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MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Dual specificity mitogen-activated protein kinase kinase 1 inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Brain Neoplasms; Carcinoma; Colonic Neoplasms; Gastrointestinal Stromal Tumors; Leukemia; Liver Diseases; Lung Neoplasms; Rectal Neoplasms; Arthritis, Rheumatoid; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cardiomegaly; Colorectal Neoplasms; Leukemia, Hairy Cell; Multiple Myeloma; Pancreatic Neoplasms; Thyroid Neoplasms; Fallopian Tube Neoplasms; Ovarian Neoplasms; Peritoneal Neoplasms; Melanoma; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Androgen Receptor antagonist
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Liver Diseases; Salivary Gland Neoplasms; Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Tyrosine-protein kinase receptor FLT3 inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Leukemia, Myeloid; Leukemia, Myeloid, Acute
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Smoothened homolog antagonist
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Leukemia, Myeloid, Acute
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Smoothened homolog antagonist
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Glioblastoma; Myelodysplastic Syndromes; Leukemia, Myeloid, Acute; Sarcoma; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Tyrosine-protein kinase receptor FLT3 inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Carcinoma, Non-Small-Cell Lung; Kidney Diseases; Liver Diseases; Blast Crisis; Myelodysplastic Syndromes; Leukemia, Myeloid, Acute; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Pneumonia; Pyelonephritis; Urinary Tract Infections; Pneumonia, Bacterial; Bacterial Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Tyrosine-protein kinase SYK inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Hematologic Neoplasms; Lymphoma; Ovarian Neoplasms; Pneumonia; Anemia, Hemolytic, Autoimmune; Glomerulonephritis, IGA; Hidradenitis Suppurativa; Lymphoma, Large B-Cell, Diffuse; Primary Myelofibrosis; Severe Acute Respiratory Syndrome; Arthritis, Rheumatoid; Purpura, Thrombocytopenic, Idiopathic; Hemorrhage
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Hyperoxaluria, Primary; Epilepsies, Myoclonic; Epilepsy; Seizures
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Neurotrophic tyrosine kinase receptor inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Irritable Bowel Syndrome; Diarrhea; Eye Infections; Tuberculosis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Muscarinic acetylcholine receptor M3 antagonist
ROUTE OF ADMINISTRATION: INHALATION
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Kidney Diseases; Liver Diseases; Lung Diseases, Obstructive; Pulmonary Disease, Chronic Obstructive
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Liver Diseases; Renal Insufficiency, Chronic; Infections; Urinary Tract Infections; Bacterial Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Cystic fibrosis transmembrane conductance regulator positive modulator
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Cystic Fibrosis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Voltage-gated potassium channel blocker
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Botulism; Multiple Sclerosis; Lambert-Eaton Myasthenic Syndrome
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Gonadotropin-releasing hormone receptor antagonist
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Polycystic Ovary Syndrome; Endometriosis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Poly [ADP-ribose] polymerase 2 inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Colorectal Neoplasms; Leukemia; Leukemia, Myeloid, Acute; Neuroendocrine Tumors; Pancreatic Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Endometrial Neoplasms; Glioblastoma; Hemangiosarcoma; Hematologic Neoplasms; Hereditary Breast and Ovarian Cancer Syndrome; Prostatic Neoplasms; Small Cell Lung Carcinoma; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Breast Neoplasms; Ovarian Neoplasms; Prostatic Neoplasms, Castration-Resistant; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Tyrosine-protein kinase JAK1 inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Graft vs Host Disease; Diabetes Mellitus, Type 1; Diabetic Nephropathies; Giant Cell Arteritis; HIV Infections; Lichen Planus; Liver Cirrhosis, Biliary; Myositis; Pneumonia; Psoriasis; Purpura, Thrombocytopenic, Idiopathic; Renal Insufficiency, Chronic; Sjogren's Syndrome; Vitiligo; Alopecia Areata; Arthritis, Juvenile; Dermatitis, Atopic; Dermatomyositis; Lupus Erythematosus, Systemic; Severe Acute Respiratory Syndrome; Uveitis; Arthritis, Rheumatoid; Immune System Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Acne Vulgaris; Bacterial Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Norepinephrine transporter substrate
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Carcinoid Tumor; Neuroblastoma; Paraganglioma; Pheochromocytoma
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Alpha-galactosidase A stabiliser
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Fabry Disease
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Thrombopoietin receptor agonist
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Liver Diseases; Thrombocytopenia
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Serine/threonine-protein kinase B-raf inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Carcinoma, Non-Small-Cell Lung; Colorectal Neoplasms; Leukemia, Hairy Cell; Multiple Myeloma; Pancreatic Neoplasms; Pulmonary Disease, Chronic Obstructive; Rectal Neoplasms; Thyroid Neoplasms; Melanoma; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Malaria, Falciparum; Severe Acute Respiratory Syndrome; Malaria, Vivax; Malaria
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Polymerase acidic protein inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Influenza, Human; Virus Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Infections; Elephantiasis, Filarial; Strongyloidiasis; Helminthiasis; Onchocerciasis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: PI3-kinase p110-delta subunit inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Liver Diseases; Melanoma; Mycosis Fungoides; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sezary Syndrome; Arthritis, Rheumatoid; Asthma; Carcinoma, Squamous Cell; Hematologic Neoplasms; Leukemia; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Peripheral; Severe Acute Respiratory Syndrome; Leukemia, Lymphocytic, Chronic, B-Cell; Lymphoma; Lymphoma, Follicular; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Serotonin 4 (5-HT4) receptor agonist
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Dyspepsia; Liver Diseases; Deglutition Disorders; Ileus; Irritable Bowel Syndrome; Intestinal Pseudo-Obstruction; Constipation
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Human immunodeficiency virus type 1 integrase inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Acquired Immunodeficiency Syndrome; HIV Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Reverse transcriptase negative allosteric modulator
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Kidney Diseases; HIV Infections; Virus Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Renal Insufficiency; Renal Insufficiency, Chronic; Pyelonephritis; Bacterial Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Macrophage colony stimulating factor receptor inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Arthritis, Rheumatoid; Breast Neoplasms; Gastrointestinal Stromal Tumors; Leukemia, Myeloid, Acute; Neurilemmoma; Prostatic Neoplasms; Glioblastoma; Hemangiosarcoma; Hodgkin Disease; Melanoma; Prostatic Neoplasms, Castration-Resistant; Triple Negative Breast Neoplasms; Giant Cell Tumors; Synovitis, Pigmented Villonodular; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Adenosine A2a receptor antagonist
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Amyotrophic Lateral Sclerosis; Liver Diseases; Substance-Related Disorders; Parkinson Disease
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Diagnostic agent
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Glioblastoma; Glioma; Parkinson Disease; Pheochromocytoma