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MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Phosphodiesterase 3A inhibitor
ROUTE OF ADMINISTRATION: INJECTION; ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Lung Diseases, Obstructive
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Glucocorticoid receptor agonist
ROUTE OF ADMINISTRATION: FOR RX COMPOUNDING; INJECTION; OPHTHALMIC; OTIC; RECTAL; TOPICAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Vitiligo; Dermatitis, Atopic; Eye Diseases; Hemorrhoids; Inflammation; Pruritus; Skin Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Cardiovascular Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Aldehyde dehydrogenase inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Amphetamine-Related Disorders; Fatigue; HIV Infections; Multiple Myeloma; Neoplasms; Prostatic Neoplasms, Castration-Resistant; Sarcoma; Alcohol-Related Disorders; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Cocaine-Related Disorders; Glioblastoma; Melanoma; Neoplasms, Germ Cell and Embryonal; Opioid-Related Disorders; Pancreatic Neoplasms; Severe Acute Respiratory Syndrome; Alcoholism; Ectoparasitic Infestations
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: INJECTION; ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Astrocytoma; Carcinoma, Merkel Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Fallopian Tube Neoplasms; Gastrointestinal Stromal Tumors; Gliosarcoma; Leukemia, Myeloid, Acute; Melanoma; Myeloproliferative Disorders; Oligodendroglioma; Sandhoff Disease; Tay-Sachs Disease; Toxoplasmosis; Urinary Bladder Neoplasms; Appendiceal Neoplasms; Arthritis, Rheumatoid; Asperger Syndrome; Autistic Disorder; Bile Duct Neoplasms; Breast Neoplasms; Burkitt Lymphoma; Carcinoma, Islet Cell; Central Nervous System Neoplasms; Digestive System Neoplasms; Gestational Trophoblastic Disease; Histiocytosis, Langerhans-Cell; Hodgkin Disease; Lymphoma, AIDS-Related; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Mantle-Cell; Lymphoma, T-Cell, Peripheral; Multiple Myeloma; Myelodysplastic Syndromes; Osteosarcoma; Ovarian Neoplasms; Peripheral Nervous System Diseases; Peritoneal Neoplasms; Sarcoma; Toxoplasmosis, Cerebral; Uveitis; Adenocarcinoma, Mucinous; Biliary Tract Neoplasms; Brain Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Neuroendocrine; Carcinoma, Pancreatic Ductal; Carcinoma, Signet Ring Cell; Cholangiocarcinoma; Choriocarcinoma; Choroid Plexus Neoplasms; Colonic Neoplasms; Colorectal Neoplasms; Colorectal Neoplasms, Hereditary Nonpolyposis; Down Syndrome; Esophageal Neoplasms; Head and Neck Neoplasms; Hydatidiform Mole; Leukemia; Leukemia, Biphenotypic, Acute; Liver Neoplasms; Lymphoma; Lymphoma, Non-Hodgkin; Medulloblastoma; Nasopharyngeal Neoplasms; Neoplasm Metastasis; Neoplasms; Neuroectodermal Tumors, Primitive; Neuroendocrine Tumors; Pancreatic Neoplasms; Pneumonia, Pneumocystis; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Pulmonary Disease, Chronic Obstructive; Rectal Neoplasms; Stomach Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Arthritis, Rheumatoid; Neoplasms; Adenocarcinoma; Biliary Tract Diseases; Biliary Tract Neoplasms; Carcinoma, Hepatocellular; Colonic Neoplasms; Pancreatic Neoplasms; Rectal Neoplasms; Stomach Neoplasms; Colorectal Neoplasms; Nasopharyngeal Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Glucosephosphate Dehydrogenase Deficiency; Malaria; Malaria, Falciparum; Malaria, Vivax
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Tyrosinase inhibitor
ROUTE OF ADMINISTRATION: TOPICAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Bradycardia; Myalgia; Stroke
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Adrenergic receptor alpha-1 agonist
ROUTE OF ADMINISTRATION: INTRAVENOUS; OPHTHALMIC
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Arrhythmias, Cardiac; Cardiovascular Diseases; Infections; Rhinitis; Acute Lung Injury; Stomach Neoplasms; Cataract; Respiratory Tract Infections; Rhinitis, Vasomotor; Common Cold; Hemorrhoids; Hypersensitivity; Hypotension; Nasal Obstruction; Pruritus; Rhinitis, Allergic, Seasonal; Shock, Septic; Sinusitis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Hypertension; Hypotension, Orthostatic; Infections; Mucositis; Neoplasms; Orthostatic Intolerance; Ovarian Cysts; Pain; Stomatitis; Acute Lung Injury; Bronchiolitis; Cognitive Dysfunction; Mydriasis; Shock, Septic; Stress Disorders, Post-Traumatic; Common Cold; Eye Diseases; Fecal Incontinence; Hypotension; Influenza, Human; Ischemic Stroke; Respiratory Tract Infections; Rhinitis, Allergic, Seasonal; Stroke; Cardiovascular Diseases; Eye Manifestations; Nasal Obstruction
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Glucocorticoid receptor agonist
ROUTE OF ADMINISTRATION: FOR RX COMPOUNDING; INJECTION; ORAL; RECTAL; TOPICAL; VAGINAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Diabetes Mellitus, Type 1; Infections; Lymphoma, Large-Cell, Anaplastic; Obesity; Tobacco Use Disorder; Addison Disease; Adrenal Cortex Neoplasms; Aging; Atrial Fibrillation; Borderline Personality Disorder; Central Nervous System Neoplasms; Conjunctivitis, Allergic; Heart Failure; Leukemia, Mast-Cell; Lymphohistiocytosis, Hemophagocytic; Lymphoma, Large B-Cell, Diffuse; Melanoma; Memory Disorders; Multiple Myeloma; Myocardial Infarction; Neoplasms; Opioid-Related Disorders; Pancreatitis; Phobic Disorders; Wounds and Injuries; Adrenal Hyperplasia, Congenital; Adrenal Insufficiency; Alcoholism; Alopecia Areata; Anemia, Refractory; Anemia, Refractory, with Excess of Blasts; Bronchopulmonary Dysplasia; Dermatitis; Eczema; Heart Arrest; Hypotension; Hypoxia; Influenza, Human; Leukemia; Leukemia, Biphenotypic, Acute; Leukemia, Erythroblastic, Acute; Leukemia, Megakaryoblastic, Acute; Leukemia, Monocytic, Acute; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Acute; Leukemia, Myelomonocytic, Chronic; Liver Cirrhosis; Lymphoma; Myelodysplastic Syndromes; Myeloproliferative Disorders; Oral Submucous Fibrosis; Pneumonia, Viral; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Psoriasis; Sepsis; Severe Acute Respiratory Syndrome; Shock, Septic; Asthma; Colitis, Ulcerative; Crohn Disease; Dermatitis, Atopic; Eye Diseases; Hemorrhoids; Herpes Labialis; Inflammation; Nasal Obstruction; Osteoarthritis; Otitis Externa; Pneumonia
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Enoyl-[acyl-carrier-protein] reductase inhibitor
ROUTE OF ADMINISTRATION: INJECTION; ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Melanoma; Acquired Immunodeficiency Syndrome; Diabetic Foot; Meningitis; Tuberculosis, Multidrug-Resistant; Ulcer; HIV Infections; Silicosis; Tuberculosis; Tuberculosis, Pulmonary
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Glucosephosphate Dehydrogenase Deficiency; Obesity; Severe Acute Respiratory Syndrome; Malaria, Falciparum; Malaria, Vivax; Pneumonia, Pneumocystis; Malaria
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Anemia, Sickle Cell; Constipation; Head and Neck Neoplasms; Neck Pain; Osteoarthritis; Wounds and Injuries; Myopia; Toothache; Cough; Pain
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Presbyopia; Mydriasis; Cardiovascular Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Adrenergic receptor alpha antagonist
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Cardiovascular Diseases; Prostatic Neoplasms, Castration-Resistant; Pheochromocytoma
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Opioid receptors; mu/kappa/delta agonist
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Cough; HIV Infections; Migraine Disorders; Pain; Spasm; Substance-Related Disorders
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Bacterial penicillin-binding protein inhibitor
ROUTE OF ADMINISTRATION: INJECTION; ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Psoriasis; Rheumatic Heart Disease; HIV Infections; Syphilis; Yaws; Bacterial Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Muscle-type nicotinic acetylcholine receptor agonist
ROUTE OF ADMINISTRATION: INJECTION
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Sodium channel alpha subunit blocker
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Anemia; Cocaine-Related Disorders; Leukemia; Lymphoma; Neuroblastoma; Anemia, Sickle Cell; Optic Neuritis; Pancreatic Neoplasms; Polyneuropathies; Sarcoma, Ewing; Thalassemia; Wounds and Injuries; Anxiety; Dementia; Depressive Disorder; Schizophrenia; Epilepsy; Seizures
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Bacterial dihydropteroate synthase inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Bacterial Infections; Eye Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Lung Neoplasms; Rectal Neoplasms; Breast Neoplasms; Cerebral Hemorrhage; Heart Diseases; Heart Failure; Neoplasms; Pre-Eclampsia; Stroke; Atherosclerosis; Coronary Disease; Diabetes Mellitus, Type 2; Hypercholesterolemia; Ovarian Neoplasms; Uterine Cervical Neoplasms; Hypertension
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Sodium channel alpha subunit blocker
ROUTE OF ADMINISTRATION: OPHTHALMIC
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Muscarinic acetylcholine receptor M1 antagonist
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Dihydrofolate reductase inhibitor
ROUTE OF ADMINISTRATION: SUBCUTANEOUS
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Fanconi Anemia; HIV Infections; Inflammation; Leukemia, Plasma Cell; Malaria; Melanoma; Scleroderma, Systemic; Severe Acute Respiratory Syndrome; Anemia, Aplastic; Anemia, Diamond-Blackfan; Anemia, Sickle Cell; Blast Crisis; Bone Marrow Failure Disorders; Burkitt Lymphoma; Carcinoma, Merkel Cell; Central Serous Chorioretinopathy; Colitis, Ulcerative; Colorectal Neoplasms; Constriction, Pathologic; Coronary Disease; Ependymoma; Fibromatosis, Aggressive; Hematologic Neoplasms; Histiocytosis, Langerhans-Cell; Immunoblastic Lymphadenopathy; Kidney Neoplasms; Leukemia, Hairy Cell; Leukemia, Large Granular Lymphocytic; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Lymphoid; Leukemia, Myelomonocytic, Juvenile; Leukemia-Lymphoma, Adult T-Cell; Lymphohistiocytosis, Hemophagocytic; Lymphoma, AIDS-Related; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Mantle-Cell; Lymphoma, T-Cell, Peripheral; Mesothelioma; Multiple Myeloma; Myasthenia Gravis; Myelodysplastic-Myeloproliferative Diseases; Myocardial Infarction; Neoplasm Metastasis; Neuroblastoma; Neurofibromatosis 1; Osteopetrosis; Ovarian Neoplasms; Polycythemia Vera; Primary Myelofibrosis; Red-Cell Aplasia, Pure; Retinitis Pigmentosa; Schizophrenia; Severe Combined Immunodeficiency; Sezary Syndrome; Shwachman-Diamond Syndrome; Urticaria; Waldenstrom Macroglobulinemia; Wiskott-Aldrich Syndrome; Alopecia Areata; Anemia, Refractory; Anemia, Refractory, with Excess of Blasts; Arthritis, Psoriatic; Asthma; Brain Neoplasms; Carcinoma, Squamous Cell; Cardiovascular Diseases; Central Nervous System Neoplasms; Choroid Plexus Neoplasms; Crohn Disease; Dermatitis, Atopic; Dermatomyositis; Gestational Trophoblastic Disease; Giant Cell Arteritis; Graft vs Host Disease; Granuloma, Lethal Midline; Granulomatosis with Polyangiitis; Head and Neck Neoplasms; Hearing Loss, Sensorineural; Hodgkin Disease; Hydatidiform Mole; Leukemia; Leukemia, Biphenotypic, Acute; Leukemia, Erythroblastic, Acute; Leukemia, Megakaryoblastic, Acute; Leukemia, Monocytic, Acute; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Leukemia, Myelomonocytic, Acute; Leukemia, Myelomonocytic, Chronic; Leukemia, Promyelocytic, Acute; Liver Cirrhosis, Biliary; Lupus Erythematosus, Systemic; Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Large-Cell, Anaplastic; Macular Edema; Medulloblastoma; Multiple Sclerosis; Myelodysplastic Syndromes; Myeloproliferative Disorders; Neuroectodermal Tumors, Primitive; Osteoarthritis; Osteosarcoma; Pemphigoid, Bullous; Precursor T-Cell Lymphoblastic Leukemia-Lymphoma; Pregnancy, Ectopic; Retroperitoneal Fibrosis; Sarcoidosis; Sarcoma; Spondylitis, Ankylosing; Urethral Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Uveitis; Uveitis, Intermediate; Vasculitis; Vitiligo; Vitreoretinopathy, Proliferative; Adenoma; Arthritis; Arthritis, Juvenile; Arthritis, Rheumatoid; Breast Neoplasms; Choriocarcinoma; Communicable Diseases; Immune System Diseases; Lung Neoplasms; Lymphoma, Non-Hodgkin; Meningeal Carcinomatosis; Mycosis Fungoides; Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Psoriasis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: DNA inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Bacterial Infections; Cystitis; Urinary Tract Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Dihydrofolate reductase inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Amyotrophic Lateral Sclerosis; Leukemia, Lymphocytic, Chronic, B-Cell; Myelodysplastic Syndromes; Sandhoff Disease; Tay-Sachs Disease; Toxoplasmosis, Cerebral; Anemia; Chorioretinitis; Depressive Disorder; HIV Infections; Malaria, Falciparum; Malaria, Vivax; Pneumonia, Pneumocystis; Pregnancy; Premature Birth; Schistosomiasis; Schizophrenia; Toxoplasmosis, Congenital; Malaria; Toxoplasmosis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Dihydrofolate reductase inhibitor
ROUTE OF ADMINISTRATION: INJECTION; ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Precursor Cell Lymphoblastic Leukemia-Lymphoma
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Carbonic anhydrase I inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Andersen Syndrome; Diabetes Mellitus, Type 1; Hypotension, Orthostatic; Melanoma; Schizophrenia; Small Cell Lung Carcinoma; Chronic Pain; Cysticercosis; Helicobacter Infections; Hypertension, Pulmonary; Kidney Diseases; Landau-Kleffner Syndrome; Macular Edema; Multiple Sclerosis; Sleep Apnea, Obstructive; Status Epilepticus; Stroke; Apnea; Carcinoma, Hepatocellular; Hydrocephalus, Normal Pressure; Pseudotumor Cerebri; Altitude Sickness; Edema; Epilepsy; Glaucoma; Glaucoma, Angle-Closure; Heart Failure; Seizures
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: DNA inhibitor
ROUTE OF ADMINISTRATION: INJECTION
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Androgen Receptor agonist
ROUTE OF ADMINISTRATION: INJECTION; SUBCUTANEOUS
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Muscular Dystrophy, Facioscapulohumeral; HIV Wasting Syndrome; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Pulmonary Disease, Chronic Obstructive; Weight Loss; Hypogonadism
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Adrenergic receptor alpha antagonist
ROUTE OF ADMINISTRATION: ORAL; SUBLINGUAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Dementia, Vascular; Fragile X Syndrome; Cardiovascular Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: INJECTION; ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Cerebral Hemorrhage; Heart Failure; Macular Degeneration; Alzheimer Disease; Hypertension
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: INJECTION; ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Blast Crisis; Herpes Simplex; Infections; Coronary Disease; Pyelonephritis; Lead Poisoning