DORZOLAMIDE


Synonyms	Dorzant Dorzolamide Dorzolamide, trans-(-)- MK-507 Trusopt
Status
Molecule Category	Free-form
ATC	S01EC03
UNII	9JDX055TW1
EPA CompTox	DTXSID7022960


InChI Key	IAVUPMFITXYVAF-XPUUQOCRSA-N
Smiles	CCN[C@H]1C[C@H](C)S(=O)(=O)c2sc(S(N)(=O)=O)cc21
InChI	InChI=1S/C10H16N2O4S3/c1-3-12-8-4-6(2)18(13,14)10-7(8)5-9(17-10)19(11,15)16/h5-6,8,12H,3-4H2,1-2H3,(H2,11,15,16)/t6-,8-/m0/s1

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Lyase	-	0.18-52	0.043	0.1995-887	2-100
Enzyme	-	0.18-52	0.043	0.1995-887	2-100
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 3 Nuclear hormone receptor subfamily 3 group C Nuclear hormone receptor subfamily 3 group C member 4	-	65	-	11	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Anopheles gambiae	-	-	-	275	-
Astrosclera willeyana	-	-	-	280	-
Bos taurus	-	-	-	43-43	-
Brucella suis	-	-	-	21-923	-
Candida albicans	-	-	-	887-887	-
Chionodraco hamatus	-	-	-	39.1	-
Colwellia psychrerythraea	-	-	-	868	-
Enterobacter sp.	-	-	-	103	-
Helicobacter pylori	-	-	-	9-73	-
Homo sapiens	-	43-65	0.043	0.1995-500	-
Legionella pneumophila subsp. pneumophila str. Philadelphia 1	-	-	-	336	-
Leishmania chagasi	-	-	-	806	-
Leishmania donovani chagasi	-	-	-	410-806	-
Leptonychotes weddellii	-	-	-	5.7-5.7	-
Methanosarcina thermophila	-	-	-	410-410	-
Mus musculus	-	-	-	18-61	-
Mycobacterium tuberculosis	-	-	-	99-744	-
Mycobacterium tuberculosis H37Rv	-	-	-	137-744	-
Nostoc commune	-	-	-	67.4-67.4	-
Oryctolagus cuniculus	-	-	-	-	68-100
Plasmodium falciparum	-	-	-	963	-
Porphyromonas gingivalis	-	-	-	685-685	-
Pseudoalteromonas haloplanktis	-	-	-	831-831	-
Rattus norvegicus	-	-	-	11	-
Saccharomyces cerevisiae	-	-	-	110	-
Salmonella enterica subsp. enterica serovar Typhimurium	-	-	-	445-607	-
Stylophora pistillata	-	-	-	18.1-113	-
Sulfurihydrogenibium yellowstonense	-	-	-	8-8	-
Thalassiosira weissflogii	-	-	-	49.6	-
Thiomicrospira crunogena XCL-2	-	-	-	7	-
Trypanosoma cruzi	-	-	-	92.9	-
Vibrio cholerae	-	-	-	6.3-87.3	-

CONTENTS