VARDENAFIL

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Search structure


Synonyms	BAY-389456 BAY38-9456 Levitra Vardenafil Vivanza
Status
Molecule Category	Free-form
ATC	G04BE09
UNII	UCE6F4125H
EPA CompTox	DTXSID3048318

Structure


InChI Key	SECKRCOLJRRGGV-UHFFFAOYSA-N
Smiles	CCCc1nc(C)c2c(=O)nc(-c3cc(S(=O)(=O)N4CCN(CC)CC4)ccc3OCC)[nH]n12
InChI	InChI=1S/C23H32N6O4S/c1-5-8-20-24-16(4)21-23(30)25-22(26-29(20)21)18-15-17(9-10-19(18)33-7-3)34(31,32)28-13-11-27(6-2)12-14-28/h9-10,15H,5-8,11-14H2,1-4H3,(H,25,26,30)

Physicochemical Descriptors

Property Name	Value
Molecular Formula	C23H32N6O4S
Molecular Weight	488.61
AlogP	2.07
Hydrogen Bond Acceptor	8.0
Hydrogen Bond Donor	1.0
Number of Rotational Bond	8.0
Polar Surface Area	112.9
Molecular species	NEUTRAL
Aromatic Rings	3.0
Heavy Atoms	34.0

Pharmacology

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Phosphodiesterase Phosphodiesterase 1 Phosphodiesterase 1A	-	230-300	-	-	-
Enzyme Phosphodiesterase Phosphodiesterase 1 Phosphodiesterase 1B	-	230-300	-	-	-
Enzyme Phosphodiesterase Phosphodiesterase 1 Phosphodiesterase 1C	-	230-300	-	-	-
Enzyme Phosphodiesterase Phosphodiesterase 10 Phosphodiesterase 10A	-	790-880	-	-	-
Enzyme Phosphodiesterase Phosphodiesterase 11 Phosphodiesterase 11A	-	130-240	-	-	-
Enzyme Phosphodiesterase Phosphodiesterase 3 Phosphodiesterase 3A	-	580	-	-	-
Enzyme Phosphodiesterase Phosphodiesterase 3 Phosphodiesterase 3B	-	580	-	-	-
Enzyme Phosphodiesterase Phosphodiesterase 5 Phosphodiesterase 5A	-	0.029-1	-	0.7-1	-
Enzyme Phosphodiesterase Phosphodiesterase 6 Phosphodiesterase 6A	-	1-11	-	-	-
Enzyme Phosphodiesterase Phosphodiesterase 6 Phosphodiesterase 6B	-	1-11	-	-	-
Enzyme Phosphodiesterase Phosphodiesterase 6 Phosphodiesterase 6C	-	1-11	-	-	-
Enzyme Phosphodiesterase Phosphodiesterase 6 Phosphodiesterase 6D	-	1-11	-	-	-
Enzyme Phosphodiesterase Phosphodiesterase 6 Phosphodiesterase 6G	-	1-11	-	-	-
Enzyme Phosphodiesterase Phosphodiesterase 6 Phosphodiesterase 6H	-	1-11	-	-	-
Enzyme Phosphodiesterase Phosphodiesterase 9 Phosphodiesterase 9A	-	460-680	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Homo sapiens	-	0.029-880	-	0.7-1	-

Cross References

Resources	Reference
ChEBI	46295
ChEMBL	CHEMBL1520
DrugBank	DB00862
DrugCentral	2809
FDA SRS	UCE6F4125H
Human Metabolome Database	HMDB0015000
Guide to Pharmacology	7320
PDB	VDN
PharmGKB	PA10229
PubChem	135400189
SureChEMBL	SCHEMBL5772
ZINC	ZINC000018324776

CONTENTS

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025