SULFAMETHIZOLE

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Search structure


Trade Names	MICROSUL PROKLAR THIOSULFIL
Synonyms	Methazol Microsul NSC-757327 Proklar Sulfamethizole Sulphamethizole Sulphamethylthiadiazole Tetracid Thiosulfil Urolucosil
Status
Molecule Category	Free-form
ATC	B05CA04 D06BA04 J01EB02 S01AB01
UNII	25W8454H16
EPA CompTox	DTXSID5023615

Structure


InChI Key	VACCAVUAMIDAGB-UHFFFAOYSA-N
Smiles	Cc1nnc(NS(=O)(=O)c2ccc(N)cc2)s1
InChI	InChI=1S/C9H10N4O2S2/c1-6-11-12-9(16-6)13-17(14,15)8-4-2-7(10)3-5-8/h2-5H,10H2,1H3,(H,12,13)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C9H10N4O2S2
Molecular Weight	270.34
AlogP	1.23
Hydrogen Bond Acceptor	6.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	3.0
Polar Surface Area	97.97
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	17.0

Pharmacology

Mechanism of Action	Action	Reference
Bacterial dihydropteroate synthase inhibitor	INHIBITOR	KEGG PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	89.01-100.62

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cricetulus griseus	-	-	-	-	89.01-100.62

Environmental Exposure

Environmental Exposure Map

Countries
Bangladesch

Cross References

Resources	Reference
ChEBI	9331
ChEMBL	CHEMBL1191
DrugBank	DB00576
DrugCentral	2512
FDA SRS	25W8454H16
Human Metabolome Database	HMDB0014715
KEGG	C08050
PharmGKB	PA164781307
PubChem	5328
SureChEMBL	SCHEMBL26453
ZINC	ZINC000000057493

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A. Ross Brown, Charles R. Tyler, and Henri Xhaard. EcoDrugPLUS: An advanced database for drug target conservation analysis and environmental risk assessment. Nucleic Acids Research. In press.

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025