EcoDrugPlus


Display Options: Drug type Therapeutic Area Route of Adminstration Mechanism of Action Indication Status


Small molecule Approved CARDIOVASCULAR; OTHER ORAL Asthma; Leukemia, Myeloid, Acute; Metabolic Diseases; Porokeratosis; Stroke; Arthritis, Rheumatoid; Breast Neoplasms; Carotid Stenosis; Cognitive Dysfunction; Fragile X Syndrome; HIV Infections; Heart Diseases; Intracranial Arteriosclerosis; Intracranial Arteriovenous Malformations; Learning Disabilities; Melanoma; Neurofibromatosis 1; Ovarian Neoplasms; Parkinson Disease; Prostatic Neoplasms, Castration-Resistant; Pulmonary Disease, Chronic Obstructive; Rett Syndrome; Xanthomatosis, Cerebrotendinous; Intermittent Claudication; Lipid Metabolism Disorders; Myocardial Ischemia; Atherosclerosis; Cardiovascular Diseases; Coronary Artery Disease; Coronary Disease; Hypercholesterolemia; Hypothyroidism HMG-CoA reductase inhibitor

Small molecule

Approved

CARDIOVASCULAR; OTHER

ORAL

Asthma; Leukemia, Myeloid, Acute; Metabolic Diseases; Porokeratosis; Stroke; Arthritis, Rheumatoid; Breast Neoplasms; Carotid Stenosis; Cognitive Dysfunction; Fragile X Syndrome; HIV Infections; Heart Diseases; Intracranial Arteriosclerosis; Intracranial Arteriovenous Malformations; Learning Disabilities; Melanoma; Neurofibromatosis 1; Ovarian Neoplasms; Parkinson Disease; Prostatic Neoplasms, Castration-Resistant; Pulmonary Disease, Chronic Obstructive; Rett Syndrome; Xanthomatosis, Cerebrotendinous; Intermittent Claudication; Lipid Metabolism Disorders; Myocardial Ischemia; Atherosclerosis; Cardiovascular Diseases; Coronary Artery Disease; Coronary Disease; Hypercholesterolemia; Hypothyroidism

HMG-CoA reductase inhibitor


Small molecule Approved OTHER; RESPIRATORY ORAL Bronchitis, Chronic; Infections; Maxillary Sinusitis; Otitis Media; Pharyngitis; Pneumonia; Sinusitis; Tonsillitis; Urinary Tract Infections Bacterial penicillin-binding protein inhibitor


Small molecule Approved OTHER INJECTION Multiple Myeloma; Myelodysplastic Syndromes; Myeloproliferative Disorders; Neoplasm Metastasis; Breast Neoplasms; Burkitt Lymphoma; Glioma; Leukemia, Myeloid, Acute; Lymphoma, AIDS-Related; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Mantle-Cell; Nasopharyngeal Neoplasms; Pancreatic Neoplasms; Penile Neoplasms; Peritoneal Neoplasms; Rhabdomyosarcoma, Alveolar; Rhabdomyosarcoma, Embryonal; Urethral Neoplasms; Urinary Bladder Neoplasms; Uterine Neoplasms; Wilms Tumor; Carcinoma; Carcinoma, Non-Small-Cell Lung; Central Nervous System Neoplasms; Dermatofibrosarcoma; Endometrial Neoplasms; Fallopian Tube Neoplasms; Fibrosarcoma; Hemangiopericytoma; Hemangiosarcoma; Histiocytoma; Hodgkin Disease; Kidney Neoplasms; Leiomyosarcoma; Leukemia; Leukemia, Biphenotypic, Acute; Liposarcoma; Lung Neoplasms; Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Peripheral; Mediastinal Neoplasms; Mesenchymoma; Neoplasms, Germ Cell and Embryonal; Neurilemmoma; Neuroblastoma; Osteosarcoma; Ovarian Neoplasms; Pheochromocytoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retroviridae Infections; Rhabdomyosarcoma; Sarcoma; Sarcoma, Alveolar Soft Part; Sarcoma, Ewing; Sarcoma, Synovial; Small Cell Lung Carcinoma; Teratoma; Uterine Cervical Neoplasms; Neoplasms; Testicular Neoplasms DNA inhibitor

Small molecule

Approved

OTHER

INJECTION

Multiple Myeloma; Myelodysplastic Syndromes; Myeloproliferative Disorders; Neoplasm Metastasis; Breast Neoplasms; Burkitt Lymphoma; Glioma; Leukemia, Myeloid, Acute; Lymphoma, AIDS-Related; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Mantle-Cell; Nasopharyngeal Neoplasms; Pancreatic Neoplasms; Penile Neoplasms; Peritoneal Neoplasms; Rhabdomyosarcoma, Alveolar; Rhabdomyosarcoma, Embryonal; Urethral Neoplasms; Urinary Bladder Neoplasms; Uterine Neoplasms; Wilms Tumor; Carcinoma; Carcinoma, Non-Small-Cell Lung; Central Nervous System Neoplasms; Dermatofibrosarcoma; Endometrial Neoplasms; Fallopian Tube Neoplasms; Fibrosarcoma; Hemangiopericytoma; Hemangiosarcoma; Histiocytoma; Hodgkin Disease; Kidney Neoplasms; Leiomyosarcoma; Leukemia; Leukemia, Biphenotypic, Acute; Liposarcoma; Lung Neoplasms; Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Peripheral; Mediastinal Neoplasms; Mesenchymoma; Neoplasms, Germ Cell and Embryonal; Neurilemmoma; Neuroblastoma; Osteosarcoma; Ovarian Neoplasms; Pheochromocytoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retroviridae Infections; Rhabdomyosarcoma; Sarcoma; Sarcoma, Alveolar Soft Part; Sarcoma, Ewing; Sarcoma, Synovial; Small Cell Lung Carcinoma; Teratoma; Uterine Cervical Neoplasms; Neoplasms; Testicular Neoplasms

DNA inhibitor


Small molecule Approved OTHER ORAL Abortion, Incomplete; Clostridium Infections; Muscle Cramp; Premature Birth; Abortion, Spontaneous; Leiomyoma; Menorrhagia; Myoma; Obesity; Pain; Postpartum Hemorrhage; Pre-Eclampsia; Pregnancy; Spondylitis, Ankylosing; Uterine Diseases; Duodenal Ulcer; Gastroesophageal Reflux; Hemorrhage; Osteoarthritis; Peptic Ulcer; Stomach Ulcer Prostanoid EP3 receptor agonist

Small molecule

Approved

OTHER

ORAL

Abortion, Incomplete; Clostridium Infections; Muscle Cramp; Premature Birth; Abortion, Spontaneous; Leiomyoma; Menorrhagia; Myoma; Obesity; Pain; Postpartum Hemorrhage; Pre-Eclampsia; Pregnancy; Spondylitis, Ankylosing; Uterine Diseases; Duodenal Ulcer; Gastroesophageal Reflux; Hemorrhage; Osteoarthritis; Peptic Ulcer; Stomach Ulcer

Prostanoid EP3 receptor agonist


Small molecule Approved Unknown Unknown Cystic Fibrosis; HIV Infections; Hepatitis C; Migraine Disorders; Metrorrhagia; Osteoporosis; Neural Tube Defects; Acne Vulgaris Progesterone receptor agonist


Small molecule Approved OTHER; UROLOGY AND KIDNEY ORAL Adrenal Hyperplasia, Congenital; Ovarian Neoplasms; Polycystic Ovary Syndrome; Prostatic Neoplasms, Castration-Resistant; Carcinoma; Neoplasms; Prostatic Neoplasms Androgen Receptor antagonist


Small molecule Approved EYE; OTHER IMPLANTATION; OPHTHALMIC; ORAL Central Nervous System Neoplasms; Kidney Diseases; Melanoma; Mesothelioma; Neuroblastoma; Carcinoma, Hepatocellular; Diabetes Mellitus, Type 1; Fallopian Tube Neoplasms; Glioblastoma; Graft vs Host Disease; Lymphoma; Ovarian Neoplasms; Peritoneal Neoplasms; Conjunctivitis; Cytomegalovirus Infections; Infections; Acquired Immunodeficiency Syndrome; Cytomegalovirus Retinitis; Eye Infections; HIV Infections; Primary Immunodeficiency Diseases; Retinitis; Virus Diseases Human herpesvirus 1 DNA polymerase inhibitor

Small molecule

Approved

EYE; OTHER

IMPLANTATION; OPHTHALMIC; ORAL

Central Nervous System Neoplasms; Kidney Diseases; Melanoma; Mesothelioma; Neuroblastoma; Carcinoma, Hepatocellular; Diabetes Mellitus, Type 1; Fallopian Tube Neoplasms; Glioblastoma; Graft vs Host Disease; Lymphoma; Ovarian Neoplasms; Peritoneal Neoplasms; Conjunctivitis; Cytomegalovirus Infections; Infections; Acquired Immunodeficiency Syndrome; Cytomegalovirus Retinitis; Eye Infections; HIV Infections; Primary Immunodeficiency Diseases; Retinitis; Virus Diseases

Human herpesvirus 1 DNA polymerase inhibitor


Small molecule Approved GASTROINTESTINAL; OTHER ORAL Alzheimer Disease; Anemia; Arthritis, Rheumatoid; Carcinoma, Medullary; Central Serous Chorioretinopathy; Child Development Disorders, Pervasive; Chronic Pain; Clostridium Infections; Colitis, Ulcerative; Communicable Diseases; Crohn Disease; Dermatitis, Atopic; Diabetes Mellitus; Diabetes Mellitus, Type 2; Erectile Dysfunction; Glaucoma; HIV Infections; Hepatitis B, Chronic; Hepatitis C; Hepatitis C, Chronic; Laryngomalacia; Melanoma; Mitochondrial Diseases; Muscular Atrophy, Spinal; Neoplasms; Psoriasis; Pulmonary Disease, Chronic Obstructive; Breast Neoplasms; Carcinoma, Squamous Cell; Colorectal Neoplasms; Cystic Fibrosis; Gastrinoma; Granuloma; Head and Neck Neoplasms; Idiopathic Pulmonary Fibrosis; Lymphoma; Lymphoma, B-Cell, Marginal Zone; Prostatic Neoplasms, Castration-Resistant; Squamous Cell Carcinoma of Head and Neck; Squamous Intraepithelial Lesions; Ulcer; Zollinger-Ellison Syndrome; Barrett Esophagus; Cough; Cysticercosis; Diabetes Mellitus, Type 1; Dyspepsia; Esophagitis, Peptic; Exocrine Pancreatic Insufficiency; Gastrointestinal Hemorrhage; Helicobacter Infections; Hemorrhage; Multiple Sclerosis, Relapsing-Remitting; Osteoarthritis; Pain; Spondylitis, Ankylosing; Stomach Neoplasms; Wounds and Injuries; Duodenal Ulcer; Esophagitis; Gastroesophageal Reflux; Heartburn; Infections; Peptic Ulcer; Stomach Ulcer Potassium-transporting ATPase inhibitor

Small molecule

Approved

GASTROINTESTINAL; OTHER

ORAL

Alzheimer Disease; Anemia; Arthritis, Rheumatoid; Carcinoma, Medullary; Central Serous Chorioretinopathy; Child Development Disorders, Pervasive; Chronic Pain; Clostridium Infections; Colitis, Ulcerative; Communicable Diseases; Crohn Disease; Dermatitis, Atopic; Diabetes Mellitus; Diabetes Mellitus, Type 2; Erectile Dysfunction; Glaucoma; HIV Infections; Hepatitis B, Chronic; Hepatitis C; Hepatitis C, Chronic; Laryngomalacia; Melanoma; Mitochondrial Diseases; Muscular Atrophy, Spinal; Neoplasms; Psoriasis; Pulmonary Disease, Chronic Obstructive; Breast Neoplasms; Carcinoma, Squamous Cell; Colorectal Neoplasms; Cystic Fibrosis; Gastrinoma; Granuloma; Head and Neck Neoplasms; Idiopathic Pulmonary Fibrosis; Lymphoma; Lymphoma, B-Cell, Marginal Zone; Prostatic Neoplasms, Castration-Resistant; Squamous Cell Carcinoma of Head and Neck; Squamous Intraepithelial Lesions; Ulcer; Zollinger-Ellison Syndrome; Barrett Esophagus; Cough; Cysticercosis; Diabetes Mellitus, Type 1; Dyspepsia; Esophagitis, Peptic; Exocrine Pancreatic Insufficiency; Gastrointestinal Hemorrhage; Helicobacter Infections; Hemorrhage; Multiple Sclerosis, Relapsing-Remitting; Osteoarthritis; Pain; Spondylitis, Ankylosing; Stomach Neoplasms; Wounds and Injuries; Duodenal Ulcer; Esophagitis; Gastroesophageal Reflux; Heartburn; Infections; Peptic Ulcer; Stomach Ulcer

Potassium-transporting ATPase inhibitor


Small molecule Approved Unknown Unknown Spondylitis, Ankylosing Unknown


Small molecule Approved CARDIOVASCULAR; OTHER ORAL Alopecia Areata; Anemia, Sickle Cell; Arthritis, Rheumatoid; Choroideremia; Chronic Pain; Cystic Fibrosis; Endotoxemia; Epilepsy; HIV Infections; Hepatitis B, Chronic; Leukemia, Lymphocytic, Chronic, B-Cell; Lupus Erythematosus, Systemic; Sleep Wake Disorders; Vascular Diseases; Atrial Fibrillation; Bipolar Disorder; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cardiomyopathy, Dilated; Carotid Artery Diseases; Cerebral Hemorrhage; Diabetes Mellitus, Type 1; Hypertension, Pulmonary; Intermittent Claudication; Leiomyoma; Lung Neoplasms; Migraine Disorders; Mucositis; Multiple Myeloma; Pancreatic Neoplasms; Pancreatitis; Parkinson Disease; Periodontitis; Peripheral Arterial Disease; Prediabetic State; Prostatic Neoplasms; Rectal Neoplasms; Sepsis; Shock, Septic; Sinusitis; Small Cell Lung Carcinoma; Smith-Lemli-Opitz Syndrome; Smoking Cessation; Urinary Bladder Neoplasms; Uveitis; Vitiligo; Waldenstrom Macroglobulinemia; Acute Coronary Syndrome; Alzheimer Disease; Aortic Valve Stenosis; Asthma; Atherosclerosis; Cholangitis, Sclerosing; Colorectal Neoplasms; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Diabetes Mellitus; Diabetic Nephropathies; Diabetic Retinopathy; Essential Hypertension; Graves Ophthalmopathy; Hyperlipidemia, Familial Combined; Hypertension; Hypertension, Portal; Hypertriglyceridemia; Inflammation; Influenza, Human; Intestinal Neoplasms; Ischemic Stroke; Lipid Metabolism Disorders; Liver Cirrhosis; Metabolic Syndrome; Multiple Sclerosis; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Myocardial Ischemia; Noonan Syndrome; Optic Neuritis; Pneumonia; Polycystic Ovary Syndrome; Pulmonary Disease, Chronic Obstructive; Renal Insufficiency, Chronic; Severe Acute Respiratory Syndrome; Stomach Neoplasms; Subarachnoid Hemorrhage; Cardiovascular Diseases; Coronary Artery Disease; Coronary Disease; Diabetes Mellitus, Type 2; Dyslipidemias; Hypercholesterolemia; Hyperlipidemias; Hyperlipoproteinemia Type II; Myocardial Infarction; Stroke HMG-CoA reductase inhibitor

Small molecule

Approved

CARDIOVASCULAR; OTHER

ORAL

Alopecia Areata; Anemia, Sickle Cell; Arthritis, Rheumatoid; Choroideremia; Chronic Pain; Cystic Fibrosis; Endotoxemia; Epilepsy; HIV Infections; Hepatitis B, Chronic; Leukemia, Lymphocytic, Chronic, B-Cell; Lupus Erythematosus, Systemic; Sleep Wake Disorders; Vascular Diseases; Atrial Fibrillation; Bipolar Disorder; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cardiomyopathy, Dilated; Carotid Artery Diseases; Cerebral Hemorrhage; Diabetes Mellitus, Type 1; Hypertension, Pulmonary; Intermittent Claudication; Leiomyoma; Lung Neoplasms; Migraine Disorders; Mucositis; Multiple Myeloma; Pancreatic Neoplasms; Pancreatitis; Parkinson Disease; Periodontitis; Peripheral Arterial Disease; Prediabetic State; Prostatic Neoplasms; Rectal Neoplasms; Sepsis; Shock, Septic; Sinusitis; Small Cell Lung Carcinoma; Smith-Lemli-Opitz Syndrome; Smoking Cessation; Urinary Bladder Neoplasms; Uveitis; Vitiligo; Waldenstrom Macroglobulinemia; Acute Coronary Syndrome; Alzheimer Disease; Aortic Valve Stenosis; Asthma; Atherosclerosis; Cholangitis, Sclerosing; Colorectal Neoplasms; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Diabetes Mellitus; Diabetic Nephropathies; Diabetic Retinopathy; Essential Hypertension; Graves Ophthalmopathy; Hyperlipidemia, Familial Combined; Hypertension; Hypertension, Portal; Hypertriglyceridemia; Inflammation; Influenza, Human; Intestinal Neoplasms; Ischemic Stroke; Lipid Metabolism Disorders; Liver Cirrhosis; Metabolic Syndrome; Multiple Sclerosis; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Myocardial Ischemia; Noonan Syndrome; Optic Neuritis; Pneumonia; Polycystic Ovary Syndrome; Pulmonary Disease, Chronic Obstructive; Renal Insufficiency, Chronic; Severe Acute Respiratory Syndrome; Stomach Neoplasms; Subarachnoid Hemorrhage; Cardiovascular Diseases; Coronary Artery Disease; Coronary Disease; Diabetes Mellitus, Type 2; Dyslipidemias; Hypercholesterolemia; Hyperlipidemias; Hyperlipoproteinemia Type II; Myocardial Infarction; Stroke

HMG-CoA reductase inhibitor


Small molecule Approved OTHER ORAL Arthritis, Rheumatoid; Osteoarthritis; Rheumatic Diseases Cyclooxygenase-2 inhibitor


Small molecule Approved Unknown Unknown Diabetic Nephropathies; Heart Diseases; Hypertension; Cardiovascular Diseases Unknown


Small molecule Approved Unknown Unknown Lupus Erythematosus, Systemic; Nephritis, Hereditary; Atherosclerosis; Coronary Disease; Diabetes Mellitus; Diabetes Mellitus, Type 2; Hypercholesterolemia; Hypertension; Cardiovascular Diseases Unknown


Small molecule Approved Unknown Unknown Cardiovascular Diseases Unknown


Small molecule Approved Unknown Unknown Carotid Stenosis; Peripheral Arterial Disease; Thrombosis Unknown


Small molecule Approved OTHER TOPICAL Psoriasis; Candidiasis; Eczema; Tinea Pedis; Adrenal Hyperplasia, Congenital; Anemia; Arthritis, Juvenile; Arthritis, Psoriatic; Arthritis, Rheumatoid; Brain Neoplasms; Bursitis; Conjunctivitis, Allergic; Dermatitis, Atopic; Endocrine System Diseases; Inflammation; Multiple Sclerosis; Neoplasms; Osteoarthritis; Peptic Ulcer; Rhinitis, Allergic; Skin Diseases; Spondylitis; Tenosynovitis; Uveitis, Posterior Glucocorticoid receptor agonist

Small molecule

Approved

OTHER

TOPICAL

Psoriasis; Candidiasis; Eczema; Tinea Pedis; Adrenal Hyperplasia, Congenital; Anemia; Arthritis, Juvenile; Arthritis, Psoriatic; Arthritis, Rheumatoid; Brain Neoplasms; Bursitis; Conjunctivitis, Allergic; Dermatitis, Atopic; Endocrine System Diseases; Inflammation; Multiple Sclerosis; Neoplasms; Osteoarthritis; Peptic Ulcer; Rhinitis, Allergic; Skin Diseases; Spondylitis; Tenosynovitis; Uveitis, Posterior

Glucocorticoid receptor agonist


Small molecule Approved OTHER ORAL Otitis Media Bacterial penicillin-binding protein inhibitor


Small molecule Approved Unknown Unknown Amphetamine-Related Disorders; Stress Disorders, Post-Traumatic; Substance-Related Disorders; Alzheimer Disease; Aortic Aneurysm, Abdominal; Breast Neoplasms; Neoplasms; Cardiomyopathy, Dilated; Diabetes Mellitus, Type 2; Hypertension; Marfan Syndrome; Cardiovascular Diseases Unknown


Small molecule Approved CARDIOVASCULAR; DIABETES DRUGS & ENDOCRINOLOGY; OTHER ORAL Cholangitis, Sclerosing; Alcoholism; Burns; Diabetic Nephropathies; HIV Infections; Huntington Disease; Metabolic Syndrome; Multiple Myeloma; Non-alcoholic Fatty Liver Disease; Obesity; Atherosclerosis; Coronary Disease; Diabetic Retinopathy; Hyperlipidemia, Familial Combined; Hyperlipidemias; Hyperlipoproteinemia Type III; Hyperlipoproteinemias; Hypertension; Hypertriglyceridemia; Lipid Metabolism Disorders; Lipodystrophy; Liver Cirrhosis, Biliary; Metabolic Diseases; Cardiovascular Diseases; Diabetes Mellitus; Diabetes Mellitus, Type 2; Dyslipidemias; Hypercholesterolemia; Hypothyroidism Peroxisome proliferator-activated receptor alpha agonist

Small molecule

Approved

CARDIOVASCULAR; DIABETES DRUGS & ENDOCRINOLOGY; OTHER

ORAL

Cholangitis, Sclerosing; Alcoholism; Burns; Diabetic Nephropathies; HIV Infections; Huntington Disease; Metabolic Syndrome; Multiple Myeloma; Non-alcoholic Fatty Liver Disease; Obesity; Atherosclerosis; Coronary Disease; Diabetic Retinopathy; Hyperlipidemia, Familial Combined; Hyperlipidemias; Hyperlipoproteinemia Type III; Hyperlipoproteinemias; Hypertension; Hypertriglyceridemia; Lipid Metabolism Disorders; Lipodystrophy; Liver Cirrhosis, Biliary; Metabolic Diseases; Cardiovascular Diseases; Diabetes Mellitus; Diabetes Mellitus, Type 2; Dyslipidemias; Hypercholesterolemia; Hypothyroidism

Peroxisome proliferator-activated receptor alpha agonist


Small molecule Approved IMMUNE SYSTEM; OTHER ORAL Multiple Sclerosis; Herpes Simplex; Meniere Disease; Autoimmune Diseases; Eye Infections; Herpes Genitalis; Herpes Labialis; Herpes Zoster; Virus Diseases Human herpesvirus 1 DNA polymerase inhibitor


Small molecule Approved CARDIOVASCULAR; IMMUNE SYSTEM; OTHER ORAL Arthritis, Rheumatoid; Carcinoma, Renal Cell; DiGeorge Syndrome; Glioblastoma; Gliosarcoma; Hypertension; Lecithin Cholesterol Acyltransferase Deficiency; Lymphoma, T-Cell; Pancreatic Neoplasms; Scleroderma, Diffuse; Small Cell Lung Carcinoma; beta-Thalassemia; Amyotrophic Lateral Sclerosis; Anemia, Aplastic; Anemia, Diamond-Blackfan; Anemia, Sickle Cell; Autoimmune Diseases; Burkitt Lymphoma; Chemical and Drug Induced Liver Injury; Crohn Disease; Epidermolysis Bullosa; Fanconi Anemia; Gout; Granuloma, Lethal Midline; HIV Infections; Hematologic Diseases; Hematologic Neoplasms; Hepatitis, Alcoholic; Histiocytosis, Langerhans-Cell; Hyperlipoproteinemia Type I; IgA Vasculitis; Immunoblastic Lymphadenopathy; Immunologic Deficiency Syndromes; Kidney Neoplasms; Leukemia, Hairy Cell; Leukemia, Large Granular Lymphocytic; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Mast-Cell; Leukemia, Myelomonocytic, Chronic; Leukemia, Myelomonocytic, Juvenile; Leukemia, Prolymphocytic, B-Cell; Leukemia, Prolymphocytic, T-Cell; Leukemia-Lymphoma, Adult T-Cell; Liver Diseases; Lymphoma; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular; Lymphoma, Large-Cell, Anaplastic; Lymphoma, T-Cell, Peripheral; Macular Degeneration; Melanoma; Multiple Sclerosis; Mycosis Fungoides; Myeloproliferative Disorders; Neuroblastoma; Neuronal Ceroid-Lipofuscinoses; Pemphigoid, Benign Mucous Membrane; Pemphigoid, Bullous; Polycythemia Vera; Primary Myelofibrosis; Psoriasis; Scleroderma, Limited; Scleroderma, Systemic; Severe Combined Immunodeficiency; Sezary Syndrome; Shwachman-Diamond Syndrome; Sjogren's Syndrome; Vasculitis; Wiskott-Aldrich Syndrome; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Carcinoma, Hepatocellular; Cardiovascular Diseases; Cystitis, Interstitial; Cytomegalovirus Infections; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Glomerulonephritis, IGA; Glomerulonephritis, Membranous; Glomerulosclerosis, Focal Segmental; Graft vs Host Disease; Granulomatosis with Polyangiitis; Heart Diseases; Hepatitis C; Hodgkin Disease; Kidney Diseases; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Lung Diseases, Interstitial; Lupus Erythematosus, Systemic; Lupus Nephritis; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Microscopic Polyangiitis; Multiple Myeloma; Myasthenia Gravis; Myelodysplastic Syndromes; Neoplasms; Nephrotic Syndrome; Neuromyelitis Optica; Pemphigus; Polyradiculopathy; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purpura, Thrombocytopenic, Idiopathic; Red-Cell Aplasia, Pure; Renal Insufficiency; Renal Insufficiency, Chronic; Sarcoidosis, Pulmonary; Takayasu Arteritis; Uveitis; Waldenstrom Macroglobulinemia Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor

Small molecule

Approved

CARDIOVASCULAR; IMMUNE SYSTEM; OTHER

ORAL

Arthritis, Rheumatoid; Carcinoma, Renal Cell; DiGeorge Syndrome; Glioblastoma; Gliosarcoma; Hypertension; Lecithin Cholesterol Acyltransferase Deficiency; Lymphoma, T-Cell; Pancreatic Neoplasms; Scleroderma, Diffuse; Small Cell Lung Carcinoma; beta-Thalassemia; Amyotrophic Lateral Sclerosis; Anemia, Aplastic; Anemia, Diamond-Blackfan; Anemia, Sickle Cell; Autoimmune Diseases; Burkitt Lymphoma; Chemical and Drug Induced Liver Injury; Crohn Disease; Epidermolysis Bullosa; Fanconi Anemia; Gout; Granuloma, Lethal Midline; HIV Infections; Hematologic Diseases; Hematologic Neoplasms; Hepatitis, Alcoholic; Histiocytosis, Langerhans-Cell; Hyperlipoproteinemia Type I; IgA Vasculitis; Immunoblastic Lymphadenopathy; Immunologic Deficiency Syndromes; Kidney Neoplasms; Leukemia, Hairy Cell; Leukemia, Large Granular Lymphocytic; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Mast-Cell; Leukemia, Myelomonocytic, Chronic; Leukemia, Myelomonocytic, Juvenile; Leukemia, Prolymphocytic, B-Cell; Leukemia, Prolymphocytic, T-Cell; Leukemia-Lymphoma, Adult T-Cell; Liver Diseases; Lymphoma; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular; Lymphoma, Large-Cell, Anaplastic; Lymphoma, T-Cell, Peripheral; Macular Degeneration; Melanoma; Multiple Sclerosis; Mycosis Fungoides; Myeloproliferative Disorders; Neuroblastoma; Neuronal Ceroid-Lipofuscinoses; Pemphigoid, Benign Mucous Membrane; Pemphigoid, Bullous; Polycythemia Vera; Primary Myelofibrosis; Psoriasis; Scleroderma, Limited; Scleroderma, Systemic; Severe Combined Immunodeficiency; Sezary Syndrome; Shwachman-Diamond Syndrome; Sjogren's Syndrome; Vasculitis; Wiskott-Aldrich Syndrome; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Carcinoma, Hepatocellular; Cardiovascular Diseases; Cystitis, Interstitial; Cytomegalovirus Infections; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Glomerulonephritis, IGA; Glomerulonephritis, Membranous; Glomerulosclerosis, Focal Segmental; Graft vs Host Disease; Granulomatosis with Polyangiitis; Heart Diseases; Hepatitis C; Hodgkin Disease; Kidney Diseases; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Lung Diseases, Interstitial; Lupus Erythematosus, Systemic; Lupus Nephritis; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Microscopic Polyangiitis; Multiple Myeloma; Myasthenia Gravis; Myelodysplastic Syndromes; Neoplasms; Nephrotic Syndrome; Neuromyelitis Optica; Pemphigus; Polyradiculopathy; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purpura, Thrombocytopenic, Idiopathic; Red-Cell Aplasia, Pure; Renal Insufficiency; Renal Insufficiency, Chronic; Sarcoidosis, Pulmonary; Takayasu Arteritis; Uveitis; Waldenstrom Macroglobulinemia

Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitor


Small molecule Approved Unknown Unknown Liver Cirrhosis, Biliary; Cardiovascular Diseases Unknown


Small molecule Approved DERMATOLOGY ORAL Bacterial Infections Bacterial 70S ribosome inhibitor


Small molecule Approved DIABETES DRUGS & ENDOCRINOLOGY; OTHER INJECTION Chordoma; Fanconi Anemia; Kidney Neoplasms; Leukemia, Myeloid, Acute; Liver Neoplasms; Mesothelioma; Myeloproliferative Disorders; Neoplasms; Neoplasms, Germ Cell and Embryonal; Neuroblastoma; Retinoblastoma; Brain Neoplasms; Breast Neoplasms; Central Nervous System Neoplasms; Colorectal Neoplasms; Endometrial Neoplasms; Fallopian Tube Neoplasms; Hodgkin Disease; Leukemia; Lymphoma; Lymphoma, Non-Hodgkin; Myelodysplastic Syndromes; Peritoneal Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Sarcoma; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Carcinoma, Squamous Cell; Hepatoblastoma; Lung Neoplasms; Multiple Myeloma; Peripheral Nervous System Diseases; Trigeminal Neuralgia; Head and Neck Neoplasms; Ovarian Neoplasms; Xerostomia Reactive metabolite scavenging agent

Small molecule

Approved

DIABETES DRUGS & ENDOCRINOLOGY; OTHER

INJECTION

Chordoma; Fanconi Anemia; Kidney Neoplasms; Leukemia, Myeloid, Acute; Liver Neoplasms; Mesothelioma; Myeloproliferative Disorders; Neoplasms; Neoplasms, Germ Cell and Embryonal; Neuroblastoma; Retinoblastoma; Brain Neoplasms; Breast Neoplasms; Central Nervous System Neoplasms; Colorectal Neoplasms; Endometrial Neoplasms; Fallopian Tube Neoplasms; Hodgkin Disease; Leukemia; Lymphoma; Lymphoma, Non-Hodgkin; Myelodysplastic Syndromes; Peritoneal Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Sarcoma; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Carcinoma, Squamous Cell; Hepatoblastoma; Lung Neoplasms; Multiple Myeloma; Peripheral Nervous System Diseases; Trigeminal Neuralgia; Head and Neck Neoplasms; Ovarian Neoplasms; Xerostomia

Reactive metabolite scavenging agent


Small molecule Approved Unknown Unknown Ependymoma; Glioma; Infectious Mononucleosis; Lung Neoplasms; Prostatic Neoplasms; Astrocytoma; Bipolar Disorder; Cytomegalovirus Infections; Glioblastoma; Hepatitis C, Chronic; Leukemia, Lymphocytic, Chronic, B-Cell; Neuralgia, Postherpetic; Psychotic Disorders; Pulmonary Disease, Chronic Obstructive; Schizophrenia; Stomatitis, Herpetic; Waldenstrom Macroglobulinemia; Encephalitis; Herpes Simplex; Neoplasms; Pregnancy; Prostatic Neoplasms, Castration-Resistant; Herpes Genitalis; Herpes Labialis; Herpes Zoster; Virus Diseases Unknown

Small molecule

Approved

Unknown

Ependymoma; Glioma; Infectious Mononucleosis; Lung Neoplasms; Prostatic Neoplasms; Astrocytoma; Bipolar Disorder; Cytomegalovirus Infections; Glioblastoma; Hepatitis C, Chronic; Leukemia, Lymphocytic, Chronic, B-Cell; Neuralgia, Postherpetic; Psychotic Disorders; Pulmonary Disease, Chronic Obstructive; Schizophrenia; Stomatitis, Herpetic; Waldenstrom Macroglobulinemia; Encephalitis; Herpes Simplex; Neoplasms; Pregnancy; Prostatic Neoplasms, Castration-Resistant; Herpes Genitalis; Herpes Labialis; Herpes Zoster; Virus Diseases

Unknown


Small molecule Approved Unknown Unknown Hepatopulmonary Syndrome; Hypotension, Orthostatic; Ischemic Stroke; Ascites; Hypotension; Shock, Septic; Spinal Cord Injuries; Cardiovascular Diseases Unknown


Small molecule Approved Unknown Unknown Status Epilepticus; Epilepsy Unknown


Small molecule Approved DIABETES DRUGS & ENDOCRINOLOGY; OTHER ORAL Cardiovascular Diseases; Heart Failure; Hypertension; Myocardial Infarction; Ventricular Dysfunction, Left Angiotensin-converting enzyme inhibitor

Small molecule

Approved

Unknown

Astrocytoma; Bone Neoplasms; Carcinoid Tumor; Diffuse Intrinsic Pontine Glioma; Digestive System Neoplasms; Endometrial Neoplasms; Kidney Neoplasms; Liver Neoplasms; Mesothelioma; Oligodendroglioma; Pulmonary Disease, Chronic Obstructive; Biliary Tract Neoplasms; Carcinoma; Carcinoma, Islet Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Central Nervous System Neoplasms; Fallopian Tube Neoplasms; Ganglioneuroblastoma; Glioblastoma; Glioma; Gliosarcoma; Head and Neck Neoplasms; Hemangiosarcoma; Leukemia; Lymphoma; Lymphoma, Non-Hodgkin; Medulloblastoma; Neuroblastoma; Ovarian Neoplasms; Peritoneal Neoplasms; Pinealoma; Rhabdomyosarcoma; Sarcoma; Triple Negative Breast Neoplasms; Wilms Tumor; Adenocarcinoma, Mucinous; Brain Neoplasms; Breast Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Neuroendocrine; Carcinoma, Pancreatic Ductal; Cholangiocarcinoma; Choroid Plexus Neoplasms; Colonic Neoplasms; Colorectal Neoplasms; Esophageal Neoplasms; Hepatoblastoma; Lung Neoplasms; Neoplasm Metastasis; Pancreatic Neoplasms; Rectal Neoplasms; Sarcoma, Ewing; Small Cell Lung Carcinoma; Stomach Neoplasms; Uterine Cervical Neoplasms; Neoplasms

Unknown


Small molecule Approved OTHER OPHTHALMIC Meniere Disease; Vitiligo; Glaucoma; Glaucoma, Open-Angle; Hypertension; Ocular Hypertension Prostanoid FP receptor agonist

Small molecule

Approved

OTHER

INJECTION

Bile Duct Neoplasms; Brain Neoplasms; Leukemia; Leukemia, Myeloid, Acute; Lymphoma, T-Cell, Cutaneous; Sarcoma, Synovial; Stomach Neoplasms; Adenocarcinoma; Adenocarcinoma of Lung; Anxiety; Biliary Tract Diseases; Carcinoma, Large Cell; Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Colonic Neoplasms; Colorectal Neoplasms; Digestive System Diseases; Endometrial Neoplasms; Esophageal Neoplasms; Gastrointestinal Stromal Tumors; Head and Neck Neoplasms; Hodgkin Disease; Kidney Neoplasms; Leiomyosarcoma; Leukemia-Lymphoma, Adult T-Cell; Liver Neoplasms; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Mantle-Cell; Lymphoma, T-Cell; Medulloblastoma; Melanoma; Multiple Myeloma; Neoplasms, Germ Cell and Embryonal; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Sarcoma, Ewing; Small Cell Lung Carcinoma; Testicular Neoplasms; Thyroid Neoplasms; Urethral Neoplasms; Biliary Tract Neoplasms; Breast Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Squamous Cell; Cholangiocarcinoma; Fallopian Tube Neoplasms; Gallbladder Neoplasms; Granuloma, Lethal Midline; Hepatoblastoma; Immunoblastic Lymphadenopathy; Lung Neoplasms; Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Peripheral; Mesothelioma; Nasopharyngeal Neoplasms; Neoplasm Metastasis; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Sarcoma; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Urogenital Neoplasms; Uterine Cervical Neoplasms; Neoplasms

Unknown

Small molecule

Approved

OTHER

TOPICAL

Adrenal Hyperplasia, Congenital; Arthritis, Juvenile; Arthritis, Psoriatic; Arthritis, Rheumatoid; Asthma; Bursitis; Colitis, Ulcerative; Conjunctivitis, Allergic; Dermatitis; Dermatitis, Atopic; Dermatitis, Seborrheic; Endocrine System Diseases; Exanthema; Inflammation; Leukemia; Lymphoma; Neoplasms; Osteoarthritis; Pruritus; Psoriasis; Serum Sickness; Skin Diseases; Spondylitis; Tenosynovitis

Glucocorticoid receptor agonist


Small molecule Approved Unknown Unknown Fibromatosis, Aggressive; Ovarian Neoplasms; Prostatic Neoplasms, Castration-Resistant; Severe Acute Respiratory Syndrome; Breast Neoplasms; Fractures, Bone; Mastodynia; Prostatic Intraepithelial Neoplasia; Neoplasms Unknown

Small molecule

Approved

Unknown

Cardiovascular Diseases; Depressive Disorder, Major; Diabetes Mellitus, Type 2; Head and Neck Neoplasms; Lupus Erythematosus, Systemic; Asthma; HIV Infections; Heart Diseases; Hypertension, Pulmonary; Intermittent Claudication; Peripheral Vascular Diseases; Pneumonia, Viral; Polycythemia Vera; Pregnancy; Respiratory Insufficiency; Scleroderma, Systemic; Venous Thromboembolism; Acute Coronary Syndrome; Angina, Stable; Aortic Valve Stenosis; Arteriosclerosis; Atherosclerosis; Atrial Fibrillation; Brain Infarction; Carotid Stenosis; Coronary Disease; Gastrointestinal Hemorrhage; Heart Defects, Congenital; Heart Failure; Hemorrhage; Influenza, Human; Intracranial Aneurysm; Intracranial Arteriosclerosis; Ischemia; Ischemic Attack, Transient; Ischemic Stroke; Myocardial Infarction; Peripheral Arterial Disease; Pneumonia; Renal Insufficiency, Chronic; ST Elevation Myocardial Infarction; Severe Acute Respiratory Syndrome; Stroke; Thrombophilia; Vascular Diseases; Thrombosis

Unknown


Small molecule Approved Unknown Unknown Hepatitis C; Acidosis, Lactic; Lipodystrophy; Sarcoma, Kaposi; Acquired Immunodeficiency Syndrome; Amyotrophic Lateral Sclerosis; HIV Infections; Tuberculosis; Virus Diseases Unknown

Small molecule

Approved

DIABETES DRUGS & ENDOCRINOLOGY; OTHER; RHEUMATOLOGY

ORAL

Breast Neoplasms; HIV Infections; Melanoma; Neoplasms; IgA Vasculitis; Lupus Erythematosus, Systemic; Lymphoproliferative Disorders; Multiple Myeloma; Pemphigoid, Bullous; Prostatic Neoplasms, Castration-Resistant; Sjogren's Syndrome; Smoldering Multiple Myeloma; Uveitis; Arthritis, Psoriatic; Central Nervous System Neoplasms; Lupus Nephritis; Myasthenia Gravis; Polymyalgia Rheumatica; Severe Acute Respiratory Syndrome; Arthritis, Rheumatoid; Immune System Diseases; Multiple Sclerosis

Dihydroorotate dehydrogenase inhibitor