|
Tested for ability to inhibit human erythrocyte carbonic-anhydrase-II- (HCA II) catalyzed carbon dioxide hydration
|
None
|
0.18
nM
|
|
|
Compound was evaluated for the inhibitory activity against Human Carbonic anhydrase II (HCA II)
|
None
|
1.1
nM
|
|
Compound was evaluated for the inhibitory activity against Human Carbonic anhydrase II (HCA II)
|
None
|
0.23
nM
|
|
Compound was evaluated for the inhibitory activity against Human Carbonic anhydrase II (HCA II)
|
None
|
7.1
nM
|
|
|
Inhibitory activity against human carbonic anhydrase II was determined
|
None
|
9.0
nM
|
|
|
Inhibitory activity against carbonic anhydrase II
|
None
|
0.18
nM
|
|
|
Inhibition of human cytosolic isozyme Carbonic anhydrase II at 20 degree C
|
None
|
9.0
nM
|
|
|
In vitro inhibitory activity against human carbonic anhydrase II (hCAII)
|
None
|
9.0
nM
|
|
|
Inhibitory activity against Human carbonic anhydrase II
|
None
|
9.0
nM
|
|
|
Inhibitory activity against human recombinant carbonic anhydrase II (CA2)
|
None
|
9.0
nM
|
|
|
Inhibitory activity against human cloned isoenzyme carbonic anhydrase II (hCA II), by esterase method.
|
None
|
9.0
nM
|
|
|
Tested for ability to compete with dansylamide for binding to human erythrocyte carbonic-anhydrase-II (HCA-II)
|
None
|
0.28
nM
|
|
|
Binding affinity against human carbonic anhydrase II (hCA -II)
|
None
|
9.0
nM
|
|
|
Compound was evaluated for the affinity towards Human Carbonic anhydrase II (HCA II)
|
None
|
2.0
nM
|
|
Compound was evaluated for the affinity towards Human Carbonic anhydrase II (HCA II)
|
None
|
0.37
nM
|
|
Compound was evaluated for the affinity towards Human Carbonic anhydrase II (HCA II)
|
None
|
5.5
nM
|
|
|
Compound was evaluated for the inhibitory constant towards Human Carbonic anhydrase II (HCA II)
|
None
|
0.37
nM
|
|
|
Inhibition of human cloned Carbonic anhydrase II
|
None
|
9.0
nM
|
|
|
Dissociation constant against Carbonic anhydrase II was reported in experiment 1
|
None
|
0.372
nM
|
|
|
Inhibition of human carbonic anhydrase II
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition constant (Ki) against human cloned carbonic anhydrase II (CAH)
|
None
|
9.0
nM
|
|
|
Inhibitory activity against human recombinant carbonic anhydrase II
|
None
|
9.0
nM
|
|
|
Inhibition of human carbonic anhydrase II
|
None
|
9.0
nM
|
|
|
Inhibitory activity against human recombinant carbonic anhydrase II
|
None
|
9.0
nM
|
|
|
Inhibitory activity against human recombinant carbonic anhydrase II (CA2)
|
None
|
9.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase II
|
None
|
9.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase II
|
None
|
9.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase II (hCA II) by using esterase assay method
|
None
|
9.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase II (CA2)
|
None
|
9.0
nM
|
|
|
Inhibition of human carbonic anhydrase II (hCA II)
|
None
|
9.0
nM
|
|
|
Ex vivo inhibition of carbonic anhydrase II in iris - ciliary body of an albino rabbit at a concentration of 0.02%
|
Oryctolagus cuniculus
|
87.0
%
|
|
|
Ex vivo inhibition of carbonic anhydrase II in iris - ciliary body of an albino rabbit at a concentration of 0.1%
|
Oryctolagus cuniculus
|
100.0
%
|
|
|
Ex vivo inhibition of carbonic anhydrase II in iris - ciliary body of an albino rabbit at a concentration of 0.5%
|
Oryctolagus cuniculus
|
100.0
%
|
|
|
Inhibitory activity against bovine carbonic anhydrase IV was determined
|
None
|
43.0
nM
|
|
|
Inhibition of bovine membrane bound isozyme carbonic anhydrase IV isolated from microsomes at 20 degree C
|
None
|
43.0
nM
|
|
|
In vitro inhibitory activity against bovine carbonic anhydrase IV (CAIV)
|
None
|
43.0
nM
|
|
|
Inhibitory activity against bovine carbonic anhydrase IV (CA4), obtained from bovine lung microsomes
|
None
|
43.0
nM
|
|
|
Inhibitory activity against bovine carbonic anhydrase IV
|
None
|
43.0
nM
|
|
|
Compound was evaluated for binding affinity against bovine Carbonic anhydrase IV
|
None
|
43.0
nM
|
|
|
Inhibition of bovine Carbonic anhydrase IV determined by esterase method
|
None
|
45.0
nM
|
|
|
Inhibition constant against bovine Carbonic anhydrase IV, isolated from lung microsomes
|
None
|
43.0
nM
|
|
|
Inhibitory activity against bovine carbonic anhydrase isozyme IV isolated from bovine lung microsomes, by esterase assay method.
|
None
|
43.0
nM
|
|
|
Inhibitory activity against bovine lung microsomes carbonic anhydrase isozyme IV (bCA IV).
|
None
|
45.0
nM
|
|
|
Inhibitory activity against bovine carbonic anhydrase IV from lung microsomes
|
None
|
43.0
nM
|
|
|
Inhibitory activity against bovine carbonic anhydrase IV (CA4), isolated from bovine lung microsomes
|
None
|
45.0
nM
|
|
|
Inhibitory activity against Carbonic anhydrase IV isolated from bovine lung
|
Bos taurus
|
43.0
nM
|
|
|
Inhibition of bovine carbonic anhydrase IV (CA4) from bovine lung microsomes
|
None
|
43.0
nM
|
|
|
Inhibition of bovine carbonic anhydrase IV from bovine lung microsomes
|
None
|
45.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase IX was determined
|
None
|
52.0
nM
|
|
|
Inhibitory activity against human tumor-associated transmembrane carbonic anhydrase IX.
|
None
|
52.0
nM
|
|
|
Inhibition constant determined against catalytic domain of human cloned carbonic anhydrase IX
|
None
|
52.0
nM
|
|
|
Inhibitory activity against human cloned carbonic anhydrase isozyme IX, by CO2 hydrase assay method.
|
None
|
52.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase IX
|
None
|
52.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase IX (hCA IX) by using CO2 hydrase assay method
|
None
|
52.0
nM
|
|
|
Inhibition of murine mitochondrial isozyme Carbonic anhydrase V at 20 degrees C
|
None
|
48.0
nM
|
|
|
Inhibitory activity against murine carbonic anhydrase XIII (mCA XIII) by using CO2 hydrase assay method
|
None
|
18.0
nM
|
|
|
Inhibition of cloned isozyme, human carbonic anhydrase II
|
None
|
9.0
nM
|
|
|
Inhibition of cloned isozyme, human carbonic anhydrase IV
|
None
|
43.0
nM
|
|
|
Inhibitory constant against human Carbonic anhydrase II
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibitory constant against human Carbonic anhydrase IX
|
Homo sapiens
|
52.0
nM
|
|
|
Ki value against human carbonic anhydrase II
|
Homo sapiens
|
9.0
nM
|
|
|
Ki value against human carbonic anhydrase VII
|
Homo sapiens
|
3.5
nM
|
|
|
Ki value against human carbonic anhydrase II (hCA II)
|
Homo sapiens
|
9.0
nM
|
|
|
Ki value against murine carbonic anhydrase XIII
|
Mus musculus
|
18.0
nM
|
|
|
Ki value against human carbonic anhydrase XII (hCA XII)
|
Homo sapiens
|
3.5
nM
|
|
|
Inhibitory activity against human Carbonic anhydrase II
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase II (hCAII)
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibitory activity against bovine carbonic anhydrase IV (bCAIV)
|
Bos taurus
|
43.0
nM
|
|
|
Inhibitory activity against cytosolic human carbonic anhydrase II
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibitory activity against Carbonic anhydrase II
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibitory activity against Carbonic anhydrase IX
|
Homo sapiens
|
52.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase II expressed in Escherichia coli BL21
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase IX expressed in Escherichia coli BL21
|
Homo sapiens
|
52.0
nM
|
|
|
Inhibitory activity against human carbonic anhydrase II
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibitory activity against membrane bound tumor associated human carbonic anhydrase IX
|
Homo sapiens
|
52.0
nM
|
|
|
Inhibitory constant against catalytic domain of human carbonic anhydrase IX
|
Homo sapiens
|
52.0
nM
|
|
|
Inhibitory constant against catalytic domain of human carbonic anhydrase XII
|
Homo sapiens
|
3.5
nM
|
|
|
Inhibitory activity against alpha carbonic anhydrase (Zn-Cam) from Methanosarcina thermophila
|
Methanosarcina thermophila
|
410.0
nM
|
|
|
Inhibitory potency against human cloned Carbonic anhydrase II expressed in Escherichia coli strain BL21
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibitory activity against catalytic domain of human carbonic anhydrase XII
|
Homo sapiens
|
3.5
nM
|
|
|
Inhibitory potency against catalytic domain of human Carbonic anhydrase IX expressed in Escherichia coli strain BL21
|
Homo sapiens
|
52.0
nM
|
|
|
Inhibitory constant against human carbonic anhydrase XIV in CO2 hydrase assay
|
Homo sapiens
|
27.0
nM
|
|
|
Inhibitory activity against human recombinant cytosolic CA2
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibitory activity against human recombinant mitochondrial isozyme CA VA
|
Homo sapiens
|
42.0
nM
|
|
|
Inhibitory activity against human recombinant mitochondrial isozyme CA VB
|
Homo sapiens
|
33.0
nM
|
|
|
Inhibitory activity against cloned human CA2
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibitory activity against CA4 isolated from bovine lung microsomes
|
Bos taurus
|
43.0
nM
|
|
|
Inhibitory activity against cloned human CA9
|
Homo sapiens
|
52.0
nM
|
|
|
Inhibitory activity against cloned human CA12
|
Homo sapiens
|
3.5
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydrase assay
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of human recombinant CA2
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of human cloned CA2 by stopped-flow CO2 hydration method
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of human cloned CA5A by stopped-flow CO2 hydration method
|
Homo sapiens
|
42.0
nM
|
|
|
Inhibition of human cloned CA5B by stopped-flow CO2 hydration method
|
Homo sapiens
|
33.0
nM
|
|
|
Inhibition of human cloned CA7 by stopped-flow CO2 hydration method
|
Homo sapiens
|
3.5
nM
|
|
|
Inhibition of catalytic domain of human cloned CA9 by stopped-flow CO2 hydration method
|
Homo sapiens
|
52.0
nM
|
|
|
Inhibition of catalytic domain of human cloned CA12 by stopped-flow CO2 hydration method
|
Homo sapiens
|
3.5
nM
|
|
|
Inhibition of murine CA13 by stopped-flow CO2 hydration method
|
Mus musculus
|
18.0
nM
|
|
|
Inhibition of human cloned CA14 by stopped-flow CO2 hydration method
|
Homo sapiens
|
27.0
nM
|
|
|
Inhibition of full length human recombinant CA VI
|
Homo sapiens
|
10.0
nM
|
|
|
Inhibition of human recombinant cytosolic isozyme CA II by stopped-flow CO2 hydrase method
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of catalytic domain of human recombinant CA IX
|
Homo sapiens
|
52.0
nM
|
|
|
Inhibition of human recombinant CA12 by CO2 hydration assay
|
Homo sapiens
|
3.5
nM
|
|
|
Inhibition of human recombinant CA14 by CO2 hydration assay
|
Homo sapiens
|
27.0
nM
|
|
|
Inhibition of human cloned CA1 by CO2 hydration method
|
Homo sapiens
|
500.0
nM
|
|
|
Inhibition of human cloned CA2 by CO2 hydration method
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of human cloned catalytic domain CA9 by CO2 hydration method
|
Homo sapiens
|
52.0
nM
|
|
|
Inhibition of human carbonic anhydrase 2
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of human carbonic anhydrase 5A
|
Homo sapiens
|
42.0
nM
|
|
|
Inhibition of human carbonic anhydrase 5B
|
Homo sapiens
|
33.0
nM
|
|
|
Inhibition of human carbonic anhydrase 6
|
Homo sapiens
|
10.0
nM
|
|
|
Inhibition of human carbonic anhydrase 7
|
Homo sapiens
|
3.5
nM
|
|
|
Inhibition of human carbonic anhydrase 9
|
Homo sapiens
|
52.0
nM
|
|
|
Inhibition of human carbonic anhydrase 12
|
Homo sapiens
|
3.5
nM
|
|
|
Inhibition of mouse carbonic anhydrase 13
|
Mus musculus
|
18.0
nM
|
|
|
Inhibition of human carbonic anhydrase 14
|
Homo sapiens
|
27.0
nM
|
|
|
Inhibition of human cloned CA1 by CO2 hydration method
|
Homo sapiens
|
500.0
nM
|
|
|
Inhibition of human cloned CA2 by CO2 hydration method
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of human CA9 catalytic domain by CO2 hydration method
|
Homo sapiens
|
52.0
nM
|
|
|
Inhibition of human full length carbonic anhydrase 2 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of human full length carbonic anhydrase 5A by stopped flow CO2 hydrase assay
|
Homo sapiens
|
42.0
nM
|
|
|
Inhibition of human full length carbonic anhydrase 5B by stopped flow CO2 hydrase assay
|
Homo sapiens
|
33.0
nM
|
|
|
Inhibition of human full length carbonic anhydrase 6 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
10.0
nM
|
|
|
Inhibition of human full length carbonic anhydrase 7 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
3.5
nM
|
|
|
Inhibition of human catalytic domain carbonic anhydrase 9 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
52.0
nM
|
|
|
Inhibition of human catalytic domain carbonic anhydrase 12 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
3.5
nM
|
|
|
Inhibition of mouse full length carbonic anhydrase 13 by stopped flow CO2 hydrase assay
|
Mus musculus
|
18.0
nM
|
|
|
Inhibition of human full length carbonic anhydrase 14 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
27.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assay
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase 1 encoded by Rv1284 by stopped flow CO2 hydration assay
|
Mycobacterium tuberculosis
|
744.0
nM
|
|
|
Inhibition of full length Mycobacterium tuberculosis H37Rv recombinant carbonic anhydrase 3 expressed in Escherichia coli BL21 by stopped flow CO2 hydration assay
|
Mycobacterium tuberculosis H37Rv
|
137.0
nM
|
|
|
Inhibition of human recombinant CA1 by stopped flow CO2 hydration assay
|
Homo sapiens
|
500.0
nM
|
|
|
Inhibition of human recombinant CA2 by stopped flow CO2 hydration assay
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of human recombinant CA9 by stopped flow CO2 hydration assay
|
Homo sapiens
|
52.0
nM
|
|
|
Inhibition of human recombinant CA12 by stopped flow CO2 hydration assay
|
Homo sapiens
|
3.5
nM
|
|
|
Inhibition of human recombinant CA2 by stopped-flow CO2 hydrase assay
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of Saccharomyces cerevisiae recombinant CA expressed in Escherichia coli by stopped-flow CO2 hydrase assay
|
Saccharomyces cerevisiae
|
110.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of human full length recombinant carbonic anhydrase 6 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
10.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 9 catalytic domain by stopped flow CO2 hydrase assay
|
Homo sapiens
|
52.0
nM
|
|
|
Inhibition of mouse recombinant carbonic anhydrase 15 by stopped flow CO2 hydrase assay
|
Mus musculus
|
61.0
nM
|
|
|
Inhibition of carbonic anhydrase 2
|
None
|
2.0
%
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration method
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of Mycobacterium tuberculosis H37Rv recombinant beta-carbonic anhydrase 1 expressed in Escherichia coli BL21 by stopped flow CO2 hydration method
|
Mycobacterium tuberculosis H37Rv
|
744.0
nM
|
|
|
Inhibition of Candida albicans recombinant Nce103 by stopped-flow CO2 hydration assay
|
Candida albicans
|
887.0
nM
|
|
|
Inhibition of Helicobacter pylori beta-carbonic anhydrase by stopped-flow CO2 hydration assay
|
Helicobacter pylori
|
9.0
nM
|
|
|
Inhibition of human recombinant CA2 by stopped-flow CO2 assay
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of cloned Stylophora pistillata alpha-CA expressed in human HEK293 cells by stopped-flow CO2 assay
|
Stylophora pistillata
|
18.1
nM
|
|
|
Inhibition of human recombinant CA2 by stopped-flow hydration assay
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of full length Mycobacterium tuberculosis H37Rv recombinant carbonic anhydrase 2 encoded by RV3588c by stopped flow CO2 hydration assay
|
Mycobacterium tuberculosis
|
99.0
nM
|
|
|
Inhibition of human full length cytosolic carbonic anhydrase 2 after 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of human full length mitochondrial carbonic anhydrase 5A after 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
42.0
nM
|
|
|
Inhibition of human full length mitochondrial carbonic anhydrase 5B after 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
33.0
nM
|
|
|
Inhibition of human full length carbonic anhydrase 6 after 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
10.0
nM
|
|
|
Inhibition of human full length cytosolic carbonic anhydrase 7 after 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
3.5
nM
|
|
|
Inhibition of human membrane-bound carbonic anhydrase 9 catalytic domain after 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
52.0
nM
|
|
|
Inhibition of human membrane-bound carbonic anhydrase 12 catalytic domain after 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
3.5
nM
|
|
|
Inhibition of mouse full length cytosolic carbonic anhydrase 13 after 15 mins by stopped-flow CO2 hydration assay
|
Mus musculus
|
18.0
nM
|
|
|
Inhibition of human full length membrane-bound carbonic anhydrase 14 after 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
27.0
nM
|
|
|
Inhibition of human carbonic anhydrase 2 by CO2 hydrase stopped flow assay
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of human carbonic anhydrase 4 by CO2 hydrase stopped flow assay
|
Homo sapiens
|
43.0
nM
|
|
|
Inhibition of human cloned full length carbonic anhydrase 2 by stopped flow CO2 hydration assay
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase Rv1284 by stopped flow CO2 hydration assay
|
Mycobacterium tuberculosis
|
744.0
nM
|
|
|
Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase Rv3273 by stopped flow CO2 hydration assay
|
Mycobacterium tuberculosis
|
137.0
nM
|
|
|
Inhibition of human recombinant CA9 catalytic domain expressed in Sf9 cells by stopped flow CO2 hydration assay
|
Homo sapiens
|
52.0
nM
|
|
|
Inhibition of human recombinant CA12 catalytic domain expressed in Sf9 cells by stopped flow CO2 hydration assay
|
Homo sapiens
|
3.5
nM
|
|
|
Inhibition of carbonic anhydrase 2
|
None
|
2.0
nM
|
|
|
Inhibition of carbonic anhydrase 4
|
None
|
43.0
nM
|
|
|
Inhibition of carbonic anhydrase in Dutch belted rabbit iris ciliary body homogenate at 0.1 uM by titration assay
|
Oryctolagus cuniculus
|
68.0
%
|
|
|
Inhibition of carbonic anhydrase in Dutch belted rabbit iris ciliary body homogenate at 10 uM by titration assay
|
Oryctolagus cuniculus
|
86.0
%
|
|
|
Inhibition of human recombinant CA2 by stopped-flow CO2 hydration assay
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of human recombinant CA6 by stopped-flow CO2 hydration assay
|
Homo sapiens
|
10.0
nM
|
|
|
Inhibition of Stylophora pistillata carbonic anhydrase by stopped-flow CO2 hydration assay
|
Stylophora pistillata
|
18.1
nM
|
|
|
Inhibition of Stylophora pistillata carbonic anhydrase 2 by stopped-flow CO2 hydration assay
|
Stylophora pistillata
|
113.0
nM
|
|
|
Inhibition of human carbonic anhydrase II by spectrophotometry at pH 7.5
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of Brucella suis carbonic anhydrase II by spectrophotometry at pH 8.3
|
Brucella suis
|
923.0
nM
|
|
|
Inhibition of Brucella suis carbonic anhydrase I by spectrophotometry at pH 8.3
|
Brucella suis
|
21.0
nM
|
|
|
Inhibition of human carbonic anhydrase 2 after 15 mins by CO2 hydrase assay at pH 7.5
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of Leptonychotes weddellii alpha-carbonic anhydrase after 15 mins by CO2 hydrase assay at pH 7.5
|
Leptonychotes weddellii
|
5.7
nM
|
|
|
Inhibition of human CA2 by CO2 hydration assay
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of human recombinant CA9 catalytic domain by CO2 hydration assay
|
Homo sapiens
|
52.0
nM
|
|
|
Inhibition of human recombinant CA12 catalytic domain by CO2 hydration assay
|
Homo sapiens
|
3.5
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 at pH 7.5 by stopped flow CO2 hydration assay
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of Salmonella Typhimurium recombinant carbonic anhydrase 1 at pH 8.3 by stopped flow CO2 hydration assay
|
Salmonella enterica subsp. enterica serovar Typhimurium
|
445.0
nM
|
|
|
Inhibition of Salmonella Typhimurium recombinant carbonic anhydrase 2 at pH 8.3 by stopped flow CO2 hydration assay
|
Salmonella enterica subsp. enterica serovar Typhimurium
|
607.0
nM
|
|
|
Inhibition of GST-tagged astrosclera willeyana Astrosclerin-3 expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay
|
Astrosclera willeyana
|
280.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of human carbonic anhydrase 2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of Candida albicans CaNce103 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method
|
Candida albicans
|
887.0
nM
|
|
|
Inhibition of recombinant Vibrio cholerae carbonic anhydrase expressed in Escherichia coli (DE3) preincubated for 15 mins by stopped-flow CO2 hydrase assay
|
Vibrio cholerae
|
6.3
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assay
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of Trypanosoma cruzi CL Brener recombinant alpha-carbonic anhydrase expressed in insect Sf9 cell Baculovirus system by stopped flow CO2 hydration assay
|
Trypanosoma cruzi
|
92.9
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 by dansylamide (DNSA) competition assay
|
Homo sapiens
|
0.1995
nM
|
|
|
Inhibition of Sulfurihydrogenibium yellowstonense YO3AOP1 recombinant carbonic anhydrase preincubated for 15 mins by CO2 hydration stopped-flow assay
|
Sulfurihydrogenibium yellowstonense
|
8.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of human cytosolic carbonic anhydrase 7 preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
3.5
nM
|
|
|
Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of human membrane bound carbonic anhydrase 12 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay
|
Homo sapiens
|
3.5
nM
|
|
|
Inhibition of human membrane bound carbonic anhydrase 9 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay
|
Homo sapiens
|
52.0
nM
|
|
|
Inhibition of human cytosolic carbonic anhydrase 7 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay
|
Homo sapiens
|
3.5
nM
|
|
|
Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins at room temperature followed by 72 hrs at 4 degC by stopped flow CO2 hydration assay
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of human carbonic anhydrase14 preincubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
27.0
nM
|
|
|
Inhibition of human carbonic anhydrase13 preincubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
18.0
nM
|
|
|
Inhibition of human carbonic anhydrase12 preincubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
3.5
nM
|
|
|
Inhibition of human carbonic anhydrase9 preincubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
52.0
nM
|
|
|
Inhibition of human carbonic anhydrase7 preincubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
3.5
nM
|
|
|
Inhibition of human carbonic anhydrase6 preincubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
10.4
nM
|
|
|
Inhibition of human carbonic anhydrase2 preincubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
9.1
nM
|
|
|
Inhibition of recombinant Leishmania donovani chagasi beta-carbonic anhydrase expressed in baculovirus infected insect Sf9 cells incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay
|
Leishmania donovani chagasi
|
806.0
nM
|
|
|
Inhibition of Thalassiosira weissflogii delta carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay
|
Thalassiosira weissflogii
|
49.6
nM
|
|
|
Inhibition of Porphyromonas gingivalis recombinant gamma-carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay
|
Porphyromonas gingivalis
|
685.0
nM
|
|
|
Inhibition of Leishmania donovani chagasi recombinant beta-carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay
|
Leishmania chagasi
|
806.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of recombinant Methanosarcina thermophila gamma-CA CAM by stopped flow CO2 hydration assay
|
Leishmania donovani chagasi
|
410.0
nM
|
|
|
Inhibition of Porphyromonas gingivalis gamma-carbonic anhydrase expressed in Escherichia coli preincubated for 15 mins by stopped flow CO2 hydration assay
|
Porphyromonas gingivalis
|
685.0
nM
|
|
|
Inhibition of human transmembrane carbonic anhydrase 12 by stopped-flow CO2 hydration assay
|
Homo sapiens
|
3.5
nM
|
|
|
Inhibition of human transmembrane carbonic anhydrase 9 by stopped-flow CO2 hydration assay
|
Homo sapiens
|
52.0
nM
|
|
|
Inhibition of human cytosolic carbonic anhydrase 2 by stopped-flow CO2 hydration assay
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of human carbonic anhydrase-2 by stopped-flow CO2 hydration assay
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of Legionella pneumophilia subsp. Pneumophila strain Philadelphia-1 carbonic anhydrase-2 assessed as CO2 hydrase activity by stopped-flow assay
|
Legionella pneumophila subsp. pneumophila str. Philadelphia 1
|
336.0
nM
|
|
|
Inhibition of Helicobacter pylori carbonic anhydrase by stopped-flow CO2 hydration assay
|
Helicobacter pylori
|
73.0
nM
|
|
|
Inhibition of human recombinant Carbonic anhydrase 2 compound preincubated for 15 mins by stopped flow CO2 hydrase assay method
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of Helicobacter pylori Beta-carbonic anhydrase compound preincubated for 15 mins by stopped flow CO2 hydrase assay method
|
Helicobacter pylori
|
73.0
nM
|
|
|
Inhibition of Porphyromonas gingivalis Gamma-carbonic anhydrase compound preincubated for 15 mins by stopped flow CO2 hydrase assay method
|
Porphyromonas gingivalis
|
685.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydration assay
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of Plasmodium falciparum Eta-carbonic anhydrase pre-incubated for 15 mins before CO2 substrate addition by stopped-flow CO2 hydration assay
|
Plasmodium falciparum
|
963.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of recombinant Methanosarcina thermophila gamma-carbonic anhydrase by stopped flow CO2 hydrase assay
|
Methanosarcina thermophila
|
410.0
nM
|
|
|
Inhibition of recombinant Porphyromonas gingivalis gamma-carbonic anhydrase by stopped flow CO2 hydrase assay
|
Porphyromonas gingivalis
|
685.0
nM
|
|
|
Inhibition of recombinant Nostoc commune gamma-carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydrase assay
|
Nostoc commune
|
67.4
nM
|
|
|
Inhibition of human carbonic anhydrase 2 pre-incubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of Anopheles gambiae carbonic anhydrase pre-incubated for 15 mins by stopped-flow CO2 hydration assay
|
Anopheles gambiae
|
275.0
nM
|
|
|
Binding affinity to human carbonic anhydrase 2 incubated for 1 hr using labeled BODIPY558/568-acetazolamide as tracer by fluorescence polarization tight binding assay
|
Homo sapiens
|
0.043
nM
|
|
|
Inhibition of human carbonic anhydrase 2 assessed as reduction in enzyme activity incubated for 30 mins by fluorescence polarization assay
|
Homo sapiens
|
43.0
nM
|
|
|
Inhibition of recombinant human transmembrane, tumor-associated form of carbonic anhydrase-12 preincubated for 15 mins by stopped flow CO2 hydration assay
|
Homo sapiens
|
3.0
nM
|
|
|
Inhibition of esterase activity of carbonic anhydrase 2 in human erythrocytes using PNF as substrate by spectrophotometer analysis
|
Homo sapiens
|
25.0
nM
|
|
|
Inhibition of Nostoc commune gamma carbonic anhydrase by CO2 hydration assay
|
Nostoc commune
|
67.4
nM
|
|
|
Inhibition of Pseudoalteromonas haloplanktis gamma carbonic anhydrase by CO2 hydration assay
|
Pseudoalteromonas haloplanktis
|
831.0
nM
|
|
|
Inhibition of Methanosarcina thermophila recombinant gamma carbonic anhydrase by stopped flow CO2 hydrase assay method
|
Methanosarcina thermophila
|
410.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase-2 by stopped flow CO2 hydrase assay method
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase-2 expressed in Escherichia coli incubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase-9 expressed in Escherichia coli incubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
52.0
nM
|
|
|
Inhibition of human recombinant carbonic anhydrase-12 expressed in Escherichia coli incubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
3.5
nM
|
|
|
Inhibition of human CA2 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of weddell seal alphaCA incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay
|
Leptonychotes weddellii
|
5.7
nM
|
|
|
Inhibition of Chionodraco hamatus alphaCA incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay
|
Chionodraco hamatus
|
39.1
nM
|
|
|
Inhibition of recombinant human carbonic anhydrase-2 by stopped flow CO2 hydrase assay
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of recombinant Sulfurihydrogenibium yellowstonense YO3AOP1 carbonic anhydrase by stopped flow CO2 hydrase assay
|
Sulfurihydrogenibium yellowstonense
|
8.0
nM
|
|
|
Inhibition of recombinant Thiomicrospira crunogena XCL-2 carbonic anhydrase by stopped flow CO2 hydrase assay
|
Thiomicrospira crunogena XCL-2
|
7.0
nM
|
|
|
Inhibition of Vibrio cholerae alpha-carbonic anhydrase using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay
|
Vibrio cholerae
|
6.3
nM
|
|
|
Inhibition of human Carbonic anhydrase2 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydrase stopped flow assay
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of Porphyromonas gingivalis gamma carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay
|
Porphyromonas gingivalis
|
685.0
nM
|
|
|
Inhibition of Nostoc commune gamma carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay
|
Nostoc commune
|
67.4
nM
|
|
|
Inhibition of Pseudoalteromonas haloplanktis gamma carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay
|
Pseudoalteromonas haloplanktis
|
831.0
nM
|
|
|
Inhibition of recombinant Colwellia psychrerythraea gamma carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay
|
Colwellia psychrerythraea
|
868.0
nM
|
|
|
Inhibition of human carbonic anhydrase 2 incubated for 15 mins by stopped-flow CO2 hydration assay
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of recombinant Enterobacter sp. B13 beta carbonic anhydrase incubated for 15 mins by stopped-flow CO2 hydration assay
|
Enterobacter sp.
|
103.0
nM
|
|
|
Inhibition of recombinant Vibrio cholerae gamma-carbonic anhydrase preincubated for 15 mins by stopped-flow CO2 hydration assay
|
Vibrio cholerae
|
87.3
nM
|
|
|
Inhibition of human carbonic anhydrase 2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of Vibrio cholerae Gamma-carbonic anhydrase assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis
|
Vibrio cholerae
|
87.3
nM
|
|
|
Inhibition of human carbonic anhydrase-2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay
|
Homo sapiens
|
52.0
nM
|
|
|
Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay
|
Homo sapiens
|
3.5
nM
|
|
|
Inhibition of full length human CA 2
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of human CA 9 catalytic domain
|
Homo sapiens
|
52.0
nM
|
|
|
Inhibition of human CA 12 catalytic domain
|
Homo sapiens
|
3.5
nM
|
|
|
Inhibition of recombinant human carbonic anhydrase 2 incubated for 6 hrs prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay
|
Homo sapiens
|
9.0
nM
|
|
|
Inhibition of recombinant human carbonic anhydrase 7 incubated for 6 hrs prior to testing measured for 10 to 100 secs by phenol red-based stopped-flow CO2 hydration assay
|
Homo sapiens
|
3.5
nM
|
|
|
Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stop flow CO2 hydrase assay
|
Homo sapiens
|
9.0
nM
|
|
|
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate
|
Severe acute respiratory syndrome coronavirus 2
|
19.06
%
|
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
-0.13
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
-0.13
%
|
|
|
Antagonist activity at recombinant human AR expressed in HEK293 cells assessed as inhibition of R1881-induced transcriptional activity measured after 24 hrs by dual luciferase reporter gene assay
|
Homo sapiens
|
65.0
nM
|
|
|
Displacement of [3H]-MIB from wild-type rat AR LBD measured after 16 hrs by scintillation counting method
|
Rattus norvegicus
|
11.0
nM
|
|
