EcoDrugPlus


Synonyms	Factiv Gemifloxacin
Status
Molecule Category	Free-form
ATC	J01MA15
UNII	OKR68Y0E4T
EPA CompTox	DTXSID3048495


InChI Key	ZRCVYEYHRGVLOC-HYARGMPZSA-N
Smiles	CO/N=C1\CN(c2nc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)CC1CN
InChI	InChI=1S/C18H20FN5O4/c1-28-22-14-8-23(6-9(14)5-20)17-13(19)4-11-15(25)12(18(26)27)7-24(10-2-3-10)16(11)21-17/h4,7,9-10H,2-3,5-6,8,20H2,1H3,(H,26,27)/b22-14+

Property Name	Value
Molecular Formula	C18H20FN5O4
Molecular Weight	389.39
AlogP	0.97
Hydrogen Bond Acceptor	8.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	5.0
Polar Surface Area	123.04
Molecular species	ZWITTERION
Aromatic Rings	2.0
Heavy Atoms	28.0

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Isomerase	-	300-500	-	-	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Escherichia coli	-	500	-	-	-
Staphylococcus aureus	-	300-400	-	-	-

Resources	Reference
ChEBI	101853
ChEMBL	CHEMBL430
DrugBank	DB01155
DrugCentral	1286
FDA SRS	OKR68Y0E4T
Human Metabolome Database	HMDB0015286
PubChem	9571107
SureChEMBL	SCHEMBL136633

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

This work is licensed under Creative Commons Attribution-ShareAlike 4.0 International License

Last update: Monday, 3 November 2025

GEMIFLOXACIN

Structure

Physicochemical Descriptors

Pharmacology

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