METHYLPHENIDATE HYDROCHLORIDE

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Search structure


Trade Names	ADHANSIA XR APTENSIO XR CONCERTA JORNAY PM METADATE CD METADATE ER METHYLIN METHYLIN ER METHYLPHENIDATE HYDROCHLORIDE QUILLICHEW ER QUILLIVANT XR RITALIN RITALIN LA RITALIN-SR
Synonyms	Adhansia xr Aptensio Aptensio xr Concerta Delmosart Equasym Equasym xl Foquest Jornay pm Matoride xl Medikinet Medikinet xl Metadate Metadate cd Metadate er
Status
Molecule Category	Salt-form
UNII	4B3SC438HI
EPA CompTox	DTXSID8020886
Parent Compound:	METHYLPHENIDATE

Structure


InChI Key	JUMYIBMBTDDLNG-UHFFFAOYSA-N
Smiles	COC(=O)C(c1ccccc1)C1CCCCN1.Cl
InChI	InChI=1S/C14H19NO2.ClH/c1-17-14(16)13(11-7-3-2-4-8-11)12-9-5-6-10-15-12;/h2-4,7-8,12-13,15H,5-6,9-10H2,1H3;1H

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C14H20ClNO2
Molecular Weight	269.77
AlogP	2.09
Hydrogen Bond Acceptor	3.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	3.0
Polar Surface Area	38.33
Molecular species	BASE
Aromatic Rings	1.0
Heavy Atoms	17.0

Pharmacology

Mechanism of Action	Action	Reference
Dopamine transporter inhibitor	INHIBITOR	PubMed DailyMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC06 neurotransmitter transporter family	-	19.9-788	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	19.9-788	-	-	-

Target Conservation


Protein: Norepinephrine transporter Description: Sodium-dependent noradrenaline transporter Organism : Homo sapiens P23975 ENSG00000103546











Protein: Dopamine transporter Description: Sodium-dependent dopamine transporter Organism : Homo sapiens Q01959 ENSG00000142319

Cross References

Resources	Reference
ChEBI	31836
ChEMBL	CHEMBL1722
FDA SRS	4B3SC438HI
KEGG	D07806
SureChEMBL	SCHEMBL41067

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025