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MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Glucocorticoid receptor agonist
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Kidney Diseases; Liver Diseases; Aspergillosis, Allergic Bronchopulmonary; Muscular Dystrophies, Limb-Girdle; Muscular Dystrophies; Muscular Dystrophy, Duchenne
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: ALK tyrosine kinase receptor inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Lymphoma, Large-Cell, Anaplastic; Carcinoma, Non-Small-Cell Lung; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Carbepenem-hydrolyzing beta-lactamase KPC inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Bacterial Infections; Renal Insufficiency; Urinary Tract Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Coagulation factor X inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Kidney Diseases; Liver Diseases; Atrial Fibrillation; Atrial Flutter; Hemorrhage; Thromboembolism; Thrombosis; Venous Thromboembolism
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Hepatitis C virus serine protease, NS3/NS4A inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Kidney Diseases; Liver Diseases; Hepatitis C; Hepatitis C, Chronic
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Synaptic vesicular amine transporter inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Tourette Syndrome; Trichotillomania; Huntington Disease; Movement Disorders; Schizophrenia
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Poly [ADP-ribose] polymerase 2 inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Fallopian Tube Neoplasms; Leukemia, Lymphocytic, Chronic, B-Cell; Lung Neoplasms; Peritoneal Neoplasms; Rectal Neoplasms; Sarcoma, Ewing; Stomach Neoplasms; Urogenital Neoplasms; Carcinoma, Pancreatic Ductal; Carcinoma, Squamous Cell; Colorectal Neoplasms; Endometrial Neoplasms; Glioblastoma; Head and Neck Neoplasms; Lymphoma; Melanoma; Mesothelioma; Pancreatic Neoplasms; Prostatic Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Hereditary Breast and Ovarian Cancer Syndrome; Ovarian Neoplasms; Prostatic Neoplasms, Castration-Resistant; Small Cell Lung Carcinoma; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Epidermal growth factor receptor erbB1 inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Carcinoma; Carcinoma, Hepatocellular; Colorectal Neoplasms; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Ovarian Neoplasms; Stomach Neoplasms; Carcinoma, Non-Small-Cell Lung; Glioblastoma; Hemangiosarcoma; Prostatic Neoplasms; Triple Negative Breast Neoplasms; Breast Neoplasms; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Tyrosine-protein kinase BTK inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Communicable Diseases; Glioblastoma; Leukemia; Leukemia, Prolymphocytic; Lymphoma; Multiple Myeloma; Arthritis, Rheumatoid; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Food Hypersensitivity; Hematologic Neoplasms; Lymphoma, Follicular; Lymphoma, Non-Hodgkin; Ovarian Neoplasms; Pancreatic Neoplasms; Waldenstrom Macroglobulinemia; Lymphoma, Large B-Cell, Diffuse; Severe Acute Respiratory Syndrome; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma, Mantle-Cell; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Hepatitis C virus serine protease, NS3/NS4A inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Hepatitis C; Hepatitis C, Chronic
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: DNA inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Vaginal Discharge; Infections; Trichomonas Infections; Vaginosis, Bacterial
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Tryptophan 5-hydroxylase inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Liver Diseases; Biliary Tract Neoplasms; Malignant Carcinoid Syndrome; Neuroendocrine Tumors; Carcinoid Heart Disease
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Mu opioid receptor antagonist
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Pancreatitis; Constipation
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Hematologic Neoplasms; Liver Diseases; Multiple Myeloma; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Chronic; Myelodysplastic Syndromes; Leukemia; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Chagas Disease; Leishmaniasis; Trypanosomiasis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Monoamine oxidase B inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Kidney Diseases; Liver Diseases; Multiple System Atrophy; Parkinson Disease
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Liver Diseases; Pneumonia; Gonorrhea; Infections; Pneumonia, Bacterial; Bacterial Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Hypersensitivity; Substance Withdrawal Syndrome; Cocaine-Related Disorders; Opioid-Related Disorders
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Cyclin-dependent kinase 4 inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Astrocytoma; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Diffuse Intrinsic Pontine Glioma; Glioblastoma; Kidney Diseases; Lymphoma; Neuroblastoma; Peritoneal Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Primary Myelofibrosis; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Rhabdoid Tumor; Carcinoma; Carcinoma, Hepatocellular; Fallopian Tube Neoplasms; Liposarcoma; Melanoma; Neoplasms; Neuroendocrine Tumors; Ovarian Neoplasms; Sarcoma; Teratoma; Thymus Neoplasms; Uterine Neoplasms; Breast Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: DNA gyrase inhibitor
ROUTE OF ADMINISTRATION: TOPICAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Wounds and Injuries; Impetigo
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Sodium/glucose cotransporter 2 inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Heart Failure; Diabetes Mellitus; Diabetes Mellitus, Type 2
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Ghrelin receptor agonist
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Cachexia
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Epidermal growth factor receptor erbB1 inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Neoplasms; Breast Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: INTRAVENOUS
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Kidney Diseases; Liver Diseases; Brain Injuries; Cerebral Hemorrhage; Stroke; Ischemic Stroke; Amyotrophic Lateral Sclerosis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Nonstructural protein 5A inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Kidney Diseases; Liver Diseases; Hepatitis C; Hepatitis C, Chronic
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Platelet-derived growth factor receptor inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Liver Diseases; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Rectal Neoplasms; Blast Crisis; Myelodysplastic Syndromes; Leukemia; Leukemia, Mast-Cell; Leukemia, Myeloid, Acute; Mastocytosis; Mastocytosis, Systemic; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Corneal Edema; Fuchs' Endothelial Dystrophy; Glaucoma
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Cyclin-dependent kinase 4 inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Colorectal Neoplasms; Cystadenocarcinoma, Serous; Diffuse Intrinsic Pontine Glioma; Glioma; Lymphoma; Lymphoma, Non-Hodgkin; Multiple Myeloma; Neoplasm Metastasis; Neuroblastoma; Neurofibromatosis 1; Osteosarcoma; Pancreatic Neoplasms; Prostatic Neoplasms; Rhabdoid Tumor; Rhabdomyosarcoma; Sarcoma, Ewing; Sarcoma, Kaposi; Brain Neoplasms; Breast Neoplasms, Male; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Pancreatic Ductal; Endometrial Neoplasms; Genital Neoplasms, Female; Glioblastoma; Head and Neck Neoplasms; Hemangiosarcoma; Lung Neoplasms; Lymphoma, Mantle-Cell; Melanoma; Meningioma; Mesothelioma; Oligodendroglioma; Ovarian Neoplasms; Prostatic Neoplasms, Castration-Resistant; Small Cell Lung Carcinoma; Thyroid Neoplasms; Triple Negative Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Liposarcoma; Breast Neoplasms; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Neurotrophic tyrosine kinase receptor inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Thrombopoietin receptor agonist
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Anemia, Aplastic; Blood Platelet Disorders; Liver Diseases; Purpura, Thrombocytopenic, Idiopathic; Thrombocytopenia; Hemorrhage
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Thrombopoietin receptor agonist
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Purpura, Thrombocytopenic, Idiopathic; Hemorrhage; Thrombocytopenia
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: ALK tyrosine kinase receptor inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Kidney Diseases; Liver Diseases; Neuroblastoma; Lymphoma, Large-Cell, Anaplastic; Carcinoma, Non-Small-Cell Lung; Lymphoma; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Cannabinoid CB1 receptor negative allosteric modulator
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Arthralgia; Bone Diseases, Metabolic; Crohn Disease; Cystitis, Interstitial; Essential Tremor; Heart Failure; Hypertension; Kidney Diseases; Lung Neoplasms; Prostatic Neoplasms; Radiculopathy; Status Epilepticus; Toothache; Alcoholism; Anxiety; Arthritis, Psoriatic; Autistic Disorder; Bipolar Disorder; Blepharospasm; Child Development Disorders, Pervasive; Chronic Pain; Cocaine-Related Disorders; Colitis, Ulcerative; Diabetic Neuropathies; Epilepsy, Absence; Fatty Liver; Graft vs Host Disease; HIV Infections; Hepatitis, Autoimmune; Huntington Disease; Intellectual Disability; Marijuana Abuse; Migraine Disorders; Myocarditis; Neoplasms; Neuralgia; Obsessive-Compulsive Disorder; Opioid-Related Disorders; Osteoarthritis, Knee; Parkinson Disease; Peripheral Nervous System Diseases; Prader-Willi Syndrome; Schizophrenia; Severe Acute Respiratory Syndrome; Sleep Initiation and Maintenance Disorders; Sleep Wake Disorders; Stress Disorders, Post-Traumatic; Sturge-Weber Syndrome; Tobacco Use Disorder; Tourette Syndrome; Trichotillomania; Amyotrophic Lateral Sclerosis; Breast Neoplasms; Fibromyalgia; Fragile X Syndrome; Osteoarthritis; Pain; Psychotic Disorders; Rett Syndrome; Spasms, Infantile; Epilepsies, Myoclonic; Epilepsy; Lennox Gastaut Syndrome; Seizures; Tuberous Sclerosis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Isocitrate dehydrogenase [NADP] cytoplasmic inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Carcinoma, Pancreatic Ductal; Liver Diseases; Myelodysplastic Syndromes; Chondrosarcoma; Glioma; Cholangiocarcinoma; Leukemia, Myeloid, Acute; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Epidermal growth factor receptor erbB1 inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Colorectal Neoplasms; Liver Diseases; Mouth Neoplasms; Neoplasm Metastasis; Brain Neoplasms; Carcinoma; Carcinoma, Squamous Cell; Glioblastoma; Head and Neck Neoplasms; Penile Neoplasms; Carcinoma, Non-Small-Cell Lung; Lung Neoplasms; Carcinoma, Non-Small-Cell Lung; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Dual specificity mitogen-activated protein kinase kinase 1 inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Brain Neoplasms; Carcinoma; Colonic Neoplasms; Gastrointestinal Stromal Tumors; Leukemia; Liver Diseases; Lung Neoplasms; Rectal Neoplasms; Arthritis, Rheumatoid; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cardiomegaly; Colorectal Neoplasms; Leukemia, Hairy Cell; Multiple Myeloma; Pancreatic Neoplasms; Thyroid Neoplasms; Fallopian Tube Neoplasms; Ovarian Neoplasms; Peritoneal Neoplasms; Melanoma; Neoplasms