EcoDrugPlus


Trade Names	LANSOPRAZOLE PREVACID PREVACID 24 HR PREVACID IV
Synonyms	A-65006 AG-1749 Agopton Lansoprazole Lansox Lanzoprazole Lanzor Limpidex NSC-758638 Ogast Ogastoro Opiren Prevacid Prevacid 24 hr Prevacid Delayed Release
Status
Molecule Category	Free-form
ATC	A02BC03
UNII	0K5C5T2QPG
EPA CompTox	DTXSID4023200

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SubStructure

Threshold (%) >= 70


InChI Key	MJIHNNLFOKEZEW-UHFFFAOYSA-N
Smiles	Cc1c(OCC(F)(F)F)ccnc1C[S+]([O-])c1nc2ccccc2[nH]1
InChI	InChI=1S/C16H14F3N3O2S/c1-10-13(20-7-6-14(10)24-9-16(17,18)19)8-25(23)15-21-11-4-2-3-5-12(11)22-15/h2-7H,8-9H2,1H3,(H,21,22)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C16H14F3N3O2S
Molecular Weight	369.37
AlogP	3.52
Hydrogen Bond Acceptor	4.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	5.0
Polar Surface Area	67.87
Molecular species	NEUTRAL
Aromatic Rings	3.0
Heavy Atoms	25.0

Mechanism of Action	Action	Reference
Potassium-transporting ATPase inhibitor	INHIBITOR	PubMed PubMed DailyMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Cytochrome P450 Cytochrome P450 family 2 Cytochrome P450 family 2C Cytochrome P450 2C19	-	-	-	-	86
Enzyme Hydrolase	-	398.11	-	-	-
Enzyme	-	398.11	-	-	38
Other cytosolic protein	-	-	-	2.5	-
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	-75.7-100.47
Transporter Primary active transporter P-type ATPase Hydrogen potassium ATPase	-	398.11	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cricetulus griseus	-	-	-	-	95.47-100.47
Entamoeba histolytica	-	346.6	-	-	-
Giardia intestinalis	-	73.1	-	-	-
Homo sapiens	-	-	-	2.5	-75.7-86
Mus musculus	-	-	-	-	57-65
Oryctolagus cuniculus	-	398.11	-	-	-
Trichomonas vaginalis	-	121.8-121.8	-	-	-

Target Conservation


Protein: Potassium-transporting ATPase Description: Potassium-transporting ATPase alpha chain 1 Organism : Homo sapiens P20648 ENSG00000105675











Protein: Potassium-transporting ATPase Description: Potassium-transporting ATPase subunit beta Organism : Homo sapiens P51164 ENSG00000186009

Cross References

Resources	Reference
ChEBI	6375
ChEMBL	CHEMBL480
DrugBank	DB00448
DrugCentral	1547
FDA SRS	0K5C5T2QPG
Human Metabolome Database	HMDB0005008
Guide to Pharmacology	7208
KEGG	D00355
PharmGKB	PA450180
PubChem	3883
SureChEMBL	SCHEMBL22365
ZINC	ZINC03830986

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

LANSOPRAZOLE

Structure

Physicochemical Descriptors

Pharmacology

Target Conservation

Related Entries

Cross References