MIDODRINE HYDROCHLORIDE

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Search structure


Trade Names	MIDODRINE HYDROCHLORIDE ORVATEN PROAMATINE
Synonyms	A-4020 LINZ Amatine Bramox Gutron Hipertan Metligine Midodrine hcl Midodrine hydrochloride Midodrine monohydrochloride Midon NSC-758429 Orvaten Proamatine ST 1085 HYDROCHLORIDE ST 1085 [AS THE BASE]
Status
Molecule Category	Salt-form
UNII	59JV96YTXV
EPA CompTox	DTXSID1047493
Parent Compound:	MIDODRINE

Structure


InChI Key	MGCQZNBCJBRZDT-UHFFFAOYSA-N
Smiles	COc1ccc(OC)c(C(O)CNC(=O)CN)c1.Cl
InChI	InChI=1S/C12H18N2O4.ClH/c1-17-8-3-4-11(18-2)9(5-8)10(15)7-14-12(16)6-13;/h3-5,10,15H,6-7,13H2,1-2H3,(H,14,16);1H

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C12H19ClN2O4
Molecular Weight	290.75
AlogP	-0.19
Hydrogen Bond Acceptor	5.0
Hydrogen Bond Donor	3.0
Number of Rotational Bond	6.0
Polar Surface Area	93.81
Molecular species	NEUTRAL
Aromatic Rings	1.0
Heavy Atoms	18.0

Pharmacology

Mechanism of Action	Action	Reference
Adrenergic receptor alpha-1 agonist	AGONIST	DailyMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	88.99-101.74

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cricetulus griseus	-	-	-	-	88.99-101.74

Target Conservation


Protein: Adrenergic receptor alpha-1 Description: Alpha-1D adrenergic receptor Organism : Homo sapiens P25100 ENSG00000171873











Protein: Adrenergic receptor alpha-1 Description: Alpha-1A adrenergic receptor Organism : Homo sapiens P35348 ENSG00000120907











Protein: Adrenergic receptor alpha-1 Description: Alpha-1B adrenergic receptor Organism : Homo sapiens P35368 ENSG00000170214

Cross References

Resources	Reference
ChEBI	31847
ChEMBL	CHEMBL1200461
FDA SRS	59JV96YTXV
PubChem	18340
SureChEMBL	SCHEMBL41463

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025