AVATROMBOPAG MALEATE

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Trade Names
Synonyms
Status
Molecule Category Mixture
UNII GDW7M2P1IS

Structure

InChI Key MISPBGHDNZYFNM-BTJKTKAUSA-N
Smiles O=C(Nc1nc(-c2cc(Cl)cs2)c(N2CCN(C3CCCCC3)CC2)s1)c1cnc(N2CCC(C(=O)O)CC2)c(Cl)c1.O=C(O)/C=C\C(=O)O
InChI
InChI=1S/C29H34Cl2N6O3S2.C4H4O4/c30-20-15-23(41-17-20)24-27(37-12-10-35(11-13-37)21-4-2-1-3-5-21)42-29(33-24)34-26(38)19-14-22(31)25(32-16-19)36-8-6-18(7-9-36)28(39)40;5-3(6)1-2-4(7)8/h14-18,21H,1-13H2,(H,39,40)(H,33,34,38);1-2H,(H,5,6)(H,7,8)/b;2-1-

Physicochemical Descriptors

Property Name Value
Molecular Formula C33H38Cl2N6O7S2
Molecular Weight 765.74
AlogP 6.58
Hydrogen Bond Acceptor 9.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 7.0
Polar Surface Area 101.9
Molecular species ACID
Aromatic Rings 3.0
Heavy Atoms 42.0

Pharmacology

Mechanism of Action Action Reference
Thrombopoietin receptor agonist AGONIST FDA FDA

Target Conservation

Protein: Thrombopoietin receptor
Description: Thrombopoietin receptor
Organism : Homo sapiens
P40238 ENSG00000117400

Cross References

Resources Reference
ChEMBL CHEMBL2105758
FDA SRS GDW7M2P1IS
PharmGKB PA166179849
PubChem 9918581
SureChEMBL SCHEMBL19610454
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