SOLIFENACIN

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Synonyms
Status
Molecule Category Free-form
ATC G04BD08
UNII A8910SQJ1U
EPA CompTox DTXSID3048289

Structure

InChI Key FBOUYBDGKBSUES-VXKWHMMOSA-N
Smiles O=C(O[C@H]1CN2CCC1CC2)N1CCc2ccccc2[C@@H]1c1ccccc1
InChI
InChI=1S/C23H26N2O2/c26-23(27-21-16-24-13-10-18(21)11-14-24)25-15-12-17-6-4-5-9-20(17)22(25)19-7-2-1-3-8-19/h1-9,18,21-22H,10-16H2/t21-,22-/m0/s1

Physicochemical Descriptors

Property Name Value
Molecular Formula C23H26N2O2
Molecular Weight 362.47
AlogP 3.86
Hydrogen Bond Acceptor 3.0
Number of Rotational Bond 2.0
Polar Surface Area 32.78
Molecular species BASE
Aromatic Rings 2.0
Heavy Atoms 27.0

Pharmacology

Targets EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Ion channel Voltage-gated ion channel Potassium channels Voltage-gated potassium channel
- 251.19 - - -
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Acetylcholine receptor
- 24 - 10-128.82 -
EC50(nM) IC50(nM) Kd(nM) Ki(nM) Inhibition(%)
Homo sapiens
- 24 - 13.18-128.82 -
Rattus norvegicus
- - - 10-120 -

Cross References

Resources Reference
ChEBI 135530
ChEMBL CHEMBL1734
DrugBank DB01591
DrugCentral 2457
FDA SRS A8910SQJ1U
Guide to Pharmacology 7483
PubChem 154059
SureChEMBL SCHEMBL188493
ZINC ZINC000003936683
CONTENTS