|
Percent of enzyme inhibition by Glutamate decarboxylase assay method
|
None
|
42.0
%
|
|
|
In vitro inhibition of Mycobacterium tuberculosis H37Rv, determined at 0.2 ug/mL
|
Mycobacterium tuberculosis
|
49.7
%
|
|
|
In vitro inhibition of Mycobacterium tuberculosis H37Rv, determined at 2 ug/mL
|
Mycobacterium tuberculosis
|
59.1
%
|
|
|
In vitro inhibition of Mycobacterium tuberculosis H37Rv, determined at 20 ug/mL
|
Mycobacterium tuberculosis
|
68.7
%
|
|
|
Brain mitochondrial activity measured at 0 min of incubation at 1 uM concentration
|
Rattus norvegicus
|
12.0
%
|
|
|
Brain mitochondrial activity measured at 0 min of incubation at 10 uM concentration
|
Rattus norvegicus
|
14.0
%
|
|
|
Brain mitochondrial activity measured at 0 min of incubation at 100 uM concentration
|
Rattus norvegicus
|
19.0
%
|
|
|
Brain mitochondrial activity measured at 120 min of incubation at 1 uM concentration
|
Rattus norvegicus
|
16.0
%
|
|
|
Brain mitochondrial activity measured at 120 min of incubation at 10 uM concentration
|
Rattus norvegicus
|
16.0
%
|
|
|
Brain mitochondrial activity measured at 120 min of incubation at 100 uM concentration
|
Rattus norvegicus
|
22.0
%
|
|
|
Antimycobacterial activity of compound against Mycobacterium tuberculosis H37Rv at 0.05 ug/mL
|
Mycobacterium tuberculosis
|
95.0
%
|
|
|
Cytotoxicity against Vero cell line
|
Chlorocebus sabaeus
|
62.5
ug.mL-1
|
|
|
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv by BACTEC-460 radiometric assay at 6.25 ug/ml
|
Mycobacterium tuberculosis
|
96.0
%
|
|
|
Antimycobacterial activity against INH-resistant Mycobacterium tuberculosis by agar dilution method at 6.25 ug/ml
|
Mycobacterium tuberculosis
|
90.0
%
|
|
|
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv
|
Mycobacterium tuberculosis
|
100.0
ug.mL-1
|
|
|
Toxicity against non-adherent human PBMC
|
Homo sapiens
|
87.08
ug.mL-1
|
|
|
Toxicity against adherent human PBMC
|
Homo sapiens
|
100.0
ug.mL-1
|
|
|
Antimycobacterial activity against drug-resistant Mycobacterium tuberculosis H37Rv at 1mg/mL by BACTEC assay
|
Mycobacterium tuberculosis
|
100.0
%
|
|
|
Cytotoxicity against Vero cells after 48 hrs by XTT method
|
Chlorocebus sabaeus
|
200.0
ug.mL-1
|
|
|
Inhibition of fatty acid synthesis in Mycobacterium bovis BCG after 60 mins
|
Mycobacterium bovis BCG
|
4.0
ug.mL-1
|
|
|
Inhibition of alpha-mycolic acid synthesis in Mycobacterium bovis BCG after 60 mins
|
Mycobacterium bovis BCG
|
1.851
ug.mL-1
|
|
|
Inhibition of methoxy-mycolic acid synthesis in Mycobacterium bovis BCG after 60 mins
|
Mycobacterium bovis BCG
|
0.63
ug.mL-1
|
|
|
Inhibition of keto-mycolic acid synthesis in Mycobacterium bovis BCG after 60 mins
|
Mycobacterium bovis BCG
|
0.69
ug.mL-1
|
|
|
Antimicrobial activity against Mycobacterium tuberculosis H37Rv at 6.25 ug/ml by alamar blue assay
|
Mycobacterium tuberculosis
|
99.0
%
|
|
|
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 at 6.25 ug/mL by radiometric method
|
Mycobacterium tuberculosis H37Rv
|
99.0
%
|
|
|
Cytotoxicity against african green monkey Vero cells after 48 hrs by MTT assay
|
Chlorocebus sabaeus
|
500.0
ug.mL-1
|
|
|
Antimicrobial activity against Mycobacterium tuberculosis H37Ra by microplate alamar blue assay
|
Mycobacterium tuberculosis H37Ra
|
0.05
ug.mL-1
|
|
|
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 at 6.25 ug/mL by BACTEC 460 radiometric assay
|
Mycobacterium tuberculosis H37Rv
|
99.0
%
|
|
|
Inhibition of Mycobacterium membrane bound ATP synthase
|
Mycobacterium
|
95.0
%
|
|
|
Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay
|
Chlorocebus sabaeus
|
62.5
ug.mL-1
|
|
|
Antitubercular activity against Mycobacterium tuberculosis H37Rv at MIC after 24 hrs by broth microdilution method
|
Mycobacterium tuberculosis H37Rv
|
95.0
%
|
|
|
Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay
|
Chlorocebus sabaeus
|
62.5
ug.mL-1
|
|
|
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv at 6.25 ug/ml by BACTEC 460
|
Mycobacterium tuberculosis H37Rv
|
99.0
%
|
|
|
Antimycobacterial activity against Mycobacterium tuberculosis H37Ra at 1 ug/ml after 6 days by microplate alamar blue assay
|
Mycobacterium tuberculosis H37Ra
|
100.0
%
|
|
|
Antimycobacterial activity against rifampin-resistant Mycobacterium tuberculosis H37Rv at 1 ug/ml by radiometric BACTEC assay
|
Mycobacterium tuberculosis H37Rv
|
100.0
%
|
|
|
Antimycobacterial activity against isoniazid-resistant Mycobacterium tuberculosis H37Rv at 2 ug/ml by radiometric BACTEC assay
|
Mycobacterium tuberculosis H37Rv
|
0.0
%
|
|
|
Antituberculosis activity against Mycobacterium tuberculosis at MIC concentration after 7 days using resazurin dye by broth microdilution assay
|
Mycobacterium tuberculosis
|
95.0
%
|
|
|
Antiinflammatory activity in rat assessed as inhibition of carrageenan-induced paw edema administered orally at dose equivalent to 70 mg/kg ibuprofen after 4 hrs
|
Rattus norvegicus
|
51.62
%
|
|
|
Analgesic activity in po dosed mouse assessed as decrease in tail flick tendency after 4 hrs by tail flick test
|
Mus musculus
|
45.9
%
|
|
|
Antitubercular activity against Mycobacterium bovis BCG at 1 ug/ml after 6 days by microplate alamar blue assay
|
Mycobacterium bovis BCG
|
100.0
%
|
|
|
Antitubercular activity against Mycobacterium tuberculosis H37Ra at 1 ug/ml after 6 days by microplate alamar blue assay
|
Mycobacterium tuberculosis H37Ra
|
100.0
%
|
|
|
Antimycobacterial activity against Mycobacterium tuberculosis after 24 hrs by MTT assay
|
Mycobacterium tuberculosis
|
300.0
nM
|
|
|
Inhibition of Mycobacterium tuberculosis dihydrofolate reductase
|
Mycobacterium tuberculosis
|
1.0
nM
|
|
|
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 assessed as inhibition of bacterial growth at 1 to 100 ug/ml after 7 days by resazurin method
|
Mycobacterium tuberculosis H37Rv
|
95.0
%
|
|
|
Inhibition of albino rat intestine alpha-glucosidase using p-nitrophenyl-alpha-D-glucopyranoside as substrate at 100 uM
|
Rattus norvegicus
|
-39.0
%
|
|
|
Antituberculosis activity against Mycobacterium tuberculosis H37Rv at 250 ug/mL after 24 hrs by Lowenstein-Jensen method
|
Mycobacterium tuberculosis H37Rv
|
99.0
%
|
|
|
Antitubercular activity against Mycobacterium tuberculosis H37Rv infected in Swiss mouse assessed as inhibition of viable bacterial counts in lungs at 25 mg/kg, po for 28 days measured on day 30 post infection
|
Mycobacterium tuberculosis H37Rv
|
99.98
%
|
|
|
Antimicrobial activity against Mycobacterium tuberculosis H37Rv in GASTD medium after 10 days by spectrophotometric analysis
|
Mycobacterium tuberculosis H37Rv
|
70.0
nM
|
|
|
Antimicrobial activity against Mycobacterium tuberculosis H37Rv in GASTD medium supplemented with 100 uM FeCl3 after 10 days by spectrophotometric analysis
|
Mycobacterium tuberculosis H37Rv
|
90.0
nM
|
|
|
Antituberculosis activity against Mycobacterium tuberculosis H37Rv at 6.25 ug/ml by BACTEC MGIT method
|
Mycobacterium tuberculosis H37Rv
|
99.0
%
|
|
|
Growth inhibition of Mycobacterium tuberculosis H37Rv at 6.25 ug/mL after 12 to 28 days relative to control
|
Mycobacterium tuberculosis H37Rv
|
99.0
%
|
|
|
Antitubercular activity against non-replicating Mycobacterium tuberculosis assessed as minimum concentration required to inhibit 90% growth after 10 days under anaerobic condition by luciferase-based low-oxygen recovery assay
|
Mycobacterium tuberculosis
|
84.0
%
|
|
|
Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay
|
Chlorocebus sabaeus
|
62.5
ug.mL-1
|
|
|
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 7 days by microplate alamar blue assay
|
Mycobacterium tuberculosis H37Rv
|
92.0
%
|
|
|
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 10 days by low oxygen recovery assay
|
Mycobacterium tuberculosis H37Rv
|
64.0
%
|
|
|
Inhibition of human liver OATP1B1 expressed in HEK293 Flp-In cells assessed as reduction in E17-betaG uptake at 20 uM by scintillation counting
|
Homo sapiens
|
29.9
%
|
|
|
Inhibition of human liver OATP1B3 expressed in HEK293 Flp-In cells assessed as reduction in [3H]E17-betaG uptake at 20 uM incubated for 5 mins by scintillation counting
|
Homo sapiens
|
18.7
%
|
|
|
Inhibition of human liver OATP2B1 expressed in HEK293 Flp-In cells assessed as reduction in [3H]E3S uptake at 20 uM incubated for 5 mins by scintillation counting
|
Homo sapiens
|
23.8
%
|
|
|
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 7 days by Resazurin assay
|
Mycobacterium tuberculosis H37Rv
|
95.0
%
|
|
|
Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay
|
Chlorocebus sabaeus
|
62.5
ug.mL-1
|
|
|
Antimicrobial activity against Mycobacterium tuberculosis H37Rv by BACTEC MGIT method
|
Mycobacterium tuberculosis H37Rv
|
99.0
%
|
|
|
Antimicrobial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 7 days by MABA
|
Mycobacterium tuberculosis H37Rv
|
100.0
%
|
|
|
Cytotoxicity against Chlorocebus aethiops (African green monkey) Vero cells assessed as inhibition of cell viability after 96 hr by MTT assay
|
Chlorocebus sabaeus
|
12.0
ug.mL-1
|
|
|
Antitubercular activity against Mycobacterium tuberculosis H37Rv MTCC 200 assessed as growth inhibition at 6.25 ug/ml by BACTEC MGIT method
|
Mycobacterium tuberculosis H37Rv
|
99.0
%
|
|
|
Antitubercular activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition at <6.25 ug/ml by primary screen assay
|
Mycobacterium tuberculosis H37Rv
|
99.0
%
|
|
|
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv at 0.2 ug/ml
|
Mycobacterium tuberculosis H37Rv
|
99.0
%
|
|
|
Cytotoxicity against african green monkey Vero cells after 72 hrs by MTT assay
|
Chlorocebus sabaeus
|
62.5
ug.mL-1
|
|
|
Antitubercular activity against Mycobacterium tuberculosis H37Rv by BacTiter-Gl Microbial Cell Viability assay
|
Mycobacterium tuberculosis H37Rv
|
130.0
nM
|
|
|
Antitubercular activity against Mycobacterium tuberculosis H37Rv by microdilution alamar Blue broth assay
|
Mycobacterium tuberculosis H37Rv
|
190.0
nM
|
|
|
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv
|
Mycobacterium tuberculosis H37Rv
|
99.0
%
|
|
|
Cytotoxicity against african green monkey Vero cells after 72 hrs by MTS-PMS assay
|
Chlorocebus sabaeus
|
100.0
ug.mL-1
|
|
|
Inhibition of Mycobacterium tuberculosis pantothenate synthetase cloned in Escherichia coli BL21 (DE3) using ATP, beta-alanine, pantoic acid as substrate assessed as NAD+ production at 100 uM measured every 12 secs for 120 secs by spectrophotometric analysis relative to control
|
Mycobacterium tuberculosis
|
0.0
%
|
|
|
Inhibition of sodium fluorescein uptake in OATP1B1-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM
|
Cricetulus griseus
|
88.4
%
|
|
|
Inhibition of sodium fluorescein uptake in OATP1B3-transfected CHO cells at an equimolar substrate-inhibitor concentration of 10 uM
|
Cricetulus griseus
|
98.94
%
|
|
|
Antimicrobial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 at 1 to 100 ug/ml after 7 days by resazurin assay
|
Mycobacterium tuberculosis H37Rv
|
95.0
%
|
|
|
Antimicrobial activity against Mycobacterium tuberculosis H37Rv after 7 days by BacTiter-Glo assay
|
Mycobacterium tuberculosis H37Rv
|
180.0
nM
|
|
|
Antituberculosis activity against Mycobacterium tuberculosis H37Rv ATCC 27294 assessed as inhibition of bacterial replication after 6 days by luminometry analysis
|
Mycobacterium tuberculosis H37Rv
|
0.04
ug.mL-1
|
|
|
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition by Alamar Blue staining-based broth microdilution assay
|
Mycobacterium tuberculosis H37Rv
|
180.0
nM
|
|
|
Antimycobacterial activity against rifampin-resistant Mycobacterium tuberculosis H37Rv SRI 1367 at MIC after 7 days by broth microdilution assay relative to control
|
Mycobacterium tuberculosis H37Rv
|
92.0
%
|
|
|
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 7 days by microplate Alamar blue assay
|
Mycobacterium tuberculosis H37Rv
|
0.18
ug.mL-1
|
|
|
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 at 0.31 ug/ml after 7 days by microplate Alamar blue assay relative to control
|
Mycobacterium tuberculosis H37Rv
|
92.9
%
|
|
|
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 at 0.63 ug/ml after 7 days by microplate Alamar blue assay relative to control
|
Mycobacterium tuberculosis H37Rv
|
93.9
%
|
|
|
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 at 1.25 to 5 ug/ml after 7 days by microplate Alamar blue assay relative to control
|
Mycobacterium tuberculosis H37Rv
|
94.0
%
|
|
|
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv after 6 days by luciferase reporter gene assay
|
Mycobacterium tuberculosis H37Rv
|
40.0
nM
|
|
|
Antitubercular activity against Mycobacterium tuberculosis H37Rv assessed as inhibition of colony formation at 250 ug/mL after 2 to 4 weeks by Lowensteine-Jensen method relative to control
|
Mycobacterium tuberculosis H37Rv
|
99.0
%
|
|
|
Antitubercular activity against Mycobacterium tuberculosis H37Rv assessed as inhibition of colony formation at 100 ug/mL after 2 to 4 weeks by Lowensteine-Jensen method relative to control
|
Mycobacterium tuberculosis H37Rv
|
99.0
%
|
|
|
Cytotoxicity against African green monkey Vero cells assessed as cell viability after 72 hrs by MTT assay
|
Chlorocebus sabaeus
|
62.5
ug.mL-1
|
|
|
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv by Lowenstein-Jensen slope method
|
Mycobacterium tuberculosis H37Rv
|
99.0
%
|
|
|
Antitubercular activity against Mycobacterium tuberculosis H37Rv strain at 6.25 ug/ml by microplate alamar blue assay
|
Mycobacterium tuberculosis H37Rv
|
99.0
%
|
|
|
Antitubercular activity against Mycobacterium tuberculosis H37Rv at 250 ug/ml
|
Mycobacterium tuberculosis H37Rv
|
99.0
%
|
|
|
Inhibition of Mycobacterium tuberculosis H37Rv isocitrate lyase assessed as glyoxylate phenyl hydrazone formation at 10 uM
|
Mycobacterium tuberculosis H37Rv
|
0.0
%
|
|
|
Antituberculosis activity against Mycobacterium tuberculosis H37Rv assessed as inhibition of colony formation at 250 ug/ml after 4 weeks of incubation
|
Mycobacterium tuberculosis H37Rv
|
99.0
%
|
|
|
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv assessed as growth inhibition by microdilution AlamarBlue broth assay
|
Mycobacterium tuberculosis H37Rv
|
180.0
nM
|
|
|
Inhibition of Mycobacterium smegmatis TMC 607 ATP synthase at 0.3 uM incubated for 10 mins prior to NADH addition measured after 1 hr by luminescence assay
|
Mycobacterium smegmatis
|
0.0
%
|
|
|
Inhibition of Mycobacterium tuberculosis H37Rv ATP synthase assessed as reduction in total ATP content at 0.5 ug/ml after 18 hrs by bead-vortexing settling method
|
Mycobacterium tuberculosis H37Rv
|
78.5
%
|
|
|
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv expressing Lux assessed as reduction in growth measured after 3 weeks by bioluminescence assay
|
Mycobacterium tuberculosis H37Rv
|
330.0
nM
|
|
|
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv infected in mouse bone-marrow derived macrophages assessed as reduction in intracellular colony forming units at 4 times antimycobacterial MIC measured during 3 hrs infection period relative to control
|
Mycobacterium tuberculosis H37Rv
|
93.0
%
|
|
|
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv infected in human blood monocyte derived macrophages assessed as reduction in intracellular colony forming units at 4 times antimycobacterial MIC measured during 3 hrs infection period relative to control
|
Mycobacterium tuberculosis H37Rv
|
84.0
%
|
|
|
Cytotoxicity against PBMC (unknown origin) assessed as reduction in cell viability after 72 hrs by MTT assay
|
Not specified
|
169.0
ug.mL-1
|
|
|
Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability after 72 hrs by MTT assay
|
Mus musculus
|
400.0
ug.mL-1
|
|
|
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv after 6 days by MTT assay
|
Mycobacterium tuberculosis H37Rv
|
220.0
nM
|
|
|
Antimycobacterial activity against isoniazid-resistant Mycobacterium tuberculosis MYC5165 after 6 days by MTT assay
|
Mycobacterium tuberculosis
|
650.0
nM
|
|
|
Antitubercular activity against Mycobacterium tuberculosis H37Rv ATCC 27294 at 6.25 ug/ml after 5 days by microplate Alamar Blue assay
|
Mycobacterium tuberculosis H37Rv
|
100.0
%
|
|
|
Antitubercular activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 5 days by micro alamar blue assay
|
Mycobacterium tuberculosis H37Rv
|
100.0
%
|
|
|
Anti-tubercular activity against rifampicin, isoniazid, ethambutol and pyrazinamide-sensitive dormant phage of Mycobacterium tuberculosis H37Ra ATCC 25177 by serial dilution method
|
Mycobacterium tuberculosis H37Ra
|
0.0023
ug.mL-1
|
|
|
Anti-tubercular activity against rifampicin, isoniazid, ethambutol and pyrazinamide-sensitive active phage of Mycobacterium tuberculosis H37Ra ATCC 25177 by serial dilution method
|
Mycobacterium tuberculosis H37Ra
|
0.0019
ug.mL-1
|
|
|
Anti-tubercular activity against rifampicin, isoniazid, ethambutol and pyrazinamide-sensitive dormant phage of Mycobacterium tuberculosis H37Ra ATCC 25177 infected in human THP1 cells by neutral red assay
|
Mycobacterium tuberculosis H37Ra
|
0.0024
ug.mL-1
|
|
|
Anti-tubercular activity against rifampicin, isoniazid, ethambutol and pyrazinamide-sensitive active phage of Mycobacterium tuberculosis H37Ra ATCC 25177 infected in human THP1 cells by neutral red assay
|
Mycobacterium tuberculosis H37Ra
|
0.0024
ug.mL-1
|
|
|
Antituberculosis activity against Mycobacterium tuberculosis H37Rv MTCC 300 at 6.25 ug/ml after 4 weeks by Lowenstein-Jensen medium method
|
Mycobacterium tuberculosis H37Rv
|
99.0
%
|
|
|
Inhibition of tyrosinase in mouse B16F10 cells assessed as reduction of melanin production at 10 uM relative to control
|
Mus musculus
|
104.0
%
|
|
|
Inhibition of tyrosinase in mouse B16F10 cells assessed as reduction of melanin production at 20 uM relative to control
|
Mus musculus
|
100.0
%
|
|
|
Inhibition of tyrosinase in mouse B16F10 cells assessed as reduction of melanin production at 50 uM relative to control
|
Mus musculus
|
102.0
%
|
|
|
Inhibition of tyrosinase in mouse B16F10 cell lysates using DOPA as substrate relative to control
|
Mus musculus
|
97.0
%
|
|
|
Cytotoxicity against C57BL/6 mouse peritoneal macrophages assessed as cell viability by lactate dehydrogenase release assay
|
Mus musculus
|
100.0
ug.mL-1
|
|
|
Antitubercular activity against Mycobacterium tuberculosis H37Ra ATCC 25177 by XTT Reduction Menadione Assay
|
Mycobacterium tuberculosis H37Ra
|
0.0025
ug.mL-1
|
|
|
Antitubercular activity against Mycobacterium bovis BCG ATCC 35743 after 10 mins by NR assay
|
Mycobacterium bovis BCG
|
0.0023
ug.mL-1
|
|
|
Antitubercular activity against active state Mycobacterium tuberculosis H37Ra assessed as viable cells after 8 days by XTT reduction menadione assay
|
Mycobacterium tuberculosis H37Ra
|
0.0013
ug.mL-1
|
|
|
Antitubercular activity against dormant state Mycobacterium tuberculosis H37Ra assessed as viable cells after 12 days by XTT reduction menadione assay
|
Mycobacterium tuberculosis H37Ra
|
0.0014
ug.mL-1
|
|
|
Antitubercular activity against active state Mycobacterium bovis BCG ATCC 35734 assessed as viable cells after 8 days by nitrate reductase assay
|
Mycobacterium bovis BCG
|
0.0012
ug.mL-1
|
|
|
Antitubercular activity against dormant state Mycobacterium bovis BCG ATCC 35734 assessed as viable cells after 12 days by nitrate reductase assay
|
Mycobacterium bovis BCG
|
0.0017
ug.mL-1
|
|
|
Antitubercular activity against dormant Mycobacterium bovis BCG ATCC 35743 by NR assay
|
Mycobacterium bovis BCG str. ATCC 35743
|
0.0023
ug.mL-1
|
|
|
Antitubercular activity against dormant Mycobacterium tuberculosis H37Ra by XTT reduction menadione assay
|
Mycobacterium tuberculosis H37Ra
|
0.0025
ug.mL-1
|
|
|
Antituberculosis activity against Mycobacterium tuberculosis H37Rv at 250 ug/ml incubated for 24 hrs measured after 2 to 4 weeks by Lowensteine-Jensen method
|
Mycobacterium tuberculosis H37Rv
|
99.0
%
|
|
|
Antimycobacterial activity against rifampicin resistant Mycobacterium tuberculosis H37Rv ATCC 35838 at 1 ug/ml
|
Mycobacterium tuberculosis H37Rv
|
100.0
%
|
|
|
Antimycobacterial activity against Mycobacterium tuberculosis H37Ra assessed as inhibition of mycobacterial replication at 0.05 ug/ml after 6 days by microplate Alamar blue assay in absence of isoniazid
|
Mycobacterium tuberculosis H37Ra
|
10.0
%
|
|
|
Antitubercular activity against dormant Mycobacterium tuberculosis H37Ra after 12 days by XTT-Menadione assay
|
Mycobacterium tuberculosis H37Ra
|
0.0025
ug.mL-1
|
|
|
Antitubercular activity against dormant Mycobacterium bovis BCG after 12 days by nitrate reductase assay
|
Mycobacterium bovis BCG
|
0.0023
ug.mL-1
|
|
|
Antimicrobial activity against Mycobacterium tuberculosis H37Rv ATCC 27294 incubated for 7 days by BacTiter-Glo cell viability assay
|
Mycobacterium tuberculosis H37Rv
|
100.0
nM
|
|
|
Cytotoxicity against mouse RAW264.7 cells assessed as inhibition of cell proliferation at 50 ug/ml after 48 hrs by MTT assay
|
Mus musculus
|
12.16
%
|
|
|
Inhibition of Mycobacterium tuberculosis H37Ra infected in human THP1 cells assessed as reduction in surviving bacteria at 1 ug/ml after 7 days by serial dilution method
|
Mycobacterium tuberculosis H37Ra
|
90.0
%
|
|
|
Inhibition of human MPO
|
Homo sapiens
|
61.0
%
|
|
|
Antitubercular activity against Mycobacterium tuberculosis H37Rv at 6 ug/mL
|
Mycobacterium tuberculosis H37Rv
|
99.0
%
|
|
|
Cytotoxicity against African green monkey Vero cells
|
Chlorocebus sabaeus
|
256.0
ug.mL-1
|
|
|
Antimicrobial activity against Mycobacterium tuberculosis H37Rv by Alamar blue assay
|
Mycobacterium tuberculosis H37Rv
|
180.0
nM
|
|
|
Cytotoxicity against monkey Vero cells assessed as decrease in cell viability after 72 hrs by MTT assay
|
Chlorocebus sabaeus
|
6.25
ug.mL-1
|
|
|
Antitubercular activity against Mycobacterium tuberculosis H37Rv at 50 ug/ml after 5 days by microplate alamar blue assay relative to control
|
Mycobacterium tuberculosis H37Rv
|
95.0
%
|
|
|
Antitubercular activity against Mycobacterium tuberculosis H37Rv at 100 ug/ml by broth microdilution method relative to control
|
Mycobacterium tuberculosis H37Rv
|
99.0
%
|
|
|
Antitubercular activity against Mycobacterium tuberculosis H37Rv ATCC 27294 after 5 days under aerobic condition
|
Mycobacterium tuberculosis H37Rv
|
131.0
nM
|
|
|
Antitubercular activity against luxABCDE expressing Mycobacterium tuberculosis H37Rv infected in human THP1 cells measured after 3 days by luminescence assay
|
Mycobacterium tuberculosis H37Rv
|
190.0
nM
|
|
|
Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 72 hrs by MTT assay
|
Chlorocebus sabaeus
|
200.0
ug.mL-1
|
|
|
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv
|
Mycobacterium tuberculosis H37Rv
|
120.0
nM
|
|
|
Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020); MIC in CAMBH media, using NBS plates, by OD(600)
|
Staphylococcus aureus subsp. aureus
|
8.75
%
|
|
Antibacterial activity against Staphylococcus aureus MRSA ATCC 43300 (CO-ADD:GP_020); MIC in CAMBH media, using NBS plates, by OD(600)
|
Staphylococcus aureus subsp. aureus
|
27.38
%
|
|
|
Antibacterial activity against Escherichia coli ATCC 25922 (CO-ADD:GN_001); MIC in CAMBH media using NBS plates, by OD(600)
|
Escherichia coli
|
0.87
%
|
|
Antibacterial activity against Escherichia coli ATCC 25922 (CO-ADD:GN_001); MIC in CAMBH media using NBS plates, by OD(600)
|
Escherichia coli
|
20.51
%
|
|
|
Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); MIC in CAMBH media using NBS plates, by OD(600)
|
Klebsiella pneumoniae
|
6.54
%
|
|
Antibacterial activity against Klebsiella pneumoniae MDR ATCC 70063 (CO-ADD:GN_003); MIC in CAMBH media using NBS plates, by OD(600)
|
Klebsiella pneumoniae
|
18.82
%
|
|
|
Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 (CO-ADD:GN_042); MIC in CAMBH media using NBS plates, by OD(600)
|
Pseudomonas aeruginosa
|
1.16
%
|
|
Antibacterial activity against Pseudomonas aeruginosa ATCC 27853 (CO-ADD:GN_042); MIC in CAMBH media using NBS plates, by OD(600)
|
Pseudomonas aeruginosa
|
12.59
%
|
|
|
Antibacterial activity against Acinetobacter baumannii ATCC 19606 (CO-ADD:GN_034); MIC in CAMBH media using NBS plates, by OD600
|
Acinetobacter baumannii
|
18.82
%
|
|
Antibacterial activity against Acinetobacter baumannii ATCC 19606 (CO-ADD:GN_034); MIC in CAMBH media using NBS plates, by OD600
|
Acinetobacter baumannii
|
7.52
%
|
|
|
Antifungal activity against Candida albicans ATCC 90028 (CO-ADD:FG_001); MIC in YNB media using NBS plates, by OD630
|
Candida albicans
|
3.95
%
|
|
Antifungal activity against Candida albicans ATCC 90028 (CO-ADD:FG_001); MIC in YNB media using NBS plates, by OD630
|
Candida albicans
|
0.98
%
|
|
|
Antifungal activity against Cryptococcus neoformans H99 ATCC 208821 (CO-ADD:FG_002); MIC in YNB media using NBS plates, by Resazurin OD(600-570)
|
Cryptococcus neoformans
|
-3.6
%
|
|
Antifungal activity against Cryptococcus neoformans H99 ATCC 208821 (CO-ADD:FG_002); MIC in YNB media using NBS plates, by Resazurin OD(600-570)
|
Cryptococcus neoformans
|
-55.93
%
|
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging
|
Homo sapiens
|
22.5
%
|
|
|
Cytotoxicity against human THP1 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay
|
Homo sapiens
|
25.0
ug.mL-1
|
|
|
Antitubercular activity against Mycobacterium tuberculosis H37Ra ATCC 25177 harboring lux gene measured after 7 days by luminometric method
|
Mycobacterium tuberculosis
|
210.0
nM
|
|
|
Antitubercular activity against Mycobacterium tuberculosis H37Ra ATCC 25177 transformed with pSMT1 luciferase reporter plasmid reduction in bacterial multiplication incubated for 7 days by luminometric assay
|
Mycobacterium tuberculosis
|
210.0
nM
|
|
|
Antibacterial activity against Mycobacterium tuberculosis H37Ra ATCC 25177 incubated for 7 days by resazurin dye based fluorimetric assay
|
Mycobacterium tuberculosis
|
250.0
nM
|
|
|
Antimycobacterial activity against Mycobacterium tuberculosis H37Ra lux incubated for 7 days by luminometric assay
|
Mycobacterium tuberculosis
|
110.0
nM
|
|
|
Antimycobacterial activity activity against Mycobacterium tuberculosis H37Rv after 7 days by rezasurin-dye based spectrophotometric analysis
|
Mycobacterium tuberculosis
|
100.0
nM
|
|
|
Antitubercular activity against Mycobacterium tuberculosis H37Rv assessed as reduction in viable colony forming unit at 1000 ug/ml incubated for 42 days by Lowensteine-Jensen method relative to control
|
Mycobacterium tuberculosis
|
99.18
%
|
|
|
Inhibition of InhA in Mycobacterium tuberculosis H37Ra assessed as reduction in mycolic acids synthesis by measuring FAME level at 200 uM incubated for 48 hrs using [14C]acetate by TLC based metabolic labeling assay relative to control
|
Mycobacterium tuberculosis H37Ra
|
100.0
%
|
|
|
Inhibition of InhA in Mycobacterium tuberculosis H37Ra assessed as reduction in mycolic acids synthesis by measuring MAME level at 200 uM incubated for 48 hrs using [14C]acetate by TLC based metabolic labeling assay relative to control
|
Mycobacterium tuberculosis H37Ra
|
100.0
%
|
|
|
Inhibition of recombinant Mycobacterium tuberculosis H37Rv ICL1 expressed in Escherichia coli BL21 (DE3) cells at 10 uM using (+)-potassium Ds-threo-isocitrate as substrate by glyoxylate phenyl hydrazone formation assay relative to control
|
Mycobacterium tuberculosis H37Rv
|
0.0
%
|
|
|
Inhibition of F0F1-ATP synthase in Mycobacterium tuberculosis H37Rv at 6.25 mg/ml using succinate as substrate preincubated for 10 mins followed by substrate addition by luciferase reporter gene assay relative to control
|
Mycobacterium tuberculosis H37Rv
|
99.0
%
|
|
|
Antitubercular activity against Mycobacterium tuberculosis H37Rv RIF-R1 harboring nrpoB S522L mutant after 5 days
|
Mycobacterium tuberculosis
|
150.0
nM
|
|
|
Antitubercular activity against Mycobacterium tuberculosis H37Rv RIF-R2 ATCC 35828 after 5 days
|
Mycobacterium tuberculosis
|
540.0
nM
|
|
|
Antitubercular activity against Mycobacterium tuberculosis H37Rv FQ-R1 harboring gyrB D94N mutant after 5 days
|
Mycobacterium tuberculosis
|
360.0
nM
|
|
|
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20µM by FRET kind of response from peptide substrate
|
Severe acute respiratory syndrome coronavirus 2
|
12.72
%
|
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
0.12
%
|
|
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
|
Chlorocebus sabaeus
|
0.12
%
|
|
|
Inhibition of PGL1 synthesis in Mycobacterium leprae infected Swiss Webster mouse macrophages assessed as decrease in [U-14C]PA incorporation at 20 uM preincubated for 4 days post infection followed by [U-14C]PA addition and measured after 7 days by liquid scintillation counter analysis relative to control
|
Mycobacterium leprae
|
29.0
%
|
|
|
Inhibition of rat bone marrow myeloperoxidase using H2O2 as substrate at 10 uM after 20 mins by TMB based method (Rvb = - 1.4 +/- 12.7%)
|
Rattus norvegicus
|
99.0
%
|
|
|
Inhibition of Electrophorus electricus AChE at 100 uM using acetylthiocholine iodide as substrate preincubated for 30 mins followed by substrate addition and measured after 10 mins by Ellman's method (Rvb = 7 +/- 7.1%)
|
Electrophorus electricus
|
5.8
%
|
|
|
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv assessed as inhibition of bacterial growth at 100 ug/ml preincubated for 72 hrs followed by phAE202 and Cacl2 addition and measured after 4 hrs by by luciferase reporter mycobacterio-phage assay
|
Mycobacterium tuberculosis
|
99.0
%
|
|
|
Cytotoxicity against human PBMC assessed as reduction in cell growth after 72 hrs by MTT assay
|
Homo sapiens
|
71.68
ug.mL-1
|
|
|
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv assessed as inhibition of bacterial growth by microdilution alamar blue broth assay
|
Mycobacterium tuberculosis
|
180.0
nM
|
|
|
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv assessed as percentage inhibition at 250 ug/ml measured after 2 to 4 weeks by Lowensteine-Jensen method relative to control
|
Mycobacterium tuberculosis
|
99.0
%
|
|
|
Antibacterial activity against Mycobacterium tuberculosis H37Ra ATCC2517 assessed as inhibition of bacterial growth measured after 17 hrs by resazurin based flourimetric assay
|
Mycobacterium tuberculosis
|
100.0
nM
|
|
|
Antimycobacterial activity against Mycobacterium bovis BCG assessed as inhibition of bacterial growth at 1 ug/ml measured by microplate alamar blue assay
|
Mycobacterium tuberculosis variant bovis BCG
|
100.0
%
|
|
|
Antimycobacterial activity against Mycobacterium tuberculosis H37Ra assessed as inhibition of bacterial growth at 1 ug/ml measured by microplate alamar blue assay
|
Mycobacterium tuberculosis
|
100.0
%
|
|
