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MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Glucocorticoid receptor agonist
ROUTE OF ADMINISTRATION: TOPICAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Glucocorticoid receptor agonist
ROUTE OF ADMINISTRATION: TOPICAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Carcinoma, Non-Small-Cell Lung; Eye Diseases; Skin Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Estrogen receptor beta modulator
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Liver Neoplasms; Carcinoma, Hepatocellular
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Human herpesvirus 1 DNA polymerase inhibitor
ROUTE OF ADMINISTRATION: BUCCAL; OPHTHALMIC; ORAL; TOPICAL
STATUS: Approved
THERAPEUTIC AREA: DERMATOLOGY; IMMUNE SYSTEM; OTHER
THERAPEUTIC INDICATION: Cytomegalovirus Infections; HIV Infections; Chickenpox; Eye Infections; Herpes Genitalis; Herpes Labialis; Herpes Simplex; Herpes Zoster; Virus Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Androgen Receptor agonist
ROUTE OF ADMINISTRATION: INJECTION
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: HIV Wasting Syndrome; Hip Fractures; Malnutrition; Eye Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Beta-2 adrenergic receptor agonist
ROUTE OF ADMINISTRATION: INHALATION
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Angiotensin-converting enzyme inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Arthritis, Rheumatoid; Cerebral Hemorrhage; Pre-Eclampsia; Proteinuria; Heart Failure; Hypertension; Ventricular Dysfunction, Left
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Erectile Dysfunction; Ischemia; Renal Insufficiency, Chronic; Cerebral Hemorrhage; Diabetes Mellitus, Type 1; Essential Hypertension; Glomerulonephritis, IGA; Heart Diseases; Melanoma; Pseudohypoaldosteronism; Stroke; Cardiomyopathies; Cardiotoxicity; Chagas Cardiomyopathy; Heart Failure; Hypertension; Influenza, Human; Leukemia, Lymphoid; Leukemia, Myeloid, Acute; Multiple Myeloma; Myocardial Ischemia; Neoplasms; Pneumonia; ST Elevation Myocardial Infarction; Severe Acute Respiratory Syndrome; Cardiovascular Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Soluble guanylate cyclase activator
ROUTE OF ADMINISTRATION: ORAL; SUBLINGUAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Muscular Dystrophy, Duchenne; Heart Failure; Diabetic Foot; Myocardial Ischemia; Angina Pectoris; Cardiovascular Diseases; Coronary Artery Disease; Hemorrhoids
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: D2-like dopamine receptor inverse agonist
ROUTE OF ADMINISTRATION: INJECTION
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Delirium; Conduct Disorder; Psychotic Disorders; Schizophrenia; Tourette Syndrome
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Glucocorticoid receptor agonist
ROUTE OF ADMINISTRATION: OPHTHALMIC
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Acne Vulgaris; Eye Diseases; Hemorrhoids
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Bacterial 70S ribosome inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: IMMUNE SYSTEM; OTHER; PREGNANCY AND GYNECOLOGY
THERAPEUTIC INDICATION: Acne Vulgaris; Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Bacterial penicillin-binding protein inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER; RESPIRATORY
THERAPEUTIC INDICATION: Bronchitis, Chronic; Infections; Maxillary Sinusitis; Otitis Media; Pharyngitis; Pneumonia; Sinusitis; Tonsillitis; Urinary Tract Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Human immunodeficiency virus type 1 reverse transcriptase inhibitor
ROUTE OF ADMINISTRATION: INJECTION; ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Severe Combined Immunodeficiency; Castleman Disease; Infections; Leukemia-Lymphoma, Adult T-Cell; Liver Cirrhosis, Biliary; Lymphoma; Lymphoma, AIDS-Related; Paraparesis, Tropical Spastic; Sarcoma, Kaposi; AIDS Dementia Complex; AIDS-Related Complex; Acquired Immunodeficiency Syndrome; Diarrhea; Pneumonia, Pneumocystis; Pregnancy; Severe Acute Respiratory Syndrome; Tuberculosis; Autoimmune Diseases; HIV Infections; Virus Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Glucocorticoid receptor agonist
ROUTE OF ADMINISTRATION: IMPLANTATION; INHALATION; NASAL; TOPICAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Hypersensitivity; Spinal Cord Injuries; Anemia, Sickle Cell; Dermatitis, Atopic; Eosinophilic Esophagitis; Pemphigoid, Bullous; Psoriasis; Breast Neoplasms; Hypertrophy; Otitis Media with Effusion; Pulmonary Disease, Chronic Obstructive; Rhinitis, Allergic, Perennial; Severe Acute Respiratory Syndrome; Sinusitis; Sleep Apnea, Obstructive; Asthma; Lung Diseases, Obstructive; Nasal Obstruction; Nasal Polyps; Rhinitis, Allergic; Rhinitis, Allergic, Seasonal; Skin Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: HMG-CoA reductase inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: CARDIOVASCULAR; OTHER
THERAPEUTIC INDICATION: Asthma; Leukemia, Myeloid, Acute; Metabolic Diseases; Porokeratosis; Stroke; Arthritis, Rheumatoid; Breast Neoplasms; Carotid Stenosis; Cognitive Dysfunction; Fragile X Syndrome; HIV Infections; Heart Diseases; Intracranial Arteriosclerosis; Intracranial Arteriovenous Malformations; Learning Disabilities; Melanoma; Neurofibromatosis 1; Ovarian Neoplasms; Parkinson Disease; Prostatic Neoplasms, Castration-Resistant; Pulmonary Disease, Chronic Obstructive; Rett Syndrome; Xanthomatosis, Cerebrotendinous; Intermittent Claudication; Lipid Metabolism Disorders; Myocardial Ischemia; Atherosclerosis; Cardiovascular Diseases; Coronary Artery Disease; Coronary Disease; Hypercholesterolemia; Hypothyroidism
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: DNA inhibitor
ROUTE OF ADMINISTRATION: INJECTION
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Multiple Myeloma; Myelodysplastic Syndromes; Myeloproliferative Disorders; Neoplasm Metastasis; Breast Neoplasms; Burkitt Lymphoma; Glioma; Leukemia, Myeloid, Acute; Lymphoma, AIDS-Related; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Mantle-Cell; Nasopharyngeal Neoplasms; Pancreatic Neoplasms; Penile Neoplasms; Peritoneal Neoplasms; Rhabdomyosarcoma, Alveolar; Rhabdomyosarcoma, Embryonal; Urethral Neoplasms; Urinary Bladder Neoplasms; Uterine Neoplasms; Wilms Tumor; Carcinoma; Carcinoma, Non-Small-Cell Lung; Central Nervous System Neoplasms; Dermatofibrosarcoma; Endometrial Neoplasms; Fallopian Tube Neoplasms; Fibrosarcoma; Hemangiopericytoma; Hemangiosarcoma; Histiocytoma; Hodgkin Disease; Kidney Neoplasms; Leiomyosarcoma; Leukemia; Leukemia, Biphenotypic, Acute; Liposarcoma; Lung Neoplasms; Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Peripheral; Mediastinal Neoplasms; Mesenchymoma; Neoplasms, Germ Cell and Embryonal; Neurilemmoma; Neuroblastoma; Osteosarcoma; Ovarian Neoplasms; Pheochromocytoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retroviridae Infections; Rhabdomyosarcoma; Sarcoma; Sarcoma, Alveolar Soft Part; Sarcoma, Ewing; Sarcoma, Synovial; Small Cell Lung Carcinoma; Teratoma; Uterine Cervical Neoplasms; Neoplasms; Testicular Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Prostanoid EP3 receptor agonist
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Abortion, Incomplete; Clostridium Infections; Muscle Cramp; Premature Birth; Abortion, Spontaneous; Leiomyoma; Menorrhagia; Myoma; Obesity; Pain; Postpartum Hemorrhage; Pre-Eclampsia; Pregnancy; Spondylitis, Ankylosing; Uterine Diseases; Duodenal Ulcer; Gastroesophageal Reflux; Hemorrhage; Osteoarthritis; Peptic Ulcer; Stomach Ulcer
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Potassium-transporting ATPase inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: GASTROINTESTINAL; OTHER
THERAPEUTIC INDICATION: Alzheimer Disease; Anemia; Arthritis, Rheumatoid; Carcinoma, Medullary; Central Serous Chorioretinopathy; Child Development Disorders, Pervasive; Chronic Pain; Clostridium Infections; Colitis, Ulcerative; Communicable Diseases; Crohn Disease; Dermatitis, Atopic; Diabetes Mellitus; Diabetes Mellitus, Type 2; Erectile Dysfunction; Glaucoma; HIV Infections; Hepatitis B, Chronic; Hepatitis C; Hepatitis C, Chronic; Laryngomalacia; Melanoma; Mitochondrial Diseases; Muscular Atrophy, Spinal; Neoplasms; Psoriasis; Pulmonary Disease, Chronic Obstructive; Breast Neoplasms; Carcinoma, Squamous Cell; Colorectal Neoplasms; Cystic Fibrosis; Gastrinoma; Granuloma; Head and Neck Neoplasms; Idiopathic Pulmonary Fibrosis; Lymphoma; Lymphoma, B-Cell, Marginal Zone; Prostatic Neoplasms, Castration-Resistant; Squamous Cell Carcinoma of Head and Neck; Squamous Intraepithelial Lesions; Ulcer; Zollinger-Ellison Syndrome; Barrett Esophagus; Cough; Cysticercosis; Diabetes Mellitus, Type 1; Dyspepsia; Esophagitis, Peptic; Exocrine Pancreatic Insufficiency; Gastrointestinal Hemorrhage; Helicobacter Infections; Hemorrhage; Multiple Sclerosis, Relapsing-Remitting; Osteoarthritis; Pain; Spondylitis, Ankylosing; Stomach Neoplasms; Wounds and Injuries; Duodenal Ulcer; Esophagitis; Gastroesophageal Reflux; Heartburn; Infections; Peptic Ulcer; Stomach Ulcer
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Progesterone receptor agonist
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Cystic Fibrosis; HIV Infections; Hepatitis C; Migraine Disorders; Metrorrhagia; Osteoporosis; Neural Tube Defects; Acne Vulgaris
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Human herpesvirus 1 DNA polymerase inhibitor
ROUTE OF ADMINISTRATION: INJECTION
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Brain Neoplasms; Neoplasm Metastasis; Uveitis, Anterior
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Human herpesvirus 1 DNA polymerase inhibitor
ROUTE OF ADMINISTRATION: IMPLANTATION; OPHTHALMIC; ORAL
STATUS: Approved
THERAPEUTIC AREA: EYE; OTHER
THERAPEUTIC INDICATION: Central Nervous System Neoplasms; Kidney Diseases; Melanoma; Mesothelioma; Neuroblastoma; Carcinoma, Hepatocellular; Diabetes Mellitus, Type 1; Fallopian Tube Neoplasms; Glioblastoma; Graft vs Host Disease; Lymphoma; Ovarian Neoplasms; Peritoneal Neoplasms; Conjunctivitis; Cytomegalovirus Infections; Infections; Acquired Immunodeficiency Syndrome; Cytomegalovirus Retinitis; Eye Infections; HIV Infections; Primary Immunodeficiency Diseases; Retinitis; Virus Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Androgen Receptor antagonist
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER; UROLOGY AND KIDNEY
THERAPEUTIC INDICATION: Adrenal Hyperplasia, Congenital; Ovarian Neoplasms; Polycystic Ovary Syndrome; Prostatic Neoplasms, Castration-Resistant; Carcinoma; Neoplasms; Prostatic Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Arachidonate 5-lipoxygenase inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Colitis, Ulcerative
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Spondylitis, Ankylosing
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Glucocorticoid receptor agonist
ROUTE OF ADMINISTRATION: TOPICAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Dermatitis, Atopic; Psoriasis; Skin Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Cyclooxygenase-2 inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Arthritis, Rheumatoid; Osteoarthritis; Rheumatic Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Angiotensin-converting enzyme inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Diabetes Mellitus; Heart Failure; Hypertension; Renal Insufficiency; Stroke
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Glucocorticoid receptor agonist
ROUTE OF ADMINISTRATION: TOPICAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Psoriasis; Candidiasis; Eczema; Tinea Pedis; Adrenal Hyperplasia, Congenital; Anemia; Arthritis, Juvenile; Arthritis, Psoriatic; Arthritis, Rheumatoid; Brain Neoplasms; Bursitis; Conjunctivitis, Allergic; Dermatitis, Atopic; Endocrine System Diseases; Inflammation; Multiple Sclerosis; Neoplasms; Osteoarthritis; Peptic Ulcer; Rhinitis, Allergic; Skin Diseases; Spondylitis; Tenosynovitis; Uveitis, Posterior
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Purinergic receptor P2Y12 antagonist
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Stroke; Thrombosis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Carotid Stenosis; Peripheral Arterial Disease; Thrombosis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Angiotensin-converting enzyme inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Heart Failure; Hypertension
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: HMG-CoA reductase inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: CARDIOVASCULAR; OTHER
THERAPEUTIC INDICATION: Alopecia Areata; Anemia, Sickle Cell; Arthritis, Rheumatoid; Choroideremia; Chronic Pain; Cystic Fibrosis; Endotoxemia; Epilepsy; HIV Infections; Hepatitis B, Chronic; Leukemia, Lymphocytic, Chronic, B-Cell; Lupus Erythematosus, Systemic; Sleep Wake Disorders; Vascular Diseases; Atrial Fibrillation; Bipolar Disorder; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cardiomyopathy, Dilated; Carotid Artery Diseases; Cerebral Hemorrhage; Diabetes Mellitus, Type 1; Hypertension, Pulmonary; Intermittent Claudication; Leiomyoma; Lung Neoplasms; Migraine Disorders; Mucositis; Multiple Myeloma; Pancreatic Neoplasms; Pancreatitis; Parkinson Disease; Periodontitis; Peripheral Arterial Disease; Prediabetic State; Prostatic Neoplasms; Rectal Neoplasms; Sepsis; Shock, Septic; Sinusitis; Small Cell Lung Carcinoma; Smith-Lemli-Opitz Syndrome; Smoking Cessation; Urinary Bladder Neoplasms; Uveitis; Vitiligo; Waldenstrom Macroglobulinemia; Acute Coronary Syndrome; Alzheimer Disease; Aortic Valve Stenosis; Asthma; Atherosclerosis; Cholangitis, Sclerosing; Colorectal Neoplasms; Depressive Disorder, Major; Depressive Disorder, Treatment-Resistant; Diabetes Mellitus; Diabetic Nephropathies; Diabetic Retinopathy; Essential Hypertension; Graves Ophthalmopathy; Hyperlipidemia, Familial Combined; Hypertension; Hypertension, Portal; Hypertriglyceridemia; Inflammation; Influenza, Human; Intestinal Neoplasms; Ischemic Stroke; Lipid Metabolism Disorders; Liver Cirrhosis; Metabolic Syndrome; Multiple Sclerosis; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Myocardial Ischemia; Noonan Syndrome; Optic Neuritis; Pneumonia; Polycystic Ovary Syndrome; Pulmonary Disease, Chronic Obstructive; Renal Insufficiency, Chronic; Severe Acute Respiratory Syndrome; Stomach Neoplasms; Subarachnoid Hemorrhage; Cardiovascular Diseases; Coronary Artery Disease; Coronary Disease; Diabetes Mellitus, Type 2; Dyslipidemias; Hypercholesterolemia; Hyperlipidemias; Hyperlipoproteinemia Type II; Myocardial Infarction; Stroke
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Diabetic Nephropathies; Heart Diseases; Hypertension; Cardiovascular Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Cardiovascular Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Lupus Erythematosus, Systemic; Nephritis, Hereditary; Atherosclerosis; Coronary Disease; Diabetes Mellitus; Diabetes Mellitus, Type 2; Hypercholesterolemia; Hypertension; Cardiovascular Diseases