IXAZOMIB

/static/temp/default.svg Search structure
Synonyms
Status
Molecule Category Free-form
ATC L01XG03
UNII 71050168A2
EPA CompTox DTXSID701025662

Structure

InChI Key MXAYKZJJDUDWDS-LBPRGKRZSA-N
Smiles CC(C)C[C@H](NC(=O)CNC(=O)c1cc(Cl)ccc1Cl)B(O)O
InChI
InChI=1S/C14H19BCl2N2O4/c1-8(2)5-12(15(22)23)19-13(20)7-18-14(21)10-6-9(16)3-4-11(10)17/h3-4,6,8,12,22-23H,5,7H2,1-2H3,(H,18,21)(H,19,20)/t12-/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C14H19BCl2N2O4
Molecular Weight 361.03

Pharmacology

Mechanism of Action Action Reference
26S proteasome inhibitor INHIBITOR EMA PubMed PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Protease Threonine protease Threonine protease PBT clan Threonine protease T1A subfamily
- 3-31 - - -
Enzyme Protease Threonine protease Threonine protease PBT clan Threonine protease T1B subfamily
- 15 - - -
Other cytosolic protein
- 6.2 - - -
Transcription factor
- 6.2 - - -
Unclassified protein
- 15 - - -
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Homo sapiens
- 3-65.5 - - -

Target Conservation

Protein: 26S proteasome
Description: Proteasome subunit beta type-11
Organism : Homo sapiens
A5LHX3 ENSG00000222028
Protein: 26S proteasome
Description: 26S proteasome non-ATPase regulatory subunit 11
Organism : Homo sapiens
O00231 ENSG00000108671
Protein: 26S proteasome
Description: 26S proteasome non-ATPase regulatory subunit 12
Organism : Homo sapiens
O00232 ENSG00000197170
Protein: 26S proteasome
Description: Proteasome subunit alpha type-7
Organism : Homo sapiens
O14818 ENSG00000101182
Protein: 26S proteasome
Description: 26S proteasome non-ATPase regulatory subunit 3
Organism : Homo sapiens
O43242 ENSG00000108344
Protein: 26S proteasome
Description: 26S proteasome regulatory subunit 6A
Organism : Homo sapiens
P17980 ENSG00000165916
Protein: 26S proteasome
Description: Proteasome subunit beta type-1
Organism : Homo sapiens
P20618 ENSG00000008018
Protein: 26S proteasome
Description: Proteasome subunit alpha type-1
Organism : Homo sapiens
P25786 ENSG00000129084
Protein: 26S proteasome
Description: Proteasome subunit alpha type-2
Organism : Homo sapiens
P25787 ENSG00000106588
Protein: 26S proteasome
Description: Proteasome subunit alpha type-3
Organism : Homo sapiens
P25788 ENSG00000100567
Protein: 26S proteasome
Description: Proteasome subunit alpha type-4
Organism : Homo sapiens
P25789 ENSG00000041357
Protein: 26S proteasome
Description: Proteasome subunit beta type-8
Organism : Homo sapiens
P28062 ENSG00000204264
Protein: 26S proteasome
Description: Proteasome subunit beta type-9
Organism : Homo sapiens
P28065 ENSG00000240065
Protein: 26S proteasome
Description: Proteasome subunit alpha type-5
Organism : Homo sapiens
P28066 ENSG00000143106
Protein: 26S proteasome
Description: Proteasome subunit beta type-4
Organism : Homo sapiens
P28070 ENSG00000159377
Protein: 26S proteasome
Description: Proteasome subunit beta type-6
Organism : Homo sapiens
P28072 ENSG00000142507
Protein: 26S proteasome
Description: Proteasome subunit beta type-5
Organism : Homo sapiens
P28074 ENSG00000100804
Protein: 26S proteasome
Description: 26S proteasome regulatory subunit 7
Organism : Homo sapiens
P35998 ENSG00000161057
Protein: 26S proteasome
Description: Proteasome subunit beta type-10
Organism : Homo sapiens
P40306 ENSG00000205220
Protein: 26S proteasome
Description: 26S proteasome regulatory subunit 6B
Organism : Homo sapiens
P43686 ENSG00000013275
Protein: 26S proteasome
Description: 26S proteasome non-ATPase regulatory subunit 8
Organism : Homo sapiens
P48556 ENSG00000099341
Protein: 26S proteasome
Description: Proteasome subunit beta type-3
Organism : Homo sapiens
P49720 ENSG00000277791
Protein: 26S proteasome
Description: Proteasome subunit beta type-2
Organism : Homo sapiens
P49721 ENSG00000126067
Protein: 26S proteasome
Description: 26S proteasome non-ATPase regulatory subunit 7
Organism : Homo sapiens
P51665 ENSG00000103035
Protein: 26S proteasome
Description: 26S proteasome complex subunit SEM1
Organism : Homo sapiens
P60896 ENSG00000127922
Protein: 26S proteasome
Description: Proteasome subunit alpha type-6
Organism : Homo sapiens
P60900 ENSG00000100902
Protein: 26S proteasome
Description: 26S proteasome regulatory subunit 4
Organism : Homo sapiens
P62191 ENSG00000100764
Protein: 26S proteasome
Description: 26S proteasome regulatory subunit 8
Organism : Homo sapiens
P62195 ENSG00000087191
Protein: 26S proteasome
Description: 26S proteasome regulatory subunit 10B
Organism : Homo sapiens
P62333 ENSG00000100519
Protein: 26S proteasome
Description: 26S proteasome non-ATPase regulatory subunit 2
Organism : Homo sapiens
Q13200 ENSG00000175166
Protein: 26S proteasome
Description: 26S proteasome non-ATPase regulatory subunit 6
Organism : Homo sapiens
Q15008 ENSG00000163636
Protein: 26S proteasome
Description: Proteasomal ubiquitin receptor ADRM1
Organism : Homo sapiens
Q16186 ENSG00000130706
Protein: 26S proteasome
Description: Proteasome subunit alpha-type 8
Organism : Homo sapiens
Q8TAA3 ENSG00000154611
Protein: 26S proteasome
Description: Proteasome subunit beta type-7
Organism : Homo sapiens
Q99436 ENSG00000136930
Protein: 26S proteasome
Description: 26S proteasome non-ATPase regulatory subunit 1
Organism : Homo sapiens
Q99460 ENSG00000173692
Protein: 26S proteasome
Description: 26S proteasome non-ATPase regulatory subunit 13
Organism : Homo sapiens
Q9UNM6 ENSG00000185627

Cross References

Resources Reference
CAS NUMBER 1072833-77-2
ChEBI 90942
ChEMBL CHEMBL2141296
DrugBank DB09570
DrugCentral 5067
FDA SRS 71050168A2
Guide to Pharmacology 8450
PDB 6V8
PubChem 25183872
SureChEMBL SCHEMBL3742758
ZINC ZINC000169946773
CONTENTS