HYDRALAZINE HYDROCHLORIDE

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Search structure


Trade Names	APRESOLINE DRALZINE HYDRALAZINE HYDROCHLORIDE
Synonyms	Apresoline Apressinum Dralzine Hydralazine hcl Hydralazine hydrochloride Hydralazini hydrochloridum MC-1101 NSC-89394
Status
Molecule Category	Salt-form
UNII	FD171B778Y
EPA CompTox	DTXSID1044645
Parent Compound:	HYDRALAZINE

Structure


InChI Key	ZUXNZUWOTSUBMN-UHFFFAOYSA-N
Smiles	Cl.NNc1nncc2ccccc12
InChI	InChI=1S/C8H8N4.ClH/c9-11-8-7-4-2-1-3-6(7)5-10-12-8;/h1-5H,9H2,(H,11,12);1H

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C8H9ClN4
Molecular Weight	196.64
AlogP	0.92
Hydrogen Bond Acceptor	4.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	1.0
Polar Surface Area	63.83
Molecular species	BASE
Aromatic Rings	2.0
Heavy Atoms	12.0

Pharmacology

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Transcription factor Nuclear receptor Nuclear hormone receptor subfamily 1 Nuclear hormone receptor subfamily 1 group I Nuclear hormone receptor subfamily 1 group I member 2	450	-	-	-	-
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC21/SLCO family of organic anion transporting polypeptides	-	-	-	-	87.74-115.08

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Cavia porcellus	-	-	-	-	75
Cricetulus griseus	-	-	-	-	87.74-115.08
Rattus norvegicus	450	-	-	-	20

Cross References

Resources	Reference
CAS NUMBER	304-20-1
ChEBI	31672
ChEMBL	CHEMBL542541
FDA SRS	FD171B778Y
PubChem	9351
SureChEMBL	SCHEMBL36271

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, Volume 54, Issue D1, 6 January 2026, Pages D1397–D1404, https://doi.org/10.1093/nar/gkaf1251

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Last update: Monday, 23^rd March 2026