Synonyms | |
Status | |
Molecule Category | Free-form |
ATC | N01BB04 |
UNII | 046O35D44R |
EPA CompTox | DTXSID7031955 |
InChI Key | MVFGUOIZUNYYSO-UHFFFAOYSA-N | |
---|---|---|
Smiles | ||
InChI |
|
Property Name | Value | |
---|---|---|
Molecular Formula | C13H20N2O | |
Molecular Weight | 220.32 | |
AlogP | 2.32 | |
Hydrogen Bond Acceptor | 2.0 | |
Hydrogen Bond Donor | 2.0 | |
Number of Rotational Bond | 5.0 | |
Polar Surface Area | 41.13 | |
Molecular species | BASE | |
Aromatic Rings | 1.0 | |
Heavy Atoms | 16.0 |
Mechanism of Action | Action | Reference | |
---|---|---|---|
Sodium channel alpha subunit blocker | BLOCKER | PubMed PubMed DailyMed |
Protein: Sodium channel alpha subunit Description: Sodium channel protein type 1 subunit alpha Organism : Homo sapiens P35498 ENSG00000144285 |
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Protein: Sodium channel alpha subunit Description: Sodium channel protein type 4 subunit alpha Organism : Homo sapiens P35499 ENSG00000007314 |
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Protein: Sodium channel alpha subunit Description: Sodium channel protein type 5 subunit alpha Organism : Homo sapiens Q14524 ENSG00000183873 |
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Protein: Sodium channel alpha subunit Description: Sodium channel protein type 9 subunit alpha Organism : Homo sapiens Q15858 ENSG00000169432 |
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Protein: Sodium channel alpha subunit Description: Sodium channel protein type 2 subunit alpha Organism : Homo sapiens Q99250 ENSG00000136531 |
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Protein: Sodium channel alpha subunit Description: Sodium channel protein type 3 subunit alpha Organism : Homo sapiens Q9NY46 ENSG00000153253 |
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Protein: Sodium channel alpha subunit Description: Sodium channel protein type 11 subunit alpha Organism : Homo sapiens Q9UI33 ENSG00000168356 |
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Protein: Sodium channel alpha subunit Description: Sodium channel protein type 8 subunit alpha Organism : Homo sapiens Q9UQD0 ENSG00000196876 |
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Protein: Sodium channel alpha subunit Description: Sodium channel protein type 10 subunit alpha Organism : Homo sapiens Q9Y5Y9 ENSG00000185313 |
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Targets | EC50(nM) | IC50(nM) | Kd(nM) | Ki(nM) | Inhibition(%) | ||
---|---|---|---|---|---|---|---|
Ion channel
Voltage-gated ion channel
Voltage-gated sodium channel
|
- | 54000 | - | - | 14-59 |
Resources | Reference | |
---|---|---|
ChEBI | 8404 | |
ChEMBL | CHEMBL1194 | |
DrugBank | DB00750 | |
DrugCentral | 2265 | |
FDA SRS | 046O35D44R | |
Human Metabolome Database | HMDB0014888 | |
Guide to Pharmacology | 7276 | |
KEGG | C07531 | |
PharmGKB | PA451101 | |
PubChem | 4906 | |
SureChEMBL | SCHEMBL25467 |