EcoDrugPlus


Trade Names	MEFENAMIC ACID PONSTEL
Synonyms	CI-473 CN-35355 Contraflam Dysman-250 Dysman-500 Gardan INF-3355 J2.344B M01AG01 Mefenamic acid Mefenaminic acid Meflam 250 Meflam 500 Mendys Mephenamic acid
Status
Molecule Category	Free-form
ATC	M01AG01
UNII	367589PJ2C
EPA CompTox	DTXSID5023243

Datasets:

Active Pharmaceutical Ingredients

Bioactive chemicals

Agrochemicals

Human Metabolites

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SubStructure

Threshold (%) >= 70


InChI Key	HYYBABOKPJLUIN-UHFFFAOYSA-N
Smiles	Cc1cccc(Nc2ccccc2C(=O)O)c1C
InChI	InChI=1S/C15H15NO2/c1-10-6-5-9-13(11(10)2)16-14-8-4-3-7-12(14)15(17)18/h3-9,16H,1-2H3,(H,17,18)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C15H15NO2
Molecular Weight	241.29
AlogP	3.75
Hydrogen Bond Acceptor	2.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	3.0
Polar Surface Area	49.33
Molecular species	ACID
Aromatic Rings	2.0
Heavy Atoms	18.0

Mechanism of Action	Action	Reference
Cyclooxygenase inhibitor	INHIBITOR	PubMed PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Oxidoreductase	-	980	-	220-810	-
Enzyme Phosphodiesterase Phosphodiesterase 4 Phosphodiesterase 4B	-	-	-	-	38.91
Enzyme Phosphodiesterase Phosphodiesterase 4 Phosphodiesterase 4D	-	-	-	-	35.54
Enzyme Protease Serine protease Serine protease PA clan Serine protease S1A subfamily	-	-	-	-	41
Enzyme	-	560	-	220-810	35.54
Secreted protein	-	-	-	-	93
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	63.23-72.63

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cricetulus griseus	-	-	-	-	63.23-72.63
Homo sapiens	-	560-980	-	220-810	35.54-93
Mus musculus	-	-	-	-	24.08-74.92
Rattus norvegicus	-	-	-	-	16.7-69.06

Target Conservation


Protein: Cyclooxygenase Description: Prostaglandin G/H synthase 1 Organism : Homo sapiens P23219 ENSG00000095303












Protein: Cyclooxygenase Description: Prostaglandin G/H synthase 2 Organism : Homo sapiens P35354 ENSG00000073756

Environmental Exposure

Countries
Croatia
Czech Republic
Germany
Hungary
Romania
Serbia
Slovenia

Cross References

Resources	Reference
ChEBI	6717
ChEMBL	CHEMBL686
DrugBank	DB00784
DrugCentral	1663
FDA SRS	367589PJ2C
Human Metabolome Database	HMDB0014922
Guide to Pharmacology	2593
KEGG	C02168
PDB	ID8
PharmGKB	PA450347
PubChem	4044
SureChEMBL	SCHEMBL3544
ZINC	ZINC000000020241

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

MEFENAMIC ACID

Structure

Physicochemical Descriptors

Pharmacology

Target Conservation

Related Entries

Environmental Exposure

Cross References