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MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: HERG blocker
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER; RESPIRATORY
THERAPEUTIC INDICATION: Long QT Syndrome; Heart Failure; Arrhythmias, Cardiac; Atrial Fibrillation
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Abdominal Pain; Cleft Palate; Postoperative Complications; Back Pain; Neoplasms; Pain; Pregnancy
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Constipation; Heartburn
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Cyclooxygenase-2 inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: MUSCULOSKELETAL; OTHER
THERAPEUTIC INDICATION: Lupus Erythematosus, Systemic; Dysmenorrhea; Pharyngitis; Toothache; Low Back Pain; Migraine Disorders; Pain; Prostatic Neoplasms; Shoulder Pain; Spondylitis, Ankylosing; Tuberculosis; Arthritis, Juvenile; Arthritis, Rheumatoid; Osteoarthritis; Rheumatic Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Diabetes Mellitus; Bipolar Disorder; Graves Disease; Congenital Hypothyroidism; Hypothyroidism; Lipid Metabolism Disorders
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Human immunodeficiency virus type 1 protease inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Anus Neoplasms; Hepatitis C; Insulin Resistance; Respiratory Distress Syndrome; Tuberculosis; Infections; Pregnancy; Sarcoma, Kaposi; Acquired Immunodeficiency Syndrome; Coronavirus Infections; Influenza, Human; Pneumonia; Severe Acute Respiratory Syndrome; HIV Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Bacterial 70S ribosome inhibitor
ROUTE OF ADMINISTRATION: INTRAVENOUS; ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Burns; Cystic Fibrosis; Hematologic Neoplasms; Meningitis; Abscess; Cellulitis; Gram-Positive Bacterial Infections; Optic Nerve Diseases; Pneumonia, Bacterial; Pneumonia, Pneumococcal; Skin Diseases; Staphylococcal Infections; Syphilis; Tuberculosis; Tuberculosis, Multidrug-Resistant; Tuberculosis, Pulmonary; Bacteremia; Bacterial Infections; Infections; Osteomyelitis; Pneumonia
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Irritable Bowel Syndrome; Digestive System Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Voltage-sensitive sodium channel alpha-subunit blocker
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: TOPICAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Nausea; Communicable Diseases; Acromegaly; Anemia; Arthritis, Psoriatic; Arthritis, Rheumatoid; Burns; Colitis, Ulcerative; Constipation; Eczema; Infections; Multiple Sclerosis; Prostatic Neoplasms; Psoriasis; Spondylitis, Ankylosing
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: INTRAVENOUS
STATUS: Approved
THERAPEUTIC AREA: HEMATOLOGY; OTHER; UROLOGY AND KIDNEY
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Sodium channel alpha subunit blocker
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER
THERAPEUTIC INDICATION: Cocaine-Related Disorders; Hearing Loss, Noise-Induced; Tobacco Use Disorder; Essential Tremor; Hearing Loss; Migraine Disorders; Obesity; Parkinson Disease; Alcoholism; Epilepsy, Complex Partial; Feeding and Eating Disorders; Psychotic Disorders; Schizophrenia; Smoking Cessation; Weight Gain; Epilepsy; Seizures
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: DNA inhibitor
ROUTE OF ADMINISTRATION: INJECTION
STATUS: Approved
THERAPEUTIC AREA: EYE
THERAPEUTIC INDICATION: Central Nervous System Neoplasms; Glioblastoma; Melanoma; Pleural Effusion; Prostatic Neoplasms, Castration-Resistant; Breast Neoplasms; Histoplasmosis; Pancreatic Neoplasms; Basal Cell Nevus Syndrome; Carcinoma, Basal Cell; Macular Degeneration; Myopia, Degenerative; Retinal Neovascularization; Wet Macular Degeneration
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Thrombin inhibitor
ROUTE OF ADMINISTRATION: INJECTION; INTRAVENOUS
STATUS: Approved
THERAPEUTIC AREA: CARDIOVASCULAR; HEMATOLOGY; OTHER
THERAPEUTIC INDICATION: Angina, Unstable; Hemorrhagic Disorders; Ischemic Stroke; Thrombocytopenia; Thrombosis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: OPHTHALMIC
STATUS: Approved
THERAPEUTIC AREA: EYE
THERAPEUTIC INDICATION: Macular Degeneration; Retinitis Pigmentosa; Glaucoma
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Cytochrome P450 inhibitor
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Cholinesterases; ACHE & BCHE inhibitor
ROUTE OF ADMINISTRATION: TRANSDERMAL
STATUS: Approved
THERAPEUTIC AREA: NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER
THERAPEUTIC INDICATION: Amphetamine-Related Disorders; Cocaine-Related Disorders; Down Syndrome; Substance-Related Disorders; Anxiety; Brain Injuries; Cognitive Dysfunction; Delirium; Dementia, Vascular; Depressive Disorder; Neurobehavioral Manifestations; Schizophrenia; Supranuclear Palsy, Progressive; Alzheimer Disease; Dementia; Parkinson Disease
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Sodium channel alpha subunit blocker
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER; PEDIATRICS
THERAPEUTIC INDICATION: Neoplasms; Multiple Sclerosis; Aggression; Anxiety; Dementia; Depressive Disorder; Epilepsies, Partial; Neuralgia; Psychomotor Agitation; Schizophrenia; Epilepsy; Seizures
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Acute Coronary Syndrome; Aspergillosis; Bacterial Infections; Multiple Sclerosis; Diabetes Mellitus, Type 1; Diabetes Mellitus, Type 2; Esophagitis; Gastrinoma; Helicobacter Infections; Prostatic Neoplasms, Castration-Resistant; Schizophrenia; Zollinger-Ellison Syndrome; Barrett Esophagus; Diabetes Mellitus; Esophageal Diseases; Gastrointestinal Hemorrhage; Heart Failure; Hemorrhage; Laryngopharyngeal Reflux; Ulcer; Gastroesophageal Reflux; Peptic Ulcer
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Pain; Periodontitis; Pulpitis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Sulfonylurea receptor 1, Kir6.2 blocker
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Diabetes Mellitus; Diabetes Mellitus, Type 2
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Gastroesophageal Reflux; Malaria, Falciparum; Malaria
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Glucocorticoid receptor antagonist
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: DIABETES DRUGS & ENDOCRINOLOGY; OTHER
THERAPEUTIC INDICATION: Anxiety; Breast Neoplasms, Male; Diabetes Mellitus; Persian Gulf Syndrome; Pregnancy; Prostatic Neoplasms, Castration-Resistant; Adenomyosis; Alcoholism; Alzheimer Disease; Bipolar Disorder; Borderline Personality Disorder; Carcinoma, Non-Small-Cell Lung; Central Serous Chorioretinopathy; Cocaine-Related Disorders; Endometrial Neoplasms; Endometriosis; Fallopian Tube Neoplasms; HIV Infections; Hepatitis C; Ovarian Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms; Stress Disorders, Post-Traumatic; Abortion, Spontaneous; Breast Neoplasms; Depressive Disorder; Depressive Disorder, Major; Leiomyoma; Meningioma; Pituitary ACTH Hypersecretion; Cushing Syndrome
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Envelope glycoprotein inhibitor
ROUTE OF ADMINISTRATION: TOPICAL
STATUS: Approved
THERAPEUTIC AREA: IMMUNE SYSTEM
THERAPEUTIC INDICATION: Herpes Simplex; Virus Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Endometritis; Appendicitis; Renal Insufficiency, Chronic; Tuberculosis; Diabetic Foot; Gonorrhea; Infections; Osteomyelitis; Pneumonia; Pyelonephritis; Urinary Tract Infections; Bacterial Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Histamine H1 receptor antagonist
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: IMMUNE SYSTEM; OTHER; RESPIRATORY
THERAPEUTIC INDICATION: Lecithin Cholesterol Acyltransferase Deficiency; Carcinoma, Non-Small-Cell Lung; Common Cold; Conjunctivitis, Allergic; Dermatitis; Dermatitis, Atopic; Eczema; Multiple Sclerosis, Chronic Progressive; Pruritus; Rhinitis, Allergic, Perennial; Hypersensitivity; Rhinitis, Allergic, Seasonal; Urticaria
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Migraine Disorders
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Hepatitis; HIV Infections; Hepatitis B, Chronic; Hepatitis C, Chronic; Hepatitis D; Liver Cirrhosis, Biliary; Severe Acute Respiratory Syndrome; Virus Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Acute Lung Injury; Carcinoma, Renal Cell; Colorectal Neoplasms; Desmoplastic Small Round Cell Tumor; Fibrosarcoma; Hematologic Neoplasms; Liver Cirrhosis; Lymphoma, Large-Cell, Anaplastic; Lymphoma, Non-Hodgkin; Pancreatic Neoplasms; Rhinitis, Allergic, Seasonal; Thymoma; Arthritis, Rheumatoid; Breast Neoplasms; Chordoma; Colonic Neoplasms; Fibroma; Fibromatosis, Aggressive; Glioblastoma; Hypereosinophilic Syndrome; Leukemia, Myeloid, Acute; Lung Neoplasms; Malaria, Falciparum; Melanoma; Scleroderma, Systemic; Spinal Cord Injuries; Stomach Neoplasms; Thyroid Neoplasms; Tuberculosis; Gastrointestinal Stromal Tumors; Graft vs Host Disease; Hypertension, Pulmonary; Leukemia; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Sarcoma; Severe Acute Respiratory Syndrome; Stroke; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Farnesyl diphosphate synthase inhibitor
ROUTE OF ADMINISTRATION: INJECTION; INTRAVENOUS; IV (INFUSION)
STATUS: Approved
THERAPEUTIC AREA: CANCER; DIABETES DRUGS & ENDOCRINOLOGY; MUSCULOSKELETAL; OTHER
THERAPEUTIC INDICATION: Adenocarcinoma; Anemia, Sickle Cell; Chondrosarcoma; Menopause; Neuroblastoma; Carcinoma, Hepatocellular; Carcinoma, Intraductal, Noninfiltrating; Carcinoma, Renal Cell; Complex Regional Pain Syndromes; Kidney Neoplasms; Leiomyosarcoma; Low Back Pain; Macular Degeneration; Mesothelioma; Nasopharyngeal Neoplasms; Osteosarcoma; Primary Myelofibrosis; Progeria; Urogenital Neoplasms; Uterine Cervical Neoplasms; beta-Thalassemia; Arthritis, Rheumatoid; Bone Diseases, Metabolic; Bone Neoplasms; Breast Neoplasms; Carcinoma, Non-Small-Cell Lung; Fractures, Bone; Giant Cell Tumors; Lung Neoplasms; Lymphoma, Non-Hodgkin; Osteoarthritis, Hip; Osteogenesis Imperfecta; Osteonecrosis; Pain; Plasmacytoma; Reflex Sympathetic Dystrophy; Sarcoma; Sarcoma, Ewing; Spinal Cord Injuries; Bone Diseases; Multiple Myeloma; Neoplasm Metastasis; Osteitis Deformans; Osteoporosis; Osteoporosis, Postmenopausal; Prostatic Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Progesterone receptor agonist
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: HIV Infections; Metrorrhagia; Pregnancy