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MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Adenosine A2a receptor antagonist
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Amyotrophic Lateral Sclerosis; Liver Diseases; Substance-Related Disorders; Parkinson Disease
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Androgen Receptor antagonist
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Breast Neoplasms; Neoplasms; Prostatic Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Janus Kinase (JAK) inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Arthritis, Juvenile; Hidradenitis Suppurativa; Lupus Erythematosus, Systemic; Vitiligo; Arthritis, Psoriatic; Colitis, Ulcerative; Crohn Disease; Dermatitis, Atopic; Giant Cell Arteritis; Spondylitis, Ankylosing; Arthritis, Rheumatoid; Immune System Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Retinoic acid receptor gamma agonist
ROUTE OF ADMINISTRATION: TOPICAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Lymphoma; Ichthyosis, Lamellar; Acne Vulgaris
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Fascioliasis; Helminthiasis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Diagnostic agent
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Glioblastoma; Glioma; Parkinson Disease; Pheochromocytoma
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: PI3-kinase p110-alpha subunit inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Esophageal Neoplasms; Gastrointestinal Stromal Tumors; Liver Diseases; Meningioma; Multiple Myeloma; Oropharyngeal Neoplasms; Pancreatic Neoplasms; Rectal Neoplasms; Stomach Neoplasms; Carcinoma, Squamous Cell; Colorectal Neoplasms; Endometrial Neoplasms; Head and Neck Neoplasms; Squamous Cell Carcinoma of Head and Neck; Ovarian Neoplasms; Breast Neoplasms; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: GABA-A receptor; anion channel positive allosteric modulator
ROUTE OF ADMINISTRATION: INTRAVENOUS
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Alcoholism; Alzheimer Disease; Brain Injuries; Essential Tremor; Stress Disorders, Post-Traumatic; Depressive Disorder; Status Epilepticus; Depression, Postpartum
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Transthyretin stabiliser
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Amyloid Neuropathies, Familial; Polyneuropathies; Amyloidosis; Amyloidosis, Familial; Cardiomyopathies
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Macrophage colony stimulating factor receptor inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Arthritis, Rheumatoid; Breast Neoplasms; Gastrointestinal Stromal Tumors; Leukemia, Myeloid, Acute; Neurilemmoma; Prostatic Neoplasms; Glioblastoma; Hemangiosarcoma; Hodgkin Disease; Melanoma; Prostatic Neoplasms, Castration-Resistant; Triple Negative Breast Neoplasms; Giant Cell Tumors; Synovitis, Pigmented Villonodular; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Transthyretin stabiliser
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Amyloid Neuropathies, Familial; Amyloidosis; Amyloidosis, Familial; Cardiomyopathies
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Disorders of Excessive Somnolence; Narcolepsy; Sleep Apnea, Obstructive; Attention Deficit Disorder with Hyperactivity
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Exportin-1 inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Colorectal Neoplasms; Diabetic Foot; Fallopian Tube Neoplasms; Gliosarcoma; Hematologic Neoplasms; Leukemia, Biphenotypic, Acute; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Lymphoma, T-Cell, Peripheral; Ovarian Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Rectal Neoplasms; Sarcoma; Urinary Bladder Neoplasms; Breast Neoplasms; Carcinoma, Squamous Cell; Glioblastoma; Leukemia, Myeloid, Acute; Liposarcoma; Lymphoma; Lymphoma, Follicular; Melanoma; Myelodysplastic Syndromes; Primary Myelofibrosis; Prostatic Neoplasms, Castration-Resistant; Sarcoma, Alveolar Soft Part; Severe Acute Respiratory Syndrome; Small Cell Lung Carcinoma; Thymoma; Endometrial Neoplasms; Lymphoma, Large B-Cell, Diffuse; Multiple Myeloma; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Tyrosine-protein kinase BTK inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Leukemia; Castleman Disease; Immunoglobulin G4-Related Disease; Lupus Nephritis; Lymphoma; Neuromyelitis Optica; Purpura, Thrombocytopenic, Idiopathic; Severe Acute Respiratory Syndrome; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphohistiocytosis, Hemophagocytic; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Waldenstrom Macroglobulinemia; Lymphoma, Mantle-Cell; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Supplement
ROUTE OF ADMINISTRATION: INTRAVENOUS
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Severe Acute Respiratory Syndrome
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Tyrosine-protein kinase JAK2 inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Kidney Diseases; Liver Diseases; Myeloproliferative Disorders; Leukemia, Neutrophilic, Chronic; Myelodysplastic Syndromes; Primary Myelofibrosis; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Sphingosine 1-phosphate receptor Edg-1 agonist
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Multiple Sclerosis; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Glutamate [NMDA] receptor negative allosteric modulator
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Kidney Diseases; Liver Diseases; Rhinitis, Allergic, Seasonal; Substance-Related Disorders; Neoplasms; Depressive Disorder, Major; Depressive Disorder
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Calcitonin gene-related peptide type 1 receptor antagonist
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Migraine Disorders
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Hemoglobin HbA positive modulator
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Kidney Diseases; Liver Diseases; Acute Lung Injury; Idiopathic Pulmonary Fibrosis; Anemia, Sickle Cell
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Supplement
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Tuberculosis, Multidrug-Resistant; Tuberculosis; Tuberculosis, Pulmonary
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Cystic Fibrosis; Pneumonia; Bacterial Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Hyperphosphatemia; Irritable Bowel Syndrome; Constipation
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Hypertension; Cardiovascular Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Cystic fibrosis transmembrane conductance regulator positive modulator
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Cystic Fibrosis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Kelch-like ECH-associated protein 1 inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Multiple Sclerosis, Relapsing-Remitting; Immune System Diseases; Multiple Sclerosis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Sphingosine 1-phosphate receptor Edg-1 agonist
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Kidney Diseases; Liver Diseases; Dermatomyositis; Multiple Sclerosis, Relapsing-Remitting; Polymyositis; Multiple Sclerosis; Multiple Sclerosis, Chronic Progressive; Immune System Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Fibroblast growth factor receptor inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Breast Neoplasms; Carcinoma, Hepatocellular; Liver Diseases; Lymphoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Multiple Myeloma; Prostatic Neoplasms; Urogenital Neoplasms; Carcinoma, Transitional Cell; Neoplasms; Urinary Bladder Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: ALK tyrosine kinase receptor inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Glioma; Leukemia, Myeloid, Acute; Carcinoma, Lobular; Melanoma; Carcinoma, Non-Small-Cell Lung; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Bacterial penicillin-binding protein inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Pneumonia, Bacterial; Sepsis; Infections; Urinary Tract Infections; Pneumonia; Bacterial Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Ultrasound contrast agent
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Membrane staining aid in ophthalmic surgery
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Bacterial beta-lactamase TEM inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Communicable Diseases; Sepsis; Hematologic Neoplasms; Bacterial Infections; Pneumonia, Bacterial; Intraabdominal Infections; Pyelonephritis; Urinary Tract Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Platelet-derived growth factor receptor alpha inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Gastrointestinal Stromal Tumors; Neoplasms