ALFUZOSIN


Synonyms	Alfuzosin NSC-760065 Uroxatral
Status
Molecule Category	Free-form
ATC	G04CA01
UNII	90347YTW5F
EPA CompTox	DTXSID6048549


InChI Key	WNMJYKCGWZFFKR-UHFFFAOYSA-N
Smiles	COc1cc2nc(N(C)CCCNC(=O)C3CCCO3)nc(N)c2cc1OC
InChI	InChI=1S/C19H27N5O4/c1-24(8-5-7-21-18(25)14-6-4-9-28-14)19-22-13-11-16(27-3)15(26-2)10-12(13)17(20)23-19/h10-11,14H,4-9H2,1-3H3,(H,21,25)(H2,20,22,23)

Property Name	Value
Molecular Formula	C19H27N5O4
Molecular Weight	389.46
AlogP	1.35
Hydrogen Bond Acceptor	8.0
Hydrogen Bond Donor	2.0
Number of Rotational Bond	8.0
Polar Surface Area	111.83
Molecular species	NEUTRAL
Aromatic Rings	2.0
Heavy Atoms	28.0

Targets	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Enzyme Hydrolase	-	18	-	-	-
Membrane receptor Family A G protein-coupled receptor Small molecule receptor (family A GPCR) Monoamine receptor Adrenergic receptor	-	-	4.898-218.78	2.8-23	-

	EC50(nM)	IC50(nM)	Kd(nM)	Ki(nM)	Inhibition(%)
Bos taurus	-	-	-	23	-
Canis lupus familiaris	-	-	134.9-218.78	-	-
Homo sapiens	-	18	-	2.8-8.2	-
Rattus norvegicus	-	-	4.898-24.55	3.5	-
hamster	-	-	-	12	-

Header

Compound Name

Maximum Phase

Compound Structure

Smile

Inchi

InchiKey

Compound Properties

Molecular Formula

Molecular Weight

ALogP

PSA

Resources	Reference
ChEBI	51141
ChEMBL	CHEMBL709
DrugBank	DB00346
DrugCentral	115
FDA SRS	90347YTW5F
Human Metabolome Database	HMDB0014490
Guide to Pharmacology	7109
PharmGKB	PA164774795
PubChem	2092
SureChEMBL	SCHEMBL34477

EcoDrug+ was developed under the PREMIER Innovative Medicines Initiative 2 Joint Undertaking (JU) under grant agreement No 875508. The JU receives support from the EU’s Horizon 2020 research and innovation programme and the European Federation of Pharmaceutical Industries and Associations (EFPIA). The views reflect only the authors’ perspective and the JU is not responsible for any use that may be made of the information EcoDrug+ contains.

Elements of EcoDrug+ were developed under the Biocenter Finland Drug Discovery and Chemical Biology network. CSC-IT Center for Science Ltd is thanked for providing computational resources. Credit is given to Ensembl for collecting species images (provided under public domain licences such as Wikimedia and NHGRI).

Content of EcoDrug+ is provided without guarantee for correctness.

Cite Us:

Ashenafi Legehar, Siobhán Monaghan, Mael Briand, Akseli Niemelä, Leo Ghemtio, Ziaurrehman Tanoli, A Ross Brown, Charles R Tyler, Henri Xhaard, EcoDrug PLUS: an advanced database for drug target conservation analysis and environmental risk assessment, Nucleic Acids Research, 2025, gkaf1251 Read...

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Last update: Monday, 3 November 2025

ALFUZOSIN

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Pharmacology

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