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MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Glucocorticoid receptor agonist
ROUTE OF ADMINISTRATION: OPHTHALMIC
STATUS: Approved
THERAPEUTIC AREA: EYE
THERAPEUTIC INDICATION: Dry Eye Syndromes; Cataract; Panuveitis; Uveitis; Inflammation; Uveitis, Anterior
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Neurokinin 1 receptor antagonist
ROUTE OF ADMINISTRATION: INJECTION; INTRAVENOUS; UNKNOWN
STATUS: Approved
THERAPEUTIC AREA: CANCER; OTHER
THERAPEUTIC INDICATION: Sarcoma; Neoplasms; Postoperative Nausea and Vomiting
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Multiple Myeloma; Nasopharyngeal Neoplasms; Genital Neoplasms, Female; Nausea; Neoplasms; Postoperative Nausea and Vomiting
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Coronary Disease
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: HIV Infections; Asthma; Heart Diseases; Acute Coronary Syndrome; Anemia, Sickle Cell; Atrial Fibrillation; Coronary Disease; Influenza, Human; Myocardial Infarction; Pneumonia; Renal Insufficiency, Chronic; ST Elevation Myocardial Infarction; Severe Acute Respiratory Syndrome; Thrombosis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Ferriprotoporphyrin IX inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: HIV Infections; Neoplasms; Schistosomiasis haematobia; Fever; Malaria, Falciparum; Malaria, Vivax; Malaria
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Sodium channel alpha subunit blocker
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER
THERAPEUTIC INDICATION: Neuralgia; Bipolar Disorder; Fibromyalgia; Migraine Disorders; Diabetic Neuropathies; Epilepsies, Partial; Epilepsy, Complex Partial; Neuralgia, Postherpetic; Epilepsy; Seizures
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Purinergic receptor P2Y12 antagonist
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Acute Coronary Syndrome; Hemorrhage; Myocardial Infarction
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Estrogen receptor alpha agonist
ROUTE OF ADMINISTRATION: INJECTION
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Atrophic Vaginitis; Dysmenorrhea; Infertility; Metrorrhagia; Atrophy; Hypogonadism; Menopause; Menorrhagia; Primary Ovarian Insufficiency
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Sphingosine 1-phosphate receptor agonist
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Breast Neoplasms; Amyotrophic Lateral Sclerosis; Multiple Sclerosis, Relapsing-Remitting; Multiple Sclerosis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: INTRAVENOUS
STATUS: Approved
THERAPEUTIC AREA: OTHER; RESPIRATORY
THERAPEUTIC INDICATION: Kidney Diseases; Meningitis; Systemic Inflammatory Response Syndrome; Sepsis; Urinary Tract Infections; Infections; Influenza, Human; Pneumonia; Pneumonia, Bacterial; Severe Acute Respiratory Syndrome; Bacterial Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: MUSCULOSKELETAL
THERAPEUTIC INDICATION: Breast Neoplasms; Renal Insufficiency; Rett Syndrome; Asthma; Optic Neuritis; Schizophrenia; Severe Acute Respiratory Syndrome; Stroke; Uveitis; Multiple Sclerosis; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Immune System Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Hematologic Diseases; Non-alcoholic Fatty Liver Disease; Prostatic Neoplasms; Renal Insufficiency; Renal Insufficiency, Chronic; Coronary Disease; Atrial Fibrillation; Stroke; Thromboembolism; Venous Thromboembolism; Venous Thrombosis; Thrombosis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Voltage-gated calcium channel modulator
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: DERMATOLOGY; NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER
THERAPEUTIC INDICATION: Kidney Diseases; Alcoholism; Diabetic Neuropathies; Migraine Disorders; Epilepsy; Neuralgia, Postherpetic; Restless Legs Syndrome
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Type-1 angiotensin II receptor antagonist
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: CARDIOVASCULAR; OTHER
THERAPEUTIC INDICATION: Hypertension; Stroke
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Essential Hypertension; Hypertension; Cardiovascular Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Cytochrome P450 17A1 inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: CANCER
THERAPEUTIC INDICATION: Carcinoma, Non-Small-Cell Lung; Liver Diseases; Renal Insufficiency; Adrenal Hyperplasia, Congenital; Salivary Gland Neoplasms; Breast Neoplasms; Neoplasms; Prostatic Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Prostanoid FP receptor agonist
ROUTE OF ADMINISTRATION: OPHTHALMIC
STATUS: Approved
THERAPEUTIC AREA: EYE
THERAPEUTIC INDICATION: Glaucoma; Glaucoma, Open-Angle; Ocular Hypertension
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Glutamine sequestering agent
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: HEMATOLOGY
THERAPEUTIC INDICATION: Cystic Fibrosis; Parkinson Disease; Urea Cycle Disorders, Inborn
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Potassium-transporting ATPase inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Duodenal Ulcer; Gastroesophageal Reflux; Stomach Ulcer; Zollinger-Ellison Syndrome
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Androgen Receptor agonist
ROUTE OF ADMINISTRATION: INTRAMUSCULAR; ORAL
STATUS: Approved
THERAPEUTIC AREA: DIABETES DRUGS & ENDOCRINOLOGY
THERAPEUTIC INDICATION: Carcinoma, Renal Cell; Coronary Disease; Prostatic Neoplasms, Castration-Resistant; Sexual Dysfunction, Physiological; Spinal Cord Injuries; Aging; Malnutrition; Respiratory Insufficiency; Hypogonadism; Klinefelter Syndrome; Neoplasms; Orchitis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Angiotensin-converting enzyme inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Aortic Aneurysm, Abdominal; Coronary Artery Disease; Hypertension; Myocardial Infarction
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Human immunodeficiency virus type 1 reverse transcriptase inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: HIV Infections; Hepatitis B, Chronic
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Human immunodeficiency virus type 1 reverse transcriptase inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Amyotrophic Lateral Sclerosis; Insulin Resistance; Hepatitis D; Leukemia, Lymphocytic, Chronic, B-Cell; Acquired Immunodeficiency Syndrome; HIV Infections; Hepatitis B, Chronic; Severe Acute Respiratory Syndrome; Virus Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Dopamine D2 receptor partial agonist
ROUTE OF ADMINISTRATION: INTRAMUSCULAR
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Psychotic Disorders; Autistic Disorder; Bipolar Disorder; Depressive Disorder, Major; Schizophrenia; Tourette Syndrome
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: 26S proteosome inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Amyloidosis, Familial; Breast Neoplasms; Leukemia, Myeloid, Acute; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Leukemia, Plasma Cell; Lymphoma; Lymphoma, Mantle-Cell; Plasmacytoma; Sarcoma, Kaposi; Waldenstrom Macroglobulinemia; Multiple Myeloma; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Glucocorticoid receptor agonist
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Kidney Diseases; Liver Diseases; Aspergillosis, Allergic Bronchopulmonary; Muscular Dystrophies, Limb-Girdle; Muscular Dystrophies; Muscular Dystrophy, Duchenne
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Tryptophan 5-hydroxylase inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Liver Diseases; Biliary Tract Neoplasms; Malignant Carcinoid Syndrome; Neuroendocrine Tumors; Carcinoid Heart Disease
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Polymerase acidic protein inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Influenza, Human; Virus Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Tyrosine-protein kinase SYK inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Hematologic Neoplasms; Lymphoma; Ovarian Neoplasms; Pneumonia; Anemia, Hemolytic, Autoimmune; Glomerulonephritis, IGA; Hidradenitis Suppurativa; Lymphoma, Large B-Cell, Diffuse; Primary Myelofibrosis; Severe Acute Respiratory Syndrome; Arthritis, Rheumatoid; Purpura, Thrombocytopenic, Idiopathic; Hemorrhage
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Tyrosine-protein kinase SYK inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Arthritis, Rheumatoid; Glomerulonephritis, IGA; Lupus Erythematosus, Systemic; Lymphoma; Anemia, Hemolytic, Autoimmune; Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: RNA-directed RNA polymerase L inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Pneumonia, Viral; Hemorrhagic Fever, Ebola; Respiratory Distress Syndrome; Severe Acute Respiratory Syndrome; Virus Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Breast Neoplasms; Carcinoma, Hepatocellular; Friedreich Ataxia; Neoplasms; Colorectal Neoplasms; Conjunctivitis, Allergic; Crohn Disease; Cytomegalovirus Infections; Fever; Malaria, Falciparum; Malaria, Vivax; Schistosomiasis; Schistosomiasis haematobia; Severe Acute Respiratory Syndrome; Malaria
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Genome polyprotein inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Investigational
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Fever; Marburg Virus Disease; Severe Acute Respiratory Syndrome
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Glutamate [NMDA] receptor antagonist
ROUTE OF ADMINISTRATION: Unknown
STATUS: Investigational
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Neuralgia; Depressive Disorder; Depressive Disorder, Major; Hypertension, Pulmonary