OMEPRAZOLE


Trade Names	OMEPRAZOLE PRILOSEC
Synonyms	Antra H 168/68 H-168/68 Losec Losec mups Mezzopram Mopral NSC-751450 NSC-759192 Omeprazole Omeran Prilosec Zanprol
Status
Molecule Category	Free-form
ATC	A02BC01
UNII	KG60484QX9
EPA CompTox	DTXSID6021080


Active Pharmaceutical Ingredients Bioactive chemicals	Exact Similarity SubStructure	Threshold (%) >= 70


InChI Key	SUBDBMMJDZJVOS-UHFFFAOYSA-N
Smiles	COc1ccc2[nH]c([S+]([O-])Cc3ncc(C)c(OC)c3C)nc2c1
InChI	InChI=1S/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)

Mechanism of Action	Action	Reference
Potassium-transporting ATPase inhibitor	INHIBITOR	FDA PubMed PubMed PubMed


Protein: Potassium-transporting ATPase Description: Potassium-transporting ATPase alpha chain 1 Organism : Homo sapiens P20648 ENSG00000105675











Protein: Potassium-transporting ATPase Description: Potassium-transporting ATPase subunit beta Organism : Homo sapiens P51164 ENSG00000186009

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Cytochrome P450 Cytochrome P450 family 2 Cytochrome P450 family 2C Cytochrome P450 2C19	-	35000	-	-	93-93
Enzyme Cytochrome P450 Cytochrome P450 family 2 Cytochrome P450 family 2C Cytochrome P450 2C9	-	-	-	45000	-
Enzyme Cytochrome P450 Cytochrome P450 family 3 Cytochrome P450 family 3A Cytochrome P450 3A4	-	77983	-	-	-
Enzyme Hydrolase	-	250-22400	-	-	100
Enzyme Transferase	-	29600	-	3400	-
Enzyme	-	250-22400	-	3400	93-93
Epigenetic regulator Reader Bromodomain	-	1700	-	-	-
Epigenetic regulator Reader Plant homeodomain	-	1700	-	-	-
Epigenetic regulator Writer Protein methyltransferase	-	1700	-	-	-
Ion channel Other ion channel Phospholemman family	-	31623	-	-	-
Membrane receptor Family A G protein-coupled receptor Peptide receptor (family A GPCR) Short peptide receptor (family A GPCR) GRP-related receptor	14000	-	-	-	-
Other nuclear protein	-	1700	-	-	-
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	11
Transporter Primary active transporter ATP-binding cassette ABCB subfamily	-	89000-97200	-	-	-
Transporter Primary active transporter P-type ATPase Hydrogen potassium ATPase	-	250-22400	-	-	100
Transporter Primary active transporter P-type ATPase Sodium potassium ATPase	-	31623	-	-	-

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