INDOMETHACIN


Synonyms	Aconip Artracin Artracin sr Berlind 75 ret Durametacin Flexin-25 continus Flexin-50 continus Flexin-75 continus Imbrilon Indo-lemmon Indo-paed Indocid ret Indocid-r Indocin Indocin sr
Status
Molecule Category	Free-form
UNII	XXE1CET956
EPA CompTox	DTXSID9020740


InChI Key	CGIGDMFJXJATDK-UHFFFAOYSA-N
Smiles	COc1ccc2c(c1)c(CC(=O)O)c(C)n2C(=O)c1ccc(Cl)cc1
InChI	InChI=1S/C19H16ClNO4/c1-11-15(10-18(22)23)16-9-14(25-2)7-8-17(16)21(11)19(24)12-3-5-13(20)6-4-12/h3-9H,10H2,1-2H3,(H,22,23)

Mechanism of Action	Action	Reference
Cyclooxygenase inhibitor	INHIBITOR	FDA ISBN

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Cytochrome P450 Cytochrome P450 family 2 Cytochrome P450 family 2C Cytochrome P450 2C8	-	-	-	-	14
Enzyme Cytochrome P450 Cytochrome P450 family 5 Cytochrome P450 family 5A Cytochrome P450 5A1	-	100	-	-	-
Enzyme Isomerase	-	500	-	-	-
Enzyme Oxidoreductase	-	2-960	92-253	-	0-110
Enzyme Protease Aspartic protease Aspartic protease AD clan Aspartic protease A22A subfamily Aspartic protease A22A regulatory subfamily	-	-	-	-	53
Enzyme Transferase	-	-	-	-	0
Enzyme	-	2-960	92-253	-	0-110
Ion channel Other ion channel Miscellaneous ion channel Presenilin ER Ca2+ leak channel family	-	-	-	-	53
Ion channel Voltage-gated ion channel Voltage-gated sodium channel	-	-	-	-	3.3-11.2
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Lipid-like ligand receptor (family A GPCR) Prostanoid receptor	389	-	-	50	-
Secreted protein	-	50	700	-	-
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 3 Nuclear hormone receptor subfamily 3 group C Nuclear hormone receptor subfamily 3 group C member 4	0.14	-	-	-	-
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	-82.4-97.38
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC47 family of multidrug and toxin extrusion transporters	-	-	-	-	6
Transporter Primary active transporter Oxidoreduction-driven transporters	-	70-610	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Bos taurus	-	4.1-560	-	-	100-100
Cavia porcellus	-	-	-	-	3.3-99
Cricetulus griseus	-	-	-	-	50.32-97.38
Homo sapiens	0.14-389	3.6-960	92-700	50	-82.4-100
Mus musculus	-	2-750	-	-	-29.9-108
Oryctolagus cuniculus	-	140-210	-	-	8-100
Ovis aries	-	4-900	-	-	0.2-100
Rattus norvegicus	-	2.9-800	-	-	-123.8-100


Protein: Cyclooxygenase Description: Prostaglandin G/H synthase 1 Organism : Homo sapiens P23219 ENSG00000095303












Protein: Cyclooxygenase Description: Prostaglandin G/H synthase 2 Organism : Homo sapiens P35354 ENSG00000073756

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