ALENDRONATE SODIUM

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Search structure


Trade Names	ALENDRONATE SODIUM BINOSTO FOSAMAX
Synonyms	Adrovance Alendronate (as sodium) Alendronate sodium Alendronate sodium hydrate Alendronate sodium trihydrate Alendronic acid monosodium salt trihydrate Binosto Fosamax Fosavance G-704,650 G-704650 MK-217 NSC-722597 NSC-758931 Sodium alendronate
Status
Molecule Category	Salt-form
UNII	2UY4M2U3RA
EPA CompTox	DTXSID7047801
Parent Compound:

Structure


InChI Key	CAKRAHQRJGUPIG-UHFFFAOYSA-M
Smiles	NCCCC(O)(P(=O)([O-])O)P(=O)(O)O.[Na+]
InChI	InChI=1S/C4H13NO7P2.Na/c5-3-1-2-4(6,13(7,8)9)14(10,11)12;/h6H,1-3,5H2,(H2,7,8,9)(H2,10,11,12);/q;+1/p-1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C4H12NNaO7P2
Molecular Weight	271.08
AlogP	-1.27
Hydrogen Bond Acceptor	4.0
Hydrogen Bond Donor	6.0
Number of Rotational Bond	5.0
Polar Surface Area	161.31
Molecular species	ZWITTERION
Aromatic Rings	0.0
Heavy Atoms	14.0

Pharmacology

Mechanism of Action	Action	Reference
Farnesyl diphosphate synthase inhibitor	INHIBITOR	ISBN PubMed PubMed PubMed PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Transferase	-	460	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	750-900	460	-	-	-
Mus musculus	-	84	-	-	93.2

Target Conservation


Protein: Farnesyl diphosphate synthase Description: Farnesyl pyrophosphate synthase Organism : Homo sapiens P14324 ENSG00000160752

Cross References

Resources	Reference
CAS NUMBER	121268-17-5
ChEMBL	CHEMBL675
FDA SRS	2UY4M2U3RA
PubChem	60736
SureChEMBL	SCHEMBL328770

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, Volume 54, Issue D1, 6 January 2026, Pages D1397–D1404, https://doi.org/10.1093/nar/gkaf1251

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Last update: Monday, 23^rd March 2026