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MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Hyperpigmentation; Lentigo; Melanosis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Histamine H1 receptor antagonist
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Angioedema; Conjunctivitis, Allergic; Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Rhinitis, Vasomotor; Urticaria
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Diabetes Mellitus, Type 1; Hematologic Neoplasms; Severe Acute Respiratory Syndrome; Acquired Immunodeficiency Syndrome; HIV Infections; Virus Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Hypoglycemia; Helicobacter Infections; Peritonitis; Bacterial Infections
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Constipation; Multiple Sclerosis; Kidney Calculi; Prostatitis; Urinary Bladder, Neurogenic; Urinary Retention; Prostatic Hyperplasia
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Anemia; Angioedemas, Hereditary; Asthma; Carcinoma, Non-Small-Cell Lung; Craniocerebral Trauma; Crohn Disease; Diabetes Mellitus, Type 2; Endotoxemia; Hypertriglyceridemia; Immune System Diseases; Lupus Erythematosus, Systemic; Malaria; Melanoma; Metabolic Diseases; Neoplasms; Non-alcoholic Fatty Liver Disease; Parkinson Disease; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Respiratory Syncytial Virus Infections; Skin Diseases; Amnesia; Arthritis, Rheumatoid; Breast Neoplasms; Burns; Cerebral Hemorrhage; Colitis, Ulcerative; Depressive Disorder; Diabetes Mellitus; Diabetic Neuropathies; Endometrial Hyperplasia; Endometrial Neoplasms; Hepatitis C; Ischemia; Myocardial Infarction; Orthomyxoviridae Infections; Ovarian Neoplasms; Periodontitis; Pre-Eclampsia; Pulmonary Disease, Chronic Obstructive; Rectal Neoplasms; Renal Artery Obstruction; Sepsis; Tuberculosis, Pulmonary; Venous Thromboembolism; Acute Coronary Syndrome; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis; Aortic Valve Stenosis; Atherosclerosis; Cardiomyopathy, Dilated; Colorectal Neoplasms; Coronary Artery Disease; Coronary Disease; HIV Infections; Heart Failure; Hip Fractures; Hypercholesterolemia; Hyperlipidemias; Hyperlipoproteinemia Type II; Hyperlipoproteinemia Type III; Hypertension; Lipid Metabolism Disorders; Metabolic Syndrome; Necrosis; Obesity; Renal Insufficiency; Scleroderma, Systemic; Severe Acute Respiratory Syndrome; Stroke; Cardiovascular Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Central Nervous System Diseases; Depressive Disorder, Major; Obesity; Tobacco Use Disorder; Alcohol Drinking; Alcoholism; Amyotrophic Lateral Sclerosis; Autistic Disorder; Cocaine-Related Disorders; Cognitive Dysfunction; Glioblastoma; Heroin Dependence; Huntington Disease; Lupus Erythematosus, Systemic; Neuralgia; Opioid-Related Disorders; Psychotic Disorders; Trichotillomania; Alzheimer Disease; Anxiety; Bipolar Disorder; Child Development Disorders, Pervasive; Depressive Disorder; Fibromyalgia; Glaucoma, Open-Angle; Ischemic Stroke; Migraine Disorders; Multiple Sclerosis; Obsessive-Compulsive Disorder; Pain; Parkinson Disease; Schizophrenia; Substance-Related Disorders; Tension-Type Headache; Dementia
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Neurokinin 1 receptor antagonist
ROUTE OF ADMINISTRATION: INTRAVENOUS; ORAL
STATUS: Approved
THERAPEUTIC AREA: CANCER; GASTROINTESTINAL; OTHER
THERAPEUTIC INDICATION: Glioblastoma; HIV Infections; Heroin Dependence; Opioid-Related Disorders; Alcoholism; Cocaine-Related Disorders; Gastroparesis; Leukemia, Myeloid, Acute; Marijuana Abuse; Pain; Pruritus; Severe Acute Respiratory Syndrome; Carcinoma, Non-Small-Cell Lung; Depressive Disorder, Major; Multiple Myeloma; Neoplasms, Germ Cell and Embryonal; Vomiting; Nausea; Neoplasms; Postoperative Nausea and Vomiting
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: 26S proteosome inhibitor
ROUTE OF ADMINISTRATION: INJECTION; INTRAVENOUS; SUBCUTANEOUS; UNKNOWN
STATUS: Approved
THERAPEUTIC AREA: CANCER
THERAPEUTIC INDICATION: Anemia, Refractory, with Excess of Blasts; Astrocytoma; Burkitt Lymphoma; Carcinoma, Medullary; Carcinoma, Renal Cell; Carcinoma, Squamous Cell; Fallopian Tube Neoplasms; Glioblastoma; Immunoblastic Lymphadenopathy; Leukemia-Lymphoma, Adult T-Cell; Lymphoma, AIDS-Related; Lymphoma, Large-Cell, Anaplastic; Mycosis Fungoides; Neuroblastoma; Oligodendroglioma; Peritoneal Neoplasms; Sezary Syndrome; Smoldering Multiple Myeloma; Uremia; Adenocarcinoma of Lung; Adenocarcinoma, Bronchiolo-Alveolar; Adenocarcinoma, Follicular; Breast Neoplasms; Bronchiolitis Obliterans; Carcinoma, Adenoid Cystic; Carcinoma, Hepatocellular; Carcinoma, Non-Small-Cell Lung; Carcinoma, Pancreatic Ductal; Castleman Disease; Central Nervous System Neoplasms; Colorectal Neoplasms; Encephalitis, Japanese; Esophageal Neoplasms; Glioma; Gliosarcoma; Graft vs Host Disease; Head and Neck Neoplasms; Hematologic Neoplasms; Hodgkin Disease; Immune System Diseases; Kidney Neoplasms; Leukemia; Leukemia, Biphenotypic, Acute; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myeloid, Acute; Leukemia, Plasma Cell; Leukemia, Promyelocytic, Acute; Lung Neoplasms; Lymphoma, B-Cell, Marginal Zone; Lymphoma, Follicular; Lymphoma, T-Cell, Peripheral; Lymphoproliferative Disorders; Melanoma; Mesothelioma; Myelodysplastic Syndromes; Nasopharyngeal Neoplasms; Neuromyelitis Optica; Ovarian Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Prostatic Neoplasms, Castration-Resistant; Red-Cell Aplasia, Pure; Sarcoma; Stomach Neoplasms; Thyroid Neoplasms; Ureteral Neoplasms; Urethral Neoplasms; Urinary Bladder Neoplasms; Uterine Cervical Neoplasms; Amyloidosis; Amyloidosis, Familial; Cholangiocarcinoma; Immunoglobulin Light-chain Amyloidosis; Lymphoma; Lymphoma, Large B-Cell, Diffuse; Lymphoma, Non-Hodgkin; Plasmacytoma; Precursor Cell Lymphoblastic Leukemia-Lymphoma; Purpura, Thrombocytopenic, Idiopathic; Renal Insufficiency, Chronic; Sarcoma, Myeloid; Waldenstrom Macroglobulinemia; Lymphoma, Mantle-Cell; Multiple Myeloma; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Hypersensitivity
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Dermatitis, Atopic; Tinea Pedis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Epidermal growth factor receptor erbB1 inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: CANCER
THERAPEUTIC INDICATION: Carcinoma, Renal Cell; Nasopharyngeal Neoplasms; Pancreatic Neoplasms; Prostatic Neoplasms; Breast Neoplasms, Male; Carcinoma; Carcinoma, Hepatocellular; Central Nervous System Neoplasms; Colorectal Neoplasms; Esophageal Neoplasms; Fallopian Tube Neoplasms; Glioblastoma; Gliosarcoma; Kidney Neoplasms; Leukemia, Myeloid, Acute; Mesothelioma; Neoplasms, Germ Cell and Embryonal; Neuroblastoma; Ovarian Neoplasms; Peritoneal Neoplasms; Prostatic Neoplasms, Castration-Resistant; Salivary Gland Neoplasms; Sarcoma; Skin Neoplasms; Small Cell Lung Carcinoma; Stomach Neoplasms; Urethral Neoplasms; Uterine Cervical Neoplasms; Uterine Neoplasms; Adenocarcinoma of Lung; Adenocarcinoma, Bronchiolo-Alveolar; Breast Neoplasms; Carcinoma, Squamous Cell; Head and Neck Neoplasms; Lung Neoplasms; Urinary Bladder Neoplasms; Carcinoma, Non-Small-Cell Lung; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Phosphodiesterase 5A inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: NEUROLOGY DRUGS & NERVOUS SYSTEM; OTHER; RESPIRATORY
THERAPEUTIC INDICATION: Astrocytoma; Depressive Disorder, Major; Glioblastoma; Heart Failure; Neoplasms; Carcinoma, Non-Small-Cell Lung; Carcinoma, Squamous Cell; Cushing Syndrome; Dementia, Vascular; Diabetes Mellitus, Type 2; Eisenmenger Complex; Essential Hypertension; Gastroparesis; Hypertension; Multiple Myeloma; Obesity; Pancreatic Neoplasms; Priapism; Scleroderma, Systemic; Sexual Dysfunction, Physiological; Stroke; Glucose Intolerance; Heart Defects, Congenital; Insulin Resistance; Lung Diseases, Interstitial; Muscular Dystrophy, Duchenne; Raynaud Disease; Transposition of Great Vessels; Erectile Dysfunction; Hypertension, Pulmonary; Prostatic Hyperplasia; Pulmonary Arterial Hypertension
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Radioactive metals chelating agent
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Voltage-gated L-type calcium channel blocker
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Acquired Immunodeficiency Syndrome; HIV Infections; Virus Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Rhinitis, Allergic, Perennial; Rhinitis, Allergic, Seasonal; Eye Manifestations; Hypersensitivity
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Human immunodeficiency virus type 1 reverse transcriptase inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Hepatitis C; Insulin Resistance; Tuberculosis; Liver Cirrhosis, Biliary; Acquired Immunodeficiency Syndrome; Hepatitis B, Chronic; Infections; Severe Acute Respiratory Syndrome; HIV Infections; Virus Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Ceramide glucosyltransferase inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Neuronal Ceroid-Lipofuscinoses; Cystic Fibrosis; HIV Infections; Spastic Paraplegia, Hereditary; Gangliosidoses, GM2; Glycogen Storage Disease; Glycogen Storage Disease Type II; Niemann-Pick Disease, Type C; Sandhoff Disease; Gaucher Disease
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Melanoma; Vomiting; Brain Neoplasms; Breast Neoplasms; Glioma; Multiple Myeloma; Stomach Neoplasms; Neoplasms; Postoperative Nausea and Vomiting; Strabismus; Nausea
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Abdominal Pain; Bone Neoplasms; Breast Neoplasms; Hematologic Neoplasms; Multiple Myeloma; Neoplasm Metastasis; Osteonecrosis; Osteoporosis; Osteoporosis, Postmenopausal; Pain; Bone Diseases
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Reperfusion Injury; Cystic Fibrosis; Prostatic Hyperplasia; Raynaud Disease; Tinnitus; Urinary Bladder, Overactive; Hypertension, Pulmonary; Erectile Dysfunction
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Carcinoma, Pancreatic Ductal; Crohn Disease; Diabetes Mellitus; Diabetes Mellitus, Type 2; Propionic Acidemia; Renal Insufficiency, Chronic; Anxiety Disorders; Breast Neoplasms; Clostridium Infections; Cross Infection; Cystic Fibrosis; Heart Failure; Irritable Bowel Syndrome; Lymphoma; Multiple Myeloma; Periodontitis; Prostatic Neoplasms, Castration-Resistant; Thalassemia; Wounds and Injuries; Colorectal Neoplasms; Coronary Disease; Diarrhea; Fetal Growth Retardation; Malnutrition; Mucositis; Multiple Organ Failure; Muscular Dystrophy, Duchenne; Neoplasms; Peripheral Nervous System Diseases; Premature Birth; Sepsis; Severe Acute Respiratory Syndrome; Stomatitis; Anemia, Sickle Cell; Short Bowel Syndrome
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Urinary Incontinence, Urge; Prostatic Hyperplasia; Urinary Bladder, Overactive; Polyuria; Urinary Incontinence
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Alcoholism; Brain Injuries; Hallucinations; Erectile Dysfunction; Parkinson Disease
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Amphetamine-Related Disorders; Autistic Disorder; Tinnitus; Child Development Disorders, Pervasive; Cocaine-Related Disorders; Feeding and Eating Disorders; Fragile X Syndrome; Anxiety; Dementia; Depressive Disorder; Schizophrenia; Alcoholism
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Carcinoma, Squamous Cell; Cheilitis; Uterine Cervical Dysplasia; Acne Vulgaris; Carcinoma, Basal Cell; Keratosis, Actinic; Skin Aging; Neoplasms
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Brain Neoplasms; Lymphoma
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Prostanoid IP receptor agonist
ROUTE OF ADMINISTRATION: INHALATION
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Humeral Fractures; Myocardial Infarction; Heart Arrest; Lung Neoplasms; Multiple Organ Failure; Pulmonary Disease, Chronic Obstructive; Renal Insufficiency, Chronic; Scleroderma, Systemic; Raynaud Disease; Respiratory Distress Syndrome; Shock, Septic; Hypertension, Pulmonary; Pulmonary Arterial Hypertension; Thrombosis
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: OPHTHALMIC
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: DNA inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: IMMUNE SYSTEM; OTHER
THERAPEUTIC INDICATION: Malaria, Vivax; Urethritis; Candidiasis; Helicobacter Infections; Stomach Neoplasms; Amebiasis; Bacterial Infections; Trichomonas Infections; Vaginal Diseases; Vaginosis, Bacterial
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Bacterial 70S ribosome inhibitor
ROUTE OF ADMINISTRATION: ORAL
STATUS: Approved
THERAPEUTIC AREA: IMMUNE SYSTEM; OTHER; RESPIRATORY
THERAPEUTIC INDICATION: Asthma; Maxillary Sinusitis; Otitis Media; Otitis Media, Suppurative; Pharyngitis; Scrub Typhus; Tonsillitis; Bacterial Infections; Infections; Pneumonia
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Diagnostic agent
ROUTE OF ADMINISTRATION: INTRAVENOUS
STATUS: Approved
THERAPEUTIC AREA: OTHER
THERAPEUTIC INDICATION: Unknown
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: DNA inhibitor
ROUTE OF ADMINISTRATION: INJECTION; INTRAVENOUS
STATUS: Approved
THERAPEUTIC AREA: CANCER
THERAPEUTIC INDICATION: Leukemia, Promyelocytic, Acute; Lymphoma, Follicular; Lymphoma, T-Cell; Graft vs Host Disease; Hematologic Diseases; Histiocytosis, Langerhans-Cell; Hodgkin Disease; Leukemia, Lymphocytic, Chronic, B-Cell; Leukemia, Myelogenous, Chronic, BCR-ABL Positive; Leukemia, Myelomonocytic, Chronic; Lymphoma; Lymphoma, Non-Hodgkin; Multiple Myeloma; Myelodysplastic Syndromes; Osteopetrosis; Leukemia; Leukemia, Myeloid, Acute; Neoplasms; Precursor Cell Lymphoblastic Leukemia-Lymphoma
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Urinary Bladder, Overactive; Polyuria; Urinary Incontinence
MOLECULE TYPE: Small molecule
MECHANISMS OF ACTION: Unknown
ROUTE OF ADMINISTRATION: Unknown
STATUS: Approved
THERAPEUTIC AREA: Unknown
THERAPEUTIC INDICATION: Pulmonary Disease, Chronic Obstructive