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MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Phosphodiesterase 4 inhibitor
ROUTE OF ADMINISTRATION: DENTAL; TOPICAL
STATUS: Approved
THERAPEUTIC AREA: IMMUNE SYSTEM; OTHER
THERAPEUTIC INDICATION: Stomatitis; Lung Diseases, Obstructive
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Human herpesvirus 1 DNA polymerase inhibitor
ROUTE OF ADMINISTRATION: TOPICAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Herpes Labialis; Virus Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: D2-like dopamine receptor antagonist
ROUTE OF ADMINISTRATION: INTRAMUSCULAR; ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Dyskinesia, Drug-Induced; Lecithin Cholesterol Acyltransferase Deficiency; Mood Disorders; Weight Loss; Amyotrophic Lateral Sclerosis; Anorexia Nervosa; Autistic Disorder; Delirium; Opioid-Related Disorders; Vomiting; Alcoholism; Anorexia; Anxiety; Borderline Personality Disorder; Dementia; Depressive Disorder; Depressive Disorder, Treatment-Resistant; Developmental Disabilities; Feeding and Eating Disorders; Gambling; Genital Neoplasms, Female; Hematologic Neoplasms; Huntington Disease; Intellectual Disability; Nausea; Neoplasms; Postoperative Nausea and Vomiting; Testicular Neoplasms; Weight Gain; Bipolar Disorder; Depressive Disorder, Major; Psychomotor Agitation; Psychotic Disorders; Schizophrenia
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Dopamine transporter releasing agent
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Attention Deficit Disorder with Hyperactivity; Narcolepsy
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Androgen Receptor antagonist
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Prostatic Neoplasms, Castration-Resistant; Neoplasms; Prostatic Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Status Epilepticus; Epilepsy
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Adrenergic receptor alpha-2 antagonist
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: DIABETES DRUGS & ENDOCRINOLOGY; OTHER
THERAPEUTIC INDICATION: Sleep Apnea, Obstructive; Alcoholism; Amphetamine-Related Disorders; Anorexia Nervosa; Cocaine-Related Disorders; Fibromyalgia; Glioma; Substance-Related Disorders; Weight Loss; Anorexia; Anxiety; Cachexia; Child Development Disorders, Pervasive; Dementia; Heroin Dependence; Nausea; Schizophrenia; Depressive Disorder; Depressive Disorder, Major; Sleep Initiation and Maintenance Disorders
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Lysosomal alpha-glucosidase inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: DIABETES DRUGS & ENDOCRINOLOGY; OTHER
THERAPEUTIC INDICATION: Diabetes Mellitus, Type 1; Diabetes Mellitus; Diabetes Mellitus, Type 2
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Myositis, Inclusion Body; Neuroblastoma; Brain Neoplasms; HIV Infections; Maple Syrup Urine Disease; Tuberculosis, Pulmonary; beta-Thalassemia
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Tubulin inhibitor
ROUTE OF ADMINISTRATION: INJECTION; INTRAVENOUS
STATUS: Approved
THERAPEUTIC AREA: CANCER; OTHER; PREGNANCY AND GYNECOLOGY
THERAPEUTIC INDICATION: Breast Neoplasms, Male; Carcinoma, Endometrioid; Carcinoma, Renal Cell; Colonic Neoplasms; Cystadenoma, Serous; Digestive System Diseases; Lymphoma; Multiple Myeloma; Myelodysplastic Syndromes; Myeloproliferative Disorders; Nausea; Sarcoma, Synovial; Vaginal Neoplasms; Vulvar Neoplasms; Adenocarcinoma; Anus Neoplasms; Biliary Tract Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Intraductal, Noninfiltrating; Carcinoma, Neuroendocrine; Carcinoma, Ovarian Epithelial; Carcinoma, Transitional Cell; Colorectal Neoplasms; Gastrointestinal Stromal Tumors; Hereditary Breast and Ovarian Cancer Syndrome; Leiomyosarcoma; Leukemia; Liver Neoplasms; Mediastinal Neoplasms; Melanoma; Osteosarcoma; Pancreatic Neoplasms; Penile Neoplasms; Retroviridae Infections; Salivary Gland Neoplasms; Sarcoma, Ewing; Small Cell Lung Carcinoma; Squamous Cell Carcinoma of Head and Neck; Testicular Neoplasms; Thyroid Carcinoma, Anaplastic; Tonsillar Neoplasms; Triple Negative Breast Neoplasms; Uterine Neoplasms; Adenocarcinoma of Lung; Anorexia; Cachexia; Carcinoma; Carcinoma, Squamous Cell; Endometrial Neoplasms; Esophageal Neoplasms; Fallopian Tube Neoplasms; Fatigue; Genital Neoplasms, Male; Head and Neck Neoplasms; Hypersensitivity; Hypopharyngeal Neoplasms; Inflammatory Breast Neoplasms; Kidney Neoplasms; Laryngeal Neoplasms; Lung Neoplasms; Mouth Neoplasms; Nasopharyngeal Neoplasms; Neoplasm Metastasis; Neutropenia; Oropharyngeal Neoplasms; Ovarian Neoplasms; Paranasal Sinus Neoplasms; Peritoneal Neoplasms; Pharyngeal Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Sarcoma; Stomach Neoplasms; Urethral Neoplasms; Urinary Bladder Neoplasms; Urogenital Neoplasms; Uterine Cervical Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Tubulin inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: IMMUNE SYSTEM
THERAPEUTIC INDICATION: Hookworm Infections; Severe Acute Respiratory Syndrome; Trichuriasis; Cysticercosis; Ectoparasitic Infestations; Elephantiasis, Filarial; Filariasis; HIV Infections; Malaria; Malnutrition; Onchocerciasis; Strongyloidiasis; Toxocariasis; Helminthiasis; Infections; Neurocysticercosis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Hypertension; Acute Kidney Injury; Renal Insufficiency; Cardiovascular Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Diagnostic
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Arthralgia; Myalgia; Rheumatic Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Hyperprolactinemia; Cocaine-Related Disorders; Fibromyalgia; Stroke; Unverricht-Lundborg Syndrome; Restless Legs Syndrome; Parkinson Disease
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Myeloproliferative Disorders; Polycythemia Vera; Thrombocythemia, Essential; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Cytochrome P450 19A1 inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER; PREGNANCY AND GYNECOLOGY
THERAPEUTIC INDICATION: Carcinoma, Non-Small-Cell Lung; Leiomyoma; Lymphoma, Non-Hodgkin; Mesothelioma; Adenomyosis; Adrenal Hyperplasia, Congenital; Anovulation; Carcinoma; Carcinoma, Lobular; Dwarfism; Endometriosis; Fallopian Tube Neoplasms; Gestational Trophoblastic Disease; Hemangiosarcoma; Hepatopulmonary Syndrome; Inflammatory Breast Neoplasms; Leiomyosarcoma; Lymphangioleiomyomatosis; Ovarian Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms; Triple Negative Breast Neoplasms; Uterine Cervical Neoplasms; Uterine Neoplasms; Abortion, Spontaneous; Azoospermia; Carcinoma, Intraductal, Noninfiltrating; Endometrial Neoplasms; Hereditary Breast and Ovarian Cancer Syndrome; Hypogonadism; Infertility; Menopause; Neoplasm Metastasis; Osteoporosis; Ovarian Hyperstimulation Syndrome; Polycystic Ovary Syndrome; Pregnancy; Prostatic Neoplasms, Castration-Resistant; Breast Neoplasms; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Fibromyalgia; Nausea
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Fibromatosis, Aggressive; Ovarian Neoplasms; Prostatic Neoplasms, Castration-Resistant; Severe Acute Respiratory Syndrome; Breast Neoplasms; Fractures, Bone; Mastodynia; Prostatic Intraepithelial Neoplasia; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Cardiovascular Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Otosclerosis; Bone Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Serotonin 1b (5-HT1b) receptor agonist
ROUTE OF ADMINISTRATION: NASAL; ORAL
STATUS: Approved
THERAPEUTIC AREA: NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER
THERAPEUTIC INDICATION: Migraine Disorders
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Carcinoma, Renal Cell; Colorectal Neoplasms; Glioblastoma; Glioma; Lung Neoplasms; Lymphoma; Neoplasms; Pancreatic Neoplasms; Sepsis; Uterine Cervical Neoplasms; Vulvar Neoplasms; Carcinoma, Non-Small-Cell Lung; Lupus Erythematosus, Systemic; Multiple Myeloma; Uterine Cervical Dysplasia; Acquired Immunodeficiency Syndrome; Carcinoma; Diarrhea; HIV Infections; Virus Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Amyotrophic Lateral Sclerosis; Cocaine-Related Disorders; Renal Colic; Substance-Related Disorders; Alzheimer Disease; Bipolar Disorder; Depressive Disorder; Fibromyalgia; Obsessive-Compulsive Disorder; Essential Tremor; Feeding and Eating Disorders; Psychotic Disorders; Restless Legs Syndrome; Schizophrenia; Tourette Syndrome; Parkinson Disease
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Kidney Diseases; Essential Hypertension; Cardiovascular Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Toll-like receptor 7 agonist
ROUTE OF ADMINISTRATION: TOPICAL
STATUS: Approved
THERAPEUTIC AREA: DERMATOLOGY; IMMUNE SYSTEM; OTHER
THERAPEUTIC INDICATION: Astrocytoma; Brain Neoplasms; Carcinoma, Squamous Cell; Colorectal Neoplasms; Diffuse Intrinsic Pontine Glioma; Ependymoma; Glioblastoma; Glioma; Influenza in Birds; Medulloblastoma; Neoplasms; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Sarcoma; Breast Neoplasms; Carcinoma in Situ; Carcinoma, Non-Small-Cell Lung; Cheilitis; Fallopian Tube Neoplasms; Hemangioma; Hepatitis B, Chronic; Keloid; Leukemia; Leukemia, Lymphocytic, Chronic, B-Cell; Liver Cirrhosis; Melanoma; Ovarian Neoplasms; Papillomavirus Infections; Port-Wine Stain; Renal Insufficiency; Uterine Cervical Neoplasms; Anus Neoplasms; Cervical Intraepithelial Neoplasia; Condylomata Acuminata; Influenza, Human; Leishmaniasis, Cutaneous; Lentigo; Paget Disease, Extramammary; Scleroderma, Localized; Squamous Intraepithelial Lesions; Vulvar Neoplasms; Carcinoma, Basal Cell; Keratosis, Actinic; Virus Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Peroxisome proliferator-activated receptor gamma agonist
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Sarcoma; Diabetes Mellitus
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Glucocorticoid receptor agonist
ROUTE OF ADMINISTRATION: TOPICAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Adrenal Hyperplasia, Congenital; Arthritis, Juvenile; Arthritis, Psoriatic; Arthritis, Rheumatoid; Asthma; Bursitis; Colitis, Ulcerative; Conjunctivitis, Allergic; Dermatitis; Dermatitis, Atopic; Dermatitis, Seborrheic; Endocrine System Diseases; Exanthema; Inflammation; Leukemia; Lymphoma; Neoplasms; Osteoarthritis; Pruritus; Psoriasis; Serum Sickness; Skin Diseases; Spondylitis; Tenosynovitis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Cardiovascular Diseases; Depressive Disorder, Major; Diabetes Mellitus, Type 2; Head and Neck Neoplasms; Lupus Erythematosus, Systemic; Asthma; HIV Infections; Heart Diseases; Hypertension, Pulmonary; Intermittent Claudication; Peripheral Vascular Diseases; Pneumonia, Viral; Polycythemia Vera; Pregnancy; Respiratory Insufficiency; Scleroderma, Systemic; Venous Thromboembolism; Acute Coronary Syndrome; Angina, Stable; Aortic Valve Stenosis; Arteriosclerosis; Atherosclerosis; Atrial Fibrillation; Brain Infarction; Carotid Stenosis; Coronary Disease; Gastrointestinal Hemorrhage; Heart Defects, Congenital; Heart Failure; Hemorrhage; Influenza, Human; Intracranial Aneurysm; Intracranial Arteriosclerosis; Ischemia; Ischemic Attack, Transient; Ischemic Stroke; Myocardial Infarction; Peripheral Arterial Disease; Pneumonia; Renal Insufficiency, Chronic; ST Elevation Myocardial Infarction; Severe Acute Respiratory Syndrome; Stroke; Thrombophilia; Vascular Diseases; Thrombosis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Central Nervous System Neoplasms; Glioblastoma; Cardiovascular Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: INTRAPLEURAL
STATUS: Approved
THERAPEUTIC AREA: OTHER; RESPIRATORY
THERAPEUTIC INDICATION: Carcinoma, Non-Small-Cell Lung; Osteoarthritis, Hip; Osteoarthritis, Knee; Radius Fractures; Pleural Effusion
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Alcohol dehydrogenase class I inhibitor
ROUTE OF ADMINISTRATION: INJECTION
STATUS: Approved
THERAPEUTIC AREA: OTHER; PHARMACOLOGY
THERAPEUTIC INDICATION: Macular Degeneration
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Obesity
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Eye Manifestations