LEVOFLOXACIN


Trade Names	IQUIX LEVAQUIN LEVAQUIN IN DEXTROSE 5% IN PLASTIC CONTAINER LEVOFLOXACIN LEVOFLOXACIN IN DEXTROSE 5% IN PLASTIC CONTAINER QUIXIN
Synonyms	Cravit DR-3355 Evoxil Floxacin Iquix L-ofloxacin Levaquin Levofloxacin Levofloxacin (as hemihydrate) Levofloxacin anhydrous Levofloxacin hemihydrate Levofloxacin hydrate NSC-758709 Nofaxin Ofloxacin s-(-)-form
Status
Molecule Category	Free-form
ATC	J01MA12 S01AE05
UNII	RIX4E89Y14
EPA CompTox	DTXSID0041060


InChI Key	GSDSWSVVBLHKDQ-JTQLQIEISA-N
Smiles	C[C@H]1COc2c(N3CCN(C)CC3)c(F)cc3c(=O)c(C(=O)O)cn1c23
InChI	InChI=1S/C18H20FN3O4/c1-10-9-26-17-14-11(16(23)12(18(24)25)8-22(10)14)7-13(19)15(17)21-5-3-20(2)4-6-21/h7-8,10H,3-6,9H2,1-2H3,(H,24,25)/t10-/m0/s1

Property Name	Value
Molecular Formula	C18H20FN3O4
Molecular Weight	361.37
AlogP	1.54
Hydrogen Bond Acceptor	6.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	2.0
Polar Surface Area	75.01
Molecular species	ACID
Aromatic Rings	2.0
Heavy Atoms	26.0

Mechanism of Action	Action	Reference
DNA gyrase inhibitor	INHIBITOR	DailyMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Ion channel Voltage-gated ion channel Potassium channels Voltage-gated potassium channel	-	-	-	-	-0.9-10
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	95.07-117.4
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC47 family of multidrug and toxin extrusion transporters	-	-	-	-	26

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Acinetobacter baumannii	-	-	-	-	10
Cricetulus griseus	-	-	-	-	95.07-117.4
Escherichia coli	-	125	-	-	10
Haemophilus influenzae	-	-	-	-	10
Homo sapiens	-	-	-	-	-0.9-26
Klebsiella pneumoniae	-	125-250	-	-	10
Mycobacterium tuberculosis	-	590-840	-	-	-
Mycobacterium tuberculosis H37Rv	-	800	-	-	-
Pseudomonas aeruginosa	-	-	-	-	10
Staphylococcus aureus	-	125-250	-	-	10-57.9
Staphylococcus epidermidis	-	250-250	-	-	-
Streptococcus pyogenes	-	-	-	-	10

Header

Compound Name

Maximum Phase

Compound Structure

Smile

Inchi

InchiKey

Compound Properties

Molecular Formula

Molecular Weight

ALogP

PSA

Resources	Reference
ChEBI	63598
ChEMBL	CHEMBL33
DrugBank	DB01137
DrugCentral	1569
FDA SRS	RIX4E89Y14
Human Metabolome Database	HMDB0001929
Guide to Pharmacology	10911
KEGG	C07660
PDB	LFX
PharmGKB	PA450214
PubChem	3033924
SureChEMBL	SCHEMBL15397
ZINC	ZINC000000538273

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025

LEVOFLOXACIN

Structure

Physicochemical Descriptors

Pharmacology

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