CODEINE PHOSPHATE

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Search structure


Synonyms	Ambenyl cough syrup Bepro Codeine phosphate Codeine phosphate anhydrous Codeine phosphate bp Codeine phosphate cii Codeine phosphate hemihydrate Codeine phosphate hydrate Codeini phosphas Colrex compound Evacode Galcodine Methylmorphine
Status
Molecule Category	Salt-form
UNII	GSL05Y1MN6
EPA CompTox	DTXSID20904612
Parent Compound:	CODEINE

Structure


InChI Key	JPGKFBXFEQWCAI-CCLYOLAMSA-N
Smiles	COc1ccc2c3c1O[C@H]1[C@@H](O)C=C[C@H]4[C@@H](C2)N(C)CC[C@@]341.O.O=P(O)(O)O
InChI	InChI=1S/C18H21NO3.H3O4P.H2O/c1-19-8-7-18-11-4-5-13(20)17(18)22-16-14(21-2)6-3-10(15(16)18)9-12(11)19;1-5(2,3)4;/h3-6,11-13,17,20H,7-9H2,1-2H3;(H3,1,2,3,4);1H2/t11-,12+,13-,17-,18-;;/m0../s1

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C18H26NO8P
Molecular Weight	415.38
AlogP	1.5
Hydrogen Bond Acceptor	4.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	1.0
Polar Surface Area	41.93
Molecular species	BASE
Aromatic Rings	1.0
Heavy Atoms	22.0

Pharmacology

Mechanism of Action	Action	Reference
Opioid receptors; mu/kappa/delta agonist	AGONIST	PubMed PubMed Wikipedia Wikipedia

Target Conservation


Protein: Opioid receptors; mu/kappa/delta Description: Mu-type opioid receptor Organism : Homo sapiens P35372 ENSG00000112038












Protein: Opioid receptors; mu/kappa/delta Description: Delta-type opioid receptor Organism : Homo sapiens P41143 ENSG00000116329










Protein: Opioid receptors; mu/kappa/delta Description: Kappa-type opioid receptor Organism : Homo sapiens P41145 ENSG00000082556

Cross References

Resources	Reference
CAS NUMBER	41444-62-6
ChEMBL	CHEMBL1201099
FDA SRS	GSL05Y1MN6
PubChem	6321303
SureChEMBL	SCHEMBL2515523

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, Volume 54, Issue D1, 6 January 2026, Pages D1397–D1404, https://doi.org/10.1093/nar/gkaf1251

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Last update: Monday, 23^rd March 2026