AMPHETAMINE

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Search structure


Trade Names	ADZENYS ER ADZENYS XR-ODT DYANAVEL XR
Synonyms	Adzenys er Adzenys xr-odt Amfetamin Amfetamine Amphetamine Amphetamine resin complex Amphetamine, dl- Dyanavel Dyanavel xr NSC-27159 Norephedrane
Status
Molecule Category	Free-form
UNII	CK833KGX7E
EPA CompTox	DTXSID4022600

Structure


InChI Key	KWTSXDURSIMDCE-UHFFFAOYSA-N
Smiles	CC(N)Cc1ccccc1
InChI	InChI=1S/C9H13N/c1-8(10)7-9-5-3-2-4-6-9/h2-6,8H,7,10H2,1H3

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C9H13N
Molecular Weight	135.21
AlogP	1.58
Hydrogen Bond Acceptor	1.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	2.0
Polar Surface Area	26.02
Molecular species	BASE
Aromatic Rings	1.0
Heavy Atoms	10.0

Pharmacology

Mechanism of Action	Action	Reference
Dopamine transporter releasing agent	RELEASING AGENT	KEGG PubMed PubMed

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Transporter Electrochemical transporter SLC superfamily of solute carriers SLC06 neurotransmitter transporter family	-	200-960	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Mus musculus	-	-	-	-	0
Rattus norvegicus	-	200-960	-	-	-

Target Conservation


Protein: Norepinephrine transporter Description: Sodium-dependent noradrenaline transporter Organism : Homo sapiens P23975 ENSG00000103546











Protein: Dopamine transporter Description: Sodium-dependent dopamine transporter Organism : Homo sapiens Q01959 ENSG00000142319

Environmental Exposure

Environmental Exposure Map

Countries
Croatia

Cross References

Resources	Reference
ChEBI	132233
ChEMBL	CHEMBL405
DrugBank	DB00182
DrugCentral	195
FDA SRS	CK833KGX7E
Human Metabolome Database	HMDB0014328
Guide to Pharmacology	4804
KEGG	C07514
PubChem	3007
SureChEMBL	SCHEMBL8858

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025