METHYLPHENIDATE


Trade Names	COTEMPLA XR-ODT DAYTRANA METHYLPHENIDATE
Synonyms	Concerta Cotempla xr-odt Daytrana Methylin Methylphenidate Methylphenidate extended release Prc-063 Threo-dl-methylphenidate
Status
Molecule Category	Free-form
ATC	N06BA04
UNII	207ZZ9QZ49
EPA CompTox	DTXSID5023299


Active Pharmaceutical Ingredients Bioactive chemicals	Exact Similarity SubStructure	Threshold (%) >= 70


InChI Key	DUGOZIWVEXMGBE-UHFFFAOYSA-N
Smiles	COC(=O)C(c1ccccc1)C1CCCCN1
InChI	InChI=1S/C14H19NO2/c1-17-14(16)13(11-7-3-2-4-8-11)12-9-5-6-10-15-12/h2-4,7-8,12-13,15H,5-6,9-10H2,1H3

Mechanism of Action	Action	Reference
Dopamine transporter inhibitor	INHIBITOR	PubMed DailyMed


Protein: Norepinephrine transporter Description: Sodium-dependent noradrenaline transporter Organism : Homo sapiens P23975 ENSG00000103546











Protein: Dopamine transporter Description: Sodium-dependent dopamine transporter Organism : Homo sapiens Q01959 ENSG00000142319

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC06 neurotransmitter transporter family	-	17-79	-	34-110	-

Assay Description	Organism	Bioactivity
Inhibition of [3H]WIN-35428 Binding to the Dopamine Transporter in Rhesus (Macaca mulatta) orCynomolgus Monkey (Macaca fascicularis) Caudate-Putamen	Cercopithecidae	17.0 nM
Tested for the ability to bind stereoselectively and enantioselectively to the dopamine transporter (DAT); Value ranges from 34 - 83 nM	None	83.0 nM
Ability to inhibit the uptake of dopamine [3H]DA in to rat brain synaptosomes	Rattus norvegicus	438.0 nM
Ability to inhibit the uptake of norepinephrine [3H]-NE in to rat brain synaptosomes	Rattus norvegicus	171.0 nM
Displacement of [125I]RTI-55 from human DAT expressing HEK293 cells	Homo sapiens	110.0 nM
Inhibition of [3H]DA uptake at human DAT expressing HEK293 cells	Homo sapiens	79.0 nM
Displacement of [125I]RTI-55 from human NET expressing HEK293 cells	Homo sapiens	660.0 nM
Inhibition of [3H]NE uptake into human NET expressing HEK293 cells	None	61.0 nM
Displacement of [3H]WIN 35,428 from human DAT expressed in HEK293E cells after 1 hr by liquid scintillation counting	Homo sapiens	34.0 nM
Displacement of [3H]Nisoxetine from human NET expressed in HEK293E cells after 1 hr by liquid scintillation counting	Homo sapiens	340.0 nM

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