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MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: GABA-A receptor; anion channel positive allosteric modulator
ROUTE OF ADMINISTRATION: INHALATION
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Sulfonylurea receptor 1, Kir6.2 blocker
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Diabetes Mellitus; Diabetes Mellitus, Type 2
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Thiazide-sensitive sodium-chloride cotransporter inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Atherosclerosis; Coronary Disease; Diabetes Mellitus, Type 2; Heart Diseases; Hypercholesterolemia; Cardiovascular Diseases; Edema; Glomerulonephritis; Heart Failure; Hypertension; Kidney Failure, Chronic; Nephrotic Syndrome; Toxemia
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Carbonic anhydrase I inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Hypokalemic Periodic Paralysis; Myotonic Disorders; Paralysis, Hyperkalemic Periodic; Glaucoma
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Bacterial penicillin-binding protein inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Pneumonia; Arthritis; Bacteremia; Bacterial Infections; Endocarditis, Bacterial; Infections; Meningitis; Scarlet Fever
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Carbonic anhydrase I inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Altitude Sickness; Uterine Cervical Neoplasms; Glaucoma; Glaucoma, Open-Angle
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Dysthymic Disorder; Somatoform Disorders; Anxiety; Chest Pain; Death, Sudden, Cardiac; Dementia; Digestive System Diseases; Gastroesophageal Reflux; Low Back Pain; Myocardial Infarction; Schizophrenia; Ventricular Fibrillation; Depressive Disorder
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Diagnostic agent
ROUTE OF ADMINISTRATION: INJECTION; INTERSTITIAL; INTRAVENOUS
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Arthritis, Rheumatoid; Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Head and Neck Neoplasms; Lung Neoplasms; Lymphedema; Melanoma; Breast Neoplasms; Periodontitis; Colorectal Neoplasms; Endometrial Neoplasms; Hirschsprung Disease; Periodontal Diseases; Retinal Perforations; Stomach Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Psychotic Disorders
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Macular Edema; Scleritis; Cataract; Dry Eye Syndromes; Otitis Externa; Uveitis, Anterior
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: DNA inhibitor
ROUTE OF ADMINISTRATION: INJECTION; INTRAVENOUS
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Anemia; Chordoma; Crohn Disease; Fallopian Tube Neoplasms; Kidney Neoplasms; Liver Neoplasms; Neoplasms, Germ Cell and Embryonal; Ovarian Neoplasms; Peritoneal Neoplasms; Severe Combined Immunodeficiency; Wiskott-Aldrich Syndrome; Anemia, Sickle Cell; Breast Neoplasms, Male; Ganglioneuroblastoma; Glioma; Hematologic Diseases; Hematologic Neoplasms; Inflammatory Breast Neoplasms; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Multiple Myeloma; Myelodysplastic Syndromes; Myeloproliferative Disorders; Osteosarcoma; Primary Myelofibrosis; Sarcoma; Brain Neoplasms; Breast Neoplasms; Central Nervous System Neoplasms; Graft vs Host Disease; Leukemia; Medulloblastoma; Neuroblastoma; Neuroectodermal Tumors, Primitive; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Retinoblastoma; Adenocarcinoma; Carcinoma; Hodgkin Disease; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Thiazide-sensitive sodium-chloride cotransporter inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Cardiovascular Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Monoamine oxidase inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: DIABETES DRUGS & ENDOCRINOLOGY
THERAPEUTIC INDICATION: Depression; Depressive Disorder; Depressive Disorder, Major
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Solute carrier family 22 member 12 inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Gout
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Thiazide-sensitive sodium-chloride cotransporter inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Cardiovascular Diseases; Hypertension
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: DNA inhibitor
ROUTE OF ADMINISTRATION: INJECTION; ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Anemia; Biliary Tract Neoplasms; Breast Carcinoma In Situ; Carcinoma, Medullary; Carcinoma, Pancreatic Ductal; Chordoma; Colonic Neoplasms; Desmoplastic Small Round Cell Tumor; Diffuse Intrinsic Pontine Glioma; Fibroma; Fibrosarcoma; Glioblastoma; Glomerulosclerosis, Focal Segmental; HIV Infections; Head and Neck Neoplasms; Hepatoblastoma; Histiocytoma; Leukemia, Plasma Cell; Liposarcoma; Liposarcoma, Myxoid; Lymphoma, B-Cell; Muscular Diseases; Myasthenia Gravis; Mycosis Fungoides; Myoepithelioma; Nasopharyngeal Neoplasms; Nausea; Neoplasm Metastasis; Osteogenesis Imperfecta; Renal Insufficiency; Sarcoma, Clear Cell; Sarcoma, Synovial; Sezary Syndrome; Stiff-Person Syndrome; Thymoma; Urinary Bladder Neoplasms; Acquired Immunodeficiency Syndrome; Adrenoleukodystrophy; Anemia, Sickle Cell; Arthritis, Rheumatoid; Blast Crisis; Breast Neoplasms, Male; Carcinoma, Merkel Cell; Castleman Disease; Colorectal Neoplasms; Crohn Disease; Endometrial Neoplasms; Epidermolysis Bullosa; Esophageal Neoplasms; Fanconi Anemia; Fucosidosis; Gangliosidosis, GM1; Gaucher Disease; Glioma; Gliosarcoma; Granulomatous Disease, Chronic; Hematologic Diseases; Hematologic Neoplasms; Hereditary Breast and Ovarian Cancer Syndrome; Histiocytosis, Langerhans-Cell; IgA Vasculitis; Immune System Diseases; Immunoglobulin Light-chain Amyloidosis; Immunologic Deficiency Syndromes; Leukemia, Lymphoid; Leukemia, Myelomonocytic, Juvenile; Leukemia, Prolymphocytic; Leukodystrophy, Globoid Cell; Leukodystrophy, Metachromatic; Liver Neoplasms; Lupus Erythematosus, Systemic; Lymphohistiocytosis, Hemophagocytic; Lymphoma, AIDS-Related; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Large-Cell, Anaplastic; Lymphoma, T-Cell; Lymphoproliferative Disorders; Mesothelioma; Mouth Neoplasms; Myelodysplastic-Myeloproliferative Diseases; Myeloproliferative Disorders; Neuroectodermal Tumors, Primitive, Peripheral; Neuroendocrine Tumors; Neuromyelitis Optica; Neuronal Ceroid-Lipofuscinoses; Niemann-Pick Diseases; Osteopetrosis; Osteosarcoma; Pancreatic Neoplasms; Peritoneal Neoplasms; Plasmacytoma; Polyradiculoneuropathy, Chronic Inflammatory Demyelinating; Primary Myelofibrosis; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Purpura, Thrombocytopenic, Idiopathic; Rectal Neoplasms; Sandhoff Disease; Sarcoidosis; Skin Neoplasms; Squamous Intraepithelial Lesions; Takayasu Arteritis; Tay-Sachs Disease; Thalassemia; Thyroid Neoplasms; Tuberculosis; Uterine Cervical Neoplasms; Vasculitis; Wolman Disease; Adenocarcinoma; Amyloidosis; Amyloidosis, Familial; Anemia, Aplastic; Anemia, Refractory; Anemia, Refractory, with Excess of Blasts; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Behcet Syndrome; Bone Marrow Failure Disorders; Brain Neoplasms; Burkitt Lymphoma; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Central Nervous System Neoplasms; Choroid Plexus Neoplasms; Condylomata Acuminata; Ependymoma; Fallopian Tube Neoplasms; Ganglioneuroblastoma; Gestational Trophoblastic Disease; Glomerulonephritis, IGA; Glomerulonephritis, Membranous; Graft vs Host Disease; Granuloma, Lethal Midline; Granulomatosis with Polyangiitis; Idiopathic Pulmonary Fibrosis; Immunoblastic Lymphadenopathy; Infertility; Inflammatory Breast Neoplasms; Kidney Diseases; Kidney Neoplasms; Leukemia; Leukemia, Biphenotypic, Acute; Leukemia, Erythroblastic, Acute; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Megakaryoblastic, Acute; Leukemia, Monocytic, Acute; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Acute; Leukemia, Myelomonocytic, Chronic; Leukemia-Lymphoma, Adult T-Cell; Lung Neoplasms; Lupus Nephritis; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Mantle-Cell; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Peripheral; Medulloblastoma; Melanoma; Menopause; Mesenchymoma; Microscopic Polyangiitis; Multiple Sclerosis; Multiple Sclerosis, Chronic Progressive; Multiple Sclerosis, Relapsing-Remitting; Myelodysplastic Syndromes; Neoplasms, Germ Cell and Embryonal; Neuroblastoma; Neuroectodermal Tumors, Primitive; Neutropenia; Ovarian Neoplasms; Pemphigus; Postoperative Nausea and Vomiting; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Pulmonary Fibrosis; Red-Cell Aplasia, Pure; Renal Insufficiency, Chronic; Retinoblastoma; Rhabdomyosarcoma; Rhabdomyosarcoma, Alveolar; Rhabdomyosarcoma, Embryonal; Sarcoma; Sarcoma, Ewing; Scleritis; Scleroderma, Localized; Scleroderma, Systemic; Small Cell Lung Carcinoma; Squamous Cell Carcinoma of Head and Neck; Testicular Neoplasms; Thrombocytopenia; Triple Negative Breast Neoplasms; Waldenstrom Macroglobulinemia; Wilms Tumor; Breast Neoplasms; Hodgkin Disease; Lymphoma; Multiple Myeloma; Neoplasms; Nephrotic Syndrome
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Head and Neck Neoplasms; Wounds and Injuries; Chronic Pain; Pain
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Anxiety; Cocaine-Related Disorders; Dementia; Depressive Disorder; Schizophrenia; Parkinson Disease
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Glaucoma
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Norepinephrine transporter releasing agent
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Bulimia Nervosa; Kidney Diseases; Liver Diseases; Substance-Related Disorders; Diabetes Mellitus; Obesity, Morbid; Obesity
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Thiazide-sensitive sodium-chloride cotransporter inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: DIABETES DRUGS & ENDOCRINOLOGY; OTHER
THERAPEUTIC INDICATION: Diabetes Mellitus; Lecithin Cholesterol Acyltransferase Deficiency; Kidney Diseases; Atherosclerosis; Coronary Disease; Death, Sudden, Cardiac; Diabetes Mellitus, Type 2; Essential Hypertension; Hypercholesterolemia; Kidney Calculi; Polycystic Kidney, Autosomal Dominant; Pre-Eclampsia; Angina Pectoris; Cardiovascular Diseases; Edema; Glomerulonephritis; Heart Failure; Hypertension; Kidney Failure, Chronic; Liver Cirrhosis; Myocardial Infarction; Nephrotic Syndrome; Toxemia
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Low Back Pain; Pain; Spasm
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Muscarinic acetylcholine receptor M1 antagonist
ROUTE OF ADMINISTRATION: INTRAMUSCULAR
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Hypotension, Orthostatic; Orthostatic Intolerance; Prediabetic State; Amyotrophic Lateral Sclerosis; Blood Coagulation Disorders; Bradycardia; Breast Neoplasms; Heart Arrest; Hemorrhage; Hypospadias; Pneumonia, Ventilator-Associated; Rhinitis, Allergic, Seasonal; Amblyopia; Anisometropia; Dwarfism, Pituitary; Headache; Myopia; Pain; Strabismus; Digestive System Diseases; Mydriasis; Poisoning
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Thiazide-sensitive sodium-chloride cotransporter inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Cardiovascular Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Voltage-gated T-type calcium channel blocker
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Migraine Disorders; Complex Regional Pain Syndromes; Neuralgia; Epilepsy, Absence; Irritable Bowel Syndrome; Seizures; Epilepsy
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Thiazide-sensitive sodium-chloride cotransporter inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Cardiovascular Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Adrenergic receptor alpha-2 agonist
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Synaptic vesicular amine transporter inhibitor
ROUTE OF ADMINISTRATION: INJECTION; ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Amphetamine-Related Disorders; Hypertension, Pulmonary; Cocaine-Related Disorders; Atherosclerosis; Cerebrovascular Disorders; Coronary Disease; Diabetes Mellitus, Type 2; Heart Diseases; Hypercholesterolemia; Hypertension
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Glaucoma; Hypertension
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Bacterial Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Acetylcholinesterase inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Glaucoma
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Cyclooxygenase inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Arthralgia; Eye Diseases; Myalgia; Rheumatic Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Thiazide-sensitive sodium-chloride cotransporter inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Thiazide-sensitive sodium-chloride cotransporter inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Diabetes Mellitus, Type 1; Atherosclerosis; Cerebrovascular Disorders; Coronary Disease; Death, Sudden, Cardiac; Diabetes Mellitus; Diabetes Mellitus, Type 2; Essential Hypertension; Heart Diseases; Hypercholesterolemia; Myocardial Infarction; Myocardial Ischemia; Angina Pectoris; Cardiovascular Diseases; Glomerulonephritis; Heart Failure; Hypertension; Kidney Failure, Chronic; Nephrotic Syndrome; Toxemia