MIRTAZAPINE


Trade Names	MIRTAZAPINE REMERON REMERON SOLTAB
Synonyms	6-azamianserin Avanza Mirataz Mirtazapin Mirtazapine Mirtazapine anhydrous Norset ORG 3770 ORG-3770 Promyrtil Remeron Remeron soltab Rexer Zispin
Status
Molecule Category	Free-form
ATC	N06AX11
UNII	A051Q2099Q
EPA CompTox	DTXSID0023325

Structure


InChI Key	RONZAEMNMFQXRA-UHFFFAOYSA-N
Smiles	CN1CCN2c3ncccc3Cc3ccccc3C2C1
InChI	InChI=1S/C17H19N3/c1-19-9-10-20-16(12-19)15-7-3-2-5-13(15)11-14-6-4-8-18-17(14)20/h2-8,16H,9-12H2,1H3

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C17H19N3
Molecular Weight	265.36
AlogP	2.48
Hydrogen Bond Acceptor	3.0
Polar Surface Area	19.37
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	20.0

Pharmacology

Mechanism of Action	Action	Reference
Adrenergic receptor alpha-2 antagonist	ANTAGONIST	DailyMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Adrenergic receptor	-	85.11-223.87	-	18-608	-
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Histamine receptor	-	-	-	1.6	-
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Serotonin receptor	-	-	-	2-265	-
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC06 neurotransmitter transporter family	-	260	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cavia porcellus	-	-	-	5.1	-
Homo sapiens	-	-	-	1.6-265	-
Rattus norvegicus	-	-	-	608	-

Target Conservation


Protein: Adrenergic receptor alpha-2 Description: Alpha-2A adrenergic receptor Organism : Homo sapiens P08913 ENSG00000150594










Protein: Adrenergic receptor alpha-2 Description: Alpha-2B adrenergic receptor Organism : Homo sapiens P18089 ENSG00000274286











Protein: Adrenergic receptor alpha-2 Description: Alpha-2C adrenergic receptor Organism : Homo sapiens P18825 ENSG00000184160









Protein: Serotonin 2a (5-HT2a) receptor Description: 5-hydroxytryptamine receptor 2A Organism : Homo sapiens P28223 ENSG00000102468













Protein: Serotonin 2c (5-HT2c) receptor Description: 5-hydroxytryptamine receptor 2C Organism : Homo sapiens P28335 ENSG00000147246

Related Entries

Environmental Exposure

Environmental Exposure Map

Countries
Croatia
Czech Republic
Germany
Hungary
Romania
Serbia
Slovakia
Slovenia

Cross References

Resources	Reference
ChEBI	6950
ChEMBL	CHEMBL654
DrugBank	DB00370
DrugCentral	1816
FDA SRS	A051Q2099Q
Human Metabolome Database	HMDB0014514
Guide to Pharmacology	7241
KEGG	C07570
PharmGKB	PA450522
PubChem	4205
SureChEMBL	SCHEMBL35408
ZINC	ZINC19702119

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025