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MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Thymidylate synthase inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Astrocytoma; Carcinoma, Hepatocellular; Colorectal Neoplasms; Gliosarcoma; Neoplasms; Oligodendroglioma; Intracranial Hypertension; Meningitis, Cryptococcal; Candidiasis; Infections; Meningitis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Bacterial penicillin-binding protein inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Glucocorticoid receptor agonist
ROUTE OF ADMINISTRATION: TOPICAL
STATUS: Approved
THERAPEUTIC AREA: DERMATOLOGY; OTHER
THERAPEUTIC INDICATION: Dermatitis, Atopic; Eye Diseases; Skin Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: GABA-A receptor; anion channel positive allosteric modulator
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Anxiety; Anxiety Disorders; Seizures
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Bacterial 70S ribosome inhibitor
ROUTE OF ADMINISTRATION: INJECTION; INTRAVENOUS; TOPICAL; VAGINAL
STATUS: Approved
THERAPEUTIC AREA: IMMUNE SYSTEM; OTHER; PREGNANCY AND GYNECOLOGY
THERAPEUTIC INDICATION: Rosacea; Vulvovaginitis; Abdominal Abscess; Abscess; Acne Vulgaris; Empyema; Endometritis; Enterocolitis, Pseudomembranous; Genital Diseases, Female; Infections; Intraabdominal Infections; Irritable Bowel Syndrome; Lung Abscess; Osteomyelitis; Parametritis; Peritonitis; Pneumonia; Respiratory Tract Infections; Sepsis; Soft Tissue Infections; Vaginosis, Bacterial
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Dopamine D2 receptor antagonist
ROUTE OF ADMINISTRATION: INJECTION
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Psoriasis; Psychotic Disorders
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Progesterone receptor agonist
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Endometrial Hyperplasia; Lymphoma; Breast Neoplasms; Hemorrhage; Leiomyoma; Pain; Pregnancy; Acne Vulgaris; Endometriosis; Hypogonadism; Primary Ovarian Insufficiency
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Glucocorticoid receptor agonist
ROUTE OF ADMINISTRATION: INJECTION
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Lymphoma; Pancreatitis; Leukemia; Multiple Myeloma; Acne Vulgaris; Eye Diseases; Hemorrhoids; Nasal Obstruction
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Amidophosphoribosyltransferase inhibitor
ROUTE OF ADMINISTRATION: INJECTION
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Androgen Receptor agonist
ROUTE OF ADMINISTRATION: INJECTION
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Atrophic Vaginitis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Glucocorticoid receptor agonist
ROUTE OF ADMINISTRATION: TOPICAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Dermatitis, Atopic; Sinusitis; Lichen Planus, Oral; Periarthritis; Eye Diseases; Hemorrhoids; Infections; Lung Diseases, Obstructive; Nasal Obstruction; Psoriasis; Skin Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Glucocorticoid receptor agonist
ROUTE OF ADMINISTRATION: INHALATION; NASAL
STATUS: Approved
THERAPEUTIC AREA: IMMUNE SYSTEM; OTHER; RESPIRATORY
THERAPEUTIC INDICATION: Enteritis; Eosinophilic Esophagitis; Infections; Folliculitis; Idiopathic Pulmonary Fibrosis; Nasal Polyps; Severe Acute Respiratory Syndrome; Small Cell Lung Carcinoma; Bronchiectasis; Bronchopulmonary Dysplasia; Croup; Graft vs Host Disease; Pulmonary Disease, Chronic Obstructive; Respiratory Distress Syndrome, Newborn; Sinusitis; Asthma; Lung Diseases, Obstructive; Nasal Obstruction; Rhinitis, Allergic; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Glucocorticoid receptor agonist
ROUTE OF ADMINISTRATION: TOPICAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Skin Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Estrogen receptor alpha modulator
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: CANCER; OTHER
THERAPEUTIC INDICATION: Brain Neoplasms; Hepatitis C, Chronic; Osteosarcoma; Adenoma; Amyotrophic Lateral Sclerosis; Central Nervous System Neoplasms; Fibromatosis, Aggressive; Glioblastoma; Glioma; Gynecomastia; HIV Infections; Hereditary Breast and Ovarian Cancer Syndrome; Infertility, Male; Melanoma; Neoplasms; Neuroendocrine Tumors; Pain; Retroperitoneal Fibrosis; Severe Acute Respiratory Syndrome; Telangiectasia, Hereditary Hemorrhagic; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Bipolar Disorder; Breast Neoplasms, Male; Carcinoma, Intraductal, Noninfiltrating; Carcinoma, Ovarian Epithelial; Endometrial Neoplasms; Fallopian Tube Neoplasms; Hyperplasia; Hypertension; Infertility; Inflammatory Breast Neoplasms; Liver Neoplasms; Menopause; Muscular Dystrophy, Duchenne; Myocardial Ischemia; Neoplasm Metastasis; Ovarian Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms, Castration-Resistant; Breast Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Breast Neoplasms; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Cyclooxygenase inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Breast Neoplasms; Carcinoma, Squamous Cell; Fibromatosis, Aggressive; Fragile X Syndrome; Leukemia, Myeloid, Acute; Melanoma; Adenomatous Polyposis Coli; Colorectal Neoplasms; Precancerous Conditions; Arthritis, Rheumatoid; Osteoarthritis; Rheumatic Diseases; Spondylitis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Glucocorticoid receptor agonist
ROUTE OF ADMINISTRATION: TOPICAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Eye Diseases; Hemorrhoids
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Androgen Receptor agonist
ROUTE OF ADMINISTRATION: INJECTION
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Sexual Dysfunction, Physiological; Diabetic Neuropathies; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Hypogonadism; Neoplasms; Orchitis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Estrogen receptor alpha agonist
ROUTE OF ADMINISTRATION: INJECTION
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Severe Acute Respiratory Syndrome; Atrophic Vaginitis; Atrophy; Breast Neoplasms; Dyspareunia; Hypogonadism; Menopause; Osteoporosis; Osteoporosis, Postmenopausal; Primary Ovarian Insufficiency
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Sulfonylurea receptor 2, Kir6.2 opener
ROUTE OF ADMINISTRATION: ORAL; TOPICAL
STATUS: Approved
THERAPEUTIC AREA: DERMATOLOGY; OTHER
THERAPEUTIC INDICATION: Ovarian Neoplasms; Alopecia; Hypertension
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Glucocorticoid receptor agonist
ROUTE OF ADMINISTRATION: TOPICAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Adrenergic receptor agonist
ROUTE OF ADMINISTRATION: OPHTHALMIC
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Bacterial penicillin-binding protein inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: DNA inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Breast Neoplasms; Kidney Neoplasms; Lymphoma; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Carcinoma; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Prostatic Neoplasms, Castration-Resistant
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Retinoic acid receptor agonist
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Alzheimer Disease; Astrocytoma; Burkitt Lymphoma; Carcinoma, Renal Cell; Epidermolysis Bullosa; Glioma; Gliosarcoma; Hodgkin Disease; Infections; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Leukemia, Promyelocytic, Acute; Lymphoma, Large B-Cell, Diffuse; Myelodysplastic Syndromes; Neoplasms; Oligodendroglioma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Wilms Tumor; Azoospermia; Emphysema; Ganglioneuroblastoma; Glioblastoma; Glomerulosclerosis, Focal Segmental; HIV Infections; Ichthyosis; Keratosis, Actinic; Klinefelter Syndrome; Leukemia; Leukemia, Myelomonocytic, Juvenile; Multiple Myeloma; Mycosis Fungoides; Prostatic Neoplasms, Castration-Resistant; Tinea Pedis; Uterine Cervical Neoplasms; Brain Neoplasms; Breast Neoplasms; Central Nervous System Neoplasms; Head and Neck Neoplasms; Kidney Neoplasms; Lung Neoplasms; Medulloblastoma; Neuroblastoma; Rosacea; Severe Acute Respiratory Syndrome; Uterine Cervical Dysplasia; Acne Vulgaris
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Sodium channel alpha subunit blocker
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Penicillin-binding protein inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Androgen Receptor agonist
ROUTE OF ADMINISTRATION: INJECTION
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Glucocorticoid receptor agonist
ROUTE OF ADMINISTRATION: TOPICAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Psoriasis; Dermatitis, Atopic; Dermatitis, Seborrheic; Skin Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: GABA-A receptor; anion channel positive modulator
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Estrogen receptor agonist
ROUTE OF ADMINISTRATION: INJECTION; ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Glucocorticoid receptor agonist
ROUTE OF ADMINISTRATION: TOPICAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Eye Diseases; Hemorrhoids; Lung Diseases, Obstructive; Nasal Obstruction
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Human herpesvirus 1 DNA polymerase inhibitor
ROUTE OF ADMINISTRATION: INJECTION
STATUS: Approved
THERAPEUTIC AREA: IMMUNE SYSTEM; OTHER
THERAPEUTIC INDICATION: Kidney Diseases; Leukemia, Biphenotypic, Acute; Lymphoma, Large B-Cell, Diffuse; Carcinoma, Non-Small-Cell Lung; HIV Infections; Meniere Disease; Prostatic Neoplasms, Castration-Resistant; Cytomegalovirus Infections; Herpes Labialis; Herpes Simplex; Infections; Keratitis, Herpetic; Multiple Sclerosis; Neoplasms; Herpes Genitalis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Penicillin-binding protein inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Bacterial Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Glucocorticoid receptor agonist
ROUTE OF ADMINISTRATION: TOPICAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Unknown