FOSTAMATINIB

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Synonyms
Status
Molecule Category Free-form
ATC B02BX09
UNII SQ8A3S5101

Structure

InChI Key GKDRMWXFWHEQQT-UHFFFAOYSA-N
Smiles COc1cc(Nc2ncc(F)c(Nc3ccc4c(n3)N(COP(=O)(O)O)C(=O)C(C)(C)O4)n2)cc(OC)c1OC
InChI
InChI=1S/C23H26FN6O9P/c1-23(2)21(31)30(11-38-40(32,33)34)20-14(39-23)6-7-17(28-20)27-19-13(24)10-25-22(29-19)26-12-8-15(35-3)18(37-5)16(9-12)36-4/h6-10H,11H2,1-5H3,(H2,32,33,34)(H2,25,26,27,28,29)

Physicochemical Descriptors

Property Name Value
Molecular Formula C23H26FN6O9P
Molecular Weight 580.47
AlogP 3.09
Hydrogen Bond Acceptor 12.0
Hydrogen Bond Donor 4.0
Number of Rotational Bond 10.0
Polar Surface Area 186.72
Molecular species ACID
Aromatic Rings 3.0
Heavy Atoms 40.0

Pharmacology

Mechanism of Action Action Reference
Tyrosine-protein kinase SYK inhibitor INHIBITOR PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Kinase Protein Kinase TK protein kinase group Tyrosine protein kinase Syk family
- 17-267 - - -
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Homo sapiens
- 17-267 - - -
Mus musculus
- - - - 58

Target Conservation

Protein: Tyrosine-protein kinase SYK
Description: Tyrosine-protein kinase SYK
Organism : Homo sapiens
P43405 ENSG00000165025

Related Entries

Cross References

Resources Reference
ChEMBL CHEMBL2103830
DrugBank DB12010
DrugCentral 5280
FDA SRS SQ8A3S5101
Guide to Pharmacology 7796
PDB 2RC
PubChem 11671467
SureChEMBL SCHEMBL1201371
ZINC ZINC000043131420
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