IXAZOMIB CITRATE

/static/temp/default.svg Search structure
Trade Names
Synonyms
Status
Molecule Category Free-form
UNII 46CWK97Z3K
Parent Compound: IXAZOMIB

Structure

InChI Key MBOMYENWWXQSNW-AWEZNQCLSA-N
Smiles CC(C)C[C@H](NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)B1OC(=O)C(CC(=O)O)(CC(=O)O)O1
InChI
InChI=1S/C20H23BCl2N2O9/c1-10(2)5-14(21-33-19(32)20(34-21,7-16(27)28)8-17(29)30)25-15(26)9-24-18(31)12-6-11(22)3-4-13(12)23/h3-4,6,10,14H,5,7-9H2,1-2H3,(H,24,31)(H,25,26)(H,27,28)(H,29,30)/t14-/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C20H23BCl2N2O9
Molecular Weight 517.13

Pharmacology

Mechanism of Action Action Reference
26S proteosome inhibitor INHIBITOR DailyMed

Target Conservation

Protein: 26S proteasome
Description: Proteasome subunit beta type-11
Organism : Homo sapiens
A5LHX3 ENSG00000222028
Protein: 26S proteasome
Description: 26S proteasome non-ATPase regulatory subunit 11
Organism : Homo sapiens
O00231 ENSG00000108671
Protein: 26S proteasome
Description: 26S proteasome non-ATPase regulatory subunit 12
Organism : Homo sapiens
O00232 ENSG00000197170
Protein: 26S proteasome
Description: Proteasome subunit alpha type-7
Organism : Homo sapiens
O14818 ENSG00000101182
Protein: 26S proteasome
Description: 26S proteasome non-ATPase regulatory subunit 3
Organism : Homo sapiens
O43242 ENSG00000108344
Protein: 26S proteasome
Description: 26S proteasome regulatory subunit 6A
Organism : Homo sapiens
P17980 ENSG00000165916
Protein: 26S proteasome
Description: Proteasome subunit beta type-1
Organism : Homo sapiens
P20618 ENSG00000008018
Protein: 26S proteasome
Description: Proteasome subunit alpha type-1
Organism : Homo sapiens
P25786 ENSG00000129084
Protein: 26S proteasome
Description: Proteasome subunit alpha type-2
Organism : Homo sapiens
P25787 ENSG00000106588
Protein: 26S proteasome
Description: Proteasome subunit alpha type-3
Organism : Homo sapiens
P25788 ENSG00000100567
Protein: 26S proteasome
Description: Proteasome subunit alpha type-4
Organism : Homo sapiens
P25789 ENSG00000041357
Protein: 26S proteasome
Description: Proteasome subunit beta type-8
Organism : Homo sapiens
P28062 ENSG00000204264
Protein: 26S proteasome
Description: Proteasome subunit beta type-9
Organism : Homo sapiens
P28065 ENSG00000240065
Protein: 26S proteasome
Description: Proteasome subunit alpha type-5
Organism : Homo sapiens
P28066 ENSG00000143106
Protein: 26S proteasome
Description: Proteasome subunit beta type-4
Organism : Homo sapiens
P28070 ENSG00000159377
Protein: 26S proteasome
Description: Proteasome subunit beta type-6
Organism : Homo sapiens
P28072 ENSG00000142507
Protein: 26S proteasome
Description: Proteasome subunit beta type-5
Organism : Homo sapiens
P28074 ENSG00000100804
Protein: 26S proteasome
Description: 26S proteasome regulatory subunit 7
Organism : Homo sapiens
P35998 ENSG00000161057
Protein: 26S proteasome
Description: Proteasome subunit beta type-10
Organism : Homo sapiens
P40306 ENSG00000205220
Protein: 26S proteasome
Description: 26S proteasome regulatory subunit 6B
Organism : Homo sapiens
P43686 ENSG00000013275
Protein: 26S proteasome
Description: 26S proteasome non-ATPase regulatory subunit 8
Organism : Homo sapiens
P48556 ENSG00000099341
Protein: 26S proteasome
Description: Proteasome subunit beta type-3
Organism : Homo sapiens
P49720 ENSG00000277791
Protein: 26S proteasome
Description: Proteasome subunit beta type-2
Organism : Homo sapiens
P49721 ENSG00000126067
Protein: 26S proteasome
Description: 26S proteasome non-ATPase regulatory subunit 7
Organism : Homo sapiens
P51665 ENSG00000103035
Protein: 26S proteasome
Description: 26S proteasome complex subunit SEM1
Organism : Homo sapiens
P60896 ENSG00000127922
Protein: 26S proteasome
Description: Proteasome subunit alpha type-6
Organism : Homo sapiens
P60900 ENSG00000100902
Protein: 26S proteasome
Description: 26S proteasome regulatory subunit 4
Organism : Homo sapiens
P62191 ENSG00000100764
Protein: 26S proteasome
Description: 26S proteasome regulatory subunit 8
Organism : Homo sapiens
P62195 ENSG00000087191
Protein: 26S proteasome
Description: 26S proteasome regulatory subunit 10B
Organism : Homo sapiens
P62333 ENSG00000100519
Protein: 26S proteasome
Description: 26S proteasome non-ATPase regulatory subunit 2
Organism : Homo sapiens
Q13200 ENSG00000175166
Protein: 26S proteasome
Description: 26S proteasome non-ATPase regulatory subunit 6
Organism : Homo sapiens
Q15008 ENSG00000163636
Protein: 26S proteasome
Description: Proteasomal ubiquitin receptor ADRM1
Organism : Homo sapiens
Q16186 ENSG00000130706
Protein: 26S proteasome
Description: Proteasome subunit alpha-type 8
Organism : Homo sapiens
Q8TAA3 ENSG00000154611
Protein: 26S proteasome
Description: Proteasome subunit beta type-7
Organism : Homo sapiens
Q99436 ENSG00000136930
Protein: 26S proteasome
Description: 26S proteasome non-ATPase regulatory subunit 1
Organism : Homo sapiens
Q99460 ENSG00000173692
Protein: 26S proteasome
Description: 26S proteasome non-ATPase regulatory subunit 13
Organism : Homo sapiens
Q9UNM6 ENSG00000185627

Cross References

Resources Reference
ChEBI 90939
ChEMBL CHEMBL3545432
FDA SRS 46CWK97Z3K
PubChem 56844015
SureChEMBL SCHEMBL4427479
ZINC ZINC000200299610
CONTENTS