FLUVASTATIN SODIUM

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Trade Names
Synonyms
Status
Molecule Category Salt-form
UNII PYF7O1FV7F
Parent Compound: FLUVASTATIN

Structure

InChI Key ZGGHKIMDNBDHJB-CALJPSDSSA-M
Smiles CC(C)n1c(/C=C/C(O)CC(O)CC(=O)[O-])c(-c2ccc(F)cc2)c2ccccc21.[Na+]
InChI
InChI=1S/C24H26FNO4.Na/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30;/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30);/q;+1/p-1/b12-11+;

Physicochemical Descriptors

Property Name Value
Molecular Formula C24H25FNNaO4
Molecular Weight 433.45
AlogP 4.63
Hydrogen Bond Acceptor 4.0
Hydrogen Bond Donor 3.0
Number of Rotational Bond 8.0
Polar Surface Area 82.69
Molecular species ACID
Aromatic Rings 3.0
Heavy Atoms 30.0

Pharmacology

Mechanism of Action Action Reference
HMG-CoA reductase inhibitor INHIBITOR DailyMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Enzyme Oxidoreductase
- 2.5-32 - - -
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Homo sapiens
- 79 - - -
Rattus norvegicus
- 4-292 - - -

Target Conservation

Protein: HMG-CoA reductase
Description: 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Organism : Homo sapiens
P04035 ENSG00000113161

Cross References

Resources Reference
ChEMBL CHEMBL2218894
FDA SRS PYF7O1FV7F
PubChem 23679527
SureChEMBL SCHEMBL556763
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