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MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Bacterial penicillin-binding protein inhibitor
ROUTE OF ADMINISTRATION: INJECTION; INTRAVENOUS
STATUS: Approved
THERAPEUTIC AREA: GASTROINTESTINAL; NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER
THERAPEUTIC INDICATION: Gram-Negative Bacterial Infections; Pancreatitis; Respiratory Insufficiency; Appendicitis; Communicable Diseases; Hematologic Neoplasms; Tuberculosis; Tuberculosis, Pulmonary; Enterobacteriaceae Infections; Neonatal Sepsis; Pneumonia; Pneumonia, Bacterial; Pneumonia, Ventilator-Associated; Pyelonephritis; Sepsis; Shock, Septic; Urinary Bladder Neoplasms; Bacteremia; Bacterial Infections; Infections; Intraabdominal Infections; Meningitis; Meningitis, Bacterial; Urinary Tract Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Eye Manifestations; Hypersensitivity; Nasal Obstruction
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Hemorrhagic Fever, Ebola; Metabolic Syndrome; Breast Neoplasms; Hepatitis C; Paraplegia; Periodontitis; Atherosclerosis; Diabetes Mellitus; Diabetes Mellitus, Type 2; Hyperlipidemia, Familial Combined; Hyperlipidemias; Hyperlipoproteinemia Type II; Hyperlipoproteinemia Type III; Hyperlipoproteinemia Type IV; Hypertriglyceridemia; Lipid Metabolism Disorders; Cardiovascular Diseases; Coronary Artery Disease; Hypercholesterolemia
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Status Epilepticus; Epilepsy
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Retinoic acid receptor agonist
ROUTE OF ADMINISTRATION: TOPICAL
STATUS: Approved
THERAPEUTIC AREA: DERMATOLOGY; OTHER
THERAPEUTIC INDICATION: Skin Diseases; Acne Vulgaris
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Amblyopia; Central Nervous System Diseases; Skin Diseases; Child Development Disorders, Pervasive; Cocaine-Related Disorders; Delirium; Diabetes Mellitus, Type 2; Fragile X Syndrome; Neuralgia; Supranuclear Palsy, Progressive; Tobacco Use Disorder; Wounds and Injuries; Alzheimer Disease; Anxiety; Aphasia; Cognitive Dysfunction; Dementia, Vascular; Depressive Disorder; Ischemic Stroke; Multiple Sclerosis; Neoplasms; Parkinson Disease; Schizophrenia; Stroke; Dementia
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Dopamine transporter releasing agent
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Attention Deficit Disorder with Hyperactivity; Narcolepsy
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: DNA gyrase inhibitor
ROUTE OF ADMINISTRATION: INJECTION; OPHTHALMIC; ORAL
STATUS: Approved
THERAPEUTIC AREA: EYE; OTHER; UROLOGY AND KIDNEY
THERAPEUTIC INDICATION: Endophthalmitis; Escherichia coli Infections; HIV Infections; Kidney Diseases; Urinary Bladder, Overactive; Appendicitis; Cellulitis; Diabetic Foot; Lymphoma, Non-Hodgkin; Neoplasms; Sarcoidosis; Tuberculosis, Multidrug-Resistant; Cataract; Cystic Fibrosis; Dyspepsia; Endocarditis; Fever; Helicobacter Infections; Hot Flashes; Influenza, Human; Maxillary Sinusitis; Neutropenia; Otitis Media; Pelvic Inflammatory Disease; Pneumonia, Bacterial; Prostatic Hyperplasia; Prostatitis; Pulmonary Disease, Chronic Obstructive; Pyelonephritis; Severe Acute Respiratory Syndrome; Skin Diseases; Staphylococcal Infections; Tuberculosis; Acne Vulgaris; Bacterial Infections; Bronchitis, Chronic; Conjunctivitis, Bacterial; Corneal Ulcer; Eye Infections; Infections; Otitis Externa; Pneumonia; Sinusitis; Urinary Tract Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Prostanoid FP receptor agonist
ROUTE OF ADMINISTRATION: OPHTHALMIC
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Meniere Disease; Vitiligo; Glaucoma; Glaucoma, Open-Angle; Hypertension; Ocular Hypertension
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Dopamine D2 receptor agonist
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: DIABETES DRUGS & ENDOCRINOLOGY; OTHER
THERAPEUTIC INDICATION: Obesity; Substance-Related Disorders; Cocaine-Related Disorders; Endometriosis; Infertility; Paget Disease, Extramammary; Pituitary ACTH Hypersecretion; Diabetes Mellitus; Ovarian Hyperstimulation Syndrome; Restless Legs Syndrome; Parkinson Disease; Pituitary Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Arachidonate 5-lipoxygenase inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER; RESPIRATORY
THERAPEUTIC INDICATION: Anemia, Sickle Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Acne Vulgaris; Idiopathic Pulmonary Fibrosis; Lung Neoplasms; Tobacco Use Disorder; Pulmonary Disease, Chronic Obstructive; Asthma
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Cysteinyl leukotriene receptor 1 antagonist
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER; RESPIRATORY
THERAPEUTIC INDICATION: Breast Neoplasms; Ovarian Neoplasms; Asthma; Lung Diseases, Obstructive
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Premature Birth; Sleep Apnea, Obstructive; Brain Neoplasms; Obesity, Morbid; Respiratory Insufficiency; Ear Neoplasms; Heart Diseases; Neoplasms; Neuralgia, Postherpetic; Opioid-Related Disorders; Pain; Stroke
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Brain Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Ovarian Epithelial; Neuroblastoma; Uterine Cervical Neoplasms; Uterine Neoplasms; Ovarian Neoplasms; Small Cell Lung Carcinoma; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Type-1 angiotensin II receptor antagonist
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: CARDIOVASCULAR; DIABETES DRUGS & ENDOCRINOLOGY; OTHER
THERAPEUTIC INDICATION: Severe Acute Respiratory Syndrome; Acute Coronary Syndrome; Aortic Valve Insufficiency; Cardiomyopathy, Hypertrophic; Nephritis, Hereditary; Peripheral Arterial Disease; Renal Insufficiency, Chronic; Atherosclerosis; Atrial Fibrillation; Chagas Cardiomyopathy; Coronary Disease; Diabetes Mellitus, Type 2; Essential Hypertension; Hypercholesterolemia; Hypertension, Pulmonary; Kidney Diseases; Lipid Metabolism Disorders; Metabolic Syndrome; Non-ST Elevated Myocardial Infarction; ST Elevation Myocardial Infarction; Cardiovascular Diseases; Diabetes Mellitus; Heart Failure; Hypertension; Myocardial Infarction; Stroke; Ventricular Dysfunction, Left
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Antifoaming agent
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: INJECTION
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Argininosuccinic Aciduria; Carbamoyl-Phosphate Synthase I Deficiency Disease; Citrullinemia; Ornithine Carbamoyltransferase Deficiency Disease; Carcinoma, Hepatocellular; Hand-Foot Syndrome; Head and Neck Neoplasms; Pain; Psoriasis; Skin Diseases; Cicatrix; Dermatitis, Atopic; Diabetes Mellitus; Diabetes Mellitus, Type 2; Radiodermatitis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: TOPICAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Diabetic Retinopathy; Dry Eye Syndromes; Glaucoma, Open-Angle; Presbyopia; Ocular Hypertension; Rosacea; Eye Manifestations; Glaucoma
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Sarcoma, Kaposi; Acquired Immunodeficiency Syndrome; HIV Infections; Virus Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Angiotensin-converting enzyme inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: DIABETES DRUGS & ENDOCRINOLOGY; OTHER
THERAPEUTIC INDICATION: Cardiovascular Diseases; Heart Failure; Hypertension; Myocardial Infarction; Ventricular Dysfunction, Left
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Carbonic anhydrase II inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER; PEDIATRICS
THERAPEUTIC INDICATION: Bulimia Nervosa; Cognitive Dysfunction; Hernias, Diaphragmatic, Congenital; Liver Diseases; Alcohol Drinking; Amphetamine-Related Disorders; Brain Ischemia; Deafness; Diabetes Mellitus; Marijuana Abuse; Multiple Sclerosis; Parkinson Disease; Sciatica; Stress Disorders, Post-Traumatic; Alcoholism; Anxiety; Bipolar Disorder; Bulimia; Cocaine-Related Disorders; Dementia; Depressive Disorder; Diabetes Mellitus, Type 2; Epilepsies, Partial; Epilepsy, Tonic-Clonic; Essential Tremor; Gambling; Headache; Hyperlipidemias; Hypertension; Hypertriglyceridemia; Metabolic Syndrome; Obesity; Obsessive-Compulsive Disorder; Pain; Prader-Willi Syndrome; Schizophrenia; Smoking Cessation; Tobacco Use Disorder; Tourette Syndrome; Epilepsy; Lennox Gastaut Syndrome; Migraine Disorders; Seizures
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Melanoma; Muscle Spasticity; Pain
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Kidney Diseases; Communicable Diseases; Hematologic Neoplasms; Enterobacteriaceae Infections; Pyelonephritis; Shock, Septic; Urinary Tract Infections; Bacterial Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: INJECTION
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Bile Duct Neoplasms; Brain Neoplasms; Leukemia; Leukemia, Myeloid, Acute; Lymphoma, T-Cell, Cutaneous; Sarcoma, Synovial; Stomach Neoplasms; Adenocarcinoma; Adenocarcinoma of Lung; Anxiety; Biliary Tract Diseases; Carcinoma, Large Cell; Carcinoma, Ovarian Epithelial; Carcinoma, Renal Cell; Colonic Neoplasms; Colorectal Neoplasms; Digestive System Diseases; Endometrial Neoplasms; Esophageal Neoplasms; Gastrointestinal Stromal Tumors; Head and Neck Neoplasms; Hodgkin Disease; Kidney Neoplasms; Leiomyosarcoma; Leukemia-Lymphoma, Adult T-Cell; Liver Neoplasms; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Mantle-Cell; Lymphoma, T-Cell; Medulloblastoma; Melanoma; Multiple Myeloma; Neoplasms, Germ Cell and Embryonal; Osteosarcoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Prostatic Neoplasms, Castration-Resistant; Rectal Neoplasms; Sarcoma, Ewing; Small Cell Lung Carcinoma; Testicular Neoplasms; Thyroid Neoplasms; Urethral Neoplasms; Biliary Tract Neoplasms; Breast Neoplasms; Carcinoma; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Carcinoma, Squamous Cell; Cholangiocarcinoma; Fallopian Tube Neoplasms; Gallbladder Neoplasms; Granuloma, Lethal Midline; Hepatoblastoma; Immunoblastic Lymphadenopathy; Lung Neoplasms; Lymphoma; Lymphoma, Follicular; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Lymphoma, T-Cell, Peripheral; Mesothelioma; Nasopharyngeal Neoplasms; Neoplasm Metastasis; Ovarian Neoplasms; Pancreatic Neoplasms; Peritoneal Neoplasms; Sarcoma; Triple Negative Breast Neoplasms; Urinary Bladder Neoplasms; Urogenital Neoplasms; Uterine Cervical Neoplasms; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Fasciitis, Plantar; Hernia, Inguinal; Rib Fractures; Appendicitis; Hallux Valgus; Joint Diseases; Leiomyoma; Neoplasms; Osteoarthritis; Postoperative Nausea and Vomiting; Rotator Cuff Injuries; Shoulder Pain; Abdominal Pain; Breast Neoplasms; Chronic Pain; Genital Neoplasms, Male; Hypotension; Knee Injuries; Osteoarthritis, Knee; Ovarian Cysts; Ovarian Neoplasms; Pain; Paralysis; Stomach Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Bacterial DNA gyrase inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: RESPIRATORY
THERAPEUTIC INDICATION: Bacterial Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Betaine-homocysteine S-methyltransferase substrate
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Infertility, Male; Hepatitis C; Hyperoxaluria, Primary; Non-alcoholic Fatty Liver Disease; Obesity; Xerostomia; Depressive Disorder; Homocystinuria
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Arthritis, Rheumatoid; Carcinoma, Non-Small-Cell Lung; Dermatitis, Atopic; Edema; Gastroesophageal Reflux; Rhinitis, Allergic, Perennial; Asthma; Diabetic Nephropathies; Pruritus; Rhinitis, Allergic, Seasonal; Hypersensitivity
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Myositis, Inclusion Body; Neuroblastoma; Brain Neoplasms; HIV Infections; Maple Syrup Urine Disease; Tuberculosis, Pulmonary; beta-Thalassemia
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Cytochrome P450 3A inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: IMMUNE SYSTEM; OTHER; PEDIATRICS
THERAPEUTIC INDICATION: Amyotrophic Lateral Sclerosis; Anus Neoplasms; Erectile Dysfunction; Glioblastoma; Hypertension; Hypertension, Pulmonary; Insulin Resistance; Kidney Diseases; Liver Diseases; Malaria; Neoplasm Metastasis; Respiratory Distress Syndrome; Tuberculosis; Hepatitis B, Chronic; Mycobacterium avium-intracellulare Infection; Neoplasms; Pregnancy; Sarcoma; Sarcoma, Kaposi; Acquired Immunodeficiency Syndrome; Coronavirus Infections; Hepatitis D; Infections; Influenza, Human; Pneumonia; Severe Acute Respiratory Syndrome; HIV Infections; Hepatitis C; Hepatitis C, Chronic; Virus Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Astrocytoma; Bone Neoplasms; Carcinoid Tumor; Diffuse Intrinsic Pontine Glioma; Digestive System Neoplasms; Endometrial Neoplasms; Kidney Neoplasms; Liver Neoplasms; Mesothelioma; Oligodendroglioma; Pulmonary Disease, Chronic Obstructive; Biliary Tract Neoplasms; Carcinoma; Carcinoma, Islet Cell; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Central Nervous System Neoplasms; Fallopian Tube Neoplasms; Ganglioneuroblastoma; Glioblastoma; Glioma; Gliosarcoma; Head and Neck Neoplasms; Hemangiosarcoma; Leukemia; Lymphoma; Lymphoma, Non-Hodgkin; Medulloblastoma; Neuroblastoma; Ovarian Neoplasms; Peritoneal Neoplasms; Pinealoma; Rhabdomyosarcoma; Sarcoma; Triple Negative Breast Neoplasms; Wilms Tumor; Adenocarcinoma, Mucinous; Brain Neoplasms; Breast Neoplasms; Carcinoma, Hepatocellular; Carcinoma, Neuroendocrine; Carcinoma, Pancreatic Ductal; Cholangiocarcinoma; Choroid Plexus Neoplasms; Colonic Neoplasms; Colorectal Neoplasms; Esophageal Neoplasms; Hepatoblastoma; Lung Neoplasms; Neoplasm Metastasis; Pancreatic Neoplasms; Rectal Neoplasms; Sarcoma, Ewing; Small Cell Lung Carcinoma; Stomach Neoplasms; Uterine Cervical Neoplasms; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Human herpesvirus 1 DNA polymerase inhibitor
ROUTE OF ADMINISTRATION: INJECTION
STATUS: Approved
THERAPEUTIC AREA: EYE; IMMUNE SYSTEM; OTHER
THERAPEUTIC INDICATION: Herpes Simplex; Kidney Diseases; Uterine Cervical Neoplasms; Anus Neoplasms; Infections; Papilloma; Sarcoma; Uterine Cervical Dysplasia; Cytomegalovirus Infections; Cytomegalovirus Retinitis; Primary Immunodeficiency Diseases; Virus Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Tinea Pedis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Retinoid receptor agonist
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: HIV Infections; Alzheimer Disease; Dermatitis; Melanoma; Psoriasis