DEXTROAMPHETAMINE SACCHARATE

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Search structure


Synonyms	D-amphetamine saccharate Dexamfetamine hemisaccharate Dexamfetamine saccharate Dexamfetaphine saccharate Dextroamphetamine saccharate
Status
Molecule Category	Mixture
UNII	283TUU52FG
EPA CompTox	DTXSID20184134


Active Pharmaceutical Ingredients Bioactive chemicals	Exact Similarity SubStructure	Threshold (%) >= 70

Structure


InChI Key	VHKVKWTWHZUFIA-DGOKBZBKSA-N
Smiles	C[C@H](N)Cc1ccccc1.O=C(O)[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C(=O)O
InChI	InChI=1S/C9H13N.C6H10O8/c1-8(10)7-9-5-3-2-4-6-9;7-1(3(9)5(11)12)2(8)4(10)6(13)14/h2-6,8H,7,10H2,1H3;1-4,7-10H,(H,11,12)(H,13,14)/t8-;1-,2-,3-,4+/m00/s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C15H23NO8
Molecular Weight	345.35
AlogP	1.58
Hydrogen Bond Acceptor	1.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	2.0
Polar Surface Area	26.02
Molecular species	BASE
Aromatic Rings	1.0
Heavy Atoms	10.0

Bioactivity

Mechanism of Action	Action	Reference
Dopamine transporter releasing agent	RELEASING AGENT	PubMed PubMed PubMed


Protein: Norepinephrine transporter Description: Sodium-dependent noradrenaline transporter Organism : Homo sapiens P23975 ENSG00000103546











Protein: Dopamine transporter Description: Sodium-dependent dopamine transporter Organism : Homo sapiens Q01959 ENSG00000142319









Protein: Synaptic vesicular amine transporter Description: Synaptic vesicular amine transporter Organism : Homo sapiens Q05940 ENSG00000165646

Cross References

Resources	Reference
ChEMBL	CHEMBL3989844
FDA SRS	283TUU52FG
PubChem	73415781
SureChEMBL	SCHEMBL578987

CONTENTS

PREMIER has received funding from the Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information this manuscript contains.

Elements of the website have been developed under projects PREMIER and the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT is thanked for providing computational resources. Content of the website is provided without guarantee for correctness. Data has been collected and integrated from multiple public sources, for the largest: FDA, HUGO Gene Nomenclature Committee, ChEMBL, IUPHAR/BPS guide to pharmacology, Reactome, UniProt, and Ensembl. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).