC-757874 SH-613 Sulfameter Sulfamethoxydiazine Sulfamethoxypyrimidine Sulfametin Sulfametoxydiazine Sulla Sulphamethoxydiazine Ultrax
Status
Molecule Category	Free-form
UNII	3L179F09D6
EPA CompTox	DTXSID5023613


InChI Key	GPTONYMQFTZPKC-UHFFFAOYSA-N
Smiles	COc1cnc(NS(=O)(=O)c2ccc(N)cc2)nc1
InChI	InChI=1S/C11H12N4O3S/c1-18-9-6-13-11(14-7-9)15-19(16,17)10-4-2-8(12)3-5-10/h2-7H,12H2,1H3,(H,13,14,15)

Property Name	Value
Molecular Formula	C11H12N4O3S
Molecular Weight	280.31
AlogP	0.87
Hydrogen Bond Acceptor	6.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	4.0
Polar Surface Area	107.2
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	19.0

Mechanism of Action	Action	Reference
Bacterial dihydropteroate synthase inhibitor	INHIBITOR	ISBN PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	112.86-233.46

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cricetulus griseus	-	-	-	-	112.86-233.46

Resources	Reference
ChEBI	53727
ChEMBL	CHEMBL1200359
DrugBank	DB06821
DrugCentral	2511
FDA SRS	3L179F09D6
PubChem	5326
SureChEMBL	SCHEMBL79417
ZINC	ZINC000000049142

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

SULFAMETER

Structure

Physicochemical Descriptors

Pharmacology

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