PRUCALOPRIDE

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Synonyms
Status
Molecule Category Free-form
ATC A06AX05
UNII 0A09IUW5TP
EPA CompTox DTXSID5057670

Structure

InChI Key ZPMNHBXQOOVQJL-UHFFFAOYSA-N
Smiles COCCCN1CCC(NC(=O)c2cc(Cl)c(N)c3c2OCC3)CC1
InChI
InChI=1S/C18H26ClN3O3/c1-24-9-2-6-22-7-3-12(4-8-22)21-18(23)14-11-15(19)16(20)13-5-10-25-17(13)14/h11-12H,2-10,20H2,1H3,(H,21,23)

Physicochemical Descriptors

Property Name Value
Molecular Formula C18H26ClN3O3
Molecular Weight 367.88
AlogP 2.09
Hydrogen Bond Acceptor 5.0
Hydrogen Bond Donor 2.0
Number of Rotational Bond 6.0
Polar Surface Area 76.82
Molecular species BASE
Aromatic Rings 1.0
Heavy Atoms 25.0

Pharmacology

Mechanism of Action Action Reference
Serotonin 4 (5-HT4) receptor agonist AGONIST PubMed
Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Serotonin receptor
5.2-26 - - 2.512-110 -
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Homo sapiens
5.2-26 - - - -
Rattus norvegicus
26 - - - -

Target Conservation

Protein: Serotonin 4 (5-HT4) receptor
Description: 5-hydroxytryptamine receptor 4
Organism : Homo sapiens
Q13639 ENSG00000164270

Related Entries

Cross References

Resources Reference
ChEBI 135552
ChEMBL CHEMBL117287
DrugBank DB06480
DrugCentral 3502
FDA SRS 0A09IUW5TP
Guide to Pharmacology 243
PubChem 3052762
SureChEMBL SCHEMBL16952
ZINC ZINC000001891034
CONTENTS